Research Topics
Genomes and Genes
| Mikko HiltunenSummaryAffiliation: University of Kuopio Country: Finland Publications
| Collaborators
|
Detail Information
Publications
Focal cerebral ischemia in rats alters APP processing and expression of Abeta peptide degrading enzymes in the thalamusMikko Hiltunen
Department of Neurology, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
Neurobiol Dis 35:103-13. 2009..These results demonstrate that focal cerebral ischemia leads to complex pathogenic events in the thalamus long after the initial insult...- Genetic analysis of genes involved in amyloid-β degradation and clearance in Alzheimer's diseaseTeemu Natunen
Institute of Clinical Medicine Neurology, University of Eastern Finland and Department of Neurology, Kuopio University Hospital, Kuopio, Finland
J Alzheimers Dis 28:553-9. 2012.... - An association study of 21 potential Alzheimer's disease risk genes in a Finnish populationTimo Sarajärvi
Institute of Clinical Medicine Neurology, University of Eastern Finland, Department of Neurology, Kuopio University Hospital, Kuopio, Finland
J Alzheimers Dis 21:763-7. 2010..Risk analysis revealed a protective effect for the minor allele carriers of rs1800629. This suggests that genetic alteration in TNF gene may play a role in AD... - Flanking markers of cystatin c (CST3) gene do not show association with Alzheimer's diseaseSeppo Helisalmi
Institute of Clinical Medicine, Unit of Neurology and Brain Research Unit, Clinical Research Center, Mediteknia, Kuopio University, Kuopio, Finland
Dement Geriatr Cogn Disord 27:318-21. 2009..In the present study we determined whether the cystatin c gene (CST3) is genetically associated with late-onset Alzheimer's disease (AD)... - Increased expression of Abeta degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathologySaila Vepsäläinen
Department of Neurology, University Hospital and University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
Neurosci Lett 438:216-20. 2008..mRNA and protein levels of NEP were also nominally up-regulated in Tg mice compared to controls. These data may reflect up-regulation of the IDE and possibly of NEP expression in response to the Abeta accumulation... - Lack of genetic association between PPARG gene polymorphisms and Finnish late-onset Alzheimer's diseaseSeppo Helisalmi
Institute of Clinical Medicine, Unit of Neurology and Brain Research Unit, Clinical Research Center, Mediteknia, Kuopio University, Kuopio, Finland
Neurosci Lett 441:233-6. 2008..We conclude that PPARG gene does not play a major role in the genetic predisposition to AD in the Finnish population... 
Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosisTimo Sarajärvi
Department of Neurology, University of Kuopio and Kuopio University Hospital, FIN 70211 Kuopio, Finland
J Biol Chem 284:34433-43. 2009..These mechanistic findings related to seladin-1 down-regulation are important in the context of AD as the oxidative stress-induced apoptosis plays a key role in the disease pathogenesis...- An association study between granulin gene polymorphisms and Alzheimer's disease in Finnish populationJayashree Viswanathan
Department of Neurology, Clinical Research Centre Mediteknia, University Hospital and University of Kuopio, Finland
Am J Med Genet B Neuropsychiatr Genet 150:747-50. 2009..These data suggest that genetic variability in the GRN gene may also increase the risk for developing AD in a gender-specific manner... - AMP-activated protein kinase: a potential player in Alzheimer's diseaseAntero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
J Neurochem 118:460-74. 2011..We will outline the potential role of AMPK function in respect to various aspects affecting AD pathogenesis... - Functional roles of amyloid-beta protein precursor and amyloid-beta peptides: evidence from experimental studiesMikko Hiltunen
Department of Neurology, University of Kuopio, Kuopio, Finland
J Alzheimers Dis 18:401-12. 2009..Thus, it is tempting to speculate that promotion of alpha-secretase-mediated cleavage of AbetaPP, which leads to increased sAbetaPPalpha production, provides a novel therapeutic strategy in the treatment of AD and brain injury... - Bepridil decreases Aβ and calcium levels in the thalamus after middle cerebral artery occlusion in ratsTimo Sarajärvi
Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
J Cell Mol Med 16:2754-67. 2012..These findings suggest that bepridil is a plausible therapeutic candidate in AD or stroke owing to its multifunctional role in key cellular events that are relevant for the pathogenesis of these diseases... - Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's diseaseAntero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
Prog Neurobiol 96:87-95. 2012..We will review here the molecular and functional characteristics of p62 protein and outline its potential role in the regulation of Alzheimer's pathogenesis... - Chronic hyperperfusion and angiogenesis follow subacute hypoperfusion in the thalamus of rats with focal cerebral ischemiaNick M E A Hayward
Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
J Cereb Blood Flow Metab 31:1119-32. 2011..Postischemic angiogenesis in the thalamus represents a novel type of remote plasticity, which may support removal of necrotic brain tissue and aid functional recovery... - Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic miceMikko Hiltunen
Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
J Cell Mol Med 16:1206-22. 2012..These findings provide evidence for new regulatory mechanisms that link type-2 diabetes and Alzheimer pathology... - Age-related macular degeneration (AMD): Alzheimer's disease in the eye?Kai Kaarniranta
Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
J Alzheimers Dis 24:615-31. 2011..However, it seems that these diseases have a different genetic background. In this review, differences and similarities of AMD and AD are thoroughly discussed... 
