C G Gahmberg

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi request reprint Regulation of integrin activity by phosphorylation
    Carl G Gahmberg
    Division of Biochemistry and Biotechnology, Department of Biosciences, University of Helsinki, Viikinkaari 5, 00014, Helsinki, Finland
    Adv Exp Med Biol 819:85-96. 2014
  2. pmc Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms
    Susanna C Fagerholm
    Division of Biochemistry, Faculty of Biosciences, University of Helsinki, FIN 00014 Helsinki, Finland
    J Cell Biol 171:705-15. 2005
  3. pmc Intercellular adhesion molecule-5 induces dendritic outgrowth by homophilic adhesion
    L Tian
    Department of Biosciences, Division of Biochemistry, Viikinkaari 5, University of Helsinki, Helsinki 00014, Finland
    J Cell Biol 150:243-52. 2000
  4. ncbi request reprint Leukocyte adhesion--a fundamental process in leukocyte physiology
    C G Gahmberg
    Department of Biosciences, University of Helsinki, Finland
    Braz J Med Biol Res 32:511-7. 1999
  5. ncbi request reprint Leukocyte integrins and inflammation
    C G Gahmberg
    Department of Biosciences, University of Helsinki, Finland
    Cell Mol Life Sci 54:549-55. 1998
  6. ncbi request reprint Leukocyte adhesion: CD11/CD18 integrins and intercellular adhesion molecules
    C G Gahmberg
    Department of Biosciences, University of Helsinki, Finland
    Curr Opin Cell Biol 9:643-50. 1997
  7. ncbi request reprint Leukocyte adhesion--an integrated molecular process at the leukocyte plasma membrane
    C G Gahmberg
    Department of Biosciences, University of Helsinki, Finland
    Biosci Rep 19:273-81. 1999
  8. ncbi request reprint Activation of leukocyte beta2-integrins
    Carl G Gahmberg
    Department of Biosciences, Division of Biochemistry, University of Helsinki, Finland
    Vox Sang 83:355-8. 2002
  9. pmc Regulation of integrin activity and signalling
    Carl G Gahmberg
    Division of Biochemistry, Faculty of Biosciences, University of Helsinki, Viikinkaari 5, 00014, Finland
    Biochim Biophys Acta 1790:431-44. 2009
  10. doi request reprint ICAM-5--a novel two-facetted adhesion molecule in the mammalian brain
    Carl G Gahmberg
    Division of Biochemistry, Faculty of Biosciences, University of Helsinki, Viikinkaari 5, 00014 Helsinki, Finland
    Immunol Lett 117:131-5. 2008

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Regulation of integrin activity by phosphorylation
    Carl G Gahmberg
    Division of Biochemistry and Biotechnology, Department of Biosciences, University of Helsinki, Viikinkaari 5, 00014, Helsinki, Finland
    Adv Exp Med Biol 819:85-96. 2014
    ..Phosphorylation reactions can be fast and reversible, thus enabling strictly directed regulatory activities both time-wise and locally in specific regions of the plasma membrane in different leukocytes. ..
  2. pmc Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms
    Susanna C Fagerholm
    Division of Biochemistry, Faculty of Biosciences, University of Helsinki, FIN 00014 Helsinki, Finland
    J Cell Biol 171:705-15. 2005
    ..Thus, site-specific phosphorylation of the integrin cytoplasmic domains is important for the dynamic regulation of these complex receptors in cells...
  3. pmc Intercellular adhesion molecule-5 induces dendritic outgrowth by homophilic adhesion
    L Tian
    Department of Biosciences, Division of Biochemistry, Viikinkaari 5, University of Helsinki, Helsinki 00014, Finland
    J Cell Biol 150:243-52. 2000
    ..Thus, ICAM-5 displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes...
