Heikki Huikuri

Summary

Affiliation: University of Oulu
Country: Finland

Publications

  1. ncbi The effect of bone marrow microenvironment on the functional properties of the therapeutic bone marrow-derived cells in patients with acute myocardial infarction
    Johanna A Miettinen
    Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu, Oulu FIN 90014, Finland
    J Transl Med 10:66. 2012
  2. ncbi Association of the beta-1 adrenergic receptor carboxyl terminal variants with left ventricular hypertrophy among diabetic and non-diabetic survivors of acute myocardial infarction
    Anna E Hakalahti
    Institute of Biomedicine, Department of Anatomy and Cell Biology, University of Oulu, PO Box 5000, FI 90014 Oulu, Finland
    Cardiovasc Diabetol 9:42. 2010
  3. ncbi Prediction of fatal or near-fatal cardiac arrhythmia events in patients with depressed left ventricular function after an acute myocardial infarction
    Heikki V Huikuri
    Department of Internal Medicine, University of Oulu, PO Box 5000, Kajaanintie 50, 90014 Oulu, Finland
    Eur Heart J 30:689-98. 2009
  4. ncbi Effects of intracoronary injection of mononuclear bone marrow cells on left ventricular function, arrhythmia risk profile, and restenosis after thrombolytic therapy of acute myocardial infarction
    Heikki V Huikuri
    Department of Internal Medicine, University of Oulu, Oulu, Finland
    Eur Heart J 29:2723-32. 2008
  5. ncbi Attenuated recovery of heart rate turbulence early after myocardial infarction identifies patients at high risk for fatal or near-fatal arrhythmic events
    Heikki V Huikuri
    Department of Internal Medicine, University of Oulu, Oulu, Finland
    Heart Rhythm 7:229-35. 2010
  6. ncbi Clinical impact of evaluation of cardiovascular control by novel methods of heart rate dynamics
    Heikki V Huikuri
    Department of Internal Medicine, Institute of Clinical Medicine, Centre of Excellence in Research, University of Oulu, Oulu 90014, Finland
    Philos Trans A Math Phys Eng Sci 367:1223-38. 2009
  7. ncbi Prediction of sudden cardiac death after myocardial infarction in the beta-blocking era
    Heikki V Huikuri
    Division of Cardiology, Department of Medicine, University of Oulu, Oulu, Finland
    J Am Coll Cardiol 42:652-8. 2003
  8. ncbi Dispersion of repolarisation and the autonomic system-can we predict torsade de pointes?
    Heikki Huikuri
    Division of Cardiology, Department of Medicine, University of Oulu, Oulu, Finland
    Cardiovasc Drugs Ther 16:93-9. 2002
  9. ncbi Heart rate variability and dispersion of QT interval in patients with vulnerability to ventricular tachycardia and ventricular fibrillation after previous myocardial infarction
    J S Perkiömäki
    Department of Medicine, University of Oulu, Finland
    J Am Coll Cardiol 30:1331-8. 1997
  10. ncbi Prediction of sudden cardiac death: appraisal of the studies and methods assessing the risk of sudden arrhythmic death
    Heikki V Huikuri
    Division of Cardiology, Department of Internal Medicine, University of Oulu, Finland
    Circulation 108:110-5. 2003

Detail Information

Publications94

  1. ncbi The effect of bone marrow microenvironment on the functional properties of the therapeutic bone marrow-derived cells in patients with acute myocardial infarction
    Johanna A Miettinen
    Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu, Oulu FIN 90014, Finland
    J Transl Med 10:66. 2012
    ..The arterial, venous and bone marrow blood gas concentrations were also compared...
  2. ncbi Association of the beta-1 adrenergic receptor carboxyl terminal variants with left ventricular hypertrophy among diabetic and non-diabetic survivors of acute myocardial infarction
    Anna E Hakalahti
    Institute of Biomedicine, Department of Anatomy and Cell Biology, University of Oulu, PO Box 5000, FI 90014 Oulu, Finland
    Cardiovasc Diabetol 9:42. 2010
    ..Diabetes mellitus (DM), on the other hand, represents a risk factor for LVH. We investigated the possible association between the Arg389Gly polymorphism and LVH among non-diabetic and diabetic acute myocardial infarction (AMI) survivors...
  3. ncbi Prediction of fatal or near-fatal cardiac arrhythmia events in patients with depressed left ventricular function after an acute myocardial infarction
    Heikki V Huikuri
    Department of Internal Medicine, University of Oulu, PO Box 5000, Kajaanintie 50, 90014 Oulu, Finland
    Eur Heart J 30:689-98. 2009
    ..To determine whether risk stratification tests can predict serious arrhythmic events after acute myocardial infarction (AMI) in patients with reduced left ventricular ejection fraction (LVEF < or = 0.40)...
  4. ncbi Effects of intracoronary injection of mononuclear bone marrow cells on left ventricular function, arrhythmia risk profile, and restenosis after thrombolytic therapy of acute myocardial infarction
    Heikki V Huikuri
    Department of Internal Medicine, University of Oulu, Oulu, Finland
    Eur Heart J 29:2723-32. 2008
    ..To assess the efficacy and safety of bone marrow cell (BMC) therapy after thrombolytic therapy of an acute ST-elevation myocardial infarction (STEMI)...
