Terho Heikkinen

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. ncbi request reprint [A burden of influenza among children]
    Terho Heikkinen
    Duodecim 122:251-2. 2006
  2. ncbi request reprint Vaccination of healthy children against seasonal influenza: a European perspective
    Terho Heikkinen
    Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland
    Pediatr Infect Dis J 32:881-8. 2013
  3. doi request reprint Effectiveness of intranasal live attenuated influenza vaccine against all-cause acute otitis media in children
    Terho Heikkinen
    Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland
    Pediatr Infect Dis J 32:669-74. 2013
  4. pmc Burden of paediatric influenza in Western Europe: a systematic review
    Evgeniya N Antonova
    MedImmune, LLC, 1 MedImmune Way, Gaithersburg, Maryland 20878, USA
    BMC Public Health 12:968. 2012
  5. pmc How to optimise the coverage rate of infant and adult immunisations in Europe
    Heinz J Schmitt
    Infectious Diseases Service at the Zentrum für Präventive Pädiatrie, Johannes Gutenberg Universitat, Mainz, Germany
    BMC Med 5:11. 2007
  6. pmc Human metapneumovirus infections in children
    Terho Heikkinen
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Emerg Infect Dis 14:101-6. 2008
  7. doi request reprint Effectiveness and safety of influenza vaccination in children: European perspective
    Terho Heikkinen
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Vaccine 29:7529-34. 2011
  8. ncbi request reprint Influenza in children
    Terho Heikkinen
    Department of Paediatrics, Turku University Hospital, Turku, Finland
    Acta Paediatr 95:778-84. 2006
  9. ncbi request reprint Should healthy children be vaccinated against influenza? A consensus report of the Summits of Independent European Vaccination Experts
    Terho Heikkinen
    Department of Pediatrics, Turku University Hospital, 20520, Turku, Finland
    Eur J Pediatr 165:223-8. 2006
  10. pmc Hospital admission of high risk infants for respiratory syncytial virus infection: implications for palivizumab prophylaxis
    T Heikkinen
    Department of Paediatrics, Turku University Hospital, FIN 20520 Turku, Finland
    Arch Dis Child Fetal Neonatal Ed 90:F64-8. 2005

Detail Information

Publications48

  1. ncbi request reprint [A burden of influenza among children]
    Terho Heikkinen
    Duodecim 122:251-2. 2006
  2. ncbi request reprint Vaccination of healthy children against seasonal influenza: a European perspective
    Terho Heikkinen
    Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland
    Pediatr Infect Dis J 32:881-8. 2013
    ..Finally, increased efforts should be made to educate both healthcare professionals and the great public about recent findings and advances in the field of pediatric influenza. ..
  3. doi request reprint Effectiveness of intranasal live attenuated influenza vaccine against all-cause acute otitis media in children
    Terho Heikkinen
    Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland
    Pediatr Infect Dis J 32:669-74. 2013
    ..However, the annual effectiveness of LAIV against all-cause AOM is unknown...
  4. pmc Burden of paediatric influenza in Western Europe: a systematic review
    Evgeniya N Antonova
    MedImmune, LLC, 1 MedImmune Way, Gaithersburg, Maryland 20878, USA
    BMC Public Health 12:968. 2012
    ..Our aim was to summarise influenza burden (in terms of health outcomes and economic burden) in children in Western Europe via a systematic literature review...
  5. pmc How to optimise the coverage rate of infant and adult immunisations in Europe
    Heinz J Schmitt
    Infectious Diseases Service at the Zentrum für Präventive Pädiatrie, Johannes Gutenberg Universitat, Mainz, Germany
    BMC Med 5:11. 2007
    ..Although vaccination has been proved to be a safe, efficacious, and cost-effective intervention, immunisation rates remain suboptimal in many European countries, resulting in poor control of many vaccine-preventable diseases...
  6. pmc Human metapneumovirus infections in children
    Terho Heikkinen
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Emerg Infect Dis 14:101-6. 2008
    ..Acute otitis media developed in 61% of hMPV-infected children <3 years of age. Our findings demonstrate that the effect of hMPV in the community is greatest in children <2 years of age...
  7. doi request reprint Effectiveness and safety of influenza vaccination in children: European perspective
    Terho Heikkinen
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Vaccine 29:7529-34. 2011
    ..The safety record of seasonal inactivated influenza vaccines is excellent even in the youngest children...
