Karl Heinz Herzig


Affiliation: University of Oulu
Country: Finland


  1. Saukkonen T, Mutt S, Jokelainen J, Saukkonen A, Raza G, Karhu T, et al. Adipokines and inflammatory markers in elderly subjects with high risk of type 2 diabetes and cardiovascular disease. Sci Rep. 2018;8:12816 pubmed publisher
    ..The associations were independent of visceral adiposity. ..
  2. Metsämarttila E, Rodilla E, Jokelainen J, Herrala S, Leppäluoto J, Keinanen Kiukaanniemi S, et al. Effect of physical activity on pulse wave velocity in elderly subjects with normal glucose, prediabetes or Type 2 Diabetes. Sci Rep. 2018;8:8045 pubmed publisher
    ..2?m/s lower (cf)PWV than those walking less than 6000 steps/day. Presence of T2D, elevated heart rate and alcohol consumption in males were associated with increased aortic stiffening in elderly subjects. ..
  3. Herzig K, Purhonen A, Räsänen K, Idziak J, Juvonen P, Phillps R, et al. Fecal pancreatic elastase-1 levels in older individuals without known gastrointestinal diseases or diabetes mellitus. BMC Geriatr. 2011;11:4 pubmed publisher
    ..In our study one fifth of healthy older individuals without any gastrointestinal disorder, surgery or diabetes mellitus suffer from pancreatic exocrine insufficiency and might benefit from enzyme supplementation therapy. ..
  4. Steubesand N, Kiehne K, Brunke G, Pahl R, Reiss K, Herzig K, et al. The expression of the beta-defensins hBD-2 and hBD-3 is differentially regulated by NF-kappaB and MAPK/AP-1 pathways in an in vitro model of Candida esophagitis. BMC Immunol. 2009;10:36 pubmed publisher
    ..Our analysis of signal transduction events demonstrate a functional interaction of epithelial cells with PMNs in response to Candida infection involving divergent signalling events that differentially govern hBD-2 and hBD-3 expression. ..
  5. Raza G, Putaala H, Hibberd A, Alhoniemi E, Tiihonen K, Mäkelä K, et al. Polydextrose changes the gut microbiome and attenuates fasting triglyceride and cholesterol levels in Western diet fed mice. Sci Rep. 2017;7:5294 pubmed publisher
    ..These results suggest that PDX in mice fed WD promoted systemic changes via regulation of the gut microbiota and gene expression in intestinal tract. ..
  6. Karhu T, Akiyama K, Vuolteenaho O, Bergmann U, Naito T, Tatemoto K, et al. Mast cell degranulation via MRGPRX2 by isolated human albumin fragments. Biochim Biophys Acta. 2017;1861:2530-2534 pubmed publisher
    ..These endogenous albumin fragments, cleaved from albumin by mast cell secreted proteases, provide a possible pathway for self-perpetuating mast cell dependent inflammation. ..
  7. Karhu T, Akiyama K, Vuolteenaho O, Bergmann U, Naito T, Tatemoto K, et al. Isolation of new ligands for orphan receptor MRGPRX1-hemorphins LVV-H7 and VV-H7. Peptides. 2017;96:61-66 pubmed publisher
    ..Here, we describe the isolation of two novel endogenous ligands for the MRGPRX1 from human platelet preparation. The isolated ligands are hemoglobin ?-chain fragments, known members of the hemorphin family. ..
  8. Herzig K, Leppäluoto J, Jokelainen J, Meugnier E, Pesenti S, Selänne H, et al. Low level activity thresholds for changes in NMR biomarkers and genes in high risk subjects for Type 2 Diabetes. Sci Rep. 2017;7:11267 pubmed publisher
    ..The effects were mediated rather by PA than body weight or fat loss. Thus, lower thresholds for PA may exist for long term prevention of cardio-metabolic diseases in sedentary overweight subjects. ..