  5. ncbi Attenuated recovery of heart rate turbulence early after myocardial infarction identifies patients at high risk for fatal or near-fatal arrhythmic events
    Heikki V Huikuri
    Department of Internal Medicine, University of Oulu, Oulu, Finland
    Heart Rhythm 7:229-35. 2010
    ..Autonomic dysfunction tends to improve over time after acute myocardial infarction (MI), but the clinical significance of autonomic remodeling is not well known...
  6. ncbi Clinical impact of evaluation of cardiovascular control by novel methods of heart rate dynamics
    Heikki V Huikuri
    Department of Internal Medicine, Institute of Clinical Medicine, Centre of Excellence in Research, University of Oulu, Oulu 90014, Finland
    Philos Trans A Math Phys Eng Sci 367:1223-38. 2009
    ....
  7. ncbi Prediction of sudden cardiac death after myocardial infarction in the beta-blocking era
    Heikki V Huikuri
    Division of Cardiology, Department of Medicine, University of Oulu, Oulu, Finland
    J Am Coll Cardiol 42:652-8. 2003
    ..This study assessed the predictive power of arrhythmia risk markers after an acute myocardial infarction (AMI)...
  8. ncbi Dispersion of repolarisation and the autonomic system-can we predict torsade de pointes?
    Heikki Huikuri
    Division of Cardiology, Department of Medicine, University of Oulu, Oulu, Finland
    Cardiovasc Drugs Ther 16:93-9. 2002
    ....
  9. ncbi Heart rate variability and dispersion of QT interval in patients with vulnerability to ventricular tachycardia and ventricular fibrillation after previous myocardial infarction
    J S Perkiömäki
    Department of Medicine, University of Oulu, Finland
    J Am Coll Cardiol 30:1331-8. 1997
    ....
  10. ncbi Prediction of sudden cardiac death: appraisal of the studies and methods assessing the risk of sudden arrhythmic death
    Heikki V Huikuri
    Division of Cardiology, Department of Internal Medicine, University of Oulu, Finland
    Circulation 108:110-5. 2003
  11. ncbi Measurement of heart rate variability by methods based on nonlinear dynamics
    Heikki V Huikuri
    Division of Cardiology, Department of Internal Medicine, University of Oulu, Finland
    J Electrocardiol 36:95-9. 2003
    ....
  12. ncbi Cardiac arrhythmias and risk stratification after myocardial infarction: results of the CARISMA pilot study
    Heikki V Huikuri
    Division of Cardiology, Department of Internal Medicine, University of Oulu, Kajaanintie 50, FIN 90220, Oulu Finland
    Pacing Clin Electrophysiol 26:416-9. 2003
    ..Clinically significant arrhythmias were recorded in a large number of patients with depressed left ventricular function early after AMI. This prompted the implantation of ICD or PM in nearly one third of patients...
  13. ncbi Heart rate dynamics and vulnerability to ventricular tachyarrhythmias
    H V Huikuri
    Department of Medicine, Oulu University Hospital, Finland
    Ann Med 29:321-5. 1997
    ....
  14. ncbi Power-law relationship of heart rate variability as a predictor of mortality in the elderly
    H V Huikuri
    Department of Medicine, University of Oulu, Finland
    Circulation 97:2031-6. 1998
    ..We studied whether analysis of 24-hour HR behavior is able to predict mortality in a random population of elderly subjects...
  15. ncbi Effects of combination antihypertensive therapy on baroreflex sensitivity and heart rate variability in systemic hypertension
    A Ylitalo
    Department of Internal Medicine, University of Oulu, Finland
    Am J Cardiol 83:885-9. 1999
    ....
  16. ncbi Heart rate variability and progression of coronary atherosclerosis
    H V Huikuri
    Division of Cardiology, Department of Medicine and Biocenter of Oulu, University of Oulu, Finland
    Arterioscler Thromb Vasc Biol 19:1979-85. 1999
    ..HR variability provided information on progression of focal coronary atherosclerosis beyond that obtained by traditional risk markers of atherosclerosis...
  17. ncbi Dynamic behavior and autonomic regulation of ectopic atrial pacemakers
    H V Huikuri
    University of Oulu, Department of Medicine, Division of Cardiology, Oulu, Finland
    Circulation 100:1416-22. 1999
    ..We compared the HR variability of tachycardias originating from the ectopic foci and the sinus node...
  18. ncbi Measurement of heart rate variability: a clinical tool or a research toy?
    H V Huikuri
    Department of Medicine, University of Oulu, Finland
    J Am Coll Cardiol 34:1878-83. 1999
    ..Further studies should also address the issue of which of the HR variability indexes, including the new nonlinear measures, is best for clinical purposes in various patient populations...