  4. ncbi request reprint Leukocyte adhesion--a fundamental process in leukocyte physiology
    C G Gahmberg
    Department of Biosciences, University of Helsinki, Finland
    Braz J Med Biol Res 32:511-7. 1999
    ..Furthermore, it is becoming increasingly apparent that changes in integrins and intercellular adhesion molecules are associated with a number of acute and chronic diseases...
  5. ncbi request reprint Leukocyte integrins and inflammation
    C G Gahmberg
    Department of Biosciences, University of Helsinki, Finland
    Cell Mol Life Sci 54:549-55. 1998
    ..Inflammation is critically dependent on integrin activity, and its regulation forms the topic of this short review...
  6. ncbi request reprint Leukocyte adhesion: CD11/CD18 integrins and intercellular adhesion molecules
    C G Gahmberg
    Department of Biosciences, University of Helsinki, Finland
    Curr Opin Cell Biol 9:643-50. 1997
    ..Furthermore, much progress has been made in the study of integrin activation and the role of leukocyte adhesion molecules in disease...
  7. ncbi request reprint Leukocyte adhesion--an integrated molecular process at the leukocyte plasma membrane
    C G Gahmberg
    Department of Biosciences, University of Helsinki, Finland
    Biosci Rep 19:273-81. 1999
    ..In this short essay, we review some recent developments in the field...
  8. ncbi request reprint Activation of leukocyte beta2-integrins
    Carl G Gahmberg
    Department of Biosciences, Division of Biochemistry, University of Helsinki, Finland
    Vox Sang 83:355-8. 2002
  9. pmc Regulation of integrin activity and signalling
    Carl G Gahmberg
    Division of Biochemistry, Faculty of Biosciences, University of Helsinki, Viikinkaari 5, 00014, Finland
    Biochim Biophys Acta 1790:431-44. 2009
    ..Due to the large number of articles dealing with integrins, we focus on what we think are the most exciting and rewarding directions of contemporary research on cell adhesion and integrins...
  10. doi request reprint ICAM-5--a novel two-facetted adhesion molecule in the mammalian brain
    Carl G Gahmberg
    Division of Biochemistry, Faculty of Biosciences, University of Helsinki, Viikinkaari 5, 00014 Helsinki, Finland
    Immunol Lett 117:131-5. 2008
    ..Recent studies show that it is important for the regulation of immunological activity in the brain and for the development of neuronal synapses and signal transmission...
  11. ncbi request reprint Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction with the leukocyte integrin CD11a/CD18
    L Tian
    Department of Biosciences, University of Helskinki, Finland
    Eur J Immunol 30:810-8. 2000
    ..This binding was blocked by monoclonal antibodies against CD11a/CD18 and ICAM-5. Thus ICAM-5 may act as a major adhesion molecule for leukocyte binding to neurons in the central nervous system...
  12. ncbi request reprint The pivotal role of the Leu-CAM and ICAM molecules in human leukocyte adhesion
    C G Gahmberg
    Department of Biochemistry, University of Helsinki, Finland
    Cell Differ Dev 32:239-45. 1990
    ..Among the most important are the Leu-CAMs or the CD11/CD18 integrin receptors, and their adhesion ligands ICAM-1 (CD54) and ICAM-2. In this review we summarize some recent work on various aspects of these molecules...
  13. ncbi request reprint A leukocyte integrin binding peptide from intercellular adhesion molecule-2 stimulates T cell adhesion and natural killer cell activity
    R Li
    Department of Biochemistry, University of Helsinki, Finland
    J Biol Chem 268:21474-7. 1993
    ..These findings show that adhesion-dependent leukocyte functions can be activated by ligand-derived peptides, and therefore provide evidence that the avidity of leukocyte integrins is up-regulated by integrin-ligand interactions...
  14. ncbi request reprint Leukocyte cell adhesion proteins: from molecular dissection to clinical applications
    C G Gahmberg
    Department of Biochemistry, University of Helsinki, Finland
    Ann Med 24:329-35. 1992
    ..It is becoming increasingly apparent that it is possible to interfere with the normal functions of the leukocyte adhesion glycoproteins, and such applications may become important in medicine...
