Terhi J Heino

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. ncbi request reprint Osteocytes inhibit osteoclastic bone resorption through transforming growth factor-beta: enhancement by estrogen
    Terhi J Heino
    Department of Anatomy, Institute of Biomedicine, University of Turku, Turku, Finland
    J Cell Biochem 85:185-97. 2002
  2. ncbi request reprint Differentiation of osteoblasts and osteocytes from mesenchymal stem cells
    Terhi J Heino
    Orthopaedic Research Unit, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Curr Stem Cell Res Ther 3:131-45. 2008
  3. doi request reprint Comparison of the osteogenic capacity of minipig and human bone marrow-derived mesenchymal stem cells
    Terhi J Heino
    Orthopaedic Research Unit, University of Turku, Turku, Finland
    J Orthop Res 30:1019-25. 2012
  4. doi request reprint Intravenous pamidronate treatment improves growth in prepubertal osteogenesis imperfecta patients
    Terhi J Heino
    Pediatric Endocrinology, Department of Women s and Children s Health, Astrid Lindgren Children s Hospital, Karolinska Institutet, Stockholm, Sweden
    Horm Res Paediatr 75:354-61. 2011
  5. doi request reprint Evidence for the role of osteocytes in the initiation of targeted remodeling
    Terhi J Heino
    Department of Anatomy, Institute of Biomedicine, University of Turku, Finland
    Technol Health Care 17:49-56. 2009
  6. doi request reprint The novel estrogen receptor G-protein-coupled receptor 30 is expressed in human bone
    Terhi J Heino
    Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children s Hospital, Q2 08, SE 171 76 Stockholm, Sweden
    J Endocrinol 197:R1-6. 2008
  7. doi request reprint Effects of alendronate and pamidronate on cultured rat metatarsal bones: failure to prevent dexamethasone-induced growth retardation
    Terhi J Heino
    Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
    Bone 42:702-9. 2008
  8. ncbi request reprint Conditioned medium from osteocytes stimulates the proliferation of bone marrow mesenchymal stem cells and their differentiation into osteoblasts
    Terhi J Heino
    Department of Anatomy, Institute of Biomedicine, University of Turku, Turku, Finland
    Exp Cell Res 294:458-68. 2004
  9. doi request reprint Transient 100 nM dexamethasone treatment reduces inter- and intraindividual variations in osteoblastic differentiation of bone marrow-derived human mesenchymal stem cells
    Jessica J Alm
    Department of Orthopaedic Surgery and Traumatology, University of Turku and Turku University Hospital, Turku, Finland
    Tissue Eng Part C Methods 18:658-66. 2012
  10. doi request reprint Circulating plastic adherent mesenchymal stem cells in aged hip fracture patients
    Jessica J Alm
    Orthopaedic Research Unit, Department of Orthopaedic Research and Traumatology, Turku University Hospital and University of Turku, Turku, Finland
    J Orthop Res 28:1634-42. 2010

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Osteocytes inhibit osteoclastic bone resorption through transforming growth factor-beta: enhancement by estrogen
    Terhi J Heino
    Department of Anatomy, Institute of Biomedicine, University of Turku, Turku, Finland
    J Cell Biochem 85:185-97. 2002
    ..Our results further suggest a novel role for TGF-beta in the regulation of communication between different bone cells and suggest that at least part of the antiresorptive effect of estrogen in bone could be mediated via osteocytes...
  2. ncbi request reprint Differentiation of osteoblasts and osteocytes from mesenchymal stem cells
    Terhi J Heino
    Orthopaedic Research Unit, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Curr Stem Cell Res Ther 3:131-45. 2008
    ..A major section of the review is dedicated to the functions of osteocytes in the regulation of bone remodeling. Finally, we present an original hypothesis about the possible role of osteocytes in future bone tissue engineering...
  3. doi request reprint Comparison of the osteogenic capacity of minipig and human bone marrow-derived mesenchymal stem cells
    Terhi J Heino
    Orthopaedic Research Unit, University of Turku, Turku, Finland
    J Orthop Res 30:1019-25. 2012
    ..This observation emphasizes the need for species-specific optimization of MSC culture protocol before direct systematic comparison of MSCs between human and various preclinical large animal models can be made...
