Seppo Heinonen

Summary

Affiliation: University of Kuopio
Country: Finland

Publications

  1. ncbi Need for and consequences of episiotomy in vaginal birth: a critical approach
    Sari Räisänen
    Department of Nursing Science, University of Kuopio, Kuopio University Hospital, PL 1777, 70211 Kuopio, Finland
    Midwifery 26:348-56. 2010
  2. pmc Up to seven-fold inter-hospital differences in obstetric anal sphincter injury rates- A birth register-based study in Finland
    Sari Räisänen
    Department of Nursing Science, University of Eastern Finland, P, O, Box 1627, 70211 Kuopio, Finland
    BMC Res Notes 3:345. 2010
  3. pmc The role of nocturnal delivery and delivery during the holiday period in Finland on obstetric anal sphincter rupture rates- a population based observational study
    Sari Räisänen
    Department of Nursing Science, University of Eastern Finland, PO Box 1627, FI 70211 Kuopio, Finland
    BMC Res Notes 3:32. 2010
  4. doi Lateral episiotomy protects primiparous but not multiparous women from obstetric anal sphincter rupture
    Sari Helena Räisänen
    Kuopio University Hospital, Kuopio, Finland
    Acta Obstet Gynecol Scand 88:1365-72. 2009
  5. doi The increased incidence of obstetric anal sphincter rupture--an emerging trend in Finland
    Sari Räisänen
    Department of Nursing Science, University of Kuopio, PL 1627, 70211 Kuopio, Finland
    Prev Med 49:535-40. 2009
  6. ncbi Plasma cell membrane glycoprotein-1 K121Q polymorphism in preeclampsia
    Tanja Saarela
    Department of Obstetrics and Gynaecology, University of Kuopio, Kuopio, Finland
    Gynecol Obstet Invest 61:124-7. 2006
  7. ncbi Low-activity haplotype of the microsomal epoxide hydrolase gene is protective against placental abruption
    Sari Toivonen
    Department of Obstetrics and Gynaecology, Kuopio University and University Hospital, Kuopio, Finland
    J Soc Gynecol Investig 11:540-4. 2004
  8. doi Flow mediated vasodilation and circulating concentrations of high sensitive C-reactive protein, interleukin-6 and tumor necrosis factor-alpha in normal pregnancy--The Cardiovascular Risk in Young Finns Study
    Heli Saarelainen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, University of Kuopio, Puijonlaaksontie 2, PO Box 1777, Kuopio FIN 70211, Finland
    Clin Physiol Funct Imaging 29:347-52. 2009
  9. ncbi Subtle changes in ADMA and l-arginine concentrations in normal pregnancies are unlikely to account for pregnancy-related increased flow-mediated dilatation
    Heli Saarelainen
    Department of Ob Gyn, Kuopio University Hospital, University of Kuopio, Kuopio, Finland
    Clin Physiol Funct Imaging 28:120-4. 2008
  10. doi Ambulatory arterial stiffness index is unchanged in uncomplicated third-trimester singleton and twin pregnancies
    Henna Kärkkäinen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, University of Eastern Finland, Finland
    Acta Obstet Gynecol Scand 90:516-23. 2011

Detail Information

Publications91

  1. ncbi Need for and consequences of episiotomy in vaginal birth: a critical approach
    Sari Räisänen
    Department of Nursing Science, University of Kuopio, Kuopio University Hospital, PL 1777, 70211 Kuopio, Finland
    Midwifery 26:348-56. 2010
    ..to describe and explain the short-term effects of lateral episiotomy, and determine the factors associated with more/less common use of episiotomy...
  2. pmc Up to seven-fold inter-hospital differences in obstetric anal sphincter injury rates- A birth register-based study in Finland
    Sari Räisänen
    Department of Nursing Science, University of Eastern Finland, P, O, Box 1627, 70211 Kuopio, Finland
    BMC Res Notes 3:345. 2010
    ..abstract:..
  3. pmc The role of nocturnal delivery and delivery during the holiday period in Finland on obstetric anal sphincter rupture rates- a population based observational study
    Sari Räisänen
    Department of Nursing Science, University of Eastern Finland, PO Box 1627, FI 70211 Kuopio, Finland
    BMC Res Notes 3:32. 2010
    ..Women (n = 2,849) with OASR were compared in terms of possible risk factors to women without OASR using stepwise logistic regression analysis...
  4. doi Lateral episiotomy protects primiparous but not multiparous women from obstetric anal sphincter rupture
    Sari Helena Räisänen
    Kuopio University Hospital, Kuopio, Finland
    Acta Obstet Gynecol Scand 88:1365-72. 2009
    ..To identify the risk factors for obstetric anal sphincter rupture (OASR)...
  5. doi The increased incidence of obstetric anal sphincter rupture--an emerging trend in Finland
    Sari Räisänen
    Department of Nursing Science, University of Kuopio, PL 1627, 70211 Kuopio, Finland
    Prev Med 49:535-40. 2009
    ..To describe recent trends in the prevalence and risk factors of obstetric anal sphincter ruptures during between 1997 and 2007 in Finland...