  8. ncbi request reprint Influenza in children
    Terho Heikkinen
    Department of Paediatrics, Turku University Hospital, Turku, Finland
    Acta Paediatr 95:778-84. 2006
    ..More widespread vaccination of children should be considered to decrease the burden of influenza on children and wider society...
  9. ncbi request reprint Should healthy children be vaccinated against influenza? A consensus report of the Summits of Independent European Vaccination Experts
    Terho Heikkinen
    Department of Pediatrics, Turku University Hospital, 20520, Turku, Finland
    Eur J Pediatr 165:223-8. 2006
    ..Annual influenza vaccination should be recommended to all children from 6 months to 3 years of age...
  10. pmc Hospital admission of high risk infants for respiratory syncytial virus infection: implications for palivizumab prophylaxis
    T Heikkinen
    Department of Paediatrics, Turku University Hospital, FIN 20520 Turku, Finland
    Arch Dis Child Fetal Neonatal Ed 90:F64-8. 2005
    ..To determine the rates of hospital admission for respiratory syncytial virus (RSV) infection among children born at different gestational ages. To assess the theoretical impact of palivizumab prophylaxis on admissions for RSV infection...
  11. ncbi request reprint Burden of influenza in children in the community
    Terho Heikkinen
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    J Infect Dis 190:1369-73. 2004
    ..However, most children with influenza are treated as outpatients, and scarce data are available on the burden of influenza in these children...
  12. ncbi request reprint A single intramuscular dose of ceftriaxone changes nasopharyngeal bacterial flora in children with acute otitis media
    T Heikkinen
    Department of Pediatrics, University of Texas Medical Branch, Galveston, USA
    Acta Paediatr 89:1316-21. 2000
    ..A single dose of ceftriaxone resulted in significant changes in the nasopharyngeal bacterial flora, increasing the relative prevalence of pneumococcal strains with decreased susceptibility to penicillin...
  13. pmc Importance of respiratory viruses in acute otitis media
    Terho Heikkinen
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Clin Microbiol Rev 16:230-41. 2003
    ..Alternatively, early treatment of the viral infection with specific antiviral agents would also be effective in reducing the occurrence of acute otitis media...
  14. ncbi request reprint The role of respiratory viruses in otitis media
    T Heikkinen
    Department of Pediatrics, Turku University Hospital, FIN 20520 Turku, Finland
    Vaccine 19:S51-5. 2000
    ..The availability of effective vaccines against the principal viruses predisposing to acute otitis media could be expected to result in a substantial reduction in the incidence of this disease...
  15. ncbi request reprint Increasing importance of viruses in acute otitis media
    T Heikkinen
    Department of Pediatrics, Turku University Hospital, Finland
    Ann Med 32:157-63. 2000
    ..Major advances in the management of acute otitis media will require further research into the mechanisms of viral infection, viral-bacterial interaction and the host inflammatory response during viral infection...
  16. ncbi request reprint Role of viruses in the pathogenesis of acute otitis media
    T Heikkinen
    Department of Pediatrics, Turku University Hospital, Finland
    Pediatr Infect Dis J 19:S17-22; discussion S22-3. 2000
    ..Increased knowledge of the detailed mechanisms of viral infection, the host inflammatory response during URI and the interaction between viruses and bacteria could lead to major advances in the prevention of AOM...
  17. ncbi request reprint The common cold
    Terho Heikkinen
    Department of Paediatrics, Turku University Hospital, Turku, Finland
    Lancet 361:51-9. 2003
    ..Although vaccines against many respiratory viruses could also become available, the ultimate prevention of the common cold seems to remain a distant aim...
  18. pmc Nasal swab versus nasopharyngeal aspirate for isolation of respiratory viruses
    Terho Heikkinen
    Department of Pediatrics, Turku University Hospital Department of Virology, University of Turku, Turku, Finland
    J Clin Microbiol 40:4337-9. 2002
    ..The sensitivity of nasal swabs was comparable to that of nasopharyngeal aspirates for the detection of all major respiratory viruses except respiratory syncytial virus...
  19. ncbi request reprint A randomized, placebo-controlled trial of the effect of antihistamine or corticosteroid treatment in acute otitis media
    Tasnee Chonmaitree
    Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas 77555 0371, USA
    J Pediatr 143:377-85. 2003
    ..To determine whether the adjunctive drugs antihistamine and corticosteroid improve immediate and long-term outcomes of acute otitis media (AOM)...
  20. ncbi request reprint Incidence of influenza in Finnish children
    Terho Heikkinen
    Departments of Pediatrics, Turku University Hospital, Turku, Finland
    Pediatr Infect Dis J 22:S204-6. 2003
    ..Influenza is an important cause of respiratory illness in children, but data on virologically confirmed influenza infections in children treated as outpatients are limited...
