Research Topics
Genomes and Genes | Reetta HuttunenSummaryAffiliation: University of Tampere Country: Finland Publications
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Publications
Case fatality associated with a hypervirulent strain in patients with culture-positive Clostridium difficile infection: a retrospective population-based studyReetta Huttunen
Department of Internal Medicine, Tampere University Hospital, Box 2000, FI 33521 Tampere, Finland
Int J Infect Dis 16:e532-5. 2012..The epidemiology of C. difficile infection (CDI) is changing, with evidence of increased incidence and severity. The first patient with a hypervirulent strain type in Pirkanmaa Hospital District, Finland was reported in September 2008...- Apoptosis markers soluble Fas (sFas), Fas Ligand (FasL) and sFas/FasL ratio in patients with bacteremia: a prospective cohort studyReetta Huttunen
Department of Internal Medicine, Tampere University Hospital, Box 2000, FI 33521 Tampere, Finland
J Infect 64:276-81. 2012..Monitoring apoptosis on a routine basis in septic patients has proved challenging. We here studied the prognostic value of apoptosis markers human soluble Fas (sFas), Fas ligand (FasL) and sFas/FasL ratio in patients with bacteremia... - New concepts in the pathogenesis, diagnosis and treatment of bacteremia and sepsisReetta Huttunen
Department of Internal Medicine, Tampere University Hospital, Box 2000, FI 33521 Tampere, Finland
J Infect 63:407-19. 2011..Treatment options currently under way are targeted to enhance immune responses, rebalance the regulation of the dysregulated immune system, remove endotoxin and block/inhibit apoptosis... 
Fatal outcome in bacteremia is characterized by high plasma cell free DNA concentration and apoptotic DNA fragmentation: a prospective cohort studyReetta Huttunen
Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
PLoS ONE 6:e21700. 2011..Recent studies have shown that apoptosis plays a critical role in the pathogenesis of sepsis. High plasma cell free DNA (cf-DNA) concentrations have been shown to be associated with sepsis outcome. The origin of cf-DNA is unclear...- High plasma level of long pentraxin 3 (PTX3) is associated with fatal disease in bacteremic patients: a prospective cohort studyReetta Huttunen
Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
PLoS ONE 6:e17653. 2011..Like C-reactive protein (CRP), it belongs to the pentraxin superfamily. Recent studies indicate that high levels of PTX3 may be associated with mortality in sepsis. The prognostic value of plasma PTX3 in bacteremic patients is unknown... - Smoking and the outcome of infectionR Huttunen
Department of Internal Medicine, Tampere University Hospital, University of Tampere Medical School, Tampere, Finland
J Intern Med 269:258-69. 2011..g. potential dose-dependent effects and the interactions between smoking and other environmental factors that may affect the course of infectious diseases) remain to be established... - High activity of indoleamine 2,3 dioxygenase enzyme predicts disease severity and case fatality in bacteremic patientsReetta Huttunen
Department of Internal Medicine, Tampere University Hospital, University of Tampere Medical School, University of Tampere, Tampere, Finland
Shock 33:149-54. 2010..The data in this report demonstrate that IDO activity is markedly increased in bacteremia patients, constituting an independent predictor of severe disease and case fatality... - Endothelial nitric oxide synthase G894T (GLU298ASP) polymorphism is associated with hypotension in patients with E. coli bacteremia but not in bacteremia caused by a gram-positive organismReetta Huttunen
Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
Shock 31:448-53. 2009..Carriage of the T allele of the eNOS gene is a risk factor for hypotension in patients with E. coli bacteremia but not in bacteremia caused by a gram-positive organism... - Gene-environment interaction between MBL2 genotype and smoking, and the risk of gram-positive bacteraemiaR Huttunen
Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
Scand J Immunol 68:438-44. 2008.... - Obesity and smoking are factors associated with poor prognosis in patients with bacteraemiaReetta Huttunen
Department of Internal Medicine, Tampere University Hospital, PL 2000, FIN 33521 Tampere, Finland
BMC Infect Dis 7:13. 2007..Bacteraemia is still a major cause of case fatality in all age groups. Our aim was to identify the major underlying conditions constituting risk factors for case fatality in bacteraemia patients... - Plasma level of soluble urokinase-type plasminogen activator receptor as a predictor of disease severity and case fatality in patients with bacteraemia: a prospective cohort studyR Huttunen
Department of Internal Medicine, Tampere University Hospital, University of Tampere Medical School, University of Tampere, Tampere, Finland
J Intern Med 270:32-40. 2011..Previous studies indicate that a high plasma concentration of the soluble form of the receptor (suPAR) predicts poor outcome in infectious diseases... 
Polymorphism of the C-reactive protein gene is associated with mortality in bacteraemiaCarita Eklund
Department of Microbiology and Immunology, University of Tampere Medical School, Finland
Scand J Infect Dis 38:1069-73. 2006..These results suggest that mortality from Streptococcus pneumoniae may be associated with polymorphism of the promoter region of the CRP gene...- Methicillin-resistant Staphylococcus aureus epidemic restricted to one health district in Finland: a population-based descriptive study in Pirkanmaa, Finland, years 2001-2011Janne Laine
Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
Scand J Infect Dis 45:45-53. 2013..The incidence of methicillin-resistant Staphylococcus aureus (MRSA) has been low in the Scandinavian countries, including Finland...