Heikki Huikuri

Summary

Affiliation: University of Oulu
Country: Finland

Publications

  1. pmc Clinical application of heart rate variability after acute myocardial infarction
    Heikki V Huikuri
    Division of Cardiology, Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu Oulu, Finland
    Front Physiol 3:41. 2012
  2. doi request reprint Heart rate variability in risk stratification of cardiac patients
    Heikki V Huikuri
    Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, and University Hospital of Oulu, Oulu, Finland Electronic address
    Prog Cardiovasc Dis 56:153-9. 2013
  3. pmc The effect of bone marrow microenvironment on the functional properties of the therapeutic bone marrow-derived cells in patients with acute myocardial infarction
    Johanna A Miettinen
    Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu, Oulu FIN 90014, Finland
    J Transl Med 10:66. 2012
  4. pmc Association of the beta-1 adrenergic receptor carboxyl terminal variants with left ventricular hypertrophy among diabetic and non-diabetic survivors of acute myocardial infarction
    Anna E Hakalahti
    Institute of Biomedicine, Department of Anatomy and Cell Biology, University of Oulu, PO Box 5000, FI 90014 Oulu, Finland
    Cardiovasc Diabetol 9:42. 2010
  5. ncbi request reprint Dispersion of repolarisation and the autonomic system-can we predict torsade de pointes?
    Heikki Huikuri
    Division of Cardiology, Department of Medicine, University of Oulu, Oulu, Finland
    Cardiovasc Drugs Ther 16:93-9. 2002
  6. ncbi request reprint Prediction of sudden cardiac death after myocardial infarction in the beta-blocking era
    Heikki V Huikuri
    Division of Cardiology, Department of Medicine, University of Oulu, Oulu, Finland
    J Am Coll Cardiol 42:652-8. 2003
  7. ncbi request reprint Measurement of heart rate variability by methods based on nonlinear dynamics
    Heikki V Huikuri
    Division of Cardiology, Department of Internal Medicine, University of Oulu, Finland
    J Electrocardiol 36:95-9. 2003
  8. doi request reprint Attenuated recovery of heart rate turbulence early after myocardial infarction identifies patients at high risk for fatal or near-fatal arrhythmic events
    Heikki V Huikuri
    Department of Internal Medicine, University of Oulu, Oulu, Finland
    Heart Rhythm 7:229-35. 2010
  9. doi request reprint Effects of intracoronary injection of mononuclear bone marrow cells on left ventricular function, arrhythmia risk profile, and restenosis after thrombolytic therapy of acute myocardial infarction
    Heikki V Huikuri
    Department of Internal Medicine, University of Oulu, Oulu, Finland
    Eur Heart J 29:2723-32. 2008
  10. pmc Prediction of fatal or near-fatal cardiac arrhythmia events in patients with depressed left ventricular function after an acute myocardial infarction
    Heikki V Huikuri
    Department of Internal Medicine, University of Oulu, PO Box 5000, Kajaanintie 50, 90014 Oulu, Finland
    Eur Heart J 30:689-98. 2009

Detail Information

Publications98

  1. pmc Clinical application of heart rate variability after acute myocardial infarction
    Heikki V Huikuri
    Division of Cardiology, Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu Oulu, Finland
    Front Physiol 3:41. 2012
    ....
  2. doi request reprint Heart rate variability in risk stratification of cardiac patients
    Heikki V Huikuri
    Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, and University Hospital of Oulu, Oulu, Finland Electronic address
    Prog Cardiovasc Dis 56:153-9. 2013
    ....
  3. pmc The effect of bone marrow microenvironment on the functional properties of the therapeutic bone marrow-derived cells in patients with acute myocardial infarction
    Johanna A Miettinen
    Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu, Oulu FIN 90014, Finland
    J Transl Med 10:66. 2012
    ..The arterial, venous and bone marrow blood gas concentrations were also compared...
  4. pmc Association of the beta-1 adrenergic receptor carboxyl terminal variants with left ventricular hypertrophy among diabetic and non-diabetic survivors of acute myocardial infarction
    Anna E Hakalahti
    Institute of Biomedicine, Department of Anatomy and Cell Biology, University of Oulu, PO Box 5000, FI 90014 Oulu, Finland
    Cardiovasc Diabetol 9:42. 2010
    ..Diabetes mellitus (DM), on the other hand, represents a risk factor for LVH. We investigated the possible association between the Arg389Gly polymorphism and LVH among non-diabetic and diabetic acute myocardial infarction (AMI) survivors...
  5. ncbi request reprint Dispersion of repolarisation and the autonomic system-can we predict torsade de pointes?
    Heikki Huikuri
    Division of Cardiology, Department of Medicine, University of Oulu, Oulu, Finland
    Cardiovasc Drugs Ther 16:93-9. 2002
    ....
  6. ncbi request reprint Prediction of sudden cardiac death after myocardial infarction in the beta-blocking era
    Heikki V Huikuri
    Division of Cardiology, Department of Medicine, University of Oulu, Oulu, Finland
    J Am Coll Cardiol 42:652-8. 2003
    ..This study assessed the predictive power of arrhythmia risk markers after an acute myocardial infarction (AMI)...
