I E Holopainen

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. ncbi request reprint Asphyxia aggravates systemic hypotension but not pulmonary hypertension in piglets with meconium aspiration
    Minna Aaltonen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Pediatr Res 53:473-8. 2003
  2. pmc Transcriptome analysis of the hippocampal CA1 pyramidal cell region after kainic acid-induced status epilepticus in juvenile rats
    Hanna B Laurén
    Department of Pharmacology, Drug Development, and Therapeutics, Institute of Biomedicine, University of Turku, Turku, Finland
    PLoS ONE 5:e10733. 2010
  3. doi request reprint Glutamate signaling in the pathophysiology and therapy of prenatal insults
    Irma E Holopainen
    Department of Pharmacology, Drug Development and Therapeutics, and MediCity Research Laboratory, Institute of Biomedicine University of Turku, Tykistokatu 6A, 4th Floor, FIN 20014 Turku, Finland
    Pharmacol Biochem Behav 100:825-34. 2012
  4. pmc Temporal profiles of age-dependent changes in cytokine mRNA expression and glial cell activation after status epilepticus in postnatal rat hippocampus
    Juha T Järvelä
    Department of Pharmacology, Drug Development, and Therapeutics, Institute of Biomedicine, University of Turku, Itainen Pitkakatu 4B, FIN 20014 Turku, Finland
    J Neuroinflammation 8:29. 2011
  5. ncbi request reprint Decreased binding of [11C]flumazenil in Angelman syndrome patients with GABA(A) receptor beta3 subunit deletions
    I E Holopainen
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland
    Ann Neurol 49:110-3. 2001
  6. ncbi request reprint Seizures in the developing brain: cellular and molecular mechanisms of neuronal damage, neurogenesis and cellular reorganization
    Irma E Holopainen
    Department of Pharmacology, Drug Development and Therapeutics, and MediCity Research Laboratory, Institute of Biomedicine, University of Turku, Tykistokatu 6A, FIN 20014 Turku, Finland
    Neurochem Int 52:935-47. 2008
  7. ncbi request reprint Organotypic hippocampal slice cultures: a model system to study basic cellular and molecular mechanisms of neuronal cell death, neuroprotection, and synaptic plasticity
    Irma E Holopainen
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Itainen Pitkakatu 4, FI 20520, Turku, Finland
    Neurochem Res 30:1521-8. 2005
  8. ncbi request reprint Mechanisms of kainate-induced region-specific neuronal death in immature organotypic hippocampal slice cultures
    I E Holopainen
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Itainen Pitkakatu 4, FIN 0520 Turku, Finland
    Neurochem Int 45:1-10. 2004
  9. ncbi request reprint Neuronal activity regulates GABAA receptor subunit expression in organotypic hippocampal slice cultures
    I E Holopainen
    Department of Pharmacology and Clinical Pharmacology, University of Turku, PharmaCity, Itainen Pitkakatu 4, FIN 20520, Turku, Finland
    Neuroscience 118:967-74. 2003
  10. ncbi request reprint Do antiepileptics phenytoin, carbamazepine, and loreclezole show GABA(A) receptor subtype selectivity in rat brain sections?
    I E Holopainen
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland
    Neurochem Res 26:89-94. 2001

Collaborators

  • Mikko Uusi-Oukari
  • Esa R Korpi
  • Kimmo A Michelsen
  • H Kokkonen
  • L J Pelliniemi
  • Markus M Lindroos
  • Christina M Krause
  • A Pitkanen
  • Francisco R Lopez-Picon
  • Minna Aaltonen
  • Tiina Kaisa Kukko-Lukjanov
  • H B Lauren
  • Hanna B Laurén
  • F R Lopez-Picon
  • Juha T Järvelä
  • Hanna Soukka
  • Lauri Halkola
  • Pekka O Kaapa
  • Jarmo Jalonen
  • Liisa S Järvelä
  • T K Kukko-Lukjanov
  • Pertti Panula
  • Niina S Jalava
  • Virpi Salonen
  • Hannu Kalimo
  • Tarja Varho
  • Francisco Lopez-Picon
  • Ilkka K Martikainen
  • J T Järvelä
  • M Grönman
  • S Ruohonen
  • J E Virta
  • Toivo T Salmi
  • Saku Ruohonen
  • Tarmo Kärki
  • Hannu Mikola
  • Päivi M Lähteenmäki
  • Maria Leino
  • Anna Plysjuk
  • Saija Hurme
  • Anne Mari Hatanpää
  • Annika M Brandt
  • Clarissa J Rios-Rojas
  • Niina Jalava
  • Minnamaija Lintunen
  • Sanna Soini
  • Tomi Taira
  • Sampsa Kallinen
  • Pirkko Sonninen
  • Jaana Lähdetie
  • Markku Komu
  • Tommi Möykkynen
  • Kadri Lauk
  • Niina Puustinen
  • Sanna L Soini
  • Jari Nissinen
  • Pentti Kero

Detail Information

Publications31

  1. ncbi request reprint Asphyxia aggravates systemic hypotension but not pulmonary hypertension in piglets with meconium aspiration
    Minna Aaltonen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Pediatr Res 53:473-8. 2003
    ....