  19. ncbi Fractal correlation properties of R-R interval dynamics and mortality in patients with depressed left ventricular function after an acute myocardial infarction
    H V Huikuri
    Division of Cardiology, Department of Medicine, University of Oulu, Finland
    Circulation 101:47-53. 2000
    ..The purpose of this study was to compare the prognostic power of new fractal and traditional measures of R-R interval variability as predictors of death after acute myocardial infarction...
  20. ncbi Heart rate variability in ischemic heart disease
    H V Huikuri
    Department of Medicine, University of Oulu, Finland
    Auton Neurosci 90:95-101. 2001
    ..These findings support the notion that heart rate variability analysis methods, such as fractal and complexity measures as well as conventional techniques, give valuable clinical information among patients with ischemic heart disease...
  21. ncbi Association between HERG K897T polymorphism and QT interval in middle-aged Finnish women
    Eeva Pietilä
    Division of Cardiology, Department of Medicine, University of Oulu, Oulu, Finland
    J Am Coll Cardiol 40:511-4. 2002
    ..The aim of this study was to test whether a recently reported polymorphism in the HERG gene coding for the rapidly activating delayed rectifier K+ channel has influence on myocardial repolarization...
  22. ncbi Electrocardiographic abnormalities and ventricular tachyarrhythmias after myocardial infarction
    Miia K Hyytinen-Oinas
    Division of Cardiology, Department of Internal Medicine, University of Oulu, Oulu, Finland
    Scand Cardiovasc J 44:15-23. 2010
    ..To assess the association of electrocardiographic repolarization and depolarization patterns to vulnerability to ventricular tachyarrhythmias...
  23. ncbi Electrocardiographic transmural dispersion of repolarization in patients with inherited short QT syndrome
    Olli Anttonen
    Department of Medicine, Paijat Hame Central Hospital, Lahti, Finland
    Ann Noninvasive Electrocardiol 13:295-300. 2008
    ..In a clinical study with acquired long QT syndrome patients, TPE/QT ratio > 0.28 indicated arrhythmia risk. We hypothesized that the TPE/QT ratio would be greater in SQTS patients than in control subjects...
  24. ncbi Heart rate variability and recurrence of atrial fibrillation after electrical cardioversion
    Saila Vikman
    Division of Cardiology, Department of Medicine, University Hospital of Tampere, University of Tampere, Finland
    Ann Med 35:36-42. 2003
    ..This study was designed to test the hypothesis that HR variability after electrical cardioversion (CV) of persistent AF predicts the recurrence of AF...
  25. ncbi Novel spectral indexes of heart rate variability as predictors of sudden and non-sudden cardiac death after an acute myocardial infarction
    Antti M Kiviniemi
    Merikoski Rehabilitation and Research Centre, Oulu, Finland
    Ann Med 39:54-62. 2007
    ..Various indexes of 24-hour heart rate variability (HRV) have been able to predict all-cause mortality after an acute myocardial infarction (AMI), but their value in predicting specific modes of cardiac death has been limited...
  26. ncbi Cardiac autonomic control in patients with refractory epilepsy before and during vagus nerve stimulation treatment: a one-year follow-up study
    Eija Ronkainen
    Department of Neurology, University of Oulu, Oulu, Finland
    Epilepsia 47:556-62. 2006
    ..One-year treatment with VNS did not have a marked effect on HR variability, suggesting that impaired cardiovascular autonomic regulation is associated with the epileptic process itself rather than with recurrent seizures...
  27. ncbi Heart rate recovery after exercise as a predictor of mortality among survivors of acute myocardial infarction
    Samuli I Nissinen
    Division of Cardiology, Department of Internal Medicine, University of Oulu, Oulu, Finland
    Am J Cardiol 91:711-4. 2003
  28. ncbi Impaired negative chronotropic response to adenosine in patients with inappropriate sinus tachycardia
    Aino-Maija Still
    Department of Internal Medicine, University of Oulu, Finland
    J Cardiovasc Electrophysiol 13:557-62. 2002
    ..7% vs 8.5%+/-8.8%; P < 0.001). CONCLUSION: The usual negative chronotropic effect of adenosine was impaired in the patients with IST. This may have important diagnostic implications and provide new insight into the mechanism(s) of IST...
  29. ncbi Fractal analysis of heart rate variability and mortality after an acute myocardial infarction
    Jari M Tapanainen
    Division of Cardiology, Department of Internal Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland
    Am J Cardiol 90:347-52. 2002
    ..90, 95% CI 2.03 to 7.49, p <0.001). Short-term fractal scaling analysis of HR variability is a powerful predictor of mortality among patients surviving an acute myocardial infarction...
  30. ncbi Heart rate turbulence after ventricular and atrial premature beats in subjects without structural heart disease
    Kai S Lindgren
    Division of Cardiology, Department of Internal Medicine, Vaasa Central Hospital, Vaasa, Finland
    J Cardiovasc Electrophysiol 14:447-52. 2003
    ..CONCLUSION: HR behavior is different in response to APBs and VBPs among subjects without structural heart disease. Different definitions and calculation formulas should be used in the analysis of HR turbulence after APBs and VPBs...