  7. ncbi request reprint Measurement of heart rate variability by methods based on nonlinear dynamics
    Heikki V Huikuri
    Division of Cardiology, Department of Internal Medicine, University of Oulu, Finland
    J Electrocardiol 36:95-9. 2003
    ....
  8. doi request reprint Attenuated recovery of heart rate turbulence early after myocardial infarction identifies patients at high risk for fatal or near-fatal arrhythmic events
    Heikki V Huikuri
    Department of Internal Medicine, University of Oulu, Oulu, Finland
    Heart Rhythm 7:229-35. 2010
    ..Autonomic dysfunction tends to improve over time after acute myocardial infarction (MI), but the clinical significance of autonomic remodeling is not well known...
  9. doi request reprint Effects of intracoronary injection of mononuclear bone marrow cells on left ventricular function, arrhythmia risk profile, and restenosis after thrombolytic therapy of acute myocardial infarction
    Heikki V Huikuri
    Department of Internal Medicine, University of Oulu, Oulu, Finland
    Eur Heart J 29:2723-32. 2008
    ..To assess the efficacy and safety of bone marrow cell (BMC) therapy after thrombolytic therapy of an acute ST-elevation myocardial infarction (STEMI)...
  10. pmc Prediction of fatal or near-fatal cardiac arrhythmia events in patients with depressed left ventricular function after an acute myocardial infarction
    Heikki V Huikuri
    Department of Internal Medicine, University of Oulu, PO Box 5000, Kajaanintie 50, 90014 Oulu, Finland
    Eur Heart J 30:689-98. 2009
    ..To determine whether risk stratification tests can predict serious arrhythmic events after acute myocardial infarction (AMI) in patients with reduced left ventricular ejection fraction (LVEF < or = 0.40)...
  11. ncbi request reprint Prediction of sudden cardiac death: appraisal of the studies and methods assessing the risk of sudden arrhythmic death
    Heikki V Huikuri
    Division of Cardiology, Department of Internal Medicine, University of Oulu, Finland
    Circulation 108:110-5. 2003
  12. doi request reprint Clinical impact of evaluation of cardiovascular control by novel methods of heart rate dynamics
    Heikki V Huikuri
    Department of Internal Medicine, Institute of Clinical Medicine, Centre of Excellence in Research, University of Oulu, Oulu 90014, Finland
    Philos Trans A Math Phys Eng Sci 367:1223-38. 2009
    ....
  13. ncbi request reprint Heart rate variability and dispersion of QT interval in patients with vulnerability to ventricular tachycardia and ventricular fibrillation after previous myocardial infarction
    J S Perkiömäki
    Department of Medicine, University of Oulu, Finland
    J Am Coll Cardiol 30:1331-8. 1997
    ....
  14. ncbi request reprint Cardiac arrhythmias and risk stratification after myocardial infarction: results of the CARISMA pilot study
    Heikki V Huikuri
    Division of Cardiology, Department of Internal Medicine, University of Oulu, Kajaanintie 50, FIN 90220, Oulu Finland
    Pacing Clin Electrophysiol 26:416-9. 2003
    ..The study tested the automatic documentation of arrhythmias by the ILR in 30 post-AMI patients...
  15. ncbi request reprint Heart rate dynamics and vulnerability to ventricular tachyarrhythmias
    H V Huikuri
    Department of Medicine, Oulu University Hospital, Finland
    Ann Med 29:321-5. 1997
    ....
  16. ncbi request reprint Power-law relationship of heart rate variability as a predictor of mortality in the elderly
    H V Huikuri
    Department of Medicine, University of Oulu, Finland
    Circulation 97:2031-6. 1998
    ..We studied whether analysis of 24-hour HR behavior is able to predict mortality in a random population of elderly subjects...
  17. ncbi request reprint Effects of combination antihypertensive therapy on baroreflex sensitivity and heart rate variability in systemic hypertension
    A Ylitalo
    Department of Internal Medicine, University of Oulu, Finland
    Am J Cardiol 83:885-9. 1999
    ....
  18. ncbi request reprint Heart rate variability and progression of coronary atherosclerosis
    H V Huikuri
    Division of Cardiology, Department of Medicine and Biocenter of Oulu, University of Oulu, Finland
    Arterioscler Thromb Vasc Biol 19:1979-85. 1999
    ..HR variability provided information on progression of focal coronary atherosclerosis beyond that obtained by traditional risk markers of atherosclerosis...
  19. ncbi request reprint Dynamic behavior and autonomic regulation of ectopic atrial pacemakers
    H V Huikuri
    University of Oulu, Department of Medicine, Division of Cardiology, Oulu, Finland
    Circulation 100:1416-22. 1999
    ..We compared the HR variability of tachycardias originating from the ectopic foci and the sinus node...
  20. ncbi request reprint Measurement of heart rate variability: a clinical tool or a research toy?
    H V Huikuri
    Department of Medicine, University of Oulu, Finland
    J Am Coll Cardiol 34:1878-83. 1999
    ..Further studies should also address the issue of which of the HR variability indexes, including the new nonlinear measures, is best for clinical purposes in various patient populations...