  2. pmc Transcriptome analysis of the hippocampal CA1 pyramidal cell region after kainic acid-induced status epilepticus in juvenile rats
    Hanna B Laurén
    Department of Pharmacology, Drug Development, and Therapeutics, Institute of Biomedicine, University of Turku, Turku, Finland
    PLoS ONE 5:e10733. 2010
    ....
  3. doi request reprint Glutamate signaling in the pathophysiology and therapy of prenatal insults
    Irma E Holopainen
    Department of Pharmacology, Drug Development and Therapeutics, and MediCity Research Laboratory, Institute of Biomedicine University of Turku, Tykistokatu 6A, 4th Floor, FIN 20014 Turku, Finland
    Pharmacol Biochem Behav 100:825-34. 2012
    ..Finally, therapeutic interventions targeted at GluRs at the young age are discussed in the light of results obtained from recent experimental HI animal models and from humans...
  4. pmc Temporal profiles of age-dependent changes in cytokine mRNA expression and glial cell activation after status epilepticus in postnatal rat hippocampus
    Juha T Järvelä
    Department of Pharmacology, Drug Development, and Therapeutics, Institute of Biomedicine, University of Turku, Itainen Pitkakatu 4B, FIN 20014 Turku, Finland
    J Neuroinflammation 8:29. 2011
    ..We have now further elucidated to what extent inflammation is activated by SE by investigating the acute expression of several cytokines and subacute glial reactivity in the postnatal rat hippocampus...
  5. ncbi request reprint Decreased binding of [11C]flumazenil in Angelman syndrome patients with GABA(A) receptor beta3 subunit deletions
    I E Holopainen
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland
    Ann Neurol 49:110-3. 2001
    ..We propose that the 15q11-q13 deletion leads to a reduced number of GABA(A)/BZ receptors, which could partly explain the neurological deficits of the AS patients...
  6. ncbi request reprint Seizures in the developing brain: cellular and molecular mechanisms of neuronal damage, neurogenesis and cellular reorganization
    Irma E Holopainen
    Department of Pharmacology, Drug Development and Therapeutics, and MediCity Research Laboratory, Institute of Biomedicine, University of Turku, Tykistokatu 6A, FIN 20014 Turku, Finland
    Neurochem Int 52:935-47. 2008
    ....
  7. ncbi request reprint Organotypic hippocampal slice cultures: a model system to study basic cellular and molecular mechanisms of neuronal cell death, neuroprotection, and synaptic plasticity
    Irma E Holopainen
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Itainen Pitkakatu 4, FI 20520, Turku, Finland
    Neurochem Res 30:1521-8. 2005
    ..Thereafter, the use of OHCs in studies focusing on neuron cell death and synaptic plasticity is discussed...
  8. ncbi request reprint Mechanisms of kainate-induced region-specific neuronal death in immature organotypic hippocampal slice cultures
    I E Holopainen
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Itainen Pitkakatu 4, FIN 0520 Turku, Finland
    Neurochem Int 45:1-10. 2004
    ..Electron microscopy showed non-apoptotic injury in the CA3a/b pyramidal neurons in KA-treated slices. Our results suggest that KA-induced neuronal death in immature OHCs is a strictly region-specific, irreversible, necrotic process...
  9. ncbi request reprint Neuronal activity regulates GABAA receptor subunit expression in organotypic hippocampal slice cultures
    I E Holopainen
    Department of Pharmacology and Clinical Pharmacology, University of Turku, PharmaCity, Itainen Pitkakatu 4, FIN 20520, Turku, Finland
    Neuroscience 118:967-74. 2003
    ....
  10. ncbi request reprint Do antiepileptics phenytoin, carbamazepine, and loreclezole show GABA(A) receptor subtype selectivity in rat brain sections?
    I E Holopainen
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland
    Neurochem Res 26:89-94. 2001
    ....
  11. ncbi request reprint Changes in neurofilament protein-immunoreactivity after kainic acid treatment of organotypic hippocampal slice cultures
    I E Holopainen
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland
    J Neurosci Res 66:620-9. 2001
    ..Kainic acid treatment induced changes, which mimicked those observed in the hippocampal region of epileptic animals...