  15. ncbi request reprint ICAM-2 and a peptide from its binding domain are efficient activators of leukocyte adhesion and integrin affinity
    A Kotovuori
    Department of Biosciences, Division of Biochemistry, University of Helsinki, Finland
    J Immunol 162:6613-20. 1999
    ..Importantly, soluble ICAM-2Fc was also able to induce T lymphocyte adhesion to purified ICAM-1, -2, and -3, and it was a more potent stimulatory molecule than ICAM-1Fc or ICAM-3Fc...
  16. ncbi request reprint Intercellular adhesion molecule-2 (CD102) binds to the leukocyte integrin CD11b/CD18 through the A domain
    J Xie
    Department of Biosciences, University of Helsinki, Finland
    J Immunol 155:3619-28. 1995
    ..In the present study, we demonstrate that the ICAM-2 protein interacts with CD11b/CD18, and the binding is through the CD11b A domain...
  17. ncbi request reprint Participation of CD11a-c/CD18, CD2 and RGD-binding receptors in endogenous and interleukin-2-stimulated NK activity of CD3-negative large granular lymphocytes
    T Timonen
    Department of Pathology, University of Helsinki, Finland
    Int J Cancer 46:1035-40. 1990
    ..In addition, RGD-binding receptors are involved in adhesion to some target cells...
  18. ncbi request reprint Migration of recombinant IL-2-activated T and natural killer cells in the intercellular space of human H-2 glioma spheroids in vitro. A study on adhesion molecules involved
    J Jaaskelainen
    Department of Neurosurgery, University of Helsinki, Finland
    J Immunol 149:260-8. 1992
    ..However, a combination of the GPEILDVPST and GRGDS peptides, which compete for the binding of alpha 4 beta 1 and alpha 5 beta 1 to fibronectin and may also affect other adhesion systems, partially prevented migration...
  19. pmc Inhibition of beta(2) integrin-mediated leukocyte cell adhesion by leucine-leucine-glycine motif-containing peptides
    E Koivunen
    Department of Biosciences, Division of Biochemistry, University of Helsinki, Viikinkaari 5, FIN-00014 Helsinki, Finland
    J Cell Biol 153:905-16. 2001
    ....
  20. pmc A peptide derived from the intercellular adhesion molecule-2 regulates the avidity of the leukocyte integrins CD11b/CD18 and CD11c/CD18
    R Li
    Department of Biochemistry, University of Helsinki, Finland
    J Cell Biol 129:1143-53. 1995
    ..These findings indicate that in addition to induction of CD11a/CD18-mediated cell adhesion, the ICAM-2 peptide may also serve as a "trigger" for high avidity ligand binding of other beta 2 integrins...
  21. ncbi request reprint Threonine phosphorylation sites in the beta 2 and beta 7 leukocyte integrin polypeptides
    Tiina J Hilden
    Department of Biosciences, Division of Biochemistry, and Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    J Immunol 170:4170-7. 2003
    ..Sequence analysis by manual radiosequencing by Edman degradation established that threonine phosphorylation occurred in the same threonine triplet as in beta(2) phosphorylation...
  22. ncbi request reprint Expression and characterization of a B cell growth promoting polypeptide derived from the 12 kDa B cell growth factor gene (BCGF 1)
    P E Kovanen
    Department of Pathology, University of Helsinki, Finland
    FEBS Lett 361:233-7. 1995
    ..The availability of biologically active recombinant 12 kDa B cell growth factor will enable its evaluation in B cell growth regulation, and provides a new means of in vitro culturing of human B lymphocytes...
  23. ncbi request reprint Identification of a negatively charged peptide motif within the catalytic domain of progelatinases that mediates binding to leukocyte beta 2 integrins
    Michael Stefanidakis
    Department of Biosciences, Division of Biochemistry, Viikinkaari 5, University of Helsinki, FIN 00014 Helsinki, Finland
    J Biol Chem 278:34674-84. 2003
    ..These results suggest that leukocytes may move in a progelatinase-beta 2 integrin complex-dependent manner...