  21. ncbi request reprint Fractal correlation properties of R-R interval dynamics and mortality in patients with depressed left ventricular function after an acute myocardial infarction
    H V Huikuri
    Division of Cardiology, Department of Medicine, University of Oulu, Finland
    Circulation 101:47-53. 2000
    ..The purpose of this study was to compare the prognostic power of new fractal and traditional measures of R-R interval variability as predictors of death after acute myocardial infarction...
  22. ncbi request reprint Heart rate variability in ischemic heart disease
    H V Huikuri
    Department of Medicine, University of Oulu, Finland
    Auton Neurosci 90:95-101. 2001
    ..These findings support the notion that heart rate variability analysis methods, such as fractal and complexity measures as well as conventional techniques, give valuable clinical information among patients with ischemic heart disease...
  23. ncbi request reprint Association between HERG K897T polymorphism and QT interval in middle-aged Finnish women
    Eeva Pietilä
    Division of Cardiology, Department of Medicine, University of Oulu, Oulu, Finland
    J Am Coll Cardiol 40:511-4. 2002
    ..The aim of this study was to test whether a recently reported polymorphism in the HERG gene coding for the rapidly activating delayed rectifier K+ channel has influence on myocardial repolarization...
  24. doi request reprint Electrocardiographic abnormalities and ventricular tachyarrhythmias after myocardial infarction
    Miia K Hyytinen-Oinas
    Division of Cardiology, Department of Internal Medicine, University of Oulu, Oulu, Finland
    Scand Cardiovasc J 44:15-23. 2010
    ..To assess the association of electrocardiographic repolarization and depolarization patterns to vulnerability to ventricular tachyarrhythmias...
  25. ncbi request reprint Electrocardiographic transmural dispersion of repolarization in patients with inherited short QT syndrome
    Olli Anttonen
    Department of Medicine, Paijat Hame Central Hospital, Lahti, Finland
    Ann Noninvasive Electrocardiol 13:295-300. 2008
    ..In a clinical study with acquired long QT syndrome patients, TPE/QT ratio > 0.28 indicated arrhythmia risk. We hypothesized that the TPE/QT ratio would be greater in SQTS patients than in control subjects...
  26. ncbi request reprint Heart rate variability and recurrence of atrial fibrillation after electrical cardioversion
    Saila Vikman
    Division of Cardiology, Department of Medicine, University Hospital of Tampere, University of Tampere, Finland
    Ann Med 35:36-42. 2003
    ..This study was designed to test the hypothesis that HR variability after electrical cardioversion (CV) of persistent AF predicts the recurrence of AF...
  27. ncbi request reprint Cardiac autonomic control in patients with refractory epilepsy before and during vagus nerve stimulation treatment: a one-year follow-up study
    Eija Ronkainen
    Department of Neurology, University of Oulu, Oulu, Finland
    Epilepsia 47:556-62. 2006
    ..To elucidate possible effect of vagus nerve stimulation (VNS) therapy on interictal heart rate (HR) variability in patients with refractory epilepsy before and after 1-year VNS treatment...
  28. ncbi request reprint Novel spectral indexes of heart rate variability as predictors of sudden and non-sudden cardiac death after an acute myocardial infarction
    Antti M Kiviniemi
    Merikoski Rehabilitation and Research Centre, Oulu, Finland
    Ann Med 39:54-62. 2007
    ..Various indexes of 24-hour heart rate variability (HRV) have been able to predict all-cause mortality after an acute myocardial infarction (AMI), but their value in predicting specific modes of cardiac death has been limited...
  29. ncbi request reprint Impaired negative chronotropic response to adenosine in patients with inappropriate sinus tachycardia
    Aino Maija Still
    Department of Internal Medicine, University of Oulu, Finland
    J Cardiovasc Electrophysiol 13:557-62. 2002
    ..Adenosine is an endogenous nucleoside that has an important role in the diagnosis and treatment of several cardiac arrhythmias. However, its effects on inappropriate sinus tachycardia (IST) are not well established...
  30. ncbi request reprint Heart rate turbulence after ventricular and atrial premature beats in subjects without structural heart disease
    Kai S Lindgren
    Division of Cardiology, Department of Internal Medicine, Vaasa Central Hospital, Vaasa, Finland
    J Cardiovasc Electrophysiol 14:447-52. 2003
    ..Studies assessing heart rate (HR) behavior after premature beats have focused on HR responses to ventricular premature beats (VBPs), but there is less information of HR behavior after atrial premature beats (APBs)...
  31. ncbi request reprint Heart rate recovery after exercise as a predictor of mortality among survivors of acute myocardial infarction
    Samuli I Nissinen
    Division of Cardiology, Department of Internal Medicine, University of Oulu, Oulu, Finland
    Am J Cardiol 91:711-4. 2003
  32. ncbi request reprint Fractal analysis of heart rate variability and mortality after an acute myocardial infarction
    Jari M Tapanainen
    Division of Cardiology, Department of Internal Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland
    Am J Cardiol 90:347-52. 2002
    ..90, 95% CI 2.03 to 7.49, p <0.001). Short-term fractal scaling analysis of HR variability is a powerful predictor of mortality among patients surviving an acute myocardial infarction...
