Per Henrik Groop

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. doi request reprint Antihypertensive treatment and resistant hypertension in patients with type 1 diabetes by stages of diabetic nephropathy
    Raija Lithovius
    Corresponding author Per Henrik Groop
    Diabetes Care 37:709-17. 2014
  2. pmc Incidence of stroke according to presence of diabetic nephropathy and severe diabetic retinopathy in patients with type 1 diabetes
    Stefanie Hägg
    Corresponding author Per Henrik Groop
    Diabetes Care 36:4140-6. 2013
  3. pmc Linagliptin lowers albuminuria on top of recommended standard treatment in patients with type 2 diabetes and renal dysfunction
    Per Henrik Groop
    Corresponding author Per Henrik Groop
    Diabetes Care 36:3460-8. 2013
  4. pmc Urinary liver-type fatty acid-binding protein and progression of diabetic nephropathy in type 1 diabetes
    Nicolae M Panduru
    Second Clinical Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
    Diabetes Care 36:2077-83. 2013
  5. pmc Functional annotations of diabetes nephropathy susceptibility loci through analysis of genome-wide renal gene expression in rat models of diabetes mellitus
    YaoMin Hu
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    BMC Med Genomics 2:41. 2009
  6. pmc A1C variability predicts incident cardiovascular events, microalbuminuria, and overt diabetic nephropathy in patients with type 1 diabetes
    Johan Wadén
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Helsinki, Finland
    Diabetes 58:2649-55. 2009
  7. pmc The cross-sectional associations between sense of coherence and diabetic microvascular complications, glycaemic control, and patients' conceptions of type 1 diabetes
    Aila J Ahola
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, Finland
    Health Qual Life Outcomes 8:142. 2010
  8. ncbi request reprint Complex relationship between blood pressure and mortality in type 2 diabetic patients: a follow-up of the Botnia Study
    Mats Rönnback
    Folkhalsan Research Center, Biomedicum Helsinki C318b, PO Box 63, FIN 00014 University of Helsinki, Helsinki, Finland
    Hypertension 47:168-73. 2006
  9. ncbi request reprint Brain natriuretic peptide: microalbuminuria for cardiac disease and diabetes?
    Per Henrik Groop
    Folkhalsan Research Center, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, 00014, Finland
    Diabetologia 48:3-5. 2005
  10. pmc The presence and severity of chronic kidney disease predicts all-cause mortality in type 1 diabetes
    Per Henrik Groop
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, Helsinki, Finland
    Diabetes 58:1651-8. 2009

Detail Information

Publications91

  1. doi request reprint Antihypertensive treatment and resistant hypertension in patients with type 1 diabetes by stages of diabetic nephropathy
    Raija Lithovius
    Corresponding author Per Henrik Groop
    Diabetes Care 37:709-17. 2014
    ..CONCLUSIONS The prevalence of uncontrolled hypertension and RH increases with advanced diabetic nephropathy. These data suggest that there is an urgent need for improvement of antihypertensive treatment. ..
  2. pmc Incidence of stroke according to presence of diabetic nephropathy and severe diabetic retinopathy in patients with type 1 diabetes
    Stefanie Hägg
    Corresponding author Per Henrik Groop
    Diabetes Care 36:4140-6. 2013
    ..Therefore, we assessed the incidence of stroke in patients with type 1 diabetes and studied the impact of diabetic nephropathy (DN) and severe diabetic retinopathy (SDR) on this risk...
  3. pmc Linagliptin lowers albuminuria on top of recommended standard treatment in patients with type 2 diabetes and renal dysfunction
    Per Henrik Groop
    Corresponding author Per Henrik Groop
    Diabetes Care 36:3460-8. 2013
    ....
  4. pmc Urinary liver-type fatty acid-binding protein and progression of diabetic nephropathy in type 1 diabetes
    Nicolae M Panduru
    Second Clinical Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
    Diabetes Care 36:2077-83. 2013
    ..This study assessed the predictive value for progression of a tubular marker, urinary liver-type fatty acid-binding protein (L-FABP), at all stages of DN...
  5. pmc Functional annotations of diabetes nephropathy susceptibility loci through analysis of genome-wide renal gene expression in rat models of diabetes mellitus
    YaoMin Hu
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    BMC Med Genomics 2:41. 2009
    ....
  6. pmc A1C variability predicts incident cardiovascular events, microalbuminuria, and overt diabetic nephropathy in patients with type 1 diabetes
    Johan Wadén
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Helsinki, Finland
    Diabetes 58:2649-55. 2009
    ..Therefore, we investigated the longitudinal associations between A1C variability and diabetes complications in patients with type 1 diabetes in the observational Finnish Diabetic Nephropathy (FinnDiane) Study...