  24. ncbi request reprint alpha-Chain phosphorylation of the human leukocyte CD11b/CD18 (Mac-1) integrin is pivotal for integrin activation to bind ICAMs and leukocyte extravasation
    Susanna C Fagerholm
    Division of Biochemistry, Faculty of Biosciences, PB56 Viikinkaari 5, 00014 University of Helsinki, Helsinki, Finland
    Blood 108:3379-86. 2006
    ..These results characterize a novel selective mechanism of Mac-1-integrin activation, which mediates leukocyte emigration from the bloodstream to the tissues...
  25. ncbi request reprint Release of soluble ICAM-5, a neuronal adhesion molecule, in acute encephalitis
    Perttu J Lindsberg
    Department of Neurology, Helsinki University Central Hospital, FIN 00029 HUS, Helsinki, Finland
    Neurology 58:446-51. 2002
    ..This led the authors to examine ICAM-5 expression during clinical CNS inflammation...
  26. ncbi request reprint Intercellular adhesion molecule-1 in extravasation of normal mononuclear and leukaemia cells
    S Mustjoki
    Departments of Virology, University of Helsinki, Finland
    Br J Haematol 113:989-1000. 2001
    ..However, as we showed that ICAM-1 mediated leukaemia cell extravasation on the cell surface, it is possible that cellular ICAM-1 has an important role in disease progression...
  27. ncbi request reprint Interfering with leukocyte integrin activation--a novel concept in the development of anti-inflammatory drugs
    Tiina J Hilden
    Division of Biochemistry, Faculty of Biosciences, University of Helsinki, Finland
    Ann Med 38:503-11. 2006
    ..Here, we present key events and players in leukocyte integrin activation, and discuss potential new drug targets in the prevention of inflammatory disease...
  28. ncbi request reprint Red-cell ICAM-4 is a ligand for the monocyte/macrophage integrin CD11c/CD18: characterization of the binding sites on ICAM-4
    Eveliina Ihanus
    Faculty of Biosciences, Division of Biochemistry, PO Box 56, Viikinkaari 5, University of Helsinki 00014, Finland
    Blood 109:802-10. 2007
    ..CD11c/CD18 is expressed on macrophages in spleen and bone marrow. Inhibition of erythrophagocytosis by anti-ICAM-4 and anti-integrin antibodies suggests a role for these interactions in removal of senescent red cells...
  29. pmc Role of leukemia cell invadosome in extramedullary infiltration
    Michael Stefanidakis
    Department of Biological and Environmental Sciences, Division of Biochemistry, University of Helsinki, Helsinki, Finland
    Blood 114:3008-17. 2009
    ..Disruption of specific protein complexes within this supramolecular target complex may yield a new class of anti-AML drugs with anti-invasion (rather than or in addition to cytotoxic) attributes...
  30. ncbi request reprint Characterization of ICAM-4 binding to the I domains of the CD11a/CD18 and CD11b/CD18 leukocyte integrins
    Eveliina Ihanus
    Department of Biosciences, Division of Biochemistry, University of Helsinki, Finland
    Eur J Biochem 270:1710-23. 2003
    ..Thus we have established that the I domains contain an ICAM-4 binding region in CD11a/CD18 and CD11b/CD18 leukocyte integrins...
  31. ncbi request reprint A CD44 monoclonal antibody differentially regulates CD11a/CD18 binding to intercellular adhesion molecules CD54, CD102 and CD50
    C Vermot-Desroches
    Department of Biosciences, University of Helsinki, Finland
    Eur J Immunol 25:2460-4. 1995
    ..The binding to ICAM-2 was not affected by either treatment. These findings show that the CD11a/CD18 integrin can be activated in a ligand-specific manner by engagement of CD44...