  33. doi request reprint New Vectorcardiographic non-planarity measure of T-wave loop improves separation between healthy subjects and myocardial infarction patients
    Mari Karsikas
    Department Electrical and Information Engineering, Computer Engineering Laboratory PO BOX 4500, 90014 University of Oulu, Finland
    Conf Proc IEEE Eng Med Biol Soc 2009:1754-7. 2009
    ..The new method separated healthy and patient groups with p-value 0.002 while PCA3 only with p-value 0.075. The new method was superior to PCA3 in separating the healthy patients from both infarction types...
  34. ncbi request reprint Influence of size and location of myocardial infarction on TCRT parameter: a computer simulation study
    Mari Karsikas
    Department Electrical and Information Engineering, Computer Engineering Laboratory, PO Box 4500, 90014 University of Oulu, Finland
    Conf Proc IEEE Eng Med Biol Soc 2007:1414-7. 2007
    ..001). TCRT turned into negative values only in case of anterior MI. The results indicate that the location of the MI should be considered when interpreting changes of TCRT values with MI patients...
  35. ncbi request reprint Successful catheter ablation of focal atrial tachycardia from the non-coronary aortic cusp
    M J Pekka Raatikainen
    Department of Internal Medicine, Division of Cardiology, University of Oulu, PO Box 5000, FIN 90014, Finland
    Europace 9:216-9. 2007
    ..Radiofrequency catheter ablation at this site terminated the tachycardia with no complications...
  36. ncbi request reprint Familial clustering of lone atrial fibrillation in patients with saddleback-type ST-segment elevation in right precordial leads
    M Juhani Junttila
    Department of Internal Medicine, Division of Cardiology, University of Oulu, PO Box 5000, Oulu 90014, Finland
    Eur Heart J 28:463-8. 2007
    ..On the basis of this finding, we studied whether there is a relationship between saddleback ST-elevation and lone AF...
  37. ncbi request reprint Association between usage of beta-blocking medication and benefit from implantable cardioverter therapy
    Timo H Mäkikallio
    Division of Cardiology, Department of Internal Medicine, University of Oulu, Oulu, Finland
    Am J Cardiol 98:1245-7. 2006
    ..81, p <0.01). In conclusion, the use of beta-blocking medication is associated with a reduced absolute mortality benefit of ICD therapy in reported randomized trials...
  38. ncbi request reprint Family history and the risk of sudden cardiac death as a manifestation of an acute coronary event
    Kari S Kaikkonen
    Department of Internal Medicine, University of Oulu, PO Box 5000 Kajaanintie 50, 90014 Oulu, Finland
    Circulation 114:1462-7. 2006
    ..This study tested the hypothesis that a family history of sudden cardiac death (SCD) is a risk factor for SCD caused by an acute coronary event...
  39. ncbi request reprint Respiratory sinus arrhythmia as a predictor of sudden cardiac death after myocardial infarction
    Mirja Peltola
    University of Oulu, Department of Internal Medicine, Division of Cardiology, Oulu, Finland
    Ann Med 40:376-82. 2008
    ....
  40. ncbi request reprint Functional significance of KCNH2 (HERG) K897T polymorphism for cardiac repolarization assessed by analysis of T-wave morphology
    Eeva H Linna
    Division of Cardiology, Department of Medicine, University of Oulu, Finland
    Ann Noninvasive Electrocardiol 11:57-62. 2006
    ....
  41. ncbi request reprint Frequency of sudden cardiac death among acute myocardial infarction survivors with optimized medical and revascularization therapy
    Timo H Mäkikallio
    Division of Cardiology, Department of Internal Medicine, University of Oulu, Lapland Central Hospital, Rovaniemi, Finland
    Am J Cardiol 97:480-4. 2006
    ..In conclusion, the incidence of SCD is low in the modern treatment era of patients after an AMI. Coronary revascularization seems to have a great effect on altered the epidemiologic pattern of SCD...
  42. ncbi request reprint Usefulness of T-wave loop and QRS complex loop to predict mortality after acute myocardial infarction
    Juha S Perkiomaki
    Division of Cardiology, Department of Medicine, University of Oulu, Oulu, Finland
    Am J Cardiol 97:353-60. 2006
    ..In conclusion, TWLD that describes the shape of the T-wave loop is a specific predictor of cardiac death and independent of the clinical risk markers in the current treatment era of patients with AMI...
  43. doi request reprint Frequency of slow oscillations in arterial pressure and R-R intervals during muscle metaboreflex activation
    Antti M Kiviniemi
    Department of Exercise and Medical Physiology, Verve Research, Oulu, Finland
    Auton Neurosci 152:88-95. 2010
    ..The present results give new insight to understand the physiology underlying the frequency of slow arterial pressure and R-R interval oscillations...
  44. ncbi request reprint Differences in 12-lead electrocardiogram between symptomatic and asymptomatic Brugada syndrome patients
    M Juhani Junttila
    Division of Cardiology, Department of Medicine, University of Oulu, Finland
    J Cardiovasc Electrophysiol 19:380-3. 2008
    ..It is not well established which BrS patients are at risk of severe arrhythmias. Our aim was to study whether standard 12-lead electrocardiogram (ECG) would give useful information for this purpose...
  45. doi request reprint Autonomic markers as predictors of nonfatal acute coronary events after myocardial infarction
    Juha S Perkiomaki
    Division of Cardiology, Department of Internal Medicine, University of Oulu, Oulu, Finland
    Ann Noninvasive Electrocardiol 13:120-9. 2008
    ....