  6. ncbi Plasma cell membrane glycoprotein-1 K121Q polymorphism in preeclampsia
    Tanja Saarela
    Department of Obstetrics and Gynaecology, University of Kuopio, Kuopio, Finland
    Gynecol Obstet Invest 61:124-7. 2006
    ..We wanted to determine whether genetic variability in the gene encoding plasma cell membrane glycoprotein-1 (PC-1) contributes to individual susceptibility to the development of preeclampsia...
  7. ncbi Low-activity haplotype of the microsomal epoxide hydrolase gene is protective against placental abruption
    Sari Toivonen
    Department of Obstetrics and Gynaecology, Kuopio University and University Hospital, Kuopio, Finland
    J Soc Gynecol Investig 11:540-4. 2004
    ..We wanted to determine whether genetic variability in the gene encoding microsomal epoxide hydrolase (EPHX) contributes to individual differences in susceptibility to the occurrence of placental abruption...
  8. doi Flow mediated vasodilation and circulating concentrations of high sensitive C-reactive protein, interleukin-6 and tumor necrosis factor-alpha in normal pregnancy--The Cardiovascular Risk in Young Finns Study
    Heli Saarelainen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, University of Kuopio, Puijonlaaksontie 2, PO Box 1777, Kuopio FIN 70211, Finland
    Clin Physiol Funct Imaging 29:347-52. 2009
    ..The aim of this study was to evaluate the effect of pregnancy on hsCRP and pro-inflammatory cytokines and their associations with vascular endothelial function...
  9. ncbi Subtle changes in ADMA and l-arginine concentrations in normal pregnancies are unlikely to account for pregnancy-related increased flow-mediated dilatation
    Heli Saarelainen
    Department of Ob Gyn, Kuopio University Hospital, University of Kuopio, Kuopio, Finland
    Clin Physiol Funct Imaging 28:120-4. 2008
    ..Our objective was to investigate whether serum concentrations of asymmetric dimethylarginine (ADMA) or l-arginine correlate to hyperlipidemia or endothelial function in normal pregnancy compared with the non-pregnant subjects...
  10. doi Ambulatory arterial stiffness index is unchanged in uncomplicated third-trimester singleton and twin pregnancies
    Henna Kärkkäinen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, University of Eastern Finland, Finland
    Acta Obstet Gynecol Scand 90:516-23. 2011
    ..To document the ambulatory arterial stiffness index (AASI) during pregnancy compared to three months after delivery in singleton and twin pregnancies...
  11. doi Gestational diabetic patients with adequate management have normal cardiovascular autonomic regulation during the third trimester of pregnancy and 3 months after delivery
    Nonna Heiskanen
    Department of Obsteterics and Gynecology, Kuopio University Hospital, University of Kuopio, P O B 1777, 70211 Kuopio, Finland
    J Diabetes Complications 24:234-41. 2010
    ..The aim of the present study was to evaluate the influence of gestational diabetes mellitus (GDM) on hemodynamics and cardiovascular autonomic regulation at rest and their responses to head-up tilt (HUT)...
  12. ncbi The administration of an adenoviral thymidine kinase suicide gene to the uterine artery of rabbits does not affect fertility: a safety study of pregnant and nonpregnant rabbits and their offspring
    Anniina Laurema
    A I Virtanen Institute, University of Kuopio, Kuopio, Finland
    J Gene Med 10:1005-11. 2008
    ..We studied the effects of AdvTK gene therapy on ovaries and germ cells in pregnant and nonpregnant rabbits and also the potential transmission of a transgene to offspring...
  13. doi Early signs of maternal iron deficiency do not influence the iron status of the newborn, but are associated with higher infant birthweight
    Mari Ervasti
    Department of Clinical Chemistry and Hematology, University of Kuopio, and Eastern Finland Laboratory Centre ISLAB, Kuopio, Finland
    Acta Obstet Gynecol Scand 88:83-90. 2009
    ..To investigate the associations between maternal iron status, pregnancy outcome and newborn iron status using sensitive and specific red blood cell indices reflecting iron-deficient erythropoiesis...
  14. pmc Under-attending free antenatal care is associated with adverse pregnancy outcomes
    Kaisa Raatikainen
    Department of Obstetrics and Gynecology, PO Box 1777, Kuopio University Hospital, 70211 Kuopio, Finland
    BMC Public Health 7:268. 2007
    ..The objective of this study was to assess the outcome of pregnancies when free and easily accessible antenatal care has been either totally lacking or low in number of visits...
  15. doi True umbilical cord knot and obstetric outcome
    Sari Räisänen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland
    Int J Gynaecol Obstet 122:18-21. 2013
    ..15 or lower, and need for neonatal intensive care in singleton pregnancies...
  16. ncbi Associations between two single nucleotide polymorphisms in the adiponectin gene and polycystic ovary syndrome
    Seppo Heinonen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland
    Gynecol Endocrinol 21:165-9. 2005
    ..9%) than in the control group (32.7%) ( p = 0.058). We conclude that polymorphisms of the adiponectin gene may be implicated in individual susceptibility to PCOS...