  32. doi request reprint Hydrophobic interaction between the SH2 domain and the kinase domain is required for the activation of Csk
    Esa T Mikkola
    Division of Biochemistry, Department of Biosciences, Faculty of Biological and Environmental Sciences, University of Helsinki, FIN 00014 Helsinki, Finland
    J Mol Biol 399:618-27. 2010
    ....
  33. ncbi request reprint P marks the spot: site-specific integrin phosphorylation regulates molecular interactions
    Susanna C Fagerholm
    Division of Biochemistry, Faculty of Biosciences, PB 56 Viikinkaari 5, 00014 University of Helsinki, Finland
    Trends Biochem Sci 29:504-12. 2004
    ..This phosphorylation might give rise to signaling specificity and fine-tuning of the integrin-mediated responses...
  34. doi request reprint Shedded neuronal ICAM-5 suppresses T-cell activation
    Li Tian
    Department of Biologic and Environmental Sciences, Faculty of Biosciences, University of Helsinki, Finland
    Blood 111:3615-25. 2008
    ..The formation of sICAM-5 is promoted by activated T cells through the cleavage of ICAM-5 from neurons. This suggests that ICAM-5 is involved in immune privilege of the brain and acts as an anti-inflammatory agent...
  35. ncbi request reprint Neuronal regulation of immune responses in the central nervous system
    Li Tian
    Neuroscience Center, University of Helsinki, Viikinkaari 4, FIN 00014, Helsinki, Finland
    Trends Immunol 30:91-9. 2009
    ..In addition, we specifically deal with the immune functions of neuronal cell adhesion molecules, many of which are key modulators of neuronal synaptic formation and plasticity...
  36. pmc Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage
    Li Tian
    Division of Biochemistry, Department of Biological and Environmental Sciences, Faculty of Biosciences, University of Helsinki, FIN 00014 Helsinki, Finland
    J Cell Biol 178:687-700. 2007
    ..Soluble ICAM-5 promotes elongation of dendritic filopodia from wild-type neurons, but not from ICAM-5-deficient neurons. Thus, MMPs are important for ICAM-5-mediated dendritic spine development...
  37. ncbi request reprint Intracellular and cell surface localization of a complex between alphaMbeta2 integrin and promatrix metalloproteinase-9 progelatinase in neutrophils
    Michael Stefanidakis
    Department of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland
    J Immunol 172:7060-8. 2004
    ..These results suggest that the translocating proMMP-9/alpha(M)beta(2) complex may be part of the cell surface machinery guiding neutrophil migration...
  38. ncbi request reprint Phosphorylation of the LFA-1 integrin beta2-chain on Thr-758 leads to adhesion, Rac-1/Cdc42 activation, and stimulation of CD69 expression in human T cells
    Susanna M Nurmi
    Division of Biochemistry, Faculty of Biosciences, University of Helsinki, 00014 Helsinki, Finland
    J Biol Chem 282:968-75. 2007
    ..These results show that Thr-758-phosphorylated LFA-1 is upstream of Rac-1/Cdc42, cell adhesion, and costimulatory activation of human T cells, thus identifying phosphorylation of Thr-758 in beta2 as a proximal element in LFA-1 signaling...
  39. ncbi request reprint Phosphorylation of the cytoplasmic domain of the integrin CD18 chain by protein kinase C isoforms in leukocytes
    Susanna Fagerholm
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, United Kingdom
    J Biol Chem 277:1728-38. 2002
    ..Thus, PKC-mediated phosphorylation of CD18 after cell stimulation could lead to the recruitment of 14-3-3 proteins to the activated integrin, which may play a role in regulating its adhesive state or ability to signal...