  46. doi request reprint Heart rate dynamics in temporal lobe epilepsy-A long-term follow-up study
    Eija Suorsa
    Department of Neurology, University of Oulu, Oulu, Finland
    Epilepsy Res 93:80-3. 2011
    ..05) in HR variability were observed. The reduction in HRV seems to be progressive in patients with chronic refractory TLE with recurrent seizures...
  47. doi request reprint Coronary angioplasty in drug eluting stent era for the treatment of unprotected left main stenosis compared to coronary artery bypass grafting
    Timo H Mäkikallio
    Division of Cardiology, Department of Internal Medicine, University of Oulu, Lapland Central Hospital, Rovaniemi, Finland
    Ann Med 40:437-43. 2008
    ..Improved outcomes of percutaneous coronary interventions (PCI) with drug-eluting stents (DES) have resulted in their expanded use for left main coronary artery (LMCA) stenosis...
  48. doi request reprint Comparison of risk profiles between survivors and victims of sudden cardiac death from an acute coronary event
    Kari S Kaikkonen
    Department of Internal Medicine, University of Oulu, Finland
    Ann Med 41:120-7. 2009
    ..This study was designed to compare the risk profiles of sudden cardiac death (SCD) victims and survivors of an acute coronary event...
  49. ncbi request reprint Predictors of long-term risk for heart failure hospitalization after acute myocardial infarction
    Juha S Perkiomaki
    Department of Medicine, University of Oulu, Finland
    Ann Noninvasive Electrocardiol 15:250-8. 2010
    ..Data on the value of baseline brain natriuretic peptide (BNP) and autonomic markers in predicting heart failure (HF) hospitalization after an acute myocardial infarction (AMI) are limited...
  50. doi request reprint Acetylcholine receptor M2 gene variants, heart rate recovery, and risk of cardiac death after an acute myocardial infarction
    Arto J Hautala
    Department of Exercise and Medical Physiology, Verve Research, Kasarmintie 13, Oulu, Finland
    Ann Med 41:197-207. 2009
    ....
  51. ncbi request reprint Dynamics and rate-dependence of the spatial angle between ventricular depolarization and repolarization wave fronts during exercise ECG
    Tuomas Kenttä
    Institute of Clinical Medicine, University of Oulu, Finland
    Ann Noninvasive Electrocardiol 15:264-75. 2010
    ..This study assessed the possible rate dependence of these variables during exercise ECG in healthy subjects...
  52. ncbi request reprint Changes in cardiovascular autonomic regulation among elderly subjects: follow-up of sixteen years
    Vesa Jokinen
    Division of Cardiology, Department of Medicine, University of Oulu, Finland
    Ann Med 37:206-12. 2005
    ..However, there are no longitudinal follow-up reports of the changes of HR dynamics in elderly subjects...
  53. doi request reprint Determinants of functional recovery after myocardial infarction of patients treated with bone marrow-derived stem cells after thrombolytic therapy
    Johanna A Miettinen
    University of Oulu, Department of Internal Medicine P O Box 5000 Kajaanintie 50, FIN 90014 University of Oulu, Oulu, Finland
    Heart 96:362-7. 2010
    ....
  54. ncbi request reprint Diabetes and haemodynamic reactions to acute coronary occlusion
    K E Juhani Airaksinen
    Cardiovascular Laboratory, Department of Medicine, University of Turku, Kiinamyllynkatu 4 8, FIN 20520 Turku, Finland
    Int J Cardiol 95:237-44. 2004
    ..Since diabetes mellitus may interfere with autonomic and myocardial function, we decided to study whether diabetes alters autonomic and haemodynamic responses to acute coronary occlusion...
  55. ncbi request reprint Temporal changes and prognostic significance of measures of heart rate dynamics after acute myocardial infarction in the beta-blocking era
    Vesa Jokinen
    Division of Cardiology, Department of Medicine, University of Oulu, Oulu, Finland
    Am J Cardiol 92:907-12. 2003
    ..Fractal HR variability and HR turbulence retain their prognostic power in the BB era, when measured either at the convalescent or late phase after AMI...
  56. ncbi request reprint Cardiovascular regulation and hippocampal sclerosis
    Hanna Ansakorpi
    Department of Neurology, University of Oulu, Finland
    Epilepsia 45:933-9. 2004
    ..It is not known whether these structural changes modify cardioregulatory function in patients with TLE...
  57. ncbi request reprint Cardiovascular autonomic function correlates with the response to aerobic training in healthy sedentary subjects
    Arto J Hautala
    Merikoski Rehabilitation and Research Center, and Department of Medicine, University of Oulu, Finland
    Am J Physiol Heart Circ Physiol 285:H1747-52. 2003
    ..High vagal activity at baseline is associated with the improvement in aerobic power caused by aerobic exercise training in healthy sedentary subjects...
  58. ncbi request reprint Effects and significance of premature beats on fractal correlation properties of R-R interval dynamics
    Mirja A Peltola
    Division of Cardiology, Department of Medicine, University of Oulu, Finland
    Ann Noninvasive Electrocardiol 9:127-35. 2004
    ..We assessed the effects and significance of PBs on fractal scaling exponents in healthy subjects and patients with a recent myocardial infarction (AMI)...