  17. ncbi Adiponectin gene haplotype is associated with preeclampsia
    Tanja Saarela
    Department of Obstetrics and Gynaecology, University of Kuopio, Kuopio, Finland
    Genet Test 10:35-9. 2006
    ..042 +/- 0.005). Polymorphisms of the adiponectin gene show a weak, but statistically significant, haplotype association with susceptibility to preeclampsia in Finnish women...
  18. pmc Does unemployment in family affect pregnancy outcome in conditions of high quality maternity care?
    Kaisa Raatikainen
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, PO Box 1777, 70211 Kuopio, Finland
    BMC Public Health 6:46. 2006
    ..The objective of this study was to assess the effects of unemployment of one or both parents on obstetric outcome in conditions of free antenatal care attended by the entire pregnant population...
  19. ncbi Tumour necrosis factor-alpha gene haplotype is associated with pre-eclampsia
    Tanja Saarela
    Department of Obstetrics and Gynaecology, University of Kuopio, Kuopio, Finland
    Mol Hum Reprod 11:437-40. 2005
    ..035+/-0.003), compared with the controls. In conclusion, the polymorphisms of the TNF-alpha gene showed a significant haplotype association with susceptibility to pre-eclampsia in the Finnish population...
  20. ncbi Serum L-homoarginine concentration is elevated during normal pregnancy and is related to flow-mediated vasodilatation
    Pirjo Valtonen
    Laboratory Centre, Department of Clinical Chemistry, Kuopio University Hospital and University of Kuopio, Kuopio, Finland
    Circ J 72:1879-84. 2008
    ..Because L-homoarginine can act as a substrate for NO production, concentrations of L-homoarginine in normal pregnancy were assessed in the present study to test whether L-homoarginine is associated with endothelial function...
  21. doi Women with hypertensive pregnancies have difficulties in regaining pre-pregnancy weight and show metabolic disturbances
    Katariina Suntio
    Department of Obstetrics and Gynecology, Kuopio University Hospital and University of Kuopio, Kuopio, Finland
    Obesity (Silver Spring) 18:282-6. 2010
    ..Thus, postpartum period appears to be critical for weight management and interventional programs are called for...
  22. ncbi Plasminogen activator inhibitor-1 polymorphism in women with pre-eclampsia
    Tanja Häkli
    Department of Obstetrics and Gynecology, Kuopio University and University Hospital, 70211 Kuopio, Finland
    Genet Test 7:265-8. 2003
    ..These results are not suggestive of an important contribution of the PAI1 genotype on preeclampsia across populations...
  23. ncbi MTHFR C677T polymorphism is not associated with placental abruption or preeclampsia in Finnish women
    Ester Jääskeläinen
    Department of Obstetrics and Gynecology, Kuopio University and University Hospital, Kuopio, Finland
    Hypertens Pregnancy 25:73-80. 2006
    ..The aim of our study was to examine genetic variability in the gene encoding methylenetetrahydrofolate reductase (MTHFR) and individual susceptibility to the placental abruption or preeclampsia...
  24. pmc Need for insulin to control gestational diabetes is reflected in the ambulatory arterial stiffness index
    Henna Kärkkäinen
    Department of Obst Gyn, Kuopio University Hospital, University of Eastern Finland, POB 1777, Kuopio FIN 70211, Finland
    BMC Pregnancy Childbirth 13:9. 2013
    ..The aim was to evaluate the metabolic profile in conjunction with vascular function using the ambulatory arterial stiffness index (AASI) in women with uncomplicated pregnancies and in women with gestational diabetes mellitus (GDM)...
  25. ncbi Preeclampsia and androgen receptor gene CAG repeat length: results from both children and women
    Tanja Saarela
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, University of Kuopio, Finland
    J Assist Reprod Genet 22:269-75. 2005
    ..We studied whether the CAG (encoding glutamine) repeat length polymorphism in the first exon of the androgen receptor (AR) gene is predictive of preeclampsia...
  26. ncbi Polymorphisms of interleukin-6, hepatic lipase and calpain-10 genes, and preeclampsia
    Tanja Saarela
    Department of Obstetrics and Gynecology, University of Kuopio, Finland
    Eur J Obstet Gynecol Reprod Biol 128:175-9. 2006
    ..We determined whether single nucleotide polymorphisms (SNPs) in interleukin-6 (IL-6), hepatic lipase (HL) and calpain-10 (CAPN-10) genes contribute to susceptibility to develop preeclampsia...
  27. ncbi Transition from overweight to obesity worsens pregnancy outcome in a BMI-dependent manner
    Kaisa Raatikainen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, 70211 Kuopio, Finland
    Obesity (Silver Spring) 14:165-71. 2006
    ..To assess pregnancy outcomes in different BMI groups...
  28. ncbi Placental ratio and risk of velamentous umbilical cord insertion are increased in women with placenta previa
    Marjo Papinniemi
    Department of Obstetrics and Gynecology, Kuopio University and University Hospital, Kuopio, Finland
    Am J Perinatol 24:353-7. 2007
    ..4, and 3.4, respectively. In conclusion, placenta previa is an infrequent pregnancy complication associated with multiparity, advanced maternal age, infertility problems, elevated placental ratio, and velamentous umbilical cord insertion...
