Jarmo Hietala

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. ncbi request reprint Measurement of serotonin 5-HT1A receptor binding using positron emission tomography and [carbonyl-(11)C]WAY-100635-considerations on the validity of cerebellum as a reference region
    Jussi Hirvonen
    Department of Psychiatry, University of Turku, Turku, Finland
    J Cereb Blood Flow Metab 27:185-95. 2007
  2. ncbi request reprint Body mass index and functioning in long-term schizophrenia. Results of the DSP project
    Raimo K R Salokangas
    Department of Psychiatry, University of Turku Psychiatric Clinic, Turku University Central Hospital, Turku Psychiatric Clinic, Kiinamyllynkatu 4 8, FI 20520 Turku, Finland
    Eur Psychiatry 22:313-8. 2007
  3. ncbi request reprint Allelic association between D2 but not D1 dopamine receptor gene and alcoholism in Finland
    J Hietala
    Department of Psychiatry, Turku University Central Hospital, Finland
    Psychiatr Genet 7:19-25. 1997
  4. ncbi request reprint Depressive symptoms and presynaptic dopamine function in neuroleptic-naive schizophrenia
    J Hietala
    Department of Psychiatry, Turku University Central Hospital, Finland
    Schizophr Res 35:41-50. 1999
  5. ncbi request reprint [Schizophrenia as a consequence of genetic modifications affecting brain development and plasticity]
    Jarmo Hietala
    Turun Yliopiston psykiatrian klinikka, Turku
    Duodecim 120:1715-6. 2004
  6. ncbi request reprint Correlation of human cold pressor pain responses with 5-HT(1A) receptor binding in the brain
    Ilkka K Martikainen
    Department of Physiology, Institute of Biomedicine, University of Turku, Turku, Finland
    Brain Res 1172:21-31. 2007
  7. doi request reprint The effects of lorazepam on extrastriatal dopamine D(2/3)-receptors-A double-blind randomized placebo-controlled PET study
    Harry Vilkman
    Turku PET Centre, University of Turku, Turku, Finland
    Psychiatry Res 174:130-7. 2009
  8. doi request reprint Striatal dopamine D2 receptors in medication-naive patients with major depressive disorder as assessed with [11C]raclopride PET
    Jussi Hirvonen
    Department of Psychiatry, University of Turku, Turku, Finland
    Psychopharmacology (Berl) 197:581-90. 2008
  9. doi request reprint Striatal μ-opioid receptor availability predicts cold pressor pain threshold in healthy human subjects
    Nora Hagelberg
    Pain Clinic and Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, Turku University Hospital, Turku, Finland
    Neurosci Lett 521:11-4. 2012
  10. ncbi request reprint Striatal dopamine synthesis in first-degree relatives of patients with schizophrenia
    Jukka Huttunen
    Department of Psychiatry, University of Turku, Turku, Finland
    Biol Psychiatry 63:114-7. 2008

Detail Information

Publications56

  1. ncbi request reprint Measurement of serotonin 5-HT1A receptor binding using positron emission tomography and [carbonyl-(11)C]WAY-100635-considerations on the validity of cerebellum as a reference region
    Jussi Hirvonen
    Department of Psychiatry, University of Turku, Turku, Finland
    J Cereb Blood Flow Metab 27:185-95. 2007
    ....
  2. ncbi request reprint Body mass index and functioning in long-term schizophrenia. Results of the DSP project
    Raimo K R Salokangas
    Department of Psychiatry, University of Turku Psychiatric Clinic, Turku University Central Hospital, Turku Psychiatric Clinic, Kiinamyllynkatu 4 8, FI 20520 Turku, Finland
    Eur Psychiatry 22:313-8. 2007
    ..The study evaluates the association of body mass index (BMI) with functioning in male and female patients with long-term schizophrenia...
  3. ncbi request reprint Allelic association between D2 but not D1 dopamine receptor gene and alcoholism in Finland
    J Hietala
    Department of Psychiatry, Turku University Central Hospital, Finland
    Psychiatr Genet 7:19-25. 1997
    ....