  31. ncbi Influence of size and location of myocardial infarction on TCRT parameter: a computer simulation study
    Mari Karsikas
    Department Electrical and Information Engineering, Computer Engineering Laboratory, PO Box 4500, 90014 University of Oulu, Finland
    Conf Proc IEEE Eng Med Biol Soc 2007:1414-7. 2007
    ..001). TCRT turned into negative values only in case of anterior MI. The results indicate that the location of the MI should be considered when interpreting changes of TCRT values with MI patients...
  32. ncbi New Vectorcardiographic non-planarity measure of T-wave loop improves separation between healthy subjects and myocardial infarction patients
    Mari Karsikas
    Department Electrical and Information Engineering, Computer Engineering Laboratory PO BOX 4500, 90014 University of Oulu, Finland
    Conf Proc IEEE Eng Med Biol Soc 2009:1754-7. 2009
    ..The new method separated healthy and patient groups with p-value 0.002 while PCA3 only with p-value 0.075. The new method was superior to PCA3 in separating the healthy patients from both infarction types...
  33. ncbi Changes in cardiovascular autonomic regulation among elderly subjects: follow-up of sixteen years
    Vesa Jokinen
    Division of Cardiology, Department of Medicine, University of Oulu, Finland
    Ann Med 37:206-12. 2005
    ..However, there are no longitudinal follow-up reports of the changes of HR dynamics in elderly subjects...
  34. ncbi Successful catheter ablation of focal atrial tachycardia from the non-coronary aortic cusp
    M J Pekka Raatikainen
    Department of Internal Medicine, Division of Cardiology, University of Oulu, PO Box 5000, FIN 90014, Finland
    Europace 9:216-9. 2007
    ..Radiofrequency catheter ablation at this site terminated the tachycardia with no complications...
  35. ncbi Familial clustering of lone atrial fibrillation in patients with saddleback-type ST-segment elevation in right precordial leads
    M Juhani Junttila
    Department of Internal Medicine, Division of Cardiology, University of Oulu, PO Box 5000, Oulu 90014, Finland
    Eur Heart J 28:463-8. 2007
    ..On the basis of this finding, we studied whether there is a relationship between saddleback ST-elevation and lone AF...
  36. ncbi Association between usage of beta-blocking medication and benefit from implantable cardioverter therapy
    Timo H Mäkikallio
    Division of Cardiology, Department of Internal Medicine, University of Oulu, Oulu, Finland
    Am J Cardiol 98:1245-7. 2006
    ..81, p <0.01). In conclusion, the use of beta-blocking medication is associated with a reduced absolute mortality benefit of ICD therapy in reported randomized trials...
  37. ncbi Family history and the risk of sudden cardiac death as a manifestation of an acute coronary event
    Kari S Kaikkonen
    Department of Internal Medicine, University of Oulu, PO Box 5000 (Kajaanintie 50, 90014 Oulu, Finland
    Circulation 114:1462-7. 2006
    ..001 for both). CONCLUSIONS: Subjects with a family history of SCD have an increased risk of dying suddenly during an acute coronary event...
  38. ncbi Usefulness of T-wave loop and QRS complex loop to predict mortality after acute myocardial infarction
    Juha S Perkiomaki
    Division of Cardiology, Department of Medicine, University of Oulu, Oulu, Finland
    Am J Cardiol 97:353-60. 2006
    ..In conclusion, TWLD that describes the shape of the T-wave loop is a specific predictor of cardiac death and independent of the clinical risk markers in the current treatment era of patients with AMI...
  39. ncbi Frequency of sudden cardiac death among acute myocardial infarction survivors with optimized medical and revascularization therapy
    Timo H Mäkikallio
    Division of Cardiology, Department of Internal Medicine, University of Oulu, Lapland Central Hospital, Rovaniemi, Finland
    Am J Cardiol 97:480-4. 2006
    ..In conclusion, the incidence of SCD is low in the modern treatment era of patients after an AMI. Coronary revascularization seems to have a great effect on altered the epidemiologic pattern of SCD...
  40. ncbi Differences in 12-lead electrocardiogram between symptomatic and asymptomatic Brugada syndrome patients
    M Juhani Junttila
    Division of Cardiology, Department of Medicine, University of Oulu, Finland
    J Cardiovasc Electrophysiol 19:380-3. 2008
    ..It is not well established which BrS patients are at risk of severe arrhythmias. Our aim was to study whether standard 12-lead electrocardiogram (ECG) would give useful information for this purpose...
  41. ncbi Autonomic markers as predictors of nonfatal acute coronary events after myocardial infarction
    Juha S Perkiomaki
    Division of Cardiology, Department of Internal Medicine, University of Oulu, Oulu, Finland
    Ann Noninvasive Electrocardiol 13:120-9. 2008
    ....
  42. ncbi Frequency of slow oscillations in arterial pressure and R-R intervals during muscle metaboreflex activation
    Antti M Kiviniemi
    Department of Exercise and Medical Physiology, Verve Research, Oulu, Finland
    Auton Neurosci 152:88-95. 2010
    ..The present results give new insight to understand the physiology underlying the frequency of slow arterial pressure and R-R interval oscillations...