  29. ncbi Induced abortion: not an independent risk factor for pregnancy outcome, but a challenge for health counseling
    Kaisa Raatikainen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Finland
    Ann Epidemiol 16:587-92. 2006
    ..The objective of this study is to assess the effects of prior induced abortions on obstetric risk factors and pregnancy outcome in conditions of free high-standard maternity care used by almost the entire pregnant population in Finland...
  30. ncbi CTLA-4 polymorphism 49A-G is associated with placental abruption and preeclampsia in Finnish women
    Ester Jääskeläinen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland
    Clin Chem Lab Med 46:169-73. 2008
    ..Our aim was to study genetic variability in the gene encoding cytotoxic T-lymphocyte antigen (CTLA-4) and individual susceptibility to the development of preeclampsia or placental abruption...
  31. doi The burden of childhood asthma and late preterm and early term births
    Maijakaisa Harju
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland Electronic address
    J Pediatr 164:295-9.e1. 2014
    ..To evaluate the association between gestational age at birth and the risk of subsequent development of asthma...
  32. doi Preclinical safety, toxicology, and biodistribution study of adenoviral gene therapy with sVEGFR-2 and sVEGFR-3 combined with chemotherapy for ovarian cancer
    Laura Tuppurainen
    Department of Molecular Medicine, A I Virtanen Institute, University of Eastern Finland, Kuopio, FIN 70211, Finland
    Hum Gene Ther Clin Dev 24:29-37. 2013
    ..According to these results, AdsVEGFR-2 and AdsVEGFR-3 gene therapy combined with chemotherapy is safe and can be brought to clinical testing in ovarian cancer patients...
  33. ncbi Endothelial nitric oxide synthase polymorphism is not associated with placental abruption in Finnish women
    Sari Toivonen
    Department of Obstetrics and Gynecology, Kuopio University and University Hospital, Kuopio, Finland
    Fetal Diagn Ther 20:508-11. 2005
    ..To study whether genetic variability in the gene encoding endothelial nitric oxide synthase (eNOS) affects individual susceptibility to the development of placental abruption during pregnancy...
  34. ncbi Susceptibility to pre-eclampsia in Finnish women is associated with R485K polymorphism in the factor V gene, not with Leiden mutation
    Fareeza Faisel
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland
    Eur J Hum Genet 12:187-91. 2004
    ..2-5.5). We conclude that the T-A-G haplotype was more frequent among the patient group than in the control group, and genetic variations in the factor V gene other than the Leiden mutation may play a role in disease susceptibility...
  35. pmc Infertility treatment and umbilical cord length-novel markers of childhood epilepsy?
    Sari Räisänen
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, Kuopio, Finland
    PLoS ONE 8:e55394. 2013
    ..Epilepsy is one of the most common neurologic disorders of childhood, affecting about 0.4-0.8% of all children up to the age of 20...
  36. pmc Preeclampsia complicated by advanced maternal age: a registry-based study on primiparous women in Finland 1997-2008
    Reeta Lamminpää
    Department of Nursing Science, University of Eastern Finland, PO, Box, 1627, Kuopio, 70211, Finland
    BMC Pregnancy Childbirth 12:47. 2012
    ..The purpose of this registry-based study was to compare the obstetric outcomes in primiparous and preeclamptic women younger and older than 35 years...
  37. doi Androgen receptor gene CAG repeat length in women with metabolic syndrome
    Jarmo Jääskeläinen
    Department of Pediatrics, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Gynecol Endocrinol 24:411-6. 2008
    ..We hypothesized that shorter AR (CAG)(n) is associated with metabolic syndrome (MBS) or its components in women...
  38. ncbi Obstetric prognosis after placental abruption
    Sari Toivonen
    Department of Obstetrics Gynecology, Kuopio University Hospital, Kuopio, Finland
    Fetal Diagn Ther 19:336-41. 2004
    ..To assess obstetric outcome in women with a history of placental abruption...
  39. doi Novel red cell indices indicating reduced availability of iron are associated with high erythropoietin concentration and low ph level in the venous cord blood of newborns
    Mari Ervasti
    Department of Clinical Chemistry and Hematology, Kuopio University, Eastern Finland Laboratory Centre, Kuopio, Finland
    Pediatr Res 64:135-40. 2008
    ..Furthermore, signs of lower hemoglobinization of red cells are associated with low umbilical vein pH in the newborns, indicating an increased risk of birth asphyxia...
  40. ncbi Obstetric outcome in post-term pregnancies: time for reappraisal in clinical management
    Minna Hovi
    Department of Gynaecology and Obstetrics, Kuopio University Hospital, Kuopio, Finland
    Acta Obstet Gynecol Scand 85:805-9. 2006
    ..The objective of this study was to determine the outcome of pregnancy in post-term cases compared with term cases in a well defined population receiving modern obstetric care...