  4. ncbi request reprint Depressive symptoms and presynaptic dopamine function in neuroleptic-naive schizophrenia
    J Hietala
    Department of Psychiatry, Turku University Central Hospital, Finland
    Schizophr Res 35:41-50. 1999
    ..g., in prediction of response to D2 receptor blocking antipsychotic drugs. A possible connection between paranoid symptomatology and subcortical hyperdopaminergia is suggested, but this remains to be further verified...
  5. ncbi request reprint [Schizophrenia as a consequence of genetic modifications affecting brain development and plasticity]
    Jarmo Hietala
    Turun Yliopiston psykiatrian klinikka, Turku
    Duodecim 120:1715-6. 2004
  6. ncbi request reprint Correlation of human cold pressor pain responses with 5-HT(1A) receptor binding in the brain
    Ilkka K Martikainen
    Department of Physiology, Institute of Biomedicine, University of Turku, Turku, Finland
    Brain Res 1172:21-31. 2007
    ..In general, subjects with high availability of 5-HT(1A) receptors have low CPP intensity accompanied by a high capacity for central suppression of pain or a sympathetic vasoconstriction response by a Valsalva maneuver...
  7. doi request reprint The effects of lorazepam on extrastriatal dopamine D(2/3)-receptors-A double-blind randomized placebo-controlled PET study
    Harry Vilkman
    Turku PET Centre, University of Turku, Turku, Finland
    Psychiatry Res 174:130-7. 2009
    ..The correlation between lorazepam-induced sedation and D(2)/D(3) receptor binding potential (BP) change further supports this hypothesis...
  8. doi request reprint Striatal dopamine D2 receptors in medication-naive patients with major depressive disorder as assessed with [11C]raclopride PET
    Jussi Hirvonen
    Department of Psychiatry, University of Turku, Turku, Finland
    Psychopharmacology (Berl) 197:581-90. 2008
    ..Previous in vivo imaging studies have studied striatal dopamine D2 receptor availability in depression but the results are equivocal thus far...
  9. doi request reprint Striatal μ-opioid receptor availability predicts cold pressor pain threshold in healthy human subjects
    Nora Hagelberg
    Pain Clinic and Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, Turku University Hospital, Turku, Finland
    Neurosci Lett 521:11-4. 2012
    ..This finding suggests that striatal μ-opioid receptor density is involved in setting individual pain threshold...
  10. ncbi request reprint Striatal dopamine synthesis in first-degree relatives of patients with schizophrenia
    Jukka Huttunen
    Department of Psychiatry, University of Turku, Turku, Finland
    Biol Psychiatry 63:114-7. 2008
    ..We investigated whether this same phenomenon is shared by individuals with increased genetic risk for schizophrenia...
  11. ncbi request reprint Association of striatal dopamine D2/D3 receptor binding potential with pain but not tactile sensitivity or placebo analgesia
    Ilkka K Martikainen
    Department of Physiology, University of Turku, Turku, Finland
    Neurosci Lett 376:149-53. 2005
    ..Moreover, striatal dopamine D2/D3 receptor BP appears not to predict individual's analgesic response to placebo...
  12. doi request reprint Effects of antidepressant drug treatment and psychotherapy on striatal and thalamic dopamine D2/3 receptors in major depressive disorder studied with [11C]raclopride PET
    Jussi Hirvonen
    Department of Psychiatry, University of Turku, Turku, Finland
    J Psychopharmacol 25:1329-36. 2011
    ..The effects of fluoxetine on thalamic dopamine systems need to be further explored...
  13. ncbi request reprint Brain dopamine d1 receptors in twins discordant for schizophrenia
    Jussi Hirvonen
    Department of Psychiatry, University of Turku, Kunnallissairaalantie 20, Bldg 9, 20700 Turku, Finland
    Am J Psychiatry 163:1747-53. 2006
    ....
  14. ncbi request reprint Gender and age affect NK1 receptors in the human brain - a positron emission tomography study with [18F]SPA-RQ
    Mikko J Nyman
    Turku PET Centre, Neuropsychiatric Imaging, Turku, Finland
    Int J Neuropsychopharmacol 10:219-29. 2007
    ..The exact physiological significance of these results remains to be elucidated but conceptually they could be involved in age-related CNS disorders or those with gender differences in prevalence...
