Affiliation: University of Tampere
Tiainen K, Raitanen J, Vaara E, Hervonen A, JylhÃ¤ M. Longitudinal changes in mobility among nonagenarians: the Vitality 90+â€‰Study. BMC Geriatr. 2015;15:124 pubmed publisher
..The prevention efforts are important and should focus even more, also among the oldest-old, on additional modifiable risk factors such as maintaining muscle strength. ..
Kananen L, Nevalainen T, JylhÃ¤vÃ¤ J, Marttila S, Hervonen A, JylhÃ¤ M, et al
. Cytomegalovirus infection accelerates epigenetic aging. Exp Gerontol. 2015;72:227-9 pubmed publisher
..5 vs. 24.0 (p < 0.02,Mannâ€“Whitney U-test) in the young controls and 76.0 vs. 70.0 (p < 0.01) in the nonagenarians). Thus, these data provide a new aspect to the CMV associated pathological processes. ..
Marttila S, Nevalainen T, Jylhävä J, Kananen L, Jylha M, Hervonen A, et al
. Human endogenous retrovirus HERV-K(HML-2) env expression is not associated with markers of immunosenescence. Exp Gerontol. 2017;97:60-63 pubmed publisher
..Thus, these data suggest that HERVs do not function as antigenic drivers of immunosenescence. On the contrary, expression of HERV-K(HML-2) env is associated with more youthful levels of B cells. ..
Marttila S, Kananen L, HÃ¤yrynen S, JylhÃ¤vÃ¤ J, Nevalainen T, Hervonen A, et al
. Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression. BMC Genomics. 2015;16:179 pubmed publisher