Jukka Holappa

Summary

Affiliation: University of Kuopio
Country: Finland

Publications

  1. ncbi N-Chloroacyl-6-O-triphenylmethylchitosans: useful intermediates for synthetic modifications of chitosan
    Jukka Holappa
    Department of Pharmaceutical Chemistry, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Biomacromolecules 6:858-63. 2005
  2. ncbi Novel water-soluble quaternary piperazine derivatives of chitosan: synthesis and characterization
    Jukka Holappa
    Department of Pharmaceutical Chemistry, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Macromol Biosci 6:139-44. 2006
  3. ncbi Synthesis of novel quaternary chitosan derivatives via N-Chloroacyl-6-O-triphenylmethylchitosans
    Jukka Holappa
    Department of Pharmaceutical Chemistry, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Biomacromolecules 7:407-10. 2006
  4. doi Effect of N-betainate and N-piperazine derivatives of chitosan on the paracellular transport of mannitol in Caco-2 cells
    Timo Korjamo
    Department of Pharmaceutics, University of Kuopio, Kuopio, Finland
    Eur J Pharm Sci 35:226-34. 2008
  5. doi Cyclodextrins and chitosan derivatives in sublingual delivery of low solubility peptides: A study using cyclosporin A, alpha-cyclodextrin and quaternary chitosan N-betainate
    Janne Mannila
    Department of Pharmaceutical Chemistry, University of Kuopio, Finland
    Int J Pharm 381:19-24. 2009

Detail Information

Publications5

  1. ncbi N-Chloroacyl-6-O-triphenylmethylchitosans: useful intermediates for synthetic modifications of chitosan
    Jukka Holappa
    Department of Pharmaceutical Chemistry, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Biomacromolecules 6:858-63. 2005
    ..Molecular weight determination by GPC-LS displayed a significant degradation of the polymer. The weight-average molar masses (M(w)) of the end products ranged from 29.6 to 49.4 kDa, when the M(w) of the starting material was 144.2 kDa...
  2. ncbi Novel water-soluble quaternary piperazine derivatives of chitosan: synthesis and characterization
    Jukka Holappa
    Department of Pharmaceutical Chemistry, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Macromol Biosci 6:139-44. 2006
    ..Water-soluble end products were thoroughly characterized with FT-IR, 1H NMR, 13C NMR and 2D 1H-13C HSQC NMR. The molecular weights of the end products were determined by GPC with triple detection...
  3. ncbi Synthesis of novel quaternary chitosan derivatives via N-Chloroacyl-6-O-triphenylmethylchitosans
    Jukka Holappa
    Department of Pharmaceutical Chemistry, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Biomacromolecules 7:407-10. 2006
    ..Full substitutions were obtained from the quaternization reactions and the obtained water-soluble quaternary chitosan derivatives were thoroughly characterized with (1)H NMR, (13)C NMR, (1)H-(13)C HSQC NMR, and FT-IR...
  4. doi Effect of N-betainate and N-piperazine derivatives of chitosan on the paracellular transport of mannitol in Caco-2 cells
    Timo Korjamo
    Department of Pharmaceutics, University of Kuopio, Kuopio, Finland
    Eur J Pharm Sci 35:226-34. 2008
    ..The quaternary group does not substitute for the activity of the free amine group. In particular, the N-betainate derivatives of chitosan should contain only the minimum number of substituents required for water solubility...
  5. doi Cyclodextrins and chitosan derivatives in sublingual delivery of low solubility peptides: A study using cyclosporin A, alpha-cyclodextrin and quaternary chitosan N-betainate
    Janne Mannila
    Department of Pharmaceutical Chemistry, University of Kuopio, Finland
    Int J Pharm 381:19-24. 2009
    ..It was also shown that alpha-CD and CH may be advantageous in sublingual delivery of lipophilic peptides, although the absolute bioavailability remains low...