  7. pmc The cross-sectional associations between sense of coherence and diabetic microvascular complications, glycaemic control, and patients' conceptions of type 1 diabetes
    Aila J Ahola
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, Finland
    Health Qual Life Outcomes 8:142. 2010
    ..This paper is a report of a study conducted among patients with type 1 diabetes to assess the associations between SOC and glycaemic control, microvascular complications, and patients' conceptions of their disease...
  8. ncbi request reprint Complex relationship between blood pressure and mortality in type 2 diabetic patients: a follow-up of the Botnia Study
    Mats Rönnback
    Folkhalsan Research Center, Biomedicum Helsinki C318b, PO Box 63, FIN 00014 University of Helsinki, Helsinki, Finland
    Hypertension 47:168-73. 2006
    ..The results suggest that the role of blood pressure as a risk marker in elderly type 2 diabetic patients with cardiovascular disease needs to be reevaluated...
  9. ncbi request reprint Brain natriuretic peptide: microalbuminuria for cardiac disease and diabetes?
    Per Henrik Groop
    Folkhalsan Research Center, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, 00014, Finland
    Diabetologia 48:3-5. 2005
  10. pmc The presence and severity of chronic kidney disease predicts all-cause mortality in type 1 diabetes
    Per Henrik Groop
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, Helsinki, Finland
    Diabetes 58:1651-8. 2009
    ..This study aimed to identify clinical features associated with premature mortality in a large contemporary cohort of adults with type 1 diabetes...
  11. ncbi request reprint HDL composition predicts new-onset cardiovascular disease in patients with type 1 diabetes
    Per Henrik Groop
    Folkhalsan Research Center, Biomedicum Helsinki, P O Box 63, FIN 00014 University of Helsinki, Finland
    Diabetes Care 30:2706-7. 2007
  12. pmc Pulse pressure predicts incident cardiovascular disease but not diabetic nephropathy in patients with type 1 diabetes (The FinnDiane Study)
    Daniel Gordin
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, Helsinki, Finland
    Diabetes Care 34:886-91. 2011
    ..Furthermore, the role of PP as a predictor of diabetic nephropathy is not known. Therefore, we prospectively investigated the associations between PP and these diabetes complications in patients with T1D...
  13. pmc Baroreflex sensitivity and its response to deep breathing predict increase in blood pressure in type 1 diabetes in a 5-year follow-up
    Milla Rosengård-Bärlund
    Division of Nephrology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Diabetes Care 34:2424-30. 2011
    ..However, potential temporal changes in BRS have not yet been addressed by longitudinal studies in type 1 diabetes. Moreover, it is not known whether low BRS predisposes to hypertension or other nonfatal diabetes complications...
  14. ncbi request reprint Mechanisms of disease: Pathway-selective insulin resistance and microvascular complications of diabetes
    Per Henrik Groop
    Helsinki University Central Hospital, Finland
    Nat Clin Pract Endocrinol Metab 1:100-10. 2005
    ..Nonetheless, insulin resistance remains an important marker of risk and a key target for intervention, because those patients who achieve a greater improvement of insulin sensitivity achieve better microvascular outcomes...
  15. ncbi request reprint Low birth weight does not increase the risk of nephropathy in Finnish type 1 diabetic patients
    Johan Fagerudd
    Folkhalsan Research Center, Biomedicum Helsinki C318b, PO Box 63, FIN 00014, University of Helsinki, Finland
    Nephrol Dial Transplant 21:2159-65. 2006
    ..We, therefore, studied the impact of birth weight on the development of diabetic nephropathy and other related traits, such as diabetic retinopathy and macrovascular disease, in Caucasian type 1 diabetic patients...
  16. ncbi request reprint Metabolic syndrome in type 1 diabetes: association with diabetic nephropathy and glycemic control (the FinnDiane study)
    Lena M Thorn
    Folkhalsan Research Center, Biomedicum Helsinki, University of Helsinki, POB 63, FIN 00014, Helsinki, Finland
    Diabetes Care 28:2019-24. 2005
    ..The aim of this study was to estimate the prevalence of the metabolic syndrome in Finnish type 1 diabetic patients and to assess whether it is associated with diabetic nephropathy or poor glycemic control...
  17. ncbi request reprint Leisure time physical activity is associated with poor glycemic control in type 1 diabetic women: the FinnDiane study
    Johan Wadén
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, P O Box 63, 00014 Helsinki, Finland
    Diabetes Care 28:777-82. 2005
    ..We studied the association between leisure time physical activity (LTPA) and glycemic control, insulin dose, and estimated glucose disposal rate (eGDR) in type 1 diabetes...
  18. ncbi request reprint Birth weight is inversely correlated to adult systolic blood pressure and pulse pressure in type 1 diabetes
    Johan Fagerudd
    Folkhalsan Institute of Genetics, Research Center, Helsinki, Finland
    Hypertension 44:832-7. 2004
    ..Given the deleterious effects of elevated arterial blood pressure in diabetes, the impact of intrauterine growth retardation on the development of end-organ damage needs to be clarified...
