Andreas Heger

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi Exhaustive enumeration of protein domain families
    Andreas Heger
    EMBL EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    J Mol Biol 328:749-67. 2003
  2. ncbi ADDA: a domain database with global coverage of the protein universe
    Andreas Heger
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Nucleic Acids Res 33:D188-91. 2005
  3. ncbi Accurate detection of very sparse sequence motifs
    Andreas Heger
    Institute of Biotechnology, University of Helsinki, Finland
    J Comput Biol 11:843-57. 2004
  4. ncbi The Pfam protein families database
    Robert D Finn
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Nucleic Acids Res 38:D211-22. 2010
  5. ncbi The Pfam protein families database
    Marco Punta
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
    Nucleic Acids Res 40:D290-301. 2012
  6. ncbi The global trace graph, a novel paradigm for searching protein sequence databases
    Andreas Heger
    Institute of Biotechnology, P O Box 56 Viikinkaari 5, FI 00014 University of Helsinki, Finland
    Bioinformatics 23:2361-7. 2007
  7. ncbi Insights into hominid evolution from the gorilla genome sequence
    Aylwyn Scally
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
    Nature 483:169-75. 2012
  8. ncbi OPTIC: orthologous and paralogous transcripts in clades
    Andreas Heger
    Department of Physiology, Anatomy and Genetics, MRC Functional Genetics Unit, University of Oxford, Le Gros Clark Building, Oxford OX1 3QX, UK
    Nucleic Acids Res 36:D267-70. 2008
  9. ncbi Sensitive pattern discovery with 'fuzzy' alignments of distantly related proteins
    Andreas Heger
    Institute of Biotechnology, P.O. Box 56, 00014 University of Helsinki Finland
    Bioinformatics 19:i130-7. 2003
  10. ncbi PairsDB atlas of protein sequence space
    Andreas Heger
    MRC Functional Genetics Unit, University of Oxford, UK
    Nucleic Acids Res 36:D276-80. 2008

Detail Information

Publications13

  1. ncbi Exhaustive enumeration of protein domain families
    Andreas Heger
    EMBL EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    J Mol Biol 328:749-67. 2003
    ..The data are publicly available at ftp://ftp.ebi.ac.uk/pub/contrib/heger/adda...
  2. ncbi ADDA: a domain database with global coverage of the protein universe
    Andreas Heger
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Nucleic Acids Res 33:D188-91. 2005
    ..The data are freely available for downloading and querying via a web interface (http://ekhidna.biocenter.helsinki.fi:9801/sqgraph/pairsdb)...
  3. ncbi Accurate detection of very sparse sequence motifs
    Andreas Heger
    Institute of Biotechnology, University of Helsinki, Finland
    J Comput Biol 11:843-57. 2004
    ....
  4. ncbi The Pfam protein families database
    Robert D Finn
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Nucleic Acids Res 38:D211-22. 2010
    ..Pfam is available via servers in the UK (http://pfam.sanger.ac.uk/), the USA (http://pfam.janelia.org/) and Sweden (http://pfam.sbc.su.se/)...
  5. ncbi The Pfam protein families database
    Marco Punta
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
    Nucleic Acids Res 40:D290-301. 2012
    ..Second, we discuss some of the features of domains of unknown function (also known as DUFs), which constitute a rapidly growing class of families within Pfam...
  6. ncbi The global trace graph, a novel paradigm for searching protein sequence databases
    Andreas Heger
    Institute of Biotechnology, P O Box 56 Viikinkaari 5, FI 00014 University of Helsinki, Finland
    Bioinformatics 23:2361-7. 2007
    ..The evolutionary signal can be difficult to detect because functional sites may consist of non-contiguous residues while segments in-between may be mutated without affecting fold or function...
  7. ncbi Insights into hominid evolution from the gorilla genome sequence
    Aylwyn Scally
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
    Nature 483:169-75. 2012
    ..The use of the genome sequence in these and future analyses will promote a deeper understanding of great ape biology and evolution...
  8. ncbi OPTIC: orthologous and paralogous transcripts in clades
    Andreas Heger
    Department of Physiology, Anatomy and Genetics, MRC Functional Genetics Unit, University of Oxford, Le Gros Clark Building, Oxford OX1 3QX, UK
    Nucleic Acids Res 36:D267-70. 2008
    ..Gene predictions, multiple alignments and phylogenetic trees are freely available to browse and download from http://genserv.anat.ox.ac.uk/clades. Further genomes and clades will be added in the future...
  9. ncbi Sensitive pattern discovery with 'fuzzy' alignments of distantly related proteins
    Andreas Heger
    Institute of Biotechnology, P.O. Box 56, 00014 University of Helsinki Finland
    Bioinformatics 19:i130-7. 2003
    ..We demonstrate the discovery of biologically meaningful patterns in an extremely diverse superfamily related to urease...
  10. ncbi PairsDB atlas of protein sequence space
    Andreas Heger
    MRC Functional Genetics Unit, University of Oxford, UK
    Nucleic Acids Res 36:D276-80. 2008
    ..Moreover, query-anchored stacked sequence alignments, profiles and consensus sequences are useful in studies of sequence conservation patterns for clues about possible functional sites...
  11. ncbi Evolution of genes and genomes on the Drosophila phylogeny
    Andrew G Clark
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nature 450:203-18. 2007
    ..These may prove to underlie differences in the ecology and behaviour of these diverse species...
  12. ncbi Uncertainty in homology inferences: assessing and improving genomic sequence alignment
    Gerton Lunter
    MRC Functional Genetics Unit, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
    Genome Res 18:298-309. 2008
    ..Alignment errors are inevitable, and should be considered when drawing conclusions from alignments. Software and alignments to assist researchers in doing this are provided at http://genserv.anat.ox.ac.uk/grape/...
  13. ncbi Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals
    Christina M Laukaitis
    Department of Medical Genetics, University of Washington, Seattle, USA and Division of Human Biology, Fred Hutchinson CancerResearch Center, Seattle, USA
    BMC Evol Biol 8:46. 2008
    ..Questions arise from imperfections in the initial mouse genome assembly and a dearth of information about the gene family structure in other rodents and mammals...