  21. ncbi request reprint The dynamics of bacteria in the middle ear during the course of acute otitis media with tympanostomy tube otorrhea
    Aino Ruohola
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Pediatr Infect Dis J 26:892-6. 2007
    ..AOM with tympanostomy tube otorrhea provides a unique opportunity to study the appearance and disappearance of pathogens during the course of the disease without stressing the child...
  22. doi request reprint Clinical presentation of influenza in unselected children treated as outpatients
    Heli Silvennoinen
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Pediatr Infect Dis J 28:372-5. 2009
    ..Influenza causes a great disease burden on children especially in the outpatient setting. The signs and symptoms of influenza in unselected children treated as outpatients have not been previously published...
  23. doi request reprint Effectiveness of inactivated influenza vaccine in children aged 9 months to 3 years: an observational cohort study
    Santtu Heinonen
    Department of Paediatrics, Turku University Hospital, Finland
    Lancet Infect Dis 11:23-9. 2011
    ..We aimed to establish the effectiveness of trivalent inactivated influenza vaccine against laboratory-confirmed influenza A and B infections in a cohort of children younger than 3 years...
  24. doi request reprint Identification of respiratory viruses with a novel point-of-care multianalyte antigen detection test in children with acute respiratory tract infection
    Lauri Ivaska
    Department of Pediatrics, Turku University Hospital, 20521 Turku, Finland
    J Clin Virol 57:136-40. 2013
    ....
  25. ncbi request reprint Recent advances in otitis media. 6. Vaccine
    G Scott Giebink
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, USA
    Ann Otol Rhinol Laryngol Suppl 194:86-103. 2005
  26. doi request reprint Early oseltamivir treatment of influenza in children 1-3 years of age: a randomized controlled trial
    Santtu Heinonen
    Departments of Pediatrics, Turku University Hospital, University of Turku, Turku, Finland
    Clin Infect Dis 51:887-94. 2010
    ..The effectiveness of oseltamivir could be substantially greater if the treatment were started earlier during the course of the illness...
  27. ncbi request reprint Antibiotic treatment of acute otorrhea through tympanostomy tube: randomized double-blind placebo-controlled study with daily follow-up
    Aino Ruohola
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Pediatrics 111:1061-7. 2003
    ..The objective of this study was to assess whether amoxicillin-clavulanate accelerates the resolution of acute tube otorrhea...
  28. doi request reprint Temporal association between rhinovirus circulation in the community and invasive pneumococcal disease in children
    Ville Peltola
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Pediatr Infect Dis J 30:456-61. 2011
    ..Mucosal coinfections with respiratory viruses and Streptococcus pneumoniae are common, but the role of rhinovirus infections in the development of invasive pneumococcal disease (IPD) in children has not been studied...
  29. ncbi request reprint Middle ear fluid histamine and leukotriene B4 in acute otitis media: effect of antihistamine or corticosteroid treatment
    David P McCormick
    Department of Pediatrics, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0371, USA
    Int J Pediatr Otorhinolaryngol 67:221-30. 2003
    ..The purpose of this study was to evaluate the ability of adjuvant drugs, antihistamine and corticosteroid, in reduction of the levels of histamine and LTB4 in the middle ear and their ability to improve outcomes of AOM...
  30. ncbi request reprint Incidence of influenza-related hospitalizations in different age groups of children in Finland: a 16-year study
    Heli Silvennoinen
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Pediatr Infect Dis J 30:e24-8. 2011
    ..children are frequently hospitalized with influenza-associated illnesses. Few virologically confirmed population-based studies of pediatric hospitalizations performed during several consecutive seasons are vailable...
  31. ncbi request reprint Microbiology of acute otitis media in children with tympanostomy tubes: prevalences of bacteria and viruses
    Aino Ruohola
    Department of Pediatrics, Turku University Hospital, Turku, FIN 20521, Finland
    Clin Infect Dis 43:1417-22. 2006
    ..Our aim was to specify the full etiology of acute middle ear infection by using modern microbiological methods concomitantly for bacterial and viral detection...
