J Hietala

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. ncbi request reprint Ligand-receptor interactions as studied by PET: implications for drug development
    J Hietala
    Department of Psychiatry, and the Turku PET Centre, Turku University Central Hospital, Finland
    Ann Med 31:438-43. 1999
  2. ncbi request reprint Effects of lorazepam administration on striatal dopamine D2 receptor binding characteristics in man--a positron emission tomography study
    J Hietala
    Department of Psychiatry 721, Turku University Central Hospital, Finland
    Psychopharmacology (Berl) 132:361-5. 1997
  3. ncbi request reprint Depressive symptoms and presynaptic dopamine function in neuroleptic-naive schizophrenia
    J Hietala
    Department of Psychiatry, Turku University Central Hospital, Finland
    Schizophr Res 35:41-50. 1999
  4. ncbi request reprint Allelic association between D2 but not D1 dopamine receptor gene and alcoholism in Finland
    J Hietala
    Department of Psychiatry, Turku University Central Hospital, Finland
    Psychiatr Genet 7:19-25. 1997
  5. ncbi request reprint High levels of dopamine activity in the basal ganglia of cigarette smokers
    R K Salokangas
    Department of Psychiatry, Turku University Central Hospital, Finland
    Am J Psychiatry 157:632-4. 2000
  6. doi request reprint Temperament, character and serotonin activity in the human brain: a positron emission tomography study based on a general population cohort
    L Tuominen
    Department of Psychiatry, University of Turku, Turku, Finland
    Psychol Med 43:881-94. 2013
  7. ncbi request reprint Deramciclane, a putative anxiolytic drug, is a serotonin 5-HT2C receptor inverse agonist but fails to induce 5-HT2C receptor down-regulation
    E P Palvimaki
    Department of Pharmacology and Clinical Pharmacology, University of Turku School of Medicine, Finland
    Psychopharmacology (Berl) 136:99-104. 1998
  8. ncbi request reprint Prediction of detached personality in healthy subjects by low dopamine transporter binding
    A Laakso
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland
    Am J Psychiatry 157:290-2. 2000
  9. ncbi request reprint [18F]CFT [(18F)WIN 35,428], a radioligand to study the dopamine transporter with PET: characterization in human subjects
    A Laakso
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland
    Synapse 28:244-50. 1998
  10. ncbi request reprint The dopamine D2 receptor 5'-flanking variant, -141C Ins/Del, is not associated with reduced dopamine D2 receptor density in vivo
    T Pohjalainen
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland
    Pharmacogenetics 9:505-9. 1999

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Ligand-receptor interactions as studied by PET: implications for drug development
    J Hietala
    Department of Psychiatry, and the Turku PET Centre, Turku University Central Hospital, Finland
    Ann Med 31:438-43. 1999
    ..Thus far, PET has been mainly applied to pharmacodynamic studies in the central nervous system but will be used also in other areas of drug development such as cardiovascular diseases and oncology...
  2. ncbi request reprint Effects of lorazepam administration on striatal dopamine D2 receptor binding characteristics in man--a positron emission tomography study
    J Hietala
    Department of Psychiatry 721, Turku University Central Hospital, Finland
    Psychopharmacology (Berl) 132:361-5. 1997
    ..In conclusion, the results suggest that striatal D2 dopamine receptor characteristics are not affected by the clinically relevant lorazepam treatment regimen used...
  3. ncbi request reprint Depressive symptoms and presynaptic dopamine function in neuroleptic-naive schizophrenia
    J Hietala
    Department of Psychiatry, Turku University Central Hospital, Finland
    Schizophr Res 35:41-50. 1999
    ..g., in prediction of response to D2 receptor blocking antipsychotic drugs. A possible connection between paranoid symptomatology and subcortical hyperdopaminergia is suggested, but this remains to be further verified...
