Sanna Kaisa Herukka

Summary

Affiliation: University of Kuopio
Country: Finland

Publications

  1. ncbi CSF Abeta42, Tau and phosphorylated Tau, APOE epsilon4 allele and MCI type in progressive MCI
    Sanna Kaisa Herukka
    Department of Neuroscience and Neurology, Brain Research Unit, Clinical Research Center, Mediteknia, University of Kuopio, 70211 Kuopio, Finland
    Neurobiol Aging 28:507-14. 2007
  2. ncbi CSF Abeta42, tau and phosphorylated tau correlate with medial temporal lobe atrophy
    Sanna Kaisa Herukka
    Department of Neurology, University of Kuopio, Kuopio, Finland
    J Alzheimers Dis 14:51-7. 2008
  3. ncbi CSF Abeta42 and tau or phosphorylated tau and prediction of progressive mild cognitive impairment
    Sanna Kaisa Herukka
    Department of Neurology, University of Kuopio, Finland
    Neurology 64:1294-7. 2005
  4. doi Disease state fingerprint in frontotemporal degeneration with reference to Alzheimer's disease and mild cognitive impairment
    Miguel Ángel Muñoz-Ruiz
    Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 35:727-39. 2013
  5. doi Genetic analysis of genes involved in amyloid-β degradation and clearance in Alzheimer's disease
    Teemu Natunen
    Institute of Clinical Medicine Neurology, University of Eastern Finland and Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    J Alzheimers Dis 28:553-9. 2012
  6. ncbi Differences in cortical thickness in healthy controls, subjects with mild cognitive impairment, and Alzheimer's disease patients: a longitudinal study
    Valtteri Julkunen
    Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    J Alzheimers Dis 21:1141-51. 2010
  7. ncbi Longitudinal changes of CSF biomarkers in Alzheimer's disease
    Toni T Seppälä
    Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 25:583-94. 2011
  8. ncbi Abeta levels in serum, CSF and brain, and cognitive deficits in APP + PS1 transgenic mice
    Li Liu
    Department of Neuroscience, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Neuroreport 14:163-6. 2003
  9. doi Comparing predictors of conversion to Alzheimer's disease using the disease state index
    Miguel Ángel Muñoz-Ruiz
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Neurodegener Dis 13:200-2. 2014
  10. doi GRN variant rs5848 reduces plasma and brain levels of granulin in Alzheimer's disease patients
    Anna Kämäläinen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 33:23-7. 2013