  4. doi request reprint Intravenous pamidronate treatment improves growth in prepubertal osteogenesis imperfecta patients
    Terhi J Heino
    Pediatric Endocrinology, Department of Women s and Children s Health, Astrid Lindgren Children s Hospital, Karolinska Institutet, Stockholm, Sweden
    Horm Res Paediatr 75:354-61. 2011
    ..Pamidronate is widely used to treat pediatric patients with osteogenesis imperfecta (OI). We aimed at delineating the effects of monthly pamidronate therapy on the growth of different body segments in prepubertal OI patients...
  5. doi request reprint Evidence for the role of osteocytes in the initiation of targeted remodeling
    Terhi J Heino
    Department of Anatomy, Institute of Biomedicine, University of Turku, Finland
    Technol Health Care 17:49-56. 2009
    ..This strongly supports the idea that damage to osteocyte cellular network has the potential to stimulate osteoclastic proliferation and therefore the activation of Basic Multicellular Units (BMUs)...
  6. doi request reprint The novel estrogen receptor G-protein-coupled receptor 30 is expressed in human bone
    Terhi J Heino
    Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children s Hospital, Q2 08, SE 171 76 Stockholm, Sweden
    J Endocrinol 197:R1-6. 2008
    ..However, the functional role of GPR30 in bone tissue remains to be elucidated...
  7. doi request reprint Effects of alendronate and pamidronate on cultured rat metatarsal bones: failure to prevent dexamethasone-induced growth retardation
    Terhi J Heino
    Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
    Bone 42:702-9. 2008
    ..Nevertheless, based on our in vitro data, both Aln and Pam appear safe to use in growing children, at least with regard to their effects on linear bone growth...
  8. ncbi request reprint Conditioned medium from osteocytes stimulates the proliferation of bone marrow mesenchymal stem cells and their differentiation into osteoblasts
    Terhi J Heino
    Department of Anatomy, Institute of Biomedicine, University of Turku, Turku, Finland
    Exp Cell Res 294:458-68. 2004
    ..We conclude that osteocytes have an active stimulatory role in controlling bone formation...
  9. doi request reprint Transient 100 nM dexamethasone treatment reduces inter- and intraindividual variations in osteoblastic differentiation of bone marrow-derived human mesenchymal stem cells
    Jessica J Alm
    Department of Orthopaedic Surgery and Traumatology, University of Turku and Turku University Hospital, Turku, Finland
    Tissue Eng Part C Methods 18:658-66. 2012
    ..With this protocol, we can reproducibly produce functional osteoblasts in vitro from the hMSC of different donor populations...
  10. doi request reprint Circulating plastic adherent mesenchymal stem cells in aged hip fracture patients
    Jessica J Alm
    Orthopaedic Research Unit, Department of Orthopaedic Research and Traumatology, Turku University Hospital and University of Turku, Turku, Finland
    J Orthop Res 28:1634-42. 2010
    ..This initial study indicates mobilization of MSCs into the circulation in response to fracture, even in very old patients, while circulating MSCs were not detectable before or after elective THA...
  11. pmc Bortezomib is cytotoxic to the human growth plate and permanently impairs bone growth in young mice
    Emma Eriksson
    Pediatric Endocrinology Unit, Department of Women s and Childrens Health, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e50523. 2012
    ..We therefore propose that longitudinal bone growth should be closely monitored in ongoing clinical pediatric trials of this promising anti-cancer drug...
  12. ncbi request reprint Bone marrow cell differentiation induced by mechanically damaged osteocytes in 3D gel-embedded culture
    Kosaku Kurata
    Department of Biorobotics, Faculty of Engineering, Kyushu Sangyo University, Fukuoka, Japan
    J Bone Miner Res 21:616-25. 2006
    ..Our results show that the damaged osteocytes activate the osteoclast precursors by soluble factors and thus can control the initial phase of targeted remodeling...