  15. ncbi request reprint Cortical glutamate-dopamine interaction and ketamine-induced psychotic symptoms in man
    Sargo Aalto
    Turku PET Centre, University of Turku, 20520, Turku, Finland
    Psychopharmacology (Berl) 182:375-83. 2005
    ..The noncompetitive glutamate N-methyl-D: -aspartate receptor antagonist ketamine induces transient psychotic symptoms in man. Involvement of dopaminergic mechanisms in these effects has been suggested...
  16. doi request reprint Short-term psychodynamic psychotherapy and fluoxetine in major depressive disorder: a randomized comparative study
    Jouko K Salminen
    Department of Psychiatry, University of Helsinki, Helsinki, Finland
    Psychother Psychosom 77:351-7. 2008
    ..We conducted a comparative study on the efficacy of STPP versus fluoxetine treatment in patients with major depressive disorder in a primary care setting...
  17. doi request reprint Perceived negative attitude of others as an early sign of psychosis
    Raimo K R Salokangas
    Department of Psychiatry, University of Turku, Turku, Finland
    Eur Psychiatry 24:233-8. 2009
    ..We studied the associations of psychiatric outpatients' self-reported functioning and interpersonal relationships with vulnerability to and risk of psychosis...
  18. ncbi request reprint The A1 allele of the human D2 dopamine receptor gene is associated with increased activity of striatal L-amino acid decarboxylase in healthy subjects
    Aki Laakso
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku University Central Hospital, Turku, Finland
    Pharmacogenet Genomics 15:387-91. 2005
    ..The finding can be explained by lower D2 receptor expression leading to decreased autoreceptor function, and suggests that dopamine and/or trace amine synthesis rate is increased in the brains of A1 allele carriers...
  19. ncbi request reprint Visualization and quantification of neurokinin-1 (NK1) receptors in the human brain
    Jarmo Hietala
    Neuropsychiatric Imaging, Turku PET Centre, Turku University Central Hospital, Finland
    Mol Imaging Biol 7:262-72. 2005
    ....
  20. ncbi request reprint Decreased brain serotonin 5-HT1A receptor availability in medication-naive patients with major depressive disorder: an in-vivo imaging study using PET and [carbonyl-11C]WAY-100635
    Jussi Hirvonen
    Department of Psychiatry, Turku PET Centre, University of Turku and Turku University Central Hospital, Turku, Finland
    Int J Neuropsychopharmacol 11:465-76. 2008
    ..Lack of correlation with overall severity of the illness may relate to a largely trait-like nature of this abnormality in depressive disorders...
  21. doi request reprint Does defense style or psychological mindedness predict treatement response in major depression?
    Kim Kronström
    Department of Psychiatry, University of Turku, Turku, Finland
    Depress Anxiety 26:689-95. 2009
    ....
  22. ncbi request reprint Striatal dopamine D1 and D2 receptor balance in twins at increased genetic risk for schizophrenia
    Jussi Hirvonen
    Department of Psychiatry, University of Turku, 20520, Finland
    Psychiatry Res 146:13-20. 2006
    ..In this sample, we did not find evidence for an association between increased genetic risk for schizophrenia and altered D1/D2 receptor balance in the striatum...
  23. ncbi request reprint Effects of fluoxetine on dopamine D2 receptors in the human brain: a positron emission tomography study with [11C]raclopride
    Jani Penttilä
    Department of Psychiatry, Paijat Hame Central Hospital, FIN 15850 Lahti, Finland
    Int J Neuropsychopharmacol 7:431-9. 2004
    ....
  24. doi request reprint Temperament trait Harm Avoidance associates with μ-opioid receptor availability in frontal cortex: a PET study using [(11)C]carfentanil
    Lauri Tuominen
    Department of Psychiatry, University of Turku, Finland
    Neuroimage 61:670-6. 2012
    ..The results have relevance in the research of vulnerability factors for affective disorders...
  25. doi request reprint Autoradiographic characterization of alpha(2C)-adrenoceptors in the human striatum
    Veronica Fagerholm
    Turku PET Centre, Turku, Finland
    Synapse 62:508-15. 2008
    ....
  26. ncbi request reprint Dopamine D2 receptor binding in the human brain is associated with the response to painful stimulation and pain modulatory capacity
    Nora Hagelberg
    Department of Anaesthesiology and Intensive Care, University of Turku, Turku, Finland
    Pain 99:273-9. 2002
    ....
