Mikko Hiltunen

Summary

Affiliation: University of Kuopio
Country: Finland

Publications

  1. doi request reprint Focal cerebral ischemia in rats alters APP processing and expression of Abeta peptide degrading enzymes in the thalamus
    Mikko Hiltunen
    Department of Neurology, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Neurobiol Dis 35:103-13. 2009
  2. doi request reprint Bepridil decreases Aβ and calcium levels in the thalamus after middle cerebral artery occlusion in rats
    Timo Sarajärvi
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    J Cell Mol Med 16:2754-67. 2012
  3. doi request reprint Ubiquilin-1 modulates γ-secretase-mediated ε-site cleavage in neuronal cells
    Jayashree Viswanathan
    Institute of Clinical Medicine Neurology, University of Eastern Finland, and Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    Biochemistry 52:3899-912. 2013
  4. doi request reprint Genetic analysis of genes involved in amyloid-β degradation and clearance in Alzheimer's disease
    Teemu Natunen
    Institute of Clinical Medicine Neurology, University of Eastern Finland and Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    J Alzheimers Dis 28:553-9. 2012
  5. doi request reprint An association study of 21 potential Alzheimer's disease risk genes in a Finnish population
    Timo Sarajärvi
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    J Alzheimers Dis 21:763-7. 2010
  6. doi request reprint GRN variant rs5848 reduces plasma and brain levels of granulin in Alzheimer's disease patients
    Anna Kämäläinen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 33:23-7. 2013
  7. doi request reprint Flanking markers of cystatin c (CST3) gene do not show association with Alzheimer's disease
    Seppo Helisalmi
    Institute of Clinical Medicine, Unit of Neurology and Brain Research Unit, Clinical Research Center, Mediteknia, Kuopio University, Kuopio, Finland
    Dement Geriatr Cogn Disord 27:318-21. 2009
  8. doi request reprint Increased expression of Abeta degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathology
    Saila Vepsäläinen
    Department of Neurology, University Hospital and University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Neurosci Lett 438:216-20. 2008
  9. ncbi request reprint Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease
    Teemu Natunen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 37:217-32. 2013
  10. pmc Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis
    Timo Sarajärvi
    Department of Neurology, University of Kuopio and Kuopio University Hospital, FIN 70211 Kuopio, Finland
    J Biol Chem 284:34433-43. 2009