  19. ncbi request reprint Altered age-related blood pressure pattern in type 1 diabetes
    Mats Rönnback
    Folkhalsan Research Center, Biomedicum Helsinki, Helsinki, Finland
    Circulation 110:1076-82. 2004
    ..Type 1 diabetes is associated with excessive cardiovascular mortality and increased arterial stiffness. We examined whether the age-related blood pressure changes in type 1 diabetic patients differ from those of the nondiabetic..
  20. pmc Adult stature and diabetes complications in patients with type 1 diabetes: the FinnDiane Study and the diabetes control and complications trial
    Johan Wadén
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Helsinki, Finland
    Diabetes 58:1914-20. 2009
    ..Therefore, we evaluated the association between adult stature and prevalence and incidence of diabetic microvascular complications...
  21. ncbi request reprint Serum adiponectin is increased in type 1 diabetic patients with nephropathy
    Markku Saraheimo
    Folkhalsan Research Center, Biomedicum Helsinki 318b, Haartmaninkatu 8, P O Box 63, FIN 00014, University of Helsinki, Helsinki, Finland
    Diabetes Care 28:1410-4. 2005
    ..To elucidate whether serum adiponectin is associated with renal function, low-grade inflammatory markers, metabolic control, and insulin resistance in type 1 diabetic patients with and without nephropathy...
  22. doi request reprint Serum adiponectin and progression of diabetic nephropathy in patients with type 1 diabetes
    Markku Saraheimo
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, Helsinki, Finland
    Diabetes Care 31:1165-9. 2008
    ..The purpose of this study was to elucidate whether serum adiponectin is associated with progression of diabetic nephropathy in type 1 diabetic patients...
  23. ncbi request reprint Leisure-time physical activity is associated with the metabolic syndrome in type 1 diabetes: effect of the PPARgamma Pro12Ala polymorphism: the FinnDiane Study
    Johan Wadén
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Helsinki, Finland
    Diabetes Care 30:1618-20. 2007
  24. pmc Metabolic syndrome as a risk factor for cardiovascular disease, mortality, and progression of diabetic nephropathy in type 1 diabetes
    Lena M Thorn
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, Helsinki, Finland
    Diabetes Care 32:950-2. 2009
    ..To assess the predictive value of the metabolic syndrome in patients with type 1 diabetes...
  25. ncbi request reprint Clustering of risk factors in parents of patients with type 1 diabetes and nephropathy
    Lena M Thorn
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, POB 63, FIN 00014, University of Helsinki, Helsinki, Finland
    Diabetes Care 30:1162-7. 2007
    ..To assess the impact of parental risk factors for diabetic nephropathy...
  26. ncbi request reprint Physical activity and diabetes complications in patients with type 1 diabetes: the Finnish Diabetic Nephropathy (FinnDiane) Study
    Johan Wadén
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Helsinki, Finland
    Diabetes Care 31:230-2. 2008
  27. pmc Effect of parental type 2 diabetes on offspring with type 1 diabetes
    Lena M Thorn
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, Helsinki, Finland
    Diabetes Care 32:63-8. 2009
    ..The purpose of this study was to study the association between a parental history of type 2 diabetes and the metabolic profile as well as the presence of the metabolic syndrome and diabetes complications in patients with type 1 diabetes...
  28. doi request reprint Arterial stiffness and vascular complications in patients with type 1 diabetes: the Finnish Diabetic Nephropathy (FinnDiane) Study
    Daniel Gordin
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, Haartmaninkatu 8, University of Helsinki, Finland
    Ann Med 44:196-204. 2012
    ..While patients with type 1 diabetes (T1D) are known to suffer from early cardiovascular disease (CVD), we examined associations between arterial stiffness and diabetic complications in a large patient group with T1D...
  29. pmc Competing-risk analysis of ESRD and death among patients with type 1 diabetes and macroalbuminuria
    Carol Forsblom
    Folkhalsan Research Center, Biomedicum Helsinki, Haartmaninkatu 8, University of Helsinki, Finland
    J Am Soc Nephrol 22:537-44. 2011
    ..This competing-risks approach has potential to highlight the appropriate targets and strategies for preventing premature mortality in patients with type 1 diabetes...
  30. pmc Chromosome 2q31.1 associates with ESRD in women with type 1 diabetes
    Niina Sandholm
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Helsinki, Finland
    J Am Soc Nephrol 24:1537-43. 2013
    ..004). Overall, these results suggest that rs4972593 is a sex-specific genetic variant associated with ESRD in patients with type 1 diabetes and may underlie the sex-specific protection against ESRD. ..