  27. doi request reprint COMT Val158Met genotype does not alter cortical or striatal dopamine D2 receptor availability in vivo
    Mika M Hirvonen
    Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland
    Mol Imaging Biol 12:192-7. 2010
    ..We studied whether the functional COMT gene polymorphism (Val158Met) associates with altered dopamine D2 receptor binding characteristics in vivo hypothesizing an effect in the cortex but not in the striatum...
  28. doi request reprint Mesolimbic dopamine release is linked to symptom severity in pathological gambling
    Juho Joutsa
    Department of Neurology, University of Turku and Turku University Hospital, Turku, Finland
    Neuroimage 60:1992-9. 2012
    ..Human reward-seeking gambling behavior, and especially pathological gambling, has been presumed to be modulated by brain dopamine...
  29. doi request reprint Measurement of striatal and extrastriatal dopamine transporter binding with high-resolution PET and [11C]PE2I: quantitative modeling and test-retest reproducibility
    Jussi Hirvonen
    Department of Psychiatry, University of Turku, Turku, Finland
    J Cereb Blood Flow Metab 28:1059-69. 2008
    ..The previously suggested involvement of the potentially brain-penetrant radioactive metabolite in the quantification should be further studied...
  30. ncbi request reprint Ketamine does not decrease striatal dopamine D2 receptor binding in man
    Sargo Aalto
    Neuropsychiatric Imaging, Turku PET Centre, Turku University Central Hospital, Kiinamyllynkatu 4 8, 20520 Turku, Finland
    Psychopharmacology (Berl) 164:401-6. 2002
    ..However, recent imaging studies addressing striatal glutamate-dopamine interaction directly in vivo in man have been controversial...
  31. ncbi request reprint Quality of life and functioning ability in subjects vulnerable to psychosis
    Tanja Svirskis
    Department of Psychiatry, University of Turku, 20700 Turku, Finland
    Compr Psychiatry 48:155-60. 2007
    ..It is well established that quality of life (QOL) and functioning ability are impaired in psychosis, especially schizophrenia. Little is known about QOL and functioning in subjects vulnerable to psychosis (VTP)...
  32. ncbi request reprint Association between the C957T polymorphism of the dopamine D2 receptor gene and schizophrenia
    Kari Hänninen
    South Karelia Central Hospital, Department of Psychiatry, Lappeenranta, Finland
    Neurosci Lett 407:195-8. 2006
    ..05). Our results are in agreement with an earlier association study suggesting that the C957T C-allele plays a role in the genetic vulnerability for schizophrenia and support the involvement of the DRD2 gene in schizophrenia pathogenesis...
  33. doi request reprint Dysfunctional brain networks and genetic risk for schizophrenia: specific neurotransmitter systems
    Jussi Hirvonen
    Department of Radiology, Turku University Hospital and University of Turku, Turku, Finland
    CNS Neurosci Ther 17:89-96. 2011
    ..g., cannabis, childhood trauma, and other psychosocial stress) in genetically vulnerable individuals...
  34. ncbi request reprint Mu-receptor agonism with alfentanil increases striatal dopamine D2 receptor binding in man
    Nora Hagelberg
    Department of Anesthesiology and Intensive Care, Turku University Central Hospital, Turku, Finland
    Synapse 45:25-30. 2002
    ..23.5 (15-52), P = 0.008). These results indicate that pharmacologically relevant concentrations of alfentanil increase D2 dopamine receptor binding in the striatum in man. This increase is assumed to reflect reduced dopamine release...
  35. ncbi request reprint Sevoflurane and propofol increase 11C-flumazenil binding to gamma-aminobutyric acidA receptors in humans
    Elina Salmi
    Turku PET Centre, Turku University Hospital, PO Box 52, FIN 20521 Turku, Finland
    Anesth Analg 99:1420-6; table of contents. 2004
    ..Our findings support the involvement of GABA(A) receptors in the mechanism of action of both anesthetics in humans...
  36. ncbi request reprint Striatal dopamine D2/D3 receptor availability correlates with individual response characteristics to pain
    Antti Pertovaara
    Department of Physiology, Institute of Biomedicine, University of Turku, Jiinamyllynkatu 10, FIN 20520 Turku, Finland
    Eur J Neurosci 20:1587-92. 2004
    ..Alternatively, striatal dopamine D2/D3 receptors could control a modulatory pathway producing a parallel shift in the stimulus-response function for sensory signals, mimicking a change in the subject's response criterion...