  12. ncbi request reprint Kainic acid-induced status epilepticus alters GABA receptor subunit mRNA and protein expression in the developing rat hippocampus
    H B Lauren
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland
    J Neurochem 94:1384-94. 2005
    ..These perturbations could result in altered functional and pharmacological properties of GABAA receptors...
  13. ncbi request reprint Status epilepticus alters zolpidem sensitivity of [3H]flunitrazepam binding in the developing rat brain
    H B Lauren
    Department of Pharmacology, Drug Development, and Therapeutics, Institute of Biomedicine, University of Turku, Itainen Pitkakatu 4, Turku, FIN 20014, Finland
    Neuroscience 146:802-11. 2007
    ..A part of these changes could be due to alterations in the cell surface expression of receptor subtypes...
  14. doi request reprint Status epilepticus alters neurogenesis and decreases the number of GABAergic neurons in the septal dentate gyrus of 9-day-old rats at the early phase of epileptogenesis
    H B Lauren
    Department of Pharmacology, Drug Development and Therapeutics, Itäinen Pitkäkatu 4 B, 20014 University of Turku, Finland
    Brain Res 1516:33-44. 2013
    ....
  15. ncbi request reprint Differential expression and localization of the phosphorylated and nonphosphorylated neurofilaments during the early postnatal development of rat hippocampus
    F R Lopez-Picon
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland
    Hippocampus 13:767-79. 2003
    ..These developmental changes could be of importance in determining the reactivity of hippocampal neurons in pathological conditions in the immature hippocampus...
  16. ncbi request reprint Histaminergic neurons protect the developing hippocampus from kainic acid-induced neuronal damage in an organotypic coculture system
    Tiina Kaisa Kukko-Lukjanov
    Department of Pharmacology and Clinical Pharmacology, University of Turku, FIN 20520 Turku, Finland
    J Neurosci 26:1088-97. 2006
    ..Our results suggest that histaminergic neurons protect the developing hippocampus from KA-induced neuronal damage, with regulation of neuronal survival being at least partly mediated through H1 and H3 receptors...
  17. ncbi request reprint Age-dependent cyclooxygenase-2 induction and neuronal damage after status epilepticus in the postnatal rat hippocampus
    Juha T Järvelä
    Department of Pharmacology, Drug Development, and Therapeutics, Institute of Biomedicine, University of Turku, Turku, Finland
    Epilepsia 49:832-41. 2008
    ..In this study, we investigated the contribution of apoptosis and inflammatory processes to neuronal damage after status epilepticus (SE) in postnatal rats...
  18. ncbi request reprint Resistance of neurofilaments to degradation, and lack of neuronal death and mossy fiber sprouting after kainic acid-induced status epilepticus in the developing rat hippocampus
    Francisco Lopez-Picon
    Department of Pharmacology and Clinical Pharmacology, FIN 20520 Turku, Finland
    Neurobiol Dis 17:415-26. 2004
    ..Our findings indicate seizure-induced reactivity of NF proteins but their resistance to degradation, which could be of importance in neuronal survival and may also prevent MF sprouting in the developing hippocampus...
  19. doi request reprint Auditory event related potentials as tools to reveal cognitive late effects in childhood cancer patients
    Liisa S Järvelä
    Department of Paediatrics, Turku University Hospital, Turku, Finland
    Clin Neurophysiol 122:62-72. 2011
    ....
  20. doi request reprint Involvement of histamine 1 receptor in seizure susceptibility and neuroprotection in immature mice
    Tiina Kaisa Kukko-Lukjanov
    Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Itainen Pitkakatu 4B, 20520 Turku, Finland
    Epilepsy Res 90:8-15. 2010
    ..Our present novel findings suggest that H1 receptors play a pivotal role in the regulation of seizure intensity and duration as well as seizure-induced neuronal damage in the immature P9 mice...
  21. ncbi request reprint The calpain inhibitor MDL-28170 and the AMPA/KA receptor antagonist CNQX inhibit neurofilament degradation and enhance neuronal survival in kainic acid-treated hippocampal slice cultures
    Francisco R Lopez-Picon
    Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Itainen Pitkakatu 4, FIN 20520 Turku, Finland
    Eur J Neurosci 23:2686-94. 2006
    ....