  59. ncbi request reprint Differences in the activation patterns between sustained and self-terminating episodes of human ventricular fibrillation
    Timo H Mäkikallio
    Division of Cardiology, University of Miami, School of Medicine, Florida, USA
    Ann Med 34:130-5. 2002
    ..Experimental studies have suggested that R-R interval dynamics during ventricular fibrillation (VF) have organized features, but whether dynamic behavior of non-sustained VF differs from sustained VF is unknown...
  60. ncbi request reprint Microvolt T-wave alternans during exercise and pacing in patients with acute myocardial infarction
    M J Pekka Raatikainen
    University of Oulu, Department of Internal Medicine, Division of Cardiology, Oulu, Finland
    Pacing Clin Electrophysiol 28:S193-7. 2005
    ..The low number of indeterminate tests and high concordance between the test results indicate that V + A pacing may provide a valuable means to assess TWA in patients who cannot complete the exercise test...
  61. ncbi request reprint Comprehensive study of autonomic function in a population with primary Sjögren's syndrome. No evidence of autonomic involvement
    Raija K Niemelä
    Division of Rheumatology, Department of Internal Medicine, University of Oulu, Finland
    J Rheumatol 30:74-9. 2003
    ....
  62. ncbi request reprint Clinical applicability of heart rate variability analysis by methods based on nonlinear dynamics
    Timo H Mäkikallio
    Division of Cardiology, Department of Medicine, University of Oulu, Oulu, Finland
    Card Electrophysiol Rev 6:250-5. 2002
    ..This article provides a review of our current knowledge of the usefulness of dynamical measures of HR fluctuation...
  63. ncbi request reprint [How do I diagnose and treat ventricular extrasystoles?]
    M J Pekka Raatikainen
    OYS n sisätautien klinikka, kardiologian osasto Kajaanintie 50 90220 Oulu
    Duodecim 118:145-54; quiz 154, 208. 2002
  64. ncbi request reprint Fractal and complexity measures of heart rate variability
    Juha S Perkiomaki
    Division of Cardiology, Department of Medicine, University of Oulu, Oulu, Finland
    Clin Exp Hypertens 27:149-58. 2005
    ....
  65. ncbi request reprint Prediction of sudden cardiac death after acute myocardial infarction: role of Holter monitoring in the modern treatment era
    Timo H Mäkikallio
    Division of Cardiology, Department of Internal Medicine, University of Oulu, PO Box 5000 Kajaanintie 50, FIN 90014, Oulu, Finland
    Eur Heart J 26:762-9. 2005
    ..We evaluated the utility of Holter-based risk variables in the prediction of sudden cardiac death (SCD) among survivors of AMI treated with modern therapy...
  66. doi request reprint Variation in the vascular endothelial growth factor gene, carotid intima-media thickness and the risk of acute myocardial infarction
    Tiia Kangas-Kontio
    Institute of Clinical Medicine, Department of Internal Medicine, Oulu University Hospital and Biocenter Oulu, Finland
    Scand J Clin Lab Invest 69:335-43. 2009
    ....
  67. doi request reprint Fractal scaling properties of heart rate dynamics and myocardial efficiency in dilated cardiomyopathy
    Tiina Marjatta Salo
    Department of Medicine, University of Turku, 20520 Turku, Finland
    Clin Res Cardiol 98:725-30. 2009
    ..Since altered heart rate (HR) fluctuations provide prognostic information in heart failure, we examined the associations between HR dynamics, myocardial efficiency and perfusion, among patients with dilated cardiomyopathy...
  68. ncbi request reprint Natriuretic peptides as predictors of non-sudden and sudden cardiac death after acute myocardial infarction in the beta-blocking era
    Jari M Tapanainen
    Division of Cardiology, Department of Internal Medicine, Oulu University Hospital, Oulu, Finland
    J Am Coll Cardiol 43:757-63. 2004
    ..This prospective study tested whether the natriuretic peptides predict cardiac death among patients using beta-blocking therapy after an acute myocardial infarction (AMI)...
  69. ncbi request reprint Circadian heart rate variability in Parkinson's disease
    Ville Pursiainen
    Department of Neurology, University of Oulu, P O Box 5000, 90014 Oulu, Finland
    J Neurol 249:1535-40. 2002
    ..The results indicate that the long-term parasympathetic cardiovascular regulation is impaired in untreated patients with Parkinson's disease. The dysfunction is more pronounced at night...
  70. ncbi request reprint Heart rate dynamics after controlled training followed by a home-based exercise program
    Arto J Hautala
    Merikoski Rehabilitation and Research Center, Kasarmintie 13, 90100, Oulu, Finland
    Eur J Appl Physiol 92:289-97. 2004
    ..44, P<0.05) after the home-based training program. The high vagal outflow to the heart after the home-based training is associated with good physical performance and body mass control...
  71. ncbi request reprint Prevalence, characteristics and natural course of inappropriate sinus tachycardia
    Aino Maija Still
    Department of Internal Medicine, Division of Cardiology, University of Oulu, P O Box 5000, FIN 900014, Finland
    Europace 7:104-12. 2005
    ..To study the prevalence, characteristics and natural course of inappropriate sinus tachycardia (IST)...