  41. ncbi Endothelial nitric oxide synthase polymorphism in preeclampsia
    Tanja Häkli
    Department of Obstetrics and Gynecology, Kuopio University and University Hospital, Kuopio, Finland
    J Soc Gynecol Investig 10:154-7. 2003
    ..We wished to determine whether genetic variability in the gene encoding endothelial nitric oxide synthase (eNOS) modifies individual susceptibility to the development of preeclampsia...
  42. ncbi Marked allelic imbalance on chromosome 5q31 does not explain alpha-catenin expression in epithelial ovarian cancer
    Hanna Tuhkanen
    Department of Pathology and Forensic Medicine, University Hospital, University of Kuopio, 70210 Kuopio, Finland
    Gynecol Oncol 94:416-21. 2004
    ..In the present work, the role of CTNNA1 as a candidate tumor suppressor gene was studied by comparing protein expression with allelic imbalance in human epithelial ovarian tumors...
  43. ncbi Polymorphism in the interleukin 1 receptor antagonist gene in women with preeclampsia
    Fareeza Faisel
    Department of Obstetrics and Gynecology, Kuopio University and University Hospital, 70211 Kuopio, Finland
    J Reprod Immunol 60:61-70. 2003
    ..Using population frequencies as a reference, an association between IL1Ra polymorphism and preeclampsia was apparent, although the clinical importance of this finding is not clear...
  44. ncbi Pre-eclampsia, placental abruption and increased risk of atopic sensitization in male adolescent offspring
    Leea Keski-Nisula
    Department of Environmental Health, National Institute for Health and Welfare, Kuopio, Finland
    Am J Reprod Immunol 62:293-300. 2009
    ..The aim of this study was to investigate maternal pre-eclampsia (PE), placental abruption (PA) and atopy among offspring...
  45. ncbi Prolonged time to pregnancy is associated with a greater risk of adverse outcomes
    Kaisa Raatikainen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, and Faculty of Medicine, Kuopio University, Kuopio, Finland
    Fertil Steril 94:1148-51. 2010
    ..51 (1.09-2.09) in women who had a TTP of 25-36 months and 1.60 (1.18-2.19) in women who had a TTP of >or=37 months compared with women with a TTP of 0-6 months...
  46. doi Cardiovascular autonomic responses to head-up tilt in gestational hypertension and normal pregnancy
    Nonna Heiskanen
    Department of Obsteterics and Gynecology, Kuopio University Hospital, University of Kuopio, Kuopio, Finland
    Blood Press 20:84-91. 2011
    ..We prospectively studied 56 pregnant women (28 with gestational hypertension and 28 healthy pregnant women) during the third trimester of pregnancy and 3 months after pregnancy...
  47. doi Maternal serum hepcidin is low at term and independent of cord blood iron status
    Mari Rehu
    Department of Clinical Chemistry, University of Eastern Finland, Eastern Finland Laboratory Centre ISLAB, Kuopio, Finland
    Eur J Haematol 85:345-52. 2010
    ..The aims of this study were to determine serum hepcidin concentrations and reference ranges in pregnant women and cord blood of newborns at term and to evaluate the associations between hepcidin concentrations and iron status parameters...
  48. doi Blood pressure and heart rate variability analysis of orthostatic challenge in normal human pregnancies
    Nonna Heiskanen
    Departments of Obstetrics and Gynecology, Kuopio University Hospital, University of Kuopio, Finland
    Clin Physiol Funct Imaging 28:384-90. 2008
    ..It is important to understand cardiovascular autonomic nervous system and haemodynamic control in normal pregnancy before being able to judge whether they are dysregulated in complicated pregnancies...
  49. ncbi Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are associated with polycystic ovary syndrome
    Seija Korhonen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland
    Fertil Steril 79:1353-7. 2003
    ..To determine whether genetic variability in the gene encoding microsomal epoxide hydrolase (EPHX) contributes to individual differences in susceptibility to the development of polycystic ovary syndrome (PCOS)...
  50. doi Decreased PAPP-A is associated with preeclampsia, premature delivery and small for gestational age infants but not with placental abruption
    Jenni K Ranta
    Department of Clinical Chemistry, School of Medicine, Faculty of Health Sciences, University of Eastern Finland and Eastern Finland Laboratory Centre, P O Box 1700, 70211 Kuopio, Finland
    Eur J Obstet Gynecol Reprod Biol 157:48-52. 2011
    ....
  51. doi Increased time-to-pregnancy and first trimester Down's syndrome screening
    Jenni K Ranta
    Eastern Finland Laboratory Centre and Institute of Clinical Medicine, Faculty of Medicine, University of Kuopio, P O Box 1700, 70211 Kuopio, Finland
    Hum Reprod 25:412-7. 2010
    ..The objective of this study was to examine the effects of TTP on first trimester Down's syndrome (DS) markers in spontaneous, chromosomally normal pregnancies and to compare the results to those in IVF pregnancies...