  43. ncbi Determinants of functional recovery after myocardial infarction of patients treated with bone marrow-derived stem cells after thrombolytic therapy
    Johanna A Miettinen
    University of Oulu, Department of Internal Medicine P O Box 5000 Kajaanintie 50, FIN 90014 University of Oulu, Oulu, Finland
    Heart 96:362-7. 2010
    ....
  44. ncbi Acetylcholine receptor M2 gene variants, heart rate recovery, and risk of cardiac death after an acute myocardial infarction
    Arto J Hautala
    Department of Exercise and Medical Physiology, Verve Research, Kasarmintie 13, Oulu, Finland
    Ann Med 41:197-207. 2009
    ....
  45. ncbi Predictors of long-term risk for heart failure hospitalization after acute myocardial infarction
    Juha S Perkiomaki
    Department of Medicine, University of Oulu, Finland
    Ann Noninvasive Electrocardiol 15:250-8. 2010
    ..Data on the value of baseline brain natriuretic peptide (BNP) and autonomic markers in predicting heart failure (HF) hospitalization after an acute myocardial infarction (AMI) are limited...
  46. ncbi Comparison of risk profiles between survivors and victims of sudden cardiac death from an acute coronary event
    Kari S Kaikkonen
    Department of Internal Medicine, University of Oulu, Finland
    Ann Med 41:120-7. 2009
    ..This study was designed to compare the risk profiles of sudden cardiac death (SCD) victims and survivors of an acute coronary event...
  47. ncbi Dynamics and rate-dependence of the spatial angle between ventricular depolarization and repolarization wave fronts during exercise ECG
    Tuomas Kenttä
    Institute of Clinical Medicine, University of Oulu, Finland
    Ann Noninvasive Electrocardiol 15:264-75. 2010
    ..This study assessed the possible rate dependence of these variables during exercise ECG in healthy subjects...
  48. ncbi Heart rate dynamics in temporal lobe epilepsy-A long-term follow-up study
    Eija Suorsa
    Department of Neurology, University of Oulu, Oulu, Finland
    Epilepsy Res 93:80-3. 2011
    ..05) in HR variability were observed. The reduction in HRV seems to be progressive in patients with chronic refractory TLE with recurrent seizures...
  49. ncbi Coronary angioplasty in drug eluting stent era for the treatment of unprotected left main stenosis compared to coronary artery bypass grafting
    Timo H Mäkikallio
    Division of Cardiology, Department of Internal Medicine, University of Oulu, Lapland Central Hospital, Rovaniemi, Finland
    Ann Med 40:437-43. 2008
    ..Improved outcomes of percutaneous coronary interventions (PCI) with drug-eluting stents (DES) have resulted in their expanded use for left main coronary artery (LMCA) stenosis...
  50. ncbi Respiratory sinus arrhythmia as a predictor of sudden cardiac death after myocardial infarction
    Mirja Peltola
    University of Oulu, Department of Internal Medicine, Division of Cardiology, Oulu, Finland
    Ann Med 40:376-82. 2008
    ....
  51. ncbi Fractal and complexity measures of heart rate variability
    Juha S Perkiomaki
    Division of Cardiology, Department of Medicine, University of Oulu, Oulu, Finland
    Clin Exp Hypertens 27:149-58. 2005
    ....
  52. ncbi Prediction of sudden cardiac death after acute myocardial infarction: role of Holter monitoring in the modern treatment era
    Timo H Mäkikallio
    Division of Cardiology, Department of Internal Medicine, University of Oulu, PO Box 5000 Kajaanintie 50, FIN 90014, Oulu, Finland
    Eur Heart J 26:762-9. 2005
    ..We evaluated the utility of Holter-based risk variables in the prediction of sudden cardiac death (SCD) among survivors of AMI treated with modern therapy...
  53. ncbi Temporal changes and prognostic significance of measures of heart rate dynamics after acute myocardial infarction in the beta-blocking era
    Vesa Jokinen
    Division of Cardiology, Department of Medicine, University of Oulu, Oulu, Finland
    Am J Cardiol 92:907-12. 2003
    ..Fractal HR variability and HR turbulence retain their prognostic power in the BB era, when measured either at the convalescent or late phase after AMI...
  54. ncbi Cardiovascular autonomic function correlates with the response to aerobic training in healthy sedentary subjects
    Arto J Hautala
    Merikoski Rehabilitation and Research Center, and Department of Medicine, University of Oulu, Finland
    Am J Physiol Heart Circ Physiol 285:H1747-52. 2003
    ..High vagal activity at baseline is associated with the improvement in aerobic power caused by aerobic exercise training in healthy sedentary subjects...
  55. ncbi Functional significance of KCNH2 (HERG) K897T polymorphism for cardiac repolarization assessed by analysis of T-wave morphology
    Eeva H Linna
    Division of Cardiology, Department of Medicine, University of Oulu, Finland
    Ann Noninvasive Electrocardiol 11:57-62. 2006
    ....