Collaborators

Detail Information

Publications41

  1. doi request reprint Focal cerebral ischemia in rats alters APP processing and expression of Abeta peptide degrading enzymes in the thalamus
    Mikko Hiltunen
    Department of Neurology, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Neurobiol Dis 35:103-13. 2009
    ..These results demonstrate that focal cerebral ischemia leads to complex pathogenic events in the thalamus long after the initial insult...
  2. doi request reprint Bepridil decreases Aβ and calcium levels in the thalamus after middle cerebral artery occlusion in rats
    Timo Sarajärvi
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    J Cell Mol Med 16:2754-67. 2012
    ..These findings suggest that bepridil is a plausible therapeutic candidate in AD or stroke owing to its multifunctional role in key cellular events that are relevant for the pathogenesis of these diseases...
  3. doi request reprint Ubiquilin-1 modulates γ-secretase-mediated ε-site cleavage in neuronal cells
    Jayashree Viswanathan
    Institute of Clinical Medicine Neurology, University of Eastern Finland, and Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    Biochemistry 52:3899-912. 2013
    ..These data suggest that ubiquilin-1 modulates γ-secretase-mediated ε-site cleavage and thus may play a role in regulating γ-secretase cleavage of various substrates...
  4. doi request reprint Genetic analysis of genes involved in amyloid-β degradation and clearance in Alzheimer's disease
    Teemu Natunen
    Institute of Clinical Medicine Neurology, University of Eastern Finland and Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    J Alzheimers Dis 28:553-9. 2012
    ....
  5. doi request reprint An association study of 21 potential Alzheimer's disease risk genes in a Finnish population
    Timo Sarajärvi
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    J Alzheimers Dis 21:763-7. 2010
    ..Risk analysis revealed a protective effect for the minor allele carriers of rs1800629. This suggests that genetic alteration in TNF gene may play a role in AD...
  6. doi request reprint GRN variant rs5848 reduces plasma and brain levels of granulin in Alzheimer's disease patients
    Anna Kämäläinen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 33:23-7. 2013
    ..Our findings suggest that the A allele of rs5848 is functionally relevant by reducing the expression of granulin...
  7. doi request reprint Flanking markers of cystatin c (CST3) gene do not show association with Alzheimer's disease
    Seppo Helisalmi
    Institute of Clinical Medicine, Unit of Neurology and Brain Research Unit, Clinical Research Center, Mediteknia, Kuopio University, Kuopio, Finland
    Dement Geriatr Cogn Disord 27:318-21. 2009
    ..In the present study we determined whether the cystatin c gene (CST3) is genetically associated with late-onset Alzheimer's disease (AD)...
  8. doi request reprint Increased expression of Abeta degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathology
    Saila Vepsäläinen
    Department of Neurology, University Hospital and University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Neurosci Lett 438:216-20. 2008
    ..mRNA and protein levels of NEP were also nominally up-regulated in Tg mice compared to controls. These data may reflect up-regulation of the IDE and possibly of NEP expression in response to the Abeta accumulation...
  9. ncbi request reprint Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease
    Teemu Natunen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 37:217-32. 2013
    ..While the present study indicates that GGA3 is involved in the cellular processes relevant for AD pathogenesis, the genetic data do not support the idea that common GGA3 polymorphisms would contribute to AD risk. ..
  10. pmc Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis
    Timo Sarajärvi
    Department of Neurology, University of Kuopio and Kuopio University Hospital, FIN 70211 Kuopio, Finland
    J Biol Chem 284:34433-43. 2009
    ..These mechanistic findings related to seladin-1 down-regulation are important in the context of AD as the oxidative stress-induced apoptosis plays a key role in the disease pathogenesis...
  11. doi request reprint Lack of genetic association between PPARG gene polymorphisms and Finnish late-onset Alzheimer's disease
    Seppo Helisalmi
    Institute of Clinical Medicine, Unit of Neurology and Brain Research Unit, Clinical Research Center, Mediteknia, Kuopio University, Kuopio, Finland
    Neurosci Lett 441:233-6. 2008
    ..We conclude that PPARG gene does not play a major role in the genetic predisposition to AD in the Finnish population...
  12. doi request reprint Targeting ubiquilin-1 in Alzheimer's disease
    Mari Takalo
    Institute of Clinical Medicine Neurology, University of Eastern Finland and Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    Expert Opin Ther Targets 17:795-810. 2013
    ..These include the amyloid precursor protein and presenilins that are intimately involved in the mechanisms of AD...
  13. pmc Effects of NR1H3 genetic variation on the expression of liver X receptor α and the progression of Alzheimer's disease
    Teemu Natunen
    Institute of Clinical Medicine Neurology, University of Eastern Finland and Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    PLoS ONE 8:e80700. 2013
    ..These results suggest that genetic variation in NR1H3 modulates the expression of LXRα and the levels of soluble Aβ42. ..