Collaborators

Detail Information

Publications18

  1. ncbi CSF Abeta42, Tau and phosphorylated Tau, APOE epsilon4 allele and MCI type in progressive MCI
    Sanna Kaisa Herukka
    Department of Neuroscience and Neurology, Brain Research Unit, Clinical Research Center, Mediteknia, University of Kuopio, 70211 Kuopio, Finland
    Neurobiol Aging 28:507-14. 2007
    ..Especially the amnestic MCI is seen as prodrome of AD. Apolipoprotein E (APOE) epsilon4 allele, abnormal CSF Abeta42, Tau and phosphorylated Tau (phospho-Tau) levels are associated with elevated risk for AD...
  2. ncbi CSF Abeta42, tau and phosphorylated tau correlate with medial temporal lobe atrophy
    Sanna Kaisa Herukka
    Department of Neurology, University of Kuopio, Kuopio, Finland
    J Alzheimers Dis 14:51-7. 2008
    ..However, the order of the changes in the CSF biomarkers and MTL atrophy remain unclear due to a small number of studied subjects and study design...
  3. ncbi CSF Abeta42 and tau or phosphorylated tau and prediction of progressive mild cognitive impairment
    Sanna Kaisa Herukka
    Department of Neurology, University of Kuopio, Finland
    Neurology 64:1294-7. 2005
    ..Abnormal biomarkers were found early in the course of Alzheimer disease (AD). The most predictive assay for AD among the patients with MCI was the combination of Abeta42 and P-tau...
  4. doi Disease state fingerprint in frontotemporal degeneration with reference to Alzheimer's disease and mild cognitive impairment
    Miguel Ángel Muñoz-Ruiz
    Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 35:727-39. 2013
    ..It has been demonstrated that it is applicable in the diagnosis of Alzheimer's disease (AD)...
  5. doi Genetic analysis of genes involved in amyloid-β degradation and clearance in Alzheimer's disease
    Teemu Natunen
    Institute of Clinical Medicine Neurology, University of Eastern Finland and Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    J Alzheimers Dis 28:553-9. 2012
    ....
  6. ncbi Differences in cortical thickness in healthy controls, subjects with mild cognitive impairment, and Alzheimer's disease patients: a longitudinal study
    Valtteri Julkunen
    Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    J Alzheimers Dis 21:1141-51. 2010
    ....
  7. ncbi Longitudinal changes of CSF biomarkers in Alzheimer's disease
    Toni T Seppälä
    Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 25:583-94. 2011
    ..More longitudinal studies of CSF biomarker dynamics are needed, especially in patients during the preclinical stage of the disease...
  8. ncbi Abeta levels in serum, CSF and brain, and cognitive deficits in APP + PS1 transgenic mice
    Li Liu
    Department of Neuroscience, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Neuroreport 14:163-6. 2003
    ..These findings support the role of insoluble Abeta42 in memory dysfunction and suggest a model with several pools (insoluble, extracellular soluble, CSF) of Abeta being in partial equilibrium with each other...
  9. doi Comparing predictors of conversion to Alzheimer's disease using the disease state index
    Miguel Ángel Muñoz-Ruiz
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Neurodegener Dis 13:200-2. 2014
    ..The Disease State Index (DSI) is a method which interprets data originating from multiple different sources, assisting the clinician in the diagnosis and follow-up of dementia diseases...
  10. doi GRN variant rs5848 reduces plasma and brain levels of granulin in Alzheimer's disease patients
    Anna Kämäläinen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 33:23-7. 2013
    ..Our findings suggest that the A allele of rs5848 is functionally relevant by reducing the expression of granulin...
  11. pmc Structural MRI in frontotemporal dementia: comparisons between hippocampal volumetry, tensor-based morphometry and voxel-based morphometry
    Miguel Ángel Muñoz-Ruiz
    Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
    PLoS ONE 7:e52531. 2012
    ..MRI is an important clinical tool for diagnosing dementia-like diseases such as Frontemporal Dementia (FTD). However there is a need to develop more accurate and standardized MRI analysis methods...
  12. doi Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain
    Tero Tapiola
    Department of Neuroscience and Neurology, Clinical Research Center Mediteknia, Kuopio University Hospital, University of Kuopio, Finland
    Arch Neurol 66:382-9. 2009
    ....
  13. ncbi Longitudinal observation on CSF Abeta42 levels in young to middle-aged amyloid precursor protein/presenilin-1 doubly transgenic mice
    Li Liu
    Department of Neuroscience and Neurology, University of Kuopio, Finland
    Neurobiol Dis 17:516-23. 2004
    ..Our results suggest that the levels of CSF Abeta42 initially reflect the rate of Abeta42 production, but after reaching a critical concentration stay in equilibrium, until plaque formation leads to decreased CSF Abeta42 levels...
  14. doi An association study of 21 potential Alzheimer's disease risk genes in a Finnish population
    Timo Sarajärvi
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    J Alzheimers Dis 21:763-7. 2010
    ..Risk analysis revealed a protective effect for the minor allele carriers of rs1800629. This suggests that genetic alteration in TNF gene may play a role in AD...
  15. pmc Cerebrospinal fluid biomarker and brain biopsy findings in idiopathic normal pressure hydrocephalus
    Okko T Pyykkö
    Neurosurgery of Neurocenter, Kuopio University Hospital, Kuopio, Finland
    PLoS ONE 9:e91974. 2014
    ..The significance of amyloid precursor protein (APP) and neuroinflammation in idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's disease (AD) is unknown...
  16. pmc Predicting AD conversion: comparison between prodromal AD guidelines and computer assisted PredictAD tool
    Yawu Liu
    Department of Neurology, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland
    PLoS ONE 8:e55246. 2013
    ....
  17. ncbi Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients
    Johanna Ojala
    Department of Neuroscience and Neurology, University of Kuopio, Canthia, P O Box 1627, FIN 70211 Kuopio, Finland
    Neurobiol Aging 30:198-209. 2009
    ..Plasma levels of IL-18 showed no correlation with the disease. In conclusion, amyloid-beta may induce the synthesis of IL-18, and IL-18 kinases involved in tau phosphorylation as a part of the amyloid-associated inflammatory reaction...
  18. ncbi Differences in cortical thickness in healthy controls, subjects with mild cognitive impairment, and Alzheimer's disease patients: a longitudinal study
    Valtteri Julkunen
    Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    J Alzheimers Dis 21:1141-51. 2010
    ....