  56. ncbi Clinical applicability of heart rate variability analysis by methods based on nonlinear dynamics
    Timo H Mäkikallio
    Division of Cardiology, Department of Medicine, University of Oulu, Oulu, Finland
    Card Electrophysiol Rev 6:250-5. 2002
    ..This article provides a review of our current knowledge of the usefulness of dynamical measures of HR fluctuation...
  57. ncbi Diabetes and haemodynamic reactions to acute coronary occlusion
    K E Juhani Airaksinen
    Cardiovascular Laboratory, Department of Medicine, University of Turku, Kiinamyllynkatu 4 8, FIN 20520 Turku, Finland
    Int J Cardiol 95:237-44. 2004
    ..Since diabetes mellitus may interfere with autonomic and myocardial function, we decided to study whether diabetes alters autonomic and haemodynamic responses to acute coronary occlusion...
  58. ncbi Comprehensive study of autonomic function in a population with primary Sjögren's syndrome. No evidence of autonomic involvement
    Raija K Niemelä
    Division of Rheumatology, Department of Internal Medicine, University of Oulu, Finland
    J Rheumatol 30:74-9. 2003
    ....
  59. ncbi Microvolt T-wave alternans during exercise and pacing in patients with acute myocardial infarction
    M J Pekka Raatikainen
    University of Oulu, Department of Internal Medicine, Division of Cardiology, Oulu, Finland
    Pacing Clin Electrophysiol 28:S193-7. 2005
    ..The low number of indeterminate tests and high concordance between the test results indicate that V + A pacing may provide a valuable means to assess TWA in patients who cannot complete the exercise test...
  60. ncbi [How do I diagnose and treat ventricular extrasystoles?]
    M J Pekka Raatikainen
    OYS n sisätautien klinikka, kardiologian osasto Kajaanintie 50 90220 Oulu
    Duodecim 118:145-54; quiz 154, 208. 2002
  61. ncbi Effects and significance of premature beats on fractal correlation properties of R-R interval dynamics
    Mirja A Peltola
    Division of Cardiology, Department of Medicine, University of Oulu, Finland
    Ann Noninvasive Electrocardiol 9:127-35. 2004
    ..We assessed the effects and significance of PBs on fractal scaling exponents in healthy subjects and patients with a recent myocardial infarction (AMI)...
  62. ncbi Differences in the activation patterns between sustained and self-terminating episodes of human ventricular fibrillation
    Timo H Mäkikallio
    Division of Cardiology, University of Miami, School of Medicine, Florida, USA
    Ann Med 34:130-5. 2002
    ..Experimental studies have suggested that R-R interval dynamics during ventricular fibrillation (VF) have organized features, but whether dynamic behavior of non-sustained VF differs from sustained VF is unknown...
  63. ncbi Cardiovascular regulation and hippocampal sclerosis
    Hanna Ansakorpi
    Department of Neurology, University of Oulu, Finland
    Epilepsia 45:933-9. 2004
    ..It is not known whether these structural changes modify cardioregulatory function in patients with TLE...
  64. ncbi Variation in the vascular endothelial growth factor gene, carotid intima-media thickness and the risk of acute myocardial infarction
    Tiia Kangas-Kontio
    Institute of Clinical Medicine, Department of Internal Medicine, Oulu University Hospital and Biocenter Oulu, Finland
    Scand J Clin Lab Invest 69:335-43. 2009
    ....
  65. ncbi Heart rate dynamics after controlled training followed by a home-based exercise program
    Arto J Hautala
    Merikoski Rehabilitation and Research Center, Kasarmintie 13, 90100, Oulu, Finland
    Eur J Appl Physiol 92:289-97. 2004
    ..44, P<0.05) after the home-based training program. The high vagal outflow to the heart after the home-based training is associated with good physical performance and body mass control...
  66. ncbi Natriuretic peptides as predictors of non-sudden and sudden cardiac death after acute myocardial infarction in the beta-blocking era
    Jari M Tapanainen
    Division of Cardiology, Department of Internal Medicine, Oulu University Hospital, Oulu, Finland
    J Am Coll Cardiol 43:757-63. 2004
    ..CONCLUSIONS: Natriuretic peptides retain their prognostic value in the beta-blocking era among survivors of AMI. Elevated BNP provides information on the risk of subsequent SCD, independent of clinical variables and left ventricular EF...
  67. ncbi Circadian heart rate variability in Parkinson's disease
    Ville Pursiainen
    Department of Neurology, University of Oulu, P. O. Box 5000, 90014 Oulu, Finland
    J Neurol 249:1535-40. 2002
    ..The results indicate that the long-term parasympathetic cardiovascular regulation is impaired in untreated patients with Parkinson's disease. The dysfunction is more pronounced at night...
  68. ncbi Physical activity and heart rate variability measured simultaneously during waking hours
    Arto J Hautala
    Dept of Exercise and Medical Physiology, Verve Research, Oulu, Finland
    Am J Physiol Heart Circ Physiol 298:H874-80. 2010
    ..Long-term HRV indexes remained relatively stable at various activity levels, making them the most robust indexes for the assessment of cardiac autonomic function during free-running ambulatory conditions...