  14. doi request reprint AMP-activated protein kinase: a potential player in Alzheimer's disease
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    J Neurochem 118:460-74. 2011
    ..We will outline the potential role of AMPK function in respect to various aspects affecting AD pathogenesis...
  15. ncbi request reprint Functional roles of amyloid-beta protein precursor and amyloid-beta peptides: evidence from experimental studies
    Mikko Hiltunen
    Department of Neurology, University of Kuopio, Kuopio, Finland
    J Alzheimers Dis 18:401-12. 2009
    ..Thus, it is tempting to speculate that promotion of alpha-secretase-mediated cleavage of AbetaPP, which leads to increased sAbetaPPalpha production, provides a novel therapeutic strategy in the treatment of AD and brain injury...
  16. doi request reprint An association study between granulin gene polymorphisms and Alzheimer's disease in Finnish population
    Jayashree Viswanathan
    Department of Neurology, Clinical Research Centre Mediteknia, University Hospital and University of Kuopio, Finland
    Am J Med Genet B Neuropsychiatr Genet 150:747-50. 2009
    ..These data suggest that genetic variability in the GRN gene may also increase the risk for developing AD in a gender-specific manner...
  17. ncbi request reprint High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status
    Mari Takalo
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    J Nutr Biochem 25:634-41. 2014
    ..Our study suggests that the high-fat diet independently of type 2 diabetes or Alzheimer's disease background induces the expression and exon 10 inclusion of tau in the brain of female mice. ..
  18. pmc Increased γ-Secretase Activity in Idiopathic Normal Pressure Hydrocephalus Patients with β-Amyloid Pathology
    Tiina Laiterä
    Institute of Clinical Medicine Neurosurgery, University of Eastern Finland, Kuopio, Finland Neurosurgery of NeuroCenter, Kuopio University Hospital, Kuopio, Finland
    PLoS ONE 9:e93717. 2014
    ..Despite the resemblances in the Aβ pathology, iNPH and AD patients appear to have marked differences in the cellular mechanisms responsible for the production of Aβ. ..
  19. doi request reprint Lack of secondary pathology in the thalamus after focal cerebral ischemia in nonhuman primates
    Anu Lipsanen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    Exp Neurol 248:224-7. 2013
    ..In conclusion, our preliminary study in marmosets did not identify Aβ and calcium pathology in the thalamus following cerebral ischemia as shown in rodents...
  20. doi request reprint Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Prog Neurobiol 96:87-95. 2012
    ..We will review here the molecular and functional characteristics of p62 protein and outline its potential role in the regulation of Alzheimer's pathogenesis...
  21. pmc Chronic hyperperfusion and angiogenesis follow subacute hypoperfusion in the thalamus of rats with focal cerebral ischemia
    Nick M E A Hayward
    Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
    J Cereb Blood Flow Metab 31:1119-32. 2011
    ..Postischemic angiogenesis in the thalamus represents a novel type of remote plasticity, which may support removal of necrotic brain tissue and aid functional recovery...
  22. doi request reprint Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Prog Neurobiol 106:33-54. 2013
    ....
  23. pmc Non-selective calcium channel blocker bepridil decreases secondary pathology in mice after photothrombotic cortical lesion
    Anu Lipsanen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    PLoS ONE 8:e60235. 2013
    ..01). The present data suggest less pronounced primary and secondary pathology in hAPPSL transgenic mice after ischemic cortical injury. Bepridil particularly decreased calcium pathology in the thalamus following ischemia...
  24. doi request reprint Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease
    Saila Vepsäläinen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    J Nutr Biochem 24:360-70. 2013
    ..These data suggest that anthocyanin-rich bilberry and blackcurrant diets favorably modulate APP processing and alleviate behavioral abnormalities in a mouse model of AD...
  25. doi request reprint Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice
    Mikko Hiltunen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    J Cell Mol Med 16:1206-22. 2012
    ..These findings provide evidence for new regulatory mechanisms that link type-2 diabetes and Alzheimer pathology...
  26. ncbi request reprint Age-related macular degeneration (AMD): Alzheimer's disease in the eye?
    Kai Kaarniranta
    Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 24:615-31. 2011
    ..However, it seems that these diseases have a different genetic background. In this review, differences and similarities of AMD and AD are thoroughly discussed...
  27. ncbi request reprint Coaccumulation of calcium and beta-amyloid in the thalamus after transient middle cerebral artery occlusion in rats
    Susanna Mäkinen
    Department of Neurology, University of Kuopio, Kuopio, Finland
    J Cereb Blood Flow Metab 28:263-8. 2008
    ..This together with insufficient clearance or atypical degradation of Abeta peptides lead to dysregulation of calcium homeostatis and coaccumulation in the thalamus...
  28. pmc Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation
    Jayashree Viswanathan
    Institute of Clinical Medicine Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Traffic 12:330-48. 2011