  32. ncbi request reprint Pulmonary abscess of viral-bacterial etiology in a neonate
    Ville Peltola
    Department of Pediatrics, Turku University Hospital, 20520 Turku, Finland
    Eur J Pediatr 166:1301-2. 2007
  33. ncbi request reprint Recent advances in otitis media. 5. Microbiology and immunology
    Stephen J Barenkamp
    Department of Pediatrics, St Louis University School of Medicine, Missouri, USA
    Ann Otol Rhinol Laryngol Suppl 194:60-85. 2005
  34. ncbi request reprint Systemic glucocorticoids in childhood expiratory wheezing: relation between age and viral etiology with efficacy
    Tuomas Jartti
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Pediatr Infect Dis J 21:873-8. 2002
  35. ncbi request reprint Validity of ultrasonography in diagnosis of acute maxillary sinusitis
    T Puhakka
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Arch Otolaryngol Head Neck Surg 126:1482-6. 2000
    ..A simple, rapid, and readily available method for diagnosing maxillary sinusitis in primary care would increase the accuracy of the diagnoses and thus reduce unnecessary antibiotic treatment...
  36. doi request reprint Feasibility of diagnosing influenza within 24 hours of symptom onset in children 1-3 years of age
    S Heinonen
    Department of Pediatrics, Turku University Hospital, Kiinamyllynkatu 4 8, 20520 Turku, Finland
    Eur J Clin Microbiol Infect Dis 30:387-92. 2011
    ..The rapid point-of-care test used was sensitive and specific for diagnosing influenza A, but its sensitivity for influenza B was limited...
  37. ncbi request reprint Accuracy of clinical diagnosis of influenza in outpatient children
    Ville Peltola
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Clin Infect Dis 41:1198-200. 2005
    ..Among 2288 infections, the overall sensitivity of the clinical diagnosis of influenza was 38% and the positive predictive value was 32%...
  38. doi request reprint Safety of MF59-adjuvanted A/H1N1 influenza vaccine in pregnancy: a comparative cohort study
    Terho Heikkinen
    Department of Pediatrics, University of Turku, Turku, Finland
    Am J Obstet Gynecol 207:177.e1-8. 2012
    ..The 2009-2010 A/H1N1 pandemic provided a unique setting to study the safety of MF59-adjuvanted vaccination in pregnancy...
  39. ncbi request reprint Clinical courses of croup caused by influenza and parainfluenza viruses
    Ville Peltola
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Pediatr Infect Dis J 21:76-8. 2002
    ..By several indicators the clinical picture of croup caused by influenza viruses was significantly more severe than that caused by parainfluenza viruses...
  40. doi request reprint Recurrent wheezing after respiratory syncytial virus or non-respiratory syncytial virus bronchiolitis in infancy: a 3-year follow-up
    H Valkonen
    Department of Pediatrics, Turku University Hospital, Finland
    Allergy 64:1359-65. 2009
    ..We determined the development of recurrent wheezing in young children within 3 years after hospitalization for RSV or non-RSV bronchiolitis...
  41. ncbi request reprint Cost-effectiveness of influenza vaccination of healthy children
    Heini Salo
    Department of Vaccines, National Public Health Institute, KTL, 00300 Helsinki, Finland
    Vaccine 24:4934-41. 2006
    ..The results show that influenza vaccination would be cost saving in all children <or=13 years of age in Finland, which advocates reconsideration of the current influenza vaccine recommendations in all countries...
  42. ncbi request reprint [What new about the common cold?]
    Terho Heikkinen
    Duodecim 119:1705-7. 2003
  43. ncbi request reprint Effectiveness of influenza vaccine to prevent acute otitis media
    Terho Heikkinen
    JAMA 291:692-3; author reply 693-4. 2004
  44. ncbi request reprint Influenza vaccines in healthy children
    Terho Heikkinen
    Lancet 365:2086-7; author reply 2087. 2005
  45. ncbi request reprint Varicella vaccination in Europe: are we ready for a universal childhood programme?
    Nitu Sengupta
    Centre for Child Health, Royal London Hospital, 38 New Road, Whitechapel, London, E1 2AX, UK
    Eur J Pediatr 167:47-55. 2008
    ..The SIEVE recommends the implementation of such a policy as soon as financially and practically possible...
  46. pmc Nasal swabs for detection of respiratory syncytial virus RNA
    Matti E Waris
    Arch Dis Child 92:1046-7. 2007
  47. ncbi request reprint Recent advances in otitis media. 7. Vaccine
    Lauren O Bakaletz
    Ann Otol Rhinol Laryngol Suppl 188:82-94. 2002
  48. ncbi request reprint Recent advances in otitis media. 6. Microbiology and immunology
    Thomas F DeMaria
    Ann Otol Rhinol Laryngol Suppl 188:62-81. 2002