  69. ncbi Fractal scaling properties of heart rate dynamics and myocardial efficiency in dilated cardiomyopathy
    Tiina Marjatta Salo
    Department of Medicine, University of Turku, 20520 Turku, Finland
    Clin Res Cardiol 98:725-30. 2009
    ..Since altered heart rate (HR) fluctuations provide prognostic information in heart failure, we examined the associations between HR dynamics, myocardial efficiency and perfusion, among patients with dilated cardiomyopathy...
  70. ncbi Short-term correlation properties of R-R interval dynamics at different exercise intensity levels
    Arto J Hautala
    Merikoski Rehabilitation and Research Center, Oulu, Finland
    Clin Physiol Funct Imaging 23:215-23. 2003
    ..Changes in alpha1 values can be detected also in high intensity levels, when the conventional measures of HR variability can not be applied...
  71. ncbi Feedback effects of circulating norepinephrine on sympathetic outflow in healthy subjects
    Mikko P Tulppo
    Merikoski Rehabilitation and Research Centre, Oulu, Finland
    Am J Physiol Heart Circ Physiol 288:H710-5. 2005
    ....
  72. ncbi Prevalence, characteristics and natural course of inappropriate sinus tachycardia
    Aino-Maija Still
    Department of Internal Medicine, Division of Cardiology, University of Oulu, P.O. Box 5000, FIN-900014, Finland
    Europace 7:104-12. 2005
    ..Despite the chronic nature of the disorder, the prognosis of IST was benign. The causal relationship between IST and hypertension and/or hostile personality type remains speculative...
  73. ncbi Influence of paper electrocardiogram digitizing on T wave and QRS complex morphology parameters
    Mari Karsikas
    University of Oulu, Department of Electrical and Information Engineering, University of Oulu, Finland
    Ann Noninvasive Electrocardiol 12:282-90. 2007
    ..However, the digitizing process, including printing, scanning, ECG contour extraction, and alignment, can produce changes to the signals, reducing the reliability of some sensitive parameters of QRS complex and T wave...
  74. ncbi Cardiovascular autonomic regulation in patients with 3243A > G mitochondrial DNA mutation
    Kirsi Majamaa-Voltti
    Department of Internal Medicine, University of Oulu, Finland
    Ann Med 36:225-31. 2004
    ..Patients with the 3243A > G mutation in mitochondrial DNA (mtDNA) have an increased risk for cardiovascular morbidity and mortality. The function of the autonomic nervous system has not been evaluated in these patients...
  75. ncbi Cardiac vagal outflow after aerobic training by analysis of high-frequency oscillation of the R-R interval
    Antti M Kiviniemi
    Merikoski Rehabilitation and Research Center, Kasarmintie 13, P.O.Box 404, 90101, Oulu, Finland
    Eur J Appl Physiol 96:686-92. 2006
    ..HF power calculated from unsaturated area detects more accurately subtle changes in the vagally mediated beat-to-beat variability of the R-R interval after aerobic training than the mean 24-h HF power...
  76. ncbi Temporal changes in cardiovascular autonomic regulation in type II diabetic patients: association with coronary risk variables and progression of coronary artery disease
    Vesa Jokinen
    Division of Cardiology, University of Oulu, Finland [corrected
    Ann Med 35:216-23. 2003
    ..Impairment in HR variability is associated with changes in common coronary risk variables and with a progression of CAD...
  77. ncbi Muscle sympathetic nerve activity at rest compared to exercise tolerance
    Arto J Hautala
    Department of Exercise and Medical Physiology, Verve Research, Kasarmintie 13, PO Box 404, 90101, Oulu, Finland
    Eur J Appl Physiol 102:533-8. 2008
    ..In conclusion, baseline sympathetic activity, measured by a microneurography at rest, may be associated with the maximal running performance of healthy subjects...
  78. ncbi Traditional and nonlinear heart rate variability are each independently associated with mortality after myocardial infarction
    Phyllis K Stein
    Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Cardiovasc Electrophysiol 16:13-20. 2005
    ..Traditional HRV predicts mortality in patients with a range of times post-MI, but the association of nonlinear HRV and outcome in this population is unknown...
  79. ncbi Physiological background of the loss of fractal heart rate dynamics
    Mikko P Tulppo
    Merikoski Rehabilitation and Research Centre, Kasarmintie 13, PO Box 404, FIN 90101 Oulu, Finland
    Circulation 112:314-9. 2005
    ..We tested the hypothesis that the fractal organization of human HR dynamics is determined by the balance between sympathetic and vagal outflow...
  80. ncbi Nonlinear heart rate variability in CABG patients and the preconditioning effect
    Zhong Kai Wu
    Department of Cardiac Surgery, Affiliated 1st Hospital, Sun Yat Sen University, Guangzhou, China
    Eur J Cardiothorac Surg 28:109-13. 2005
    ..Short brief myocardial ischemia has been reported to influence HRV. We therefore hypothesis that the protective mechanism of ischemic preconditioning (IP) may involve in cardiac autonomic regulation...