  37. ncbi request reprint Differential associations between brain 5-HT(1A) receptor binding and response to pain versus touch
    Ilkka K Martikainen
    Department of Physiology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, Turku 20520, Finland
    J Neural Transm 116:821-30. 2009
    ..Certainty ratings of the responses, but not hit rates, in the pain memory task were correlated with 5-HT(1A) BP (ND) in the dorsal raphe...
  38. ncbi request reprint Subanesthetic ketamine does not affect 11C-flumazenil binding in humans
    Elina Salmi
    Turku PET Centre, PO Box 52, FIN 20521 Turku, Finland
    Anesth Analg 101:722-5, table of contents. 2005
    ..Ketamine did not affect (11)C-flumazenil binding to GABA(A) receptor in the brain, indicating that this mechanism is of minor importance in the actions of subanesthetic ketamine...
  39. ncbi request reprint Mapping neurotransmitter networks with PET: an example on serotonin and opioid systems
    Lauri Tuominen
    Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland Department of Psychiatry, University of Turku, Turku, Finland
    Hum Brain Mapp 35:1875-84. 2014
    ....
  40. ncbi request reprint Brain serotonin 1A receptor binding in bulimia nervosa
    Jari Tiihonen
    Department of Psychiatry, University Hospital, University of Helsinki, Helsinki, Finland
    Biol Psychiatry 55:871-3. 2004
    ..Experimental studies suggest that the therapeutic antidepressant effect of SSRIs is mediated via 5-HT(1A) receptors. The aim of this study was to measure brain 5-HT(1A) receptor binding among nonmedicated patients with bulimia nervosa...
  41. ncbi request reprint Negative symptoms and neuroleptics in catatonic schizophrenia
    Raimo K R Salokangas
    Department of Psychiatry, University of Turku, FIN 20520 Turku, Finland
    Schizophr Res 59:73-6. 2003
    ..046) higher ND scores than other patients. Patients with catatonic schizophrenia are highly vulnerable to negative symptoms related to neuroleptic drugs, probably because of a defect in their dopaminergic neuronal pathways...
  42. ncbi request reprint Synthesis and characterization of a potent, selective, radiolabeled substance-P antagonist for NK1 receptor quantitation: ([18F]SPA-RQ)
    Olof Solin
    Turku PET Centre, Turku, Finland
    Mol Imaging Biol 6:373-84. 2004
    ..To develop and characterize a radiolabelled Substance-P antagonist useful for quantitation of neurokinin-1 receptors in the brain via PET imaging...
  43. ncbi request reprint Striatal dopamine D2 receptors in modulation of pain in humans: a review
    Nora Hagelberg
    Turku PET Centre, Turku University Central Hospital and University of Turku, 20520 Turku, Finland
    Eur J Pharmacol 500:187-92. 2004
    ..We propose that the striatal dopamine D2 receptor may be an important target for the diagnosis and treatment of chronic pain...
  44. ncbi request reprint Prolonged central mu-opioid receptor occupancy after single and repeated nalmefene dosing
    Kimmo Ingman
    Clinical Research Services Turku CRST, University of Turku, FIN 20521 Turku, Finland
    Neuropsychopharmacology 30:2245-53. 2005
    ..These results support the rational of administering nalmefene when needed before alcohol drinking, and they additionally suggest that a high mu-opioid receptor occupancy can be maintained when nalmefene is taken once daily...
  45. ncbi request reprint Increased caudate dopamine D2 receptor availability as a genetic marker for schizophrenia
    Jussi Hirvonen
    Department of Pharmacology and Clinical Pharmacology, and Turku PET Centre, University of Turku, Kiinamyllynkatu, Turku 20520, Finland
    Arch Gen Psychiatry 62:371-8. 2005
    ..Relative hyperfunction of the subcortical dopamine system has been previously suggested to be one of the key pathophysiologic mechanisms in schizophrenic psychosis...