  52. ncbi Smoking in early gestation or through pregnancy: a decision crucial to pregnancy outcome
    Kaisa Raatikainen
    Department of Obstetrics and Gynaecology, PO Box 1777, Kuopio University Hospital, 70211 Kuopio, Finland
    Prev Med 44:59-63. 2007
    ..To assess maternal risk profile and pregnancy outcome of women who continued to smoke, reduced smoking to less than five cigarettes per day or did not smoke during pregnancy...
  53. ncbi Transduction patterns and efficiencies in rabbit uterine tissues after intraluminal uterine adenovirus administration vary with the reproductive cycle
    Anniina Laurema
    A I Virtanen Institute, Kuopio, Finland
    Acta Obstet Gynecol Scand 86:1035-40. 2007
    ..This study was undertaken to investigate the potential of gene therapy to transfect and destroy endometriun at different stages of the reproductive cycle in rabbits...
  54. doi Maternal fecundity and asthma among offspring-is the risk programmed preconceptionally? Retrospective observational study
    Maijakaisa Harju
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, Kuopio, Finland
    Fertil Steril 99:761-767.e1. 2013
    ..To evaluate the association between maternal fecundity factors and time to pregnancy and risk of asthma in offspring...
  55. ncbi Assessment of attitudes towards assisted reproduction: a survey among medical students and parous women
    Katri Heikkilä
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland
    Gynecol Endocrinol 22:613-9. 2006
    ..The present paper explores attitudes towards different aspects of assisted reproductive technologies among parous women and future doctors (third- and fourth-year medical students)...
  56. pmc Flow-mediated vasodilation is not attenuated in hypertensive pregnancies despite biochemical signs of inflammation
    Heli Saarelainen
    Department of Ob Gyn, Kuopio University Hospital, University of Eastern Finland, 70211 Kuopio, Finland
    ISRN Obstet Gynecol 2012:709464. 2012
    ..Conclusions. Brachial artery FMD was not attenuated in the third trimester hypertensive pregnancies compared to normal pregnancies, whereas circulating concentrations of hsCRP and IL-6 and TNF-α reacted to hypertensive complications...
  57. ncbi Polymorphism in the peroxisome proliferator-activated receptor-gamma gene in women with preeclampsia
    Jaana Laasanen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland
    Early Hum Dev 69:77-82. 2002
    ..To investigate peroxisome proliferator-activated receptor-gamma (PPARgamma) genotype frequencies in women with preeclampsia and elucidate its role in the pathogenesis of preeclampsia...
  58. ncbi Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are jointly associated with preeclampsia
    Jaana Laasanen
    Department of Obstetrics and Gynecology, Kuopio University and University Hospital, Kuopio, Finland
    Eur J Hum Genet 10:569-73. 2002
    ..61 (95% CI: 1.12-2.32). The use of two intragenic SNPs jointly in haplotype analysis of association demonstrated that the genetically determined high-activity haplotype T-A (Tyr113-His139) was significantly associated with preeclampsia...
  59. pmc Antiangiogenic gene therapy with soluble VEGFR-1, -2, and -3 reduces the growth of solid human ovarian carcinoma in mice
    Hanna Sallinen
    Department of Molecular Medicine, A I Virtanen Institute, University of Kuopio, Kuopio, Finland
    Mol Ther 17:278-84. 2009
    ..The results suggest that the combined antiangiogenic gene therapy is a potential approach for the treatment of ovarian cancer patients...
  60. ncbi Frequent gene dosage alterations in stromal cells of epithelial ovarian carcinomas
    Hanna Tuhkanen
    Department of Pathology and Forensic Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Int J Cancer 119:1345-53. 2006
    ..Epithelial-mesenchymal transition may generate transformed cancer cells and modify the tumor microenvironment with distinct properties...
  61. ncbi Gamma 2 actin gene (enteric type) polymorphism is not associated with obstetric cholestasis or preeclampsia
    Jaana Laasanen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland
    Fetal Diagn Ther 23:36-40. 2008
    ..To determine whether genetic variability in the intron 1 region of the gamma 2 actin gene (enteric type) contributes to the development of obstetric complications...
  62. ncbi A BRCA2 mutation, 4088insA, in a Finnish breast and ovarian cancer family associated with favourable clinical course
    Jaana M Hartikainen
    Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Kuopio, Finland
    Anticancer Res 27:4295-300. 2007
    ..The clinical course and response to treatment in mutation carriers have been reported infrequently and are assumed to be worse than in sporadic breast cancer...
  63. ncbi Socioeconomic status affects the prevalence, but not the perinatal outcomes, of in vitro fertilization pregnancies
    Sari Räisänen
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, PO Box 100, 70029 Kuopio, Finland
    Hum Reprod 28:3118-25. 2013
    ..Does maternal socioeconomic status (SES) confound or modify the association between IVF and perinatal outcome among singleton births?..
  64. doi Antiangiogenic gene therapy with soluble VEGF-receptors -1, -2 and -3 together with paclitaxel prolongs survival of mice with human ovarian carcinoma
    Minna Sopo
    Department of Molecular Medicine, A I Virtanen Institute, University of Eastern Finland, Kuopio, Finland
    Int J Cancer 131:2394-401. 2012
    ..01). These results show potential of the antiangiogenic gene therapy to improve efficacy of chemotherapy with paclitaxel and support testing of this approach in a phase I clinical trial for the treatment of ovarian cancer...