    ..Collectively, our results indicate that specific ubiquilin-1 TVs can cause PS1 accumulation and aggresome formation, which may impact AD pathogenesis or susceptibility...
  29. doi request reprint Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Eur J Neurosci 34:3-11. 2011
    ..We will review the astroglial changes occurring during aging and emphasize that senescent astrocytes can have an important role in age-related neuroinflammation and neuronal degeneration...
  30. doi request reprint Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregation
    Annakaisa Haapasalo
    Department of Neurology, University of Kuopio, and Kuopio University Hospital, Kuopio, Finland
    Biochem Soc Trans 38:150-5. 2010
    ..Here, we review the current knowledge of ubiquilin-1 and PS in protein aggregation and related events that potentially influence neurodegeneration...
  31. ncbi request reprint Epigenetic regulation of ASC/TMS1 expression: potential role in apoptosis and inflammasome function
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, PO Box 1627, 70211, Kuopio, Finland
    Cell Mol Life Sci 71:1855-64. 2014
    ..We will also review the role of aberrant methylation of ASC/TMS1 promoter in the function of inflammasomes, a major host defense system, in cellular housekeeping and carcinogenesis. ..
  32. doi request reprint Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease
    Henna Martiskainen
    Kuopio University Hospital, Institute of Clinical Medicine Neurology, University of Eastern Finland and Department of Neurology, Kuopio, Finland
    Expert Opin Ther Targets 17:781-94. 2013
    ..Based on the prevailing amyloid cascade hypothesis, it is conceivable that lowering the β-amyloid (Aβ) levels is sufficient to slow down the disease process, if started early enough...
  33. pmc High risk population isolate reveals low frequency variants predisposing to intracranial aneurysms
    Mitja I Kurki
    Neurosurgery, Neurocenter, Kuopio University Hospital, Kuopio, Finland Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
    PLoS Genet 10:e1004134. 2014
    ..This study illustrates the utility of population isolates, familial enrichment, dense genotype imputation and alternate phenotyping in search for variants associated with complex diseases. ..
  34. doi request reprint Chronic ibuprofen treatment does not affect the secondary pathology in the thalamus or improve behavioral outcome in middle cerebral artery occlusion rats
    Anu Lipsanen
    Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
    Pharmacol Biochem Behav 99:468-74. 2011
    ..The present data do not support the idea that ibuprofen reduces the secondary Aβ/calcium pathology in the thalamus or associated sensorimotor impairment following cerebral ischemia...
  35. doi request reprint Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Prog Neurobiol 93:99-110. 2011
    ..We will review the role of Hsp90 chaperone network in the regulation of tau biology and pathology in Alzheimer's disease...
  36. pmc Cerebrospinal fluid biomarker and brain biopsy findings in idiopathic normal pressure hydrocephalus
    Okko T Pyykkö
    Neurosurgery of Neurocenter, Kuopio University Hospital, Kuopio, Finland
    PLoS ONE 9:e91974. 2014
    ..The significance of amyloid precursor protein (APP) and neuroinflammation in idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's disease (AD) is unknown...
  37. pmc Γ-secretase components as predictors of breast cancer outcome
    Hanna M Peltonen
    Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland Biocenter Kuopio and Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland Imaging Center, Clinical Pathology, Kuopio University Hospital, Kuopio, Finland
    PLoS ONE 8:e79249. 2013
    ....
  38. doi request reprint Radiation-induced genomic instability in Caenorhabditis elegans
    Katriina Huumonen
    Department of Environmental Science, University of Eastern Finland, Kuopio, Finland
    Mutat Res 748:36-41. 2012
    ..To the best of our knowledge, this is the first publication reporting radiation-induced genomic instability in C. elegans...
  39. doi request reprint Immunohistochemical visualization of amyloid-beta protein precursor and amyloid-beta in extra- and intracellular compartments in the human brain
    Leena Aho
    Department of Clinical Medicine, Unit of Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 20:1015-28. 2010
    ..The staining results and conclusions depended strongly on the chosen antibody and the pretreatment strategy and thus multiple antibodies must be used when assessing the intracellular accumulation of Abeta...
  40. ncbi request reprint Stimulated dopamine overflow and alpha-synuclein expression in the nucleus accumbens core distinguish rats bred for differential ethanol preference
    Anssi Pelkonen
    School of Pharmacy, University of Eastern Finland, Kuopio, Finland
    J Neurochem 114:1168-76. 2010
    ..These results indicate that high expression of alpha-syn may contribute to the reduced DA overflow and the possible activation of re-uptake in the nucleus accumbens core of AA rats in comparison with ANA rats...
  41. ncbi request reprint Somatostatin genetic variants modify the risk for Alzheimer's disease among Finnish patients
    Saila Vepsäläinen
    Department of Neurology, University Hospital and University of Kuopio, 70211, Kuopio, Finland
    J Neurol 254:1504-8. 2007
    ..This first genetic association study between somatostatin and AD indicates that genetic variations in the somatostatin gene may modify the risk for AD among Finnish AD subjects...