  46. ncbi request reprint Regional brain morphology and duration of illness in never-medicated first-episode patients with schizophrenia
    Jarmo Hietala
    Schizophr Res 64:79-81. 2003
  47. ncbi request reprint Voxel-based NK1 receptor occupancy measurements with [(18)F]SPA-RQ and positron emission tomography: a procedure for assessing errors from image reconstruction and physiological modeling
    Esa Wallius
    Institute of Signal Processing, Tampere University of Technology, 33101, Tampere, Finland
    Mol Imaging Biol 9:284-94. 2007
    ..This study introduces a general procedure for assessing errors that arise from the applied image processing methods in PET receptor occupancy studies using the neurokinin-1 (NK1) receptor occupancy study as an example...
  48. ncbi request reprint Alfentanil increases cortical dopamine D2/D3 receptor binding in healthy subjects
    Nora Hagelberg
    Turku PET Centre, University of Turku, P O Box 52, FIN 20521 Turku, Finland
    Pain 109:86-93. 2004
    ..The association of the uplifting effect of alfentanil with increased D2/D3 binding in the posterior cingulate cortex suggests that cortical dopamine may be involved in the behavioral effects of opioids...
  49. ncbi request reprint Evaluation of the automatic three-dimensional delineation of caudate and putamen for PET receptor occupancy studies
    Esa Wallius
    Institute of Signal Processing, Tampere University of Technology, Tampere, Finland
    Nucl Med Commun 29:53-65. 2008
    ..The aim of this study was to evaluate, and confirm the feasibility of two automatic, paired, three-dimensional delineation methods of striatal structures (caudate and putamen) for the purposes of PET receptor occupancy studies...
  50. ncbi request reprint Sex differences in striatal presynaptic dopamine synthesis capacity in healthy subjects
    Aki Laakso
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland
    Biol Psychiatry 52:759-63. 2002
    ..We explored further the basis of this phenomenon in an independent study and hypothesized that striatal presynaptic dopamine synthesis capacity would also be elevated in women...
  51. ncbi request reprint A volumetric MRI study of the entorhinal cortex in first episode neuroleptic-naive schizophrenia
    Christian C Joyal
    Institut Philippe Pinel de Montreal, Montreal, Canada
    Biol Psychiatry 51:1005-7. 2002
    ..Imaging studies have frequently reported volume loss of limbic structures in schizophrenia, yet there appears to be no quantitative data on entorhinal cortex volumes in patients with neuroleptic naive first-episode schizophrenia...
  52. ncbi request reprint Personality traits and striatal dopamine synthesis capacity in healthy subjects
    Aki Laakso
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Kiinamyllynkatu 4 8, 20520 Turku, Finland
    Am J Psychiatry 160:904-10. 2003
    ..g., social detachment and novelty seeking). The authors studied whether presynaptic dopamine function is also associated with personality traits...
  53. ncbi request reprint The amygdala and schizophrenia: a volumetric magnetic resonance imaging study in first-episode, neuroleptic-naive patients
    Christian C Joyal
    Institut Philippe Pinel de Montréal CCJ, Montreal, Canada
    Biol Psychiatry 54:1302-4. 2003
    ..The attempts to evaluate amygdaloid volumes using magnetic resonance imaging (MRI) in patients with schizophrenia have yielded highly divergent results...
  54. ncbi request reprint Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant
    Mats Bergstrom
    Uppsala Positron Emission Tomography Centre, Uppsala, Sweden
    Biol Psychiatry 55:1007-12. 2004
    ....
  55. ncbi request reprint Dopamine D2/D3 receptor binding in the anterior cingulate cortex and executive functioning
    Ville Lumme
    Turku PET Centre, University of Turku, c o Turku University Central Hospital, PO Box 52, FIN 20521 Turku, Finland
    Psychiatry Res 156:69-74. 2007
    ..An independent voxel-based receptor parametric mapping analysis confirmed these findings. The results indicate that executive functioning in healthy volunteers is modulated by D(2)/D(3) receptors in the anterior cingulate cortex...
  56. ncbi request reprint Lack of efficacy of the substance p (neurokinin1 receptor) antagonist aprepitant in the treatment of major depressive disorder
    Martin Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island, USA
    Biol Psychiatry 59:216-23. 2006
    ..An early clinical trial suggested that the substance P (neurokinin(1) receptor) antagonist, aprepitant, might provide a unique mechanism of antidepressant activity. Phase III trials were conducted to confirm these findings...