  65. ncbi Fibrinogen and factor VII promoter polymorphisms in women with preeclampsia
    Jaana Laasanen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland
    Obstet Gynecol 100:317-20. 2002
    ..To determine whether genetic variability in the promoter regions of the genes encoding fibrinogen and factor VII contribute to individual differences in susceptibility to the development of preeclampsia...
  66. ncbi The 121Q allele of the plasma cell membrane glycoprotein 1 gene predisposes to polycystic ovary syndrome
    Seppo Heinonen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, 70211 Kuopio, Finland
    Fertil Steril 82:743-5. 2004
    ..121Q allele) having an odds ratio of 1.90 (95% confidence interval 1.11-3.26). This suggests that impaired insulin signaling is of etiologic importance in PCOS...
  67. doi High episiotomy rate protects from obstetric anal sphincter ruptures: a birth register-study on delivery intervention policies in Finland
    Sari Räisänen
    Department of Nursing Science, University of Eastern Finland, 70211 Kuopio, Finland
    Scand J Public Health 39:457-63. 2011
    ..To assess the impact of hospital episiotomy policy on obstetric and anal sphincter rupture (OASR, n = 2448) rates and risks among singleton vaginal deliveries in Finland between 1997 and 2007...
  68. doi Maternal pro-hepcidin at term correlates with cord blood pro-hepcidin at birth
    Mari Ervasti
    Department of Clinical Chemistry and Hematology, Kuopio University, Kuopio, Finland
    Eur J Obstet Gynecol Reprod Biol 147:161-5. 2009
    ....
  69. ncbi Reproductive risk factors, Doppler findings, and outcome of affected births in placental abruption: a population-based analysis
    Sari Toivonen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Finland
    Am J Perinatol 19:451-60. 2002
    ..Current antepartum methods of detecting uteroplacental problems, including Doppler ultrasonography, are not effective in prenatal prediction of placental abruption. The outcome of affected births is still poor...
  70. ncbi Use of advanced red blood cell and reticulocyte indices improves the accuracy in diagnosing iron deficiency in pregnant women at term
    Mari Ervasti
    Department of Clinical Chemistry and Hematology, Kuopio University Hospital, Kuopio, Finland
    Eur J Haematol 79:539-45. 2007
    ..g. hemodilution or accelerated erythropoiesis. This study tests whether cell indices will give a more reliable measure of iron deficiency in pregnant women at term...
  71. ncbi Haplotypic association of DDAH1 with susceptibility to pre-eclampsia
    Fareeza Akbar
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, University of Kuopio, Kuopio, Finland
    Mol Hum Reprod 11:73-7. 2005
    ..93; 95% confidence interval: 1.54-9.99) who had two copies of the high-risk haplotypes (H2 or H3). The observed haplotypic association provides the first evidence of the importance of DDAH1 polymorphisms in pre-eclampsia susceptibility...
  72. doi Intrauterine bacterial growth at birth and risk of asthma and allergic sensitization among offspring at the age of 15 to 17 years
    Leea Keski-Nisula
    Environmental Health Department, National Institute for Health and Welfare, Kuopio, Finland
    J Allergy Clin Immunol 123:1305-11. 2009
    ..Microbial colonization of the airways and intestine during birth might have an effect on the risk of asthma and allergic diseases later in life...
  73. ncbi Tumor suppressor and growth regulatory genes are overexpressed in severe early-onset preeclampsia--an array study on case-specific human preeclamptic placental tissue
    Annaleena Heikkilä
    A I Virtanen Institute, University of Kuopio, Kuopio, Finland
    Acta Obstet Gynecol Scand 84:679-89. 2005
    ..We used DNA array technique to compare placental gene expression profile in severe early-onset preeclampsia from 25 to 27 gestational weeks with strictly non-affected placental samples from similar gestational weeks...
  74. ncbi The effects of valproate exposure in utero on behavior and the need for educational support in school-aged children
    Katriina Viinikainen
    Kuopio Epilepsy Center, Department of Neurology, Kuopio University Hospital and University of Kuopio, POB 1777, 70211, Kuopio, Finland
    Epilepsy Behav 9:636-40. 2006
    ..Larger studies with a prospective design are needed to confirm these findings...
  75. ncbi Fertility in women with active epilepsy
    Katriina Viinikainen
    Kuopio Epilepsy Center, Department of Neurology, Kuopio University Hospital, POB 1777, 70211 Kuopio, Finland
    Neurology 69:2107-8. 2007
  76. ncbi Androgen receptor gene CAG length polymorphism in women with polycystic ovary syndrome
    Jarmo Jääskeläinen
    Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland
    Fertil Steril 83:1724-8. 2005
    ..To determine whether the CAG repeat length of the androgen receptor (AR) gene contributes to individual differences in the susceptibility to the development of polycystic ovary syndrome (PCOS)...