  72. ncbi request reprint Feedback effects of circulating norepinephrine on sympathetic outflow in healthy subjects
    Mikko P Tulppo
    Merikoski Rehabilitation and Research Centre, Oulu, Finland
    Am J Physiol Heart Circ Physiol 288:H710-5. 2005
    ....
  73. doi request reprint Physical activity and heart rate variability measured simultaneously during waking hours
    Arto J Hautala
    Dept of Exercise and Medical Physiology, Verve Research, Oulu, Finland
    Am J Physiol Heart Circ Physiol 298:H874-80. 2010
    ..Long-term HRV indexes remained relatively stable at various activity levels, making them the most robust indexes for the assessment of cardiac autonomic function during free-running ambulatory conditions...
  74. ncbi request reprint Short-term correlation properties of R-R interval dynamics at different exercise intensity levels
    Arto J Hautala
    Merikoski Rehabilitation and Research Center, Oulu, Finland
    Clin Physiol Funct Imaging 23:215-23. 2003
    ..Changes in alpha1 values can be detected also in high intensity levels, when the conventional measures of HR variability can not be applied...
  75. ncbi request reprint Influence of paper electrocardiogram digitizing on T wave and QRS complex morphology parameters
    Mari Karsikas
    University of Oulu, Department of Electrical and Information Engineering, University of Oulu, Finland
    Ann Noninvasive Electrocardiol 12:282-90. 2007
    ..However, the digitizing process, including printing, scanning, ECG contour extraction, and alignment, can produce changes to the signals, reducing the reliability of some sensitive parameters of QRS complex and T wave...
  76. ncbi request reprint Cardiac vagal outflow after aerobic training by analysis of high-frequency oscillation of the R-R interval
    Antti M Kiviniemi
    Merikoski Rehabilitation and Research Center, Kasarmintie 13, P O Box 404, 90101, Oulu, Finland
    Eur J Appl Physiol 96:686-92. 2006
    ..HF power calculated from unsaturated area detects more accurately subtle changes in the vagally mediated beat-to-beat variability of the R-R interval after aerobic training than the mean 24-h HF power...
  77. ncbi request reprint Temporal changes in cardiovascular autonomic regulation in type II diabetic patients: association with coronary risk variables and progression of coronary artery disease
    Vesa Jokinen
    Division of Cardiology, University of Oulu, Finland corrected
    Ann Med 35:216-23. 2003
    ....
  78. ncbi request reprint Cardiovascular autonomic regulation in patients with 3243A > G mitochondrial DNA mutation
    Kirsi Majamaa-Voltti
    Department of Internal Medicine, University of Oulu, Finland
    Ann Med 36:225-31. 2004
    ..Patients with the 3243A > G mutation in mitochondrial DNA (mtDNA) have an increased risk for cardiovascular morbidity and mortality. The function of the autonomic nervous system has not been evaluated in these patients...
  79. doi request reprint Total testosterone levels, metabolic parameters, cardiac remodeling and exercise capacity in coronary artery disease patients with different stages of glucose tolerance
    Olavi Ukkola
    Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu and Clinical Research Center of Oulu University Hospital, Finland
    Ann Med 45:206-12. 2013
    ..The correlation between total testosterone levels, exercise capacity, and metabolic and echocardiographic parameters was studied in 1097 male subjects with coronary artery disease (CAD) and different stages of glucose tolerance...
  80. ncbi request reprint Muscle sympathetic nerve activity at rest compared to exercise tolerance
    Arto J Hautala
    Department of Exercise and Medical Physiology, Verve Research, Kasarmintie 13, PO Box 404, 90101, Oulu, Finland
    Eur J Appl Physiol 102:533-8. 2008
    ..In conclusion, baseline sympathetic activity, measured by a microneurography at rest, may be associated with the maximal running performance of healthy subjects...
  81. ncbi request reprint Effects of carvedilol on heart rate dynamics in patients with congestive heart failure
    Mustafa Ridha
    Cardiology 111 A, V A Medical Center, 1201 NW 16th Street, Miami, FL 33125, USA
    Ann Noninvasive Electrocardiol 7:133-8. 2002
    ..This study was designed to test the effects of carvedilol, a nonselective beta-blocker with alpha-1 blocking properties, on HR dynamics in patients with CHF...
  82. ncbi request reprint Physiological background of the loss of fractal heart rate dynamics
    Mikko P Tulppo
    Merikoski Rehabilitation and Research Centre, Kasarmintie 13, PO Box 404, FIN 90101 Oulu, Finland
    Circulation 112:314-9. 2005
    ..We tested the hypothesis that the fractal organization of human HR dynamics is determined by the balance between sympathetic and vagal outflow...
  83. ncbi request reprint Fractal correlation properties of R-R interval dynamics in asymptomatic relatives of patients with dilated cardiomyopathy
    Niall G Mahon
    Department of Cardiological Sciences, St George s Hospital Medical School, London, UK
    Eur J Heart Fail 4:151-8. 2002
    ..The aim of this study was to compare values of proportional, variant(1) and conventional HRV indices in LVE relatives with dilated cardiomyopathy patients and normal controls...