  4. ncbi request reprint Allelic association between D2 but not D1 dopamine receptor gene and alcoholism in Finland
    J Hietala
    Department of Psychiatry, Turku University Central Hospital, Finland
    Psychiatr Genet 7:19-25. 1997
    ....
  5. ncbi request reprint High levels of dopamine activity in the basal ganglia of cigarette smokers
    R K Salokangas
    Department of Psychiatry, Turku University Central Hospital, Finland
    Am J Psychiatry 157:632-4. 2000
    ..The authors' goal was to study presynaptic dopamine activity in smoking and nonsmoking human subjects in vivo...
  6. doi request reprint Temperament, character and serotonin activity in the human brain: a positron emission tomography study based on a general population cohort
    L Tuominen
    Department of Psychiatry, University of Turku, Turku, Finland
    Psychol Med 43:881-94. 2013
    ..In secondary analyses, 5-HTT BPND was correlated with other TCI dimensions...
  7. ncbi request reprint Deramciclane, a putative anxiolytic drug, is a serotonin 5-HT2C receptor inverse agonist but fails to induce 5-HT2C receptor down-regulation
    E P Palvimaki
    Department of Pharmacology and Clinical Pharmacology, University of Turku School of Medicine, Finland
    Psychopharmacology (Berl) 136:99-104. 1998
    ..In conclusion, these data indicate that deramciclane is a 5-HT2C receptor inverse agonist and occupies 5-HT2C receptors during treatment, and that chronic treatment with deramciclane does not lead to 5-HT2C receptor down-regulation...
  8. ncbi request reprint Prediction of detached personality in healthy subjects by low dopamine transporter binding
    A Laakso
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland
    Am J Psychiatry 157:290-2. 2000
    ..The authors investigated whether a similar correlation exists between striatal dopamine transporter binding and detached personality...
  9. ncbi request reprint [18F]CFT [(18F)WIN 35,428], a radioligand to study the dopamine transporter with PET: characterization in human subjects
    A Laakso
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland
    Synapse 28:244-50. 1998
    ..With a high resolution 3D PET scanner, the quantification of extrastriatal dopamine transporters should become possible...
  10. ncbi request reprint The dopamine D2 receptor 5'-flanking variant, -141C Ins/Del, is not associated with reduced dopamine D2 receptor density in vivo
    T Pohjalainen
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland
    Pharmacogenetics 9:505-9. 1999
    ....
  11. ncbi request reprint Combined treatment with citalopram and buspirone: effects on serotonin 5-HT2A and 5-HT2C receptors in the rat brain
    E Syvalahti
    Department of Pharmacology and Clinical Pharmacology, University of Turku, 20520 Turku, Finland
    Pharmacopsychiatry 39:1-8. 2006
    ..We wanted to elucidate whether the proposed advantages of citalopram-buspirone combination treatment are related to changes in 5-HT(2A/C) receptor-mediated neurotransmission...
  12. ncbi request reprint Measurement of striatal and thalamic dopamine D2 receptor binding with 11C-raclopride
    J Hirvonen
    Department of Pharmacology and Clinical Pharmacology, University of Turku, and Turku PET Centre, Turku University Central Hospital, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Nucl Med Commun 24:1207-14. 2003
    ..However, the signal-to-noise ratio for quantification may become too low especially in receptor occupancy-type studies, leading to an artefactual underestimation of measured D2 receptor occupancy...
  13. ncbi request reprint Prediction of psychosis in clinical high-risk patients by the Schizotypal Personality Questionnaire. Results of the EPOS project
    R K R Salokangas
    Department of Psychiatry, University of Turku, Turku, Finland Psychiatric Clinic, Turku University Central Hospital, Turku, Finland Turku Psychiatric Clinic, Turku Mental Health Centre, Turku, Finland Electronic address
    Eur Psychiatry 28:469-75. 2013
    ..It is also possible that they increase transition to psychosis (TTP) among clinical high-risk patients (CHR). Our aim was to investigate whether schizotypal features predict TTP in CHR patients...