  77. ncbi Reproductive risk factors, pregnancy characteristics and obstetric outcome in female doctors
    Seppo Heinonen
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland
    BJOG 109:261-4. 2002
    ..To compare maternal risk factors, pregnancy characteristics and outcome in female doctors, teachers, and the general obstetric population...
  78. ncbi Clinical significance of true umbilical knots: a population-based analysis
    Urpu Airas
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Finland
    Am J Perinatol 19:127-32. 2002
    ..Surviving fetuses with true knots are likely to suffer temporary distress during delivery, but affected newborns recover soon after birth. Thus, monitored vaginal delivery appears to be a safe option for fetuses with true knots...
  79. pmc Polymorphism in the tumor necrosis factor-alpha gene in women with preeclampsia
    Jaana Heiskanen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Finland
    J Assist Reprod Genet 19:220-3. 2002
    ..We determined whether genetic variability in the gene encoding for tumor necrosis factor-alpha (TNF-alpha) contributes to individual differences in susceptibility to the development of preeclampsia...
  80. ncbi Community-based, prospective, controlled study of obstetric and neonatal outcome of 179 pregnancies in women with epilepsy
    Katriina Viinikainen
    Department of Neurology, Kuopio University Hospital and University of Kuopio, Kuopio, Finland
    Epilepsia 47:186-92. 2006
    ..This study evaluated obstetric and neonatal outcome in a community-based cohort of women with active epilepsy (WWAE) compared with the general pregnant population receiving modern obstetric care...
  81. ncbi A survey of the attitudes of infertile and parous women towards the availability of assisted reproductive technology
    Katri Heikkilä
    Department of Obstetrics and Gynaecology, Kuopio University and University Hospital, 70211 Kuopio, Finland
    BJOG 111:1229-35. 2004
    ..The aim of the study was to assess differences in attitudes towards aspects of assisted reproduction technology between infertile and parous women...
  82. ncbi Ophthalmologic and neurologic findings in two children exposed to vigabatrin in utero
    Iiris Sorri
    Department of Ophthalmology, Kuopio University Hospital, P O Box 1777, FIN 70211 Kupio, Finland
    Epilepsy Res 65:117-20. 2005
    ..We explored ophthalmic and neurologic findings in two children who have been exposed prenatally to VGB...
  83. ncbi Anaemia in the first but not in the second or third trimester is a risk factor for low birth weight
    Henna Hämäläinen
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland
    Clin Nutr 22:271-5. 2003
    ..To assess pregnancy outcome in women with anaemia during pregnancy...
  84. ncbi Marriage still protects pregnancy
    Kaisa Raatikainen
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland
    BJOG 112:1411-6. 2005
    ..To assess the risk factors and outcome of pregnancy outside marriage in the 1990s, in conditions of a high percentage of extramarital pregnancies and high standard maternity care, used by the entire pregnant population...
  85. pmc Need for critical care in gynaecology: a population-based analysis
    Seppo Heinonen
    Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland
    Crit Care 6:371-5. 2002
    ..The purpose of this study was to note potential gynaecological risk factors leading to intensive care and to estimate the frequency, costs and outcome of management...
  86. ncbi Good outcome of teenage pregnancies in high-quality maternity care
    Kaisa Raatikainen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland
    Eur J Public Health 16:157-61. 2006
    ....
  87. ncbi Normalization of vasoactive changes in preeclampsia precedes clinical recovery
    Nonna Makkonen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, 70211 Kuopio, Finland
    Hypertens Pregnancy 21:51-64. 2002
    ..The objective of this study is to compare the serum levels of fibronectin, nitric oxide (NO), cyclic guanosine-monophosphate, endothelin-1, and 6-keto-prostaglandin-F 1alpha in women with and without preeclampsia before and after delivery...
  88. ncbi Spontaneous and stimulated interleukin-6 and tumor necrosis factor-alpha production at delivery and three months after birth
    Leea Keski-Nisula
    Department of Environmental Health, National Public Health Institute, Kuopio, Finland
    Eur Cytokine Netw 15:67-72. 2004
    ..To study the production and interrelations of maternal and neonatal cytokines (IL-6 and TNF-alpha) during labor, after vaginal delivery and at three months after delivery...
  89. ncbi Fetal macrosomia--a continuing obstetric challenge
    Nonna Heiskanen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland
    Biol Neonate 90:98-103. 2006
    ..Macrosomic fetuses represent a continuing challenge in obstetrics...
  90. doi Dynamic magnetic resonance imaging of the behavior of the mid-urethra in healthy and stress incontinent women
    Kirsi Marja Rinne
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland
    Acta Obstet Gynecol Scand 89:373-9. 2010
    ..Our aim was to image the behavior of the mid-urethra in healthy volunteers and in stress urinary incontinence (SUI) patients by dynamic magnetic resonance imaging (MRI)...
  91. doi Cumulative baby take-home rate among women with PCOS treated by IVF
    Paula Kuivasaari-Pirinen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland
    Gynecol Endocrinol 26:582-9. 2010
    ..This study was designed to evaluate cumulative live birth rates after an in vitro fertilisation (IVF) programme in polycystic ovary syndrome (PCOS) women...