  81. ncbi Effects of carvedilol on heart rate dynamics in patients with congestive heart failure
    Mustafa Ridha
    Cardiology (111-A, V.A. Medical Center, 1201 NW 16th Street, Miami, FL 33125, USA
    Ann Noninvasive Electrocardiol 7:133-8. 2002
    ..It also improves LVEF and functional capacity. These specific changes in HR behavior caused by carvedilol treatment may reflect the normalization of impaired cardiovascular neural regulation of patients with CHF...
  82. ncbi Relation of heart rate dynamics to the occurrence of myocardial ischemia after coronary artery bypass grafting
    Timo T Laitio
    Department of Anesthesiology, Turku University Hospital, Turku, Finland
    Am J Cardiol 89:1176-81. 2002
    ....
  83. ncbi Risks in risk stratification: what is relevant in practice?
    Timo H Mäkikallio
    Circulation 105:e69-70. 2002
  84. ncbi Fractal correlation properties of R-R interval dynamics in asymptomatic relatives of patients with dilated cardiomyopathy
    Niall G Mahon
    Department of Cardiological Sciences, St George s Hospital Medical School, London, UK
    Eur J Heart Fail 4:151-8. 2002
    ..The aim of this study was to compare values of proportional, variant(1) and conventional HRV indices in LVE relatives with dilated cardiomyopathy patients and normal controls...
  85. ncbi Heart rate recovery after maximal exercise is associated with acetylcholine receptor M2 (CHRM2) gene polymorphism
    Arto J Hautala
    Pennington Biomedical Research Center, Human Genomics Laboratory, Louisiana State University System, Baton Rouge, Louisiana, USA
    Am J Physiol Heart Circ Physiol 291:H459-66. 2006
    ..025) and after endurance training (P = 0.005). These data suggest that DNA sequence variation at the CHRM2 locus is a potential modifier of HR recovery in the sedentary state and after short-term endurance training in healthy individuals...
  86. ncbi The breakdown of fractal heart rate dynamics predicts prolonged postoperative myocardial ischemia
    Timo T Laitio
    Department of Anesthesiology and Intensive Care, Turku University Hospital, Turku, Finland
    Anesth Analg 98:1239-44, table of contents. 2004
    ..Preoperatively increased randomness in heart rate variability was predictive for postoperative, silent prolonged myocardial ischemia. Prolonged myocardial ischemia increases the risk for adverse cardiac events...
  87. ncbi Saturation of high-frequency oscillations of R-R intervals in healthy subjects and patients after acute myocardial infarction during ambulatory conditions
    Antti M Kiviniemi
    Merikoski Rehabilitation and Research Center, Kasarmintie 13, PO Box 404, FIN-90101 Oulu, Finland
    Am J Physiol Heart Circ Physiol 287:H1921-7. 2004
    ..This saturation effect may bias the quantification of cardiac vagal function when HR variability is analyzed from Holter recordings...
  88. ncbi [Are ACE inhibitors and angiotensin receptor blockers useful in the treatment of atrial fibrillation?]
    M J Raatikainen
    Duodecim 119:1505-7. 2003
  89. ncbi Origin and significance of heart rate variability
    Mikko Tulppo
    J Am Coll Cardiol 43:2278-80. 2004
  90. ncbi Exercise training improves baroreflex sensitivity in type 2 diabetes
    Antti Loimaala
    South Karelian Central Hospital, Department of Clinical Physiology and Nuclear Medicine, Lappeenranta, Finland
    Diabetes 52:1837-42. 2003
    ..These beneficial effects in reflectory autonomic regulation and glucose control caused by exercise may be associated with improved prognosis of type 2 diabetes patients...
  91. ncbi Abnormalities in fractal heart rate dynamics in Chagas disease
    Marcos Roberto de Sousa
    Hospital das Clínicas and Internal Medicine Department, School of Medicine, Federal University of Minas Gerais, Minas Gerais, Brazil
    Ann Noninvasive Electrocardiol 11:145-53. 2006
    ....
  92. ncbi Long-term alterations of heart rate dynamics after coronary artery bypass graft surgery
    Timo T Laitio
    Department of Anesthesiology and Intensive Care, Turku University Hospital, Turku, Finland
    Anesth Analg 102:1026-31. 2006
    ..01 after 1 yr). The predictive value of temporary and persistent long-term changes of the HR dynamics after CABG surgery for long-term outcome is not clear...
  93. ncbi Heart rate turbulence after atrial premature beats before spontaneous onset of atrial fibrillation
    Saila Vikman
    Heart Center, University Hospital of Tampere, Biokatu 6, PL 2000, 33521 Tampere, Finland
    J Am Coll Cardiol 45:278-84. 2005
    ..This study was designed to assess the temporal changes in vagal responses to atrial premature beats before spontaneous onset of atrial fibrillation (AF)...
  94. ncbi The prognostic accuracy of different QT interval measures
    Kaspar Lund
    Department of Cardiology, Skejby University Hospital, DK 8200 Aarhus N, Denmark
    Ann Noninvasive Electrocardiol 7:10-6. 2002
    ..The purpose of this study was to analyze the prognostic accuracy of all known ways to select the lead...