  84. ncbi request reprint Nonlinear heart rate variability in CABG patients and the preconditioning effect
    Zhong Kai Wu
    Department of Cardiac Surgery, Affiliated 1st Hospital, Sun Yat Sen University, Guangzhou, China
    Eur J Cardiothorac Surg 28:109-13. 2005
    ..Short brief myocardial ischemia has been reported to influence HRV. We therefore hypothesis that the protective mechanism of ischemic preconditioning (IP) may involve in cardiac autonomic regulation...
  85. ncbi request reprint Risks in risk stratification: what is relevant in practice?
    Timo H Mäkikallio
    Circulation 105:e69-70. 2002
  86. ncbi request reprint Heart rate recovery after maximal exercise is associated with acetylcholine receptor M2 (CHRM2) gene polymorphism
    Arto J Hautala
    Pennington Biomedical Research Center, Human Genomics Laboratory, Louisiana State University System, Baton Rouge, Louisiana, USA
    Am J Physiol Heart Circ Physiol 291:H459-66. 2006
    ..025) and after endurance training (P = 0.005). These data suggest that DNA sequence variation at the CHRM2 locus is a potential modifier of HR recovery in the sedentary state and after short-term endurance training in healthy individuals...
  87. ncbi request reprint Long-term alterations of heart rate dynamics after coronary artery bypass graft surgery
    Timo T Laitio
    Department of Anesthesiology and Intensive Care, Turku University Hospital, Turku, Finland
    Anesth Analg 102:1026-31. 2006
    ..01 after 1 yr). The predictive value of temporary and persistent long-term changes of the HR dynamics after CABG surgery for long-term outcome is not clear...
  88. ncbi request reprint Relation of heart rate dynamics to the occurrence of myocardial ischemia after coronary artery bypass grafting
    Timo T Laitio
    Department of Anesthesiology, Turku University Hospital, Turku, Finland
    Am J Cardiol 89:1176-81. 2002
    ....
  89. ncbi request reprint The breakdown of fractal heart rate dynamics predicts prolonged postoperative myocardial ischemia
    Timo T Laitio
    Department of Anesthesiology and Intensive Care, Turku University Hospital, Turku, Finland
    Anesth Analg 98:1239-44, table of contents. 2004
    ..7 (95% confidence interval, 1.9-51.4; P = 0.0018). Breakdown of fractal-like heart rate dynamics is predictive for postoperative prolonged myocardial ischemia in elderly patients having emergency surgery for traumatic hip fracture...
  90. ncbi request reprint Origin and significance of heart rate variability
    Mikko Tulppo
    J Am Coll Cardiol 43:2278-80. 2004
  91. ncbi request reprint Saturation of high-frequency oscillations of R-R intervals in healthy subjects and patients after acute myocardial infarction during ambulatory conditions
    Antti M Kiviniemi
    Merikoski Rehabilitation and Research Center, Kasarmintie 13, PO Box 404, FIN 90101 Oulu, Finland
    Am J Physiol Heart Circ Physiol 287:H1921-7. 2004
    ..This saturation effect may bias the quantification of cardiac vagal function when HR variability is analyzed from Holter recordings...
  92. ncbi request reprint [Are ACE inhibitors and angiotensin receptor blockers useful in the treatment of atrial fibrillation?]
    M J Raatikainen
    Duodecim 119:1505-7. 2003
  93. ncbi request reprint Exercise training improves baroreflex sensitivity in type 2 diabetes
    Antti Loimaala
    South Karelian Central Hospital, Department of Clinical Physiology and Nuclear Medicine, Lappeenranta, Finland
    Diabetes 52:1837-42. 2003
    ..These beneficial effects in reflectory autonomic regulation and glucose control caused by exercise may be associated with improved prognosis of type 2 diabetes patients...
  94. ncbi request reprint Heart rate turbulence after atrial premature beats before spontaneous onset of atrial fibrillation
    Saila Vikman
    Heart Center, University Hospital of Tampere, Biokatu 6, PL 2000, 33521 Tampere, Finland
    J Am Coll Cardiol 45:278-84. 2005
    ..This study was designed to assess the temporal changes in vagal responses to atrial premature beats before spontaneous onset of atrial fibrillation (AF)...
  95. ncbi request reprint Traditional and nonlinear heart rate variability are each independently associated with mortality after myocardial infarction
    Phyllis K Stein
    Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Cardiovasc Electrophysiol 16:13-20. 2005
    ..Traditional HRV predicts mortality in patients with a range of times post-MI, but the association of nonlinear HRV and outcome in this population is unknown...
  96. ncbi request reprint Abnormalities in fractal heart rate dynamics in Chagas disease
    Marcos Roberto de Sousa
    Hospital das Clínicas and Internal Medicine Department, School of Medicine, Federal University of Minas Gerais, Minas Gerais, Brazil
    Ann Noninvasive Electrocardiol 11:145-53. 2006
    ....
  97. ncbi request reprint The prognostic accuracy of different QT interval measures
    Kaspar Lund
    Department of Cardiology, Skejby University Hospital, DK 8200 Aarhus N, Denmark
    Ann Noninvasive Electrocardiol 7:10-6. 2002
    ..The purpose of this study was to analyze the prognostic accuracy of all known ways to select the lead...