  14. ncbi request reprint The A1 allele of the D2 dopamine receptor gene is associated with high dopamine transporter density in detoxified alcoholics
    T P Laine
    Department of Psychiatry, University of Oulu, FIN-90220 Oulu, Finland
    Alcohol Alcohol 36:262-5. 2001
    ..0 +/- 1.2 (mean +/- SD) vs 6.9 +/- 1.1, P = 0.035]. We suggest that the TaqI A RFLP is in linkage disequilibrium with a gene variant modifying DAT density in alcoholics...
  15. doi request reprint No association between serotonin 5-HT 1A receptors and spirituality among patients with major depressive disorders or healthy volunteers
    H Karlsson
    Department of Psychiatry, University of Helsinki, Turku, Finland
    Mol Psychiatry 16:282-5. 2011
    ..These results do not support the idea that the serotonin system forms the biological basis of spiritual experiences among patients suffering from major depressive disorder or among healthy volunteers...
  16. ncbi request reprint Sertindole is a serotonin 5-HT2c inverse agonist and decreases agonist but not antagonist binding to 5-HT2c receptors after chronic treatment
    J Hietala
    Department of Psychiatry and Turku PET Center, Turku University Central Hospital, Finland
    Psychopharmacology (Berl) 157:180-7. 2001
    ..The 5-HT2c receptor downregulation during repeated dosing may contribute to therapeutic efficacy and/or side effects of sertindole treatment...
  17. ncbi request reprint Cigarette smoking in long-term schizophrenia
    R K R Salokangas
    Department of Psychiatry, University of Turku Psychiatric Clinic, Turku University Central Hospital, 20520 Turku, Finland
    Eur Psychiatry 21:219-23. 2006
    ..Cigarette smoking is a great health problem and prevalent among subjects with schizophrenia. Our aim was to investigate the prevalence and associations of cigarette smoking in patients with long-term schizophrenia...
  18. ncbi request reprint Structural magnetic resonance imaging in patients with first-episode schizophrenia, psychotic and severe non-psychotic depression and healthy controls. Results of the schizophrenia and affective psychoses (SAP) project
    R K R Salokangas
    Department of Psychiatry, University of Turku, Turku University Central Hospital and Turku Psychiatric Clinic, Finland
    Br J Psychiatry Suppl 43:s58-65. 2002
    ..Structural brain abnormalities are prevalent in patients with schizophrenia and affective disorders...
  19. ncbi request reprint Measurement of cortical dopamine d1 receptor binding with 11C[SCH23390]: a test-retest analysis
    J Hirvonen
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland
    J Cereb Blood Flow Metab 21:1146-50. 2001
    ..These aspects should be considered when designing studies on the cortical D1-like receptors...
  20. ncbi request reprint C957T polymorphism of the dopamine D2 receptor (DRD2) gene affects striatal DRD2 availability in vivo
    M Hirvonen
    Mol Psychiatry 9:1060-1. 2004
  21. ncbi request reprint Extrastriatal dopamine D(2) receptors in Parkinson's disease: a longitudinal study
    V Kaasinen
    Department of Neurology, Turku PES Centre, Turku, Finland
    J Neural Transm 110:591-601. 2003
    ..Our longitudinal study shows first evidence concerning cortical D(2) receptor loss in the progression of PD, although it is not possible to distinguish between the effects of the therapy and the disease...
  22. ncbi request reprint Decreased striatal dopamine transporter binding in vivo in chronic schizophrenia
    A Laakso
    Department of Pharmacology and Clinical Pharmacology, University of Turku, 20520, Turku, Finland
    Schizophr Res 52:115-20. 2001
    ....
  23. ncbi request reprint Ethanol consumption and DRD2 gene TaqI a polymorphism among socially drinking males
    Tero Hallikainen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Kuopio, Finland
    Am J Med Genet A 119:152-5. 2003
    ..These results in the large sample of non-alcoholic males are also opposite to some previous findings on the higher A1 allele frequency among alcoholic populations...