  31. pmc Metabolic phenotypes, vascular complications, and premature deaths in a population of 4,197 patients with type 1 diabetes
    Ville Petteri Mäkinen
    Department of Biomedical Engineering and Computational Science, Helsinki University of Technology, Helsinki, Finland
    Diabetes 57:2480-7. 2008
    ..Here, the goal was to reveal previously undetected association patterns between clinical diagnoses and biochemistry in the FinnDiane dataset...
  32. ncbi request reprint Development of new peripheral arterial occlusive disease in patients with type 2 diabetes during a mean follow-up of 11 years
    Milla Kallio
    Department of Vascular Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Diabetes Care 26:1241-5. 2003
    ..To assess the occurrence and development of new peripheral arterial occlusive disease (PAOD), its risk factors, and the outcome in patients with type 2 diabetes...
  33. doi request reprint Effect of hot flushes on vascular function: a randomized controlled trial
    Pauliina Tuomikoski
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Obstet Gynecol 114:777-85. 2009
    ..To compare the vascular responses to hormone therapy in women with and without hot flushes...
  34. pmc Latent autoimmune diabetes in adults differs genetically from classical type 1 diabetes diagnosed after the age of 35 years
    Mette K Andersen
    Research Program for Molecular Medicine, Helsinki University, Helsinki, Finland
    Diabetes Care 33:2062-4. 2010
    ..We studied differences between patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes, and classical type 1 diabetes diagnosed after age 35 years...
  35. doi request reprint Association of the SLC22A1, SLC22A2, and SLC22A3 genes encoding organic cation transporters with diabetic nephropathy and hypertension
    Riitta Sallinen
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, Helsinki, Finland
    Ann Med 42:296-304. 2010
    ..Diabetic nephropathy (DN) is a severe long-term complication of diabetes characterized by continuous albuminuria, a relentless decline in renal function, and an increased arterial blood pressure...
  36. doi request reprint Zinc transporter type 8 autoantibodies (ZnT8A): prevalence and phenotypic associations in latent autoimmune diabetes patients and patients with adult onset type 1 diabetes
    Mette K Andersen
    Research Program for Molecular Medicine, Helsinki University and Department of Medicine, Helsinki University Hospital, Helsinki, Finland
    Autoimmunity 46:251-8. 2013
    ..Our aim was to assess the prevalence of ZnT8 autoantibodies (ZnT8A) in patients with adult-onset diabetes, and to characterize associations between ZnT8A and phenotype, as well as SLC30A8 and HLA-DQB1 genotypes...
  37. ncbi request reprint The functional -374 T/A RAGE gene polymorphism is associated with proteinuria and cardiovascular disease in type 1 diabetic patients
    Kim Pettersson-Fernholm
    Department of Medicine, Division of Nephrology, Helsinki University Central Hospital, Helsinki, Finland
    Diabetes 52:891-4. 2003
    ....
  38. pmc Network of vascular diseases, death and biochemical characteristics in a set of 4,197 patients with type 1 diabetes (the FinnDiane Study)
    Ville Petteri Mäkinen
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, Finland
    Cardiovasc Diabetol 8:54. 2009
    ..Therefore, the aim of this study was to describe the association patterns between clinical and biochemical features of diabetic complications...
  39. doi request reprint Evidence for abnormal glucose uptake or metabolism in thalamus during acute hyperglycaemia in type 1 diabetes--a 1H MRS study
    Outi Heikkilä
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Haarmaninkatu 8, Helsinki, Finland
    Metab Brain Dis 25:227-34. 2010
    ..The high exposure of cortex to excess glucose and the altered glucose uptake or metabolism in the thalamus may thus contribute to hyperglycaemia related cognitive dysfunction...
  40. pmc Novel susceptibility locus at 22q11 for diabetic nephropathy in type 1 diabetes
    Maija Wessman
    Folkhalsan Research Center, Folkhalsan Institute of Genetics, Biomedicum Helsinki, Helsinki, Finland
    PLoS ONE 6:e24053. 2011
    ..So far only the 3q21-q25 region has repeatedly been indicated as a susceptibility region for DN. The aim of this study was to search for new DN susceptibility loci in Finnish, Danish and French T1D families...
  41. pmc Osteoprotegerin is an independent predictor of vascular events in Finnish adults with type 1 diabetes
    Daniel Gordin
    Division of Nephrology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Diabetes Care 36:1827-33. 2013
    ..Osteoprotegerin (OPG) is involved in the process of vascular calcification. We investigated whether OPG is associated with the development and progression of diabetes complications in adults with type 1 diabetes (T1D)...