Coaccumulation of calcium and beta-amyloid in the thalamus after transient middle cerebral artery occlusion in ratsSusanna Mäkinen
Department of Neurology, University of Kuopio, Kuopio, Finland
J Cereb Blood Flow Metab 28:263-8. 2008..This together with insufficient clearance or atypical degradation of Abeta peptides lead to dysregulation of calcium homeostatis and coaccumulation in the thalamus...- GRN variant rs5848 reduces plasma and brain levels of granulin in Alzheimer's disease patientsAnna Kämäläinen
Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
J Alzheimers Dis 33:23-7. 2013..Our findings suggest that the A allele of rs5848 is functionally relevant by reducing the expression of granulin... - Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formationJayashree Viswanathan
Institute of Clinical Medicine Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
Traffic 12:330-48. 2011..Collectively, our results indicate that specific ubiquilin-1 TVs can cause PS1 accumulation and aggresome formation, which may impact AD pathogenesis or susceptibility... - Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregationAnnakaisa Haapasalo
Department of Neurology, University of Kuopio, and Kuopio University Hospital, Kuopio, Finland
Biochem Soc Trans 38:150-5. 2010..Here, we review the current knowledge of ubiquilin-1 and PS in protein aggregation and related events that potentially influence neurodegeneration... - Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotypeAntero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
Eur J Neurosci 34:3-11. 2011..We will review the astroglial changes occurring during aging and emphasize that senescent astrocytes can have an important role in age-related neuroinflammation and neuronal degeneration... - Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's diseaseSaila Vepsäläinen
Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
J Nutr Biochem 24:360-70. 2013..These data suggest that anthocyanin-rich bilberry and blackcurrant diets favorably modulate APP processing and alleviate behavioral abnormalities in a mouse model of AD... - Chronic ibuprofen treatment does not affect the secondary pathology in the thalamus or improve behavioral outcome in middle cerebral artery occlusion ratsAnu Lipsanen
Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
Pharmacol Biochem Behav 99:468-74. 2011..The present data do not support the idea that ibuprofen reduces the secondary Aβ/calcium pathology in the thalamus or associated sensorimotor impairment following cerebral ischemia... - Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's diseaseAntero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
Prog Neurobiol 93:99-110. 2011..We will review the role of Hsp90 chaperone network in the regulation of tau biology and pathology in Alzheimer's disease... - Radiation-induced genomic instability in Caenorhabditis elegansKatriina Huumonen
Department of Environmental Science, University of Eastern Finland, Kuopio, Finland
Mutat Res 748:36-41. 2012..To the best of our knowledge, this is the first publication reporting radiation-induced genomic instability in C. elegans... - Stimulated dopamine overflow and alpha-synuclein expression in the nucleus accumbens core distinguish rats bred for differential ethanol preferenceAnssi Pelkonen
School of Pharmacy, University of Eastern Finland, Kuopio, Finland
J Neurochem 114:1168-76. 2010..These results indicate that high expression of alpha-syn may contribute to the reduced DA overflow and the possible activation of re-uptake in the nucleus accumbens core of AA rats in comparison with ANA rats... - Immunohistochemical visualization of amyloid-beta protein precursor and amyloid-beta in extra- and intracellular compartments in the human brainLeena Aho
Department of Clinical Medicine, Unit of Neurology, University of Eastern Finland, Kuopio, Finland
J Alzheimers Dis 20:1015-28. 2010..The staining results and conclusions depended strongly on the chosen antibody and the pretreatment strategy and thus multiple antibodies must be used when assessing the intracellular accumulation of Abeta... - Somatostatin genetic variants modify the risk for Alzheimer's disease among Finnish patientsSaila Vepsäläinen
Department of Neurology, University Hospital and University of Kuopio, 70211, Kuopio, Finland
J Neurol 254:1504-8. 2007..This first genetic association study between somatostatin and AD indicates that genetic variations in the somatostatin gene may modify the risk for AD among Finnish AD subjects...