  22. ncbi request reprint Inhaled nitric oxide treatment inhibits neuronal injury after meconium aspiration in piglets
    Minna Aaltonen
    Research Centre of Applied and Preventive Cardiovascular Medicine CAPC, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
    Early Hum Dev 83:77-85. 2007
    ..Meconium aspiration-induced hypertensive lung injury is frequently associated with neuronal damage. Inhaled nitric oxide (iNO) is widely used in the treatment of pulmonary hypertension, but its effects on the brain are poorly known...
  23. ncbi request reprint Meconium aspiration induces oxidative injury in the hippocampus of newborn piglets
    Minna Aaltonen
    Research Centre of Applied and Preventive Cardiovascular Medicine CAPC, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
    Early Hum Dev 81:439-47. 2005
    ..Meconium aspiration-induced hypertensive lung injury has been associated with neuronal damage in the newborn, but the mechanisms of the injury are poorly known...
  24. ncbi request reprint Meconium aspiration induces neuronal injury in piglets
    Minna Aaltonen
    Research Centre of Applied and Preventive Cardiovascular Medicine CAPC, University Hospital of Turku, Turku, Finland
    Acta Paediatr 94:1468-75. 2005
    ..We aimed to determine the neuronal injury induced by pulmonary meconium contamination alone and with concurrent asphyxia...
  25. ncbi request reprint Maturation of cultured hippocampal slices results in increased excitability in granule cells
    Markus M Lindroos
    Department of Pharmacology, University of Turku, Itainen Pitkakatu 4, FIN 20520 Turku, Finland
    Int J Dev Neurosci 23:65-73. 2005
    ..Cultured immature hippocampal slices could thus serve as an additional in vitro model to elucidate mechanisms of synaptic plasticity and cellular reactivity in response to external damage in the developing hippocampus...
  26. ncbi request reprint Changes in microtubule-associated protein-2 (MAP2) expression during development and after status epilepticus in the immature rat hippocampus
    Niina S Jalava
    Department of Pharmacology, Drug Development, and Therapeutics, Institute of Biomedicine, University of Turku, Itainen Pitkakatu 4B, FIN 20014 Turku, Finland
    Int J Dev Neurosci 25:121-31. 2007
    ..Moreover, high-molecular weight MAP2s may play a role in nerve cell survival during cell stress...
  27. ncbi request reprint Selective changes in gamma-aminobutyric acid type A receptor subunits in the hippocampus in spontaneously seizing rats with chronic temporal lobe epilepsy
    Hanna B Laurén
    Department of Pharmacology and Clinical Pharmacology, PharmaCity, University of Turku, Itainen Pitkakatu 4, FIN 20520 Turku, Finland
    Neurosci Lett 349:58-62. 2003
    ..Our results suggest that GABA(A) receptor undergoes region selective subunit changes during epileptogenesis in the hippocampus of rats with chronic temporal lobe epilepsy...
  28. ncbi request reprint Kainate down-regulates a subset of GABAA receptor subunits expressed in cultured mouse cerebellar granule cells
    Ilkka K Martikainen
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland
    Cerebellum 3:27-38. 2004
    ..In conclusion, chronic kainate treatment of cerebellar granule cells selectively down-regulates oil, alpha6 and beta2 subunits resulting in altered GABAA receptor pharmacology...
  29. ncbi request reprint AMPA/kainate receptor-mediated up-regulation of GABAA receptor delta subunit mRNA expression in cultured rat cerebellar granule cells is dependent on NMDA receptor activation
    Virpi Salonen
    Department of Pharmacology, Drug Design and Therapeutics, University of Turku, Itainen Pitkakatu 4, FIN 20520 Turku, Finland
    Brain Res 1087:33-40. 2006
    ..Up-regulation of delta during prolonged glutamate receptor activation or cell membrane depolarization may be a mechanism to increase tonic inhibition to counteract excessive excitation...
  30. ncbi request reprint Quantitative HMRS and MRI volumetry indicate neuronal damage in the hippocampus of children with focal epilepsy and infrequent seizures
    Tarja Varho
    Child and Adolescence Health Care of Turku City, Finland
    Epilepsia 46:696-703. 2005
    ..We have now studied eventual metabolic and volume changes in the hippocampus of children with nonsymptomatic focal epilepsy taking antiepileptic medication (AEDs) but still having infrequent seizures...
  31. ncbi request reprint Brain oscillatory EEG event-related desynchronization (ERD) and -sychronization (ERS) responses during an auditory memory task are altered in children with epilepsy
    Christina M Krause
    Cognitive Science Unit, Department of Psychology, University of Helsinki, 00014 Helsinki, Finland
    Seizure 17:1-10. 2008
    ..The purpose of this study was to assess the effect of infrequent seizures on cognitive skills in children with non-symptomatic focal epilepsy taking antiepileptic medication but still having infrequent seizures...