  42. pmc Genetic examination of SETD7 and SUV39H1/H2 methyltransferases and the risk of diabetes complications in patients with type 1 diabetes
    Anna Syreeni
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, Helsinki, Finland
    Diabetes 60:3073-80. 2011
    ..In this study, we investigated genetic polymorphisms of the SETD7, SUV39H1, and SUV39H2 methyltransferases as predictors of risk for micro- and macrovascular complications in type 1 diabetes...
  43. doi request reprint Health-related quality of life in patients with type 1 diabetes--association with diabetic complications (the FinnDiane Study)
    Aila J Ahola
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, Helsinki, Finland
    Nephrol Dial Transplant 25:1903-8. 2010
    ..We aimed to assess HRQoL and its association with diabetic complications in a large sample of patients with type 1 diabetes...
  44. pmc Bacterial endotoxin activity in human serum is associated with dyslipidemia, insulin resistance, obesity, and chronic inflammation
    Mariann I Lassenius
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, Helsinki, Finland
    Diabetes Care 34:1809-15. 2011
    ....
  45. doi request reprint Depression is associated with the metabolic syndrome among patients with type 1 diabetes
    Aila J Ahola
    Folkh and x00E4 lsan Institute of Genetics, Folkh and x00E4 lsan Research Center, Biomedicum Helsinki, Finland
    Ann Med 42:495-501. 2010
    ..In this paper the relationship between depression and the metabolic syndrome among patients with type 1 diabetes was evaluated...
  46. doi request reprint Cerebellar glucose during fasting and acute hyperglycemia in nondiabetic men and in men with type 1 diabetes
    Outi Heikkilä
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, University of Helsinki, Haarmaninkatu 8, P O Box 63, 00014 Helsinki, Finland
    Cerebellum 9:336-44. 2010
    ..The increase in tissue water during acute hyperglycemia may serve to protect the cerebellum from the potentially deleterious effects of the excess glucose...
  47. ncbi request reprint Incidence of end-stage renal disease in patients with type 1 diabetes
    Patrik Finne
    Finnish Registry for Kidney Diseases, Helsinki, Finland
    JAMA 294:1782-7. 2005
    ..End-stage renal disease (ESRD) is one of the most severe complications of type 1 diabetes. Yet, data on patients' risk of developing ESRD are sparse...
  48. ncbi request reprint Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with proteinuria, coronary heart disease, and glycemic control in type 1 diabetic patients
    Kim Pettersson-Fernholm
    Department of Medicine, Division of Nephrology, Helsinki University Central Hospital, and Folkhälsan Research Center, Biomedicum, University of Helsinki, Helsinki, Finland
    Diabetes Care 27:503-9. 2004
    ..Therefore, we investigated the impact of the Leu7Pro polymorphism on diabetic nephropathy, cardiovascular risk factors, and cardiovascular disease in type 1 diabetic patients...
  49. pmc Elevated MBL concentrations are not an indication of association between the MBL2 gene and type 1 diabetes or diabetic nephropathy
    Mari A Kaunisto
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Helsinki, Finland
    Diabetes 58:1710-4. 2009
    ..Furthermore, we studied the association between MBL2 polymorphisms and MBL concentration...
  50. doi request reprint Circulating ACE2 activity is increased in patients with type 1 diabetes and vascular complications
    Aino Soro-Paavonen
    Division of Nephrology, Department of Medicine, Helsinki University Central Hospital, and Folkhälsan Research Center, Helsinki, Finland
    J Hypertens 30:375-83. 2012
    ..The role of ACE2 in human pathophysiology is unknown. We examined whether ACE2 activity is altered in patients with type 1 diabetes (T1D), with and without diabetic nephropathy...
  51. doi request reprint Sense of coherence, food selection and leisure time physical activity in type 1 diabetes
    Aila J Ahola
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, University of Helsinki, Finland
    Scand J Public Health 40:621-8. 2012
    ..We hypothesized that patients with weak sense of coherence have less prudent food choices and lower physical activity...
  52. doi request reprint Many patients with Type 1 diabetes estimate their prandial insulin need inappropriately
    Aila J Ahola
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, Helsinki, Finland
    J Diabetes 2:194-202. 2010
    ..The aim of the present study was to determine how often patients with Type 1 diabetes achieve normal postprandial glucose concentrations and to evaluate factors associated with postprandial hypo- and hyperglycemia...
  53. pmc Effects of long-term fenofibrate treatment on markers of renal function in type 2 diabetes: the FIELD Helsinki substudy
    Carol Forsblom
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum, Helsinki, Finland
    Diabetes Care 33:215-20. 2010
    ..We explored if there were changes in commonly available markers of renal function during fenofibrate treatment in the FIELD Helsinki cohort excluding statin users...
  54. doi request reprint Acute hyperglycaemia induces an inflammatory response in young patients with type 1 diabetes
    Daniel Gordin
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, Finland
    Ann Med 40:627-33. 2008
    ..Stress-induced hyperglycaemia in turn is shown to worsen the prognosis of patients suffering from an acute myocardial infarction. However, the mechanisms behind these findings are incompletely known...
  55. ncbi request reprint Dopamine D3 receptor gene polymorphisms, blood pressure and nephropathy in type 1 diabetic patients
    Kim J Pettersson-Fernholm
    Department of Medicine, Division of Nephrology, Helsinki University Central Hospital, Finland
    Nephrol Dial Transplant 19:1432-6. 2004
    ....
  56. doi request reprint Factors associated with impaired kidney function and its impact on long-term outcome in young ischemic stroke
    Jukka Putaala
    Department of Neurology, Helsinki University Central Hospital, Haartmaninkatu 4, FIN 00290, Helsinki, Finland
    Stroke 42:2459-64. 2011
    ..After ischemic stroke, kidney dysfunction is linked to poor outcomes in the elderly, but regarding young patients, data are lacking...
  57. ncbi request reprint Implementation of guidelines for the prevention of diabetic nephropathy
    Johan Fagerudd
    Folkhalsan Research Center, University of Helsinki, Helsinki, Finland
    Diabetes Care 27:803-4. 2004
  58. ncbi request reprint Polymorphisms in the nephrin gene and diabetic nephropathy in type 1 diabetic patients
    Kim Pettersson-Fernholm
    Department of Medicine, Division of Nephrology, Helsinki University Central Hospital, Helsinki, Finland
    Kidney Int 63:1205-10. 2003
    ..We tested the hypothesis of whether any of the polymorphisms identified in the coding region of the nephrin gene were associated with diabetic nephropathy...
  59. pmc Decline in the cumulative incidence of severe diabetic retinopathy in patients with type 1 diabetes
    Janne P Kytö
    Department of Ophthalmology, Helsinki University Central Hospital, Helsinki, Finland
    Diabetes Care 34:2005-7. 2011
    ..To determine if the cumulative incidence of severe retinopathy in patients with type 1 diabetes has changed...
  60. pmc Time trends in mortality in patients with type 1 diabetes: nationwide population based cohort study
    Valma Harjutsalo
    Folkhalsan Institute of Genetics, Folkhälsan Research Centre, Biomedicum Helsinki, Haartmaninkatu 8, PO Box 63, FIN 00014, Helsinki, Finland
    BMJ 343:d5364. 2011
    ..To examine short and long term time trends in mortality among patients with early onset (age 0-14 years) and late onset (15-29 years) type 1 diabetes and causes of deaths over time...
  61. ncbi request reprint Association analysis of the AIRE and insulin genes in Finnish type 1 diabetic patients
    Joni A Turunen
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki C318b, University of Helsinki, P O Box 63, Haartmaninkatu 8, 00014, Helsinki, Finland
    Immunogenetics 58:331-8. 2006
    ..In conclusion, the AIRE gene does not seem to contribute to disease susceptibility in Finnish type 1 diabetic patients, whereas the insulin gene represents a notable risk factor for disease in this population...
  62. pmc Age at onset and the risk of proliferative retinopathy in type 1 diabetes
    Kustaa Hietala
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, Helsinki, Finland
    Diabetes Care 33:1315-9. 2010
    ..Age at onset of type 1 diabetes influences the risk of microvascular complications. However, the long-term risk of proliferative retinopathy within the wide spectrum of age at onset of type 1 diabetes is less well known...
  63. pmc Heritability of proliferative diabetic retinopathy
    Kustaa Hietala
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, Helsinki, Finland
    Diabetes 57:2176-80. 2008
    ..We investigated whether similar clustering exists for proliferative retinopathy in families with two or more siblings with type 1 diabetes...
  64. ncbi request reprint Nephrinuria in diabetic nephropathy of type 1 diabetes
    Anu Pätäri
    Department of Bacteriology and Immunology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Diabetes 52:2969-74. 2003
    ..Nephrinuria may have prognostic value and become a marker of susceptibility for kidney complications in diabetes...
  65. ncbi request reprint Pulse wave reflection in currently and previously preeclamptic women
    Mats Rönnback
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Hypertens Pregnancy 24:171-80. 2005
    ..This study tested the hypothesis that preeclampsia and a history of preeclampsia are associated with increased pulse wave reflection...
  66. ncbi request reprint Diagnosing diabetic nephropathy by 1H NMR metabonomics of serum
    Ville Petteri Mäkinen
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    MAGMA 19:281-96. 2006
    ..Conversely, in this study, these independent diagnostic data are used to provide a realistic testing case for applying (1)H NMR metabonomics of serum in a diagnostic fashion...
  67. doi request reprint Energy and nutrient intakes and adherence to dietary guidelines among Finnish adults with type 1 diabetes
    Aila J Ahola
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, Finland
    Ann Med 44:73-81. 2012
    ..Implementation of diet is an under-studied phenomenon. We aimed to describe the nutrient intake of a large sample of adult Finnish patients with type 1 diabetes and assess whether they meet the recommendations...
  68. doi request reprint Risk for metabolic syndrome predisposes to alterations in the thalamic metabolism
    Outi Heikkilä
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki C330b, University of Helsinki, P O Box 63, 00014 Helsinki, Finland
    Metab Brain Dis 23:315-24. 2008
    ..78, p = 0.013), but not with the thalamic glucose level. In conclusion, the increased tCr level in the Risk group suggests that a family history of type 2 diabetes together with MetS risk factors alters thalamic energy metabolism...
  69. pmc Age at onset of type 1 diabetes in parents and recurrence risk in offspring
    Valma Harjutsalo
    Folkhalsan Institute of Genetics, Folkhälsan Research Centre, Biomedicum Helsinki, Helsinki, Finland
    Diabetes 59:210-4. 2010
    ....
  70. ncbi request reprint Equol production capability is associated with favorable vascular function in postmenopausal women using tibolone; no effect with soy supplementation
    Riina Törmälä
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
    Atherosclerosis 198:174-8. 2008
    ..We studied the effects of equol production and soy supplementation on vascular function in postmenopausal women under long-term tibolone use...
  71. pmc Serum lipopolysaccharide activity is associated with the progression of kidney disease in finnish patients with type 1 diabetes
    Mariann Nymark
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, Finland
    Diabetes Care 32:1689-93. 2009
    ..The aim of the study was to investigate whether serum lipopolysaccharide (LPS) activities are associated with the progression of kidney disease in patients with type 1 diabetes...
  72. doi request reprint Longitudinal trends in use and costs of prescription medication in patients with type 1 diabetes: the impact of renal disease
    Raija Lithovius
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, Finland
    Ann Med 45:112-9. 2013
    ..We estimated trends in prescription medication costs in out-patients with type 1 diabetes by various stages of diabetic nephropathy (DN), before the development of end-stage renal disease, between 1995 and 2005...
  73. pmc New susceptibility loci associated with kidney disease in type 1 diabetes
    Niina Sandholm
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, Helsinki, Finland
    PLoS Genet 8:e1002921. 2012
    ..1 × 10(-7)), a gene with type 2 diabetes DN differential expression and in the same intron as a variant with cis-eQTL expression of ERBB4. All these detected associations represent new signals in the pathogenesis of DN...
  74. doi request reprint Characterization of the humoral immune response to islet antigen 2 in children with newly diagnosed type 1 diabetes
    Anna Mäkinen
    Scientific Laboratory, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Biomedicum I, PO Box 63, FI 00014 Helsinki, Finland
    Eur J Endocrinol 159:19-26. 2008
    ....
  75. ncbi request reprint A quality assessment survey of SNP genotyping laboratories
    Paivi Lahermo
    Finnish Genome Center, University of Helsinki, Helsinki, Finland
    Hum Mutat 27:711-4. 2006
    ..Lessons from the survey are that special attention should be given to the quality of the DNA samples prior to genotyping, and that a conservative approach for calling the genotypes should be used to achieve a high accuracy...
  76. doi request reprint New approaches to the treatment of nephropathy in diabetes
    Merlin C Thomas
    University of Helsinki, Folkha lsan Research Center, Folkha lsan Institute of Genetics, Biomedicum, Finland
    Expert Opin Investig Drugs 20:1057-71. 2011
    ..Given the ever-growing burden of diabetic kidney disease, there is a substantial opportunity for better and more targeted (?smarter?) therapeutic interventions in this context...
  77. doi request reprint Evidence for a role of hot flushes in vascular function in recently postmenopausal women
    Pauliina Tuomikoski
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Obstet Gynecol 113:902-8. 2009
    ..We hypothesized that vascular function may differ in women with and without vasomotor hot flushes...
  78. pmc Survival of patients with type 1 diabetes receiving renal replacement therapy in 1980-2007
    Mikko Haapio
    Helsinki University Central Hospital, Division of Nephrology, Helsinki, Finland
    Diabetes Care 33:1718-23. 2010
    ..We investigated whether survival of patients with type 1 diabetes receiving RRT has improved over time and whether improvement can be attributable to progress in dialysis treatment or diabetes care...
  79. doi request reprint Towards understanding the inherited susceptibility for nephropathy in diabetes
    Merlin C Thomas
    Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Curr Opin Nephrol Hypertens 21:195-202. 2012
    ..Any inherited predisposition for nephropathy is far more complicated. This article reviews the recent advances in understanding of the genetics and epigenetics of diabetic nephropathy...
  80. ncbi request reprint Impaired vascular dilatation in women with a history of pre-eclampsia
    Katja H Lampinen
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    J Hypertens 24:751-6. 2006
    ..We studied endothelial function and arterial compliance in non-pregnant, previously pre-eclamptic women...
  81. ncbi request reprint A functional polymorphism in the manganese superoxide dismutase gene and diabetic nephropathy
    Anna Möllsten
    Department of Clinical Sciences, Paediatrics, Clinical Chemistry, Umea University, S 90185 Umea, Sweden
    Diabetes 56:265-9. 2007
    ....
  82. ncbi request reprint Glu298Asp and NOS4ab polymorphisms in diabetic nephropathy
    Anna Möllsten
    Department of Clinical Sciences, Umea University, Umea, Sweden
    Ann Med 38:522-8. 2006
    ..We therefore studied association between DN and two polymorphisms in NOS3, Glu298Asp and NOS4ab, in Caucasian type 1 diabetes (T1D) patients...
  83. ncbi request reprint European rational approach for the genetics of diabetic complications--EURAGEDIC: patient populations and strategy
    Lise Tarnow
    Steno Diabetes Center, Copenhagen, Denmark
    Nephrol Dial Transplant 23:161-8. 2008
    ..The main objective of the EURAGEDIC study was to address these problems...
  84. pmc 1H NMR metabonomics approach to the disease continuum of diabetic complications and premature death
    Ville Petteri Mäkinen
    Computational Medicine Research Group, Laboratory of Computational Engineering, Systems Biology and Bioinformation Technology, Helsinki University of Technology, Finland
    Mol Syst Biol 4:167. 2008
    ..However, it also promises cost-effective solutions through high-throughput analytics and advanced computational methods, as applied here in a case that is representative of the real clinical situation...
  85. doi request reprint A relationship between insulin sensitivity and vasodilation in women with a history of preeclamptic pregnancy
    Katja H Lampinen
    Department of Obstetrics and Gynecology, Helsinki University Hospital, Department of Obstetrics and Gynecology, Haartmaninkatu 2, 00290 Helsinki, Finland
    Hypertension 52:394-401. 2008
    ..The present study indicates a relation between insulin sensitivity with vascular dilatory function in women with previous preeclampsia. Furthermore, early onset preeclampsia correlates with impaired insulin sensitivity later in life...
  86. ncbi request reprint Analysis of 14 candidate genes for diabetic nephropathy on chromosome 3q in European populations: strongest evidence for association with a variant in the promoter region of the adiponectin gene
    Nathalie Vionnet
    INSERM U525, Centre National de Genotypage, 2, rue Gaston Crémieux, 91006 Evry Cedex, France
    Diabetes 55:3166-74. 2006
    ..50 [0.27-0.92], P = 0.026). The overall significance for this variant (nominal P = 0.011) suggests that ADIPOQ might be involved in the development of diabetic nephropathy...
  87. ncbi request reprint Serum lipids and the progression of nephropathy in type 1 diabetes
    Merlin C Thomas
    The Baker Heart Research Institute, Melbourne, Australia
    Diabetes Care 29:317-22. 2006
    ..However, different lipid variables may be important at different stages of nephropathy. This study examines the pattern of dyslipidemia associated with the progression of nephropathy in patients with type 1 diabetes...
  88. ncbi request reprint Association between angiotensin-converting enzyme gene polymorphisms and diabetic nephropathy: case-control, haplotype, and family-based study in three European populations
    Samy Hadjadj
    CHU de Poitiers, Department of Diabetology, Poitiers University Hospital, Poitiers, France
    J Am Soc Nephrol 18:1284-91. 2007
    ..This study population is suitable to search for additional candidate genes for DN...
  89. doi request reprint A multi-metabolite analysis of serum by 1H NMR spectroscopy: early systemic signs of Alzheimer's disease
    Taru Tukiainen
    Computational Medicine Research Group, Department of Biomedical Engineering and Computational Science, Helsinki University of Technology, P O Box 9203, FI 02015 HUT, Finland
    Biochem Biophys Res Commun 375:356-61. 2008
    ..The analyses also feature the role of elevated glycoproteins in the risk for AD, supporting the view that coexistence of inflammation and the MetS forms a high risk condition for cognitive decline...
  90. ncbi request reprint VEGF gene variability and type 1 diabetes: evidence for a protective role
    Roberto Del Bo
    Department of Neurological Sciences, Centro Dino Ferrari, University of Milan, Milan, Italy
    Immunogenetics 58:107-12. 2006
    ..In conclusion, because the expected functional consequence of both genotype combinations is a reduced VEGF expression in diabetic patients, we propose a protective role of VEGF in the development of type 1 diabetes...
  91. ncbi request reprint Screening for chronic kidney disease in patients with diabetes: are we missing the point?
    Merlin C Thomas
    Diabetes and Metabolic Division, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Nat Clin Pract Nephrol 4:2-3. 2008