  40. ncbi request reprint Differential expression of cytokines (IL-2, IFN-gamma, IL-10) and adhesion molecules (VCAM-1, LFA-1, CD44) between spleen and lymph nodes associates with remission in chronic relapsing experimental autoimmune encephalomyelitis
    J Yang
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Finland
    Scand J Immunol 56:286-93. 2002
    ..Our results suggest that a differential and polarized expression profile of certain cytokines and CAMs in spleen versus LN could provide molecular correlates of the cyclic pathogenesis of CR-EAE...
  41. ncbi request reprint alpha-Actinin-dependent cytoskeletal anchorage is important for ICAM-5-mediated neuritic outgrowth
    Henrietta Nyman-Huttunen
    Division of Biochemistry, Faculty of Biosciences, PO Box 56 Viikinkaari 5, 00014 University of Helsinki, Finland
    J Cell Sci 119:3057-66. 2006
    ....
  42. ncbi request reprint Lck tyrosine kinase is important for activation of the CD11a/CD18-integrins in human T lymphocytes
    Susanna Fagerholm
    Department of Biosciences, Division of Biochemistry, University of Helsinki, Helsinki, Finland
    Eur J Immunol 32:1670-8. 2002
    ..Retransfection of human Lck in JCaM1.6 cells restored adhesion. Thus, Lck is involved in regulating CD11a/CD18-integrins in T cells...
  43. ncbi request reprint Oncoplacental protein SP1--a constitutive and inducible late differentiation marker of the human myelomonocytic lineage
    M Heikinheimo
    Department of Biochemistry, Children s Hospital, University of Helsinki, Finland
    Blood 70:1279-83. 1987
    ..Thus SP1 provides a late differentiation marker for the myelomonocytic lineage and is strongly induced during macrophage differentiation or by TPA treatment of ML-2 cells...
  44. ncbi request reprint 14-3-3 proteins bind both filamin and alphaLbeta2 integrin in activated T cells
    Susanna M Nurmi
    Division of Biochemistry, Faculty of Biosciences, PB 56 Viikinkaari 5D, 00014 University of Helsinki, Helsinki, Finland
    Ann N Y Acad Sci 1090:318-25. 2006
    ..Here, we show that filamin associates with 14-3-3 proteins in activated T cells. 14-3-3 association with T cell membrane and cytoskeleton proteins after cell stimulation may mediate numerous T cell functions...
  45. ncbi request reprint Ezrin is a substrate for Lck in T cells
    Matti Autero
    Department of Biosciences, Division of Biochemistry, University of Helsinki, Helsinki, Finland
    FEBS Lett 535:82-6. 2003
    ..Lck phosphorylated ezrin in vitro, and the major phosphotyrosine was identified as Y145. These results identify ezrin as the first cytoskeletal substrate for Lck...
  46. ncbi request reprint Importance of molecular studies on major blood groups--intercellular adhesion molecule-4, a blood group antigen involved in multiple cellular interactions
    Anne Toivanen
    Division of Biochemistry, Faculty of Biosciences, P O Box 56, Viikinkaari 5, 00014 University of Helsinki, Finland
    Biochim Biophys Acta 1780:456-66. 2008
    ..In this article we discuss molecular properties of major blood group antigens, describe ICAM-4 in more detail, and show that phagocytosis of senescent red cells is in part ICAM-4/beta(2)-integrin dependent...
  47. ncbi request reprint LDL-receptor-related protein regulates beta2-integrin-mediated leukocyte adhesion
    Patricia P E M Spijkers
    Laboratory for Thrombosis and Haemostasis, Department of Haematology, University Medical Center Utrecht, The Netherlands
    Blood 105:170-7. 2005
    ....
  48. pmc An unusual allosteric mobility of the C-terminal helix of a high-affinity alphaL integrin I domain variant bound to ICAM-5
    Hongmin Zhang
    Department of Medical Oncology and Department of Cancer Biology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Mol Cell 31:432-7. 2008
    ..This remarkable feature allows the alpha7 helix to trigger integrin's large-scale conformational changes with little energy penalty. It serves as a mechanistic example of how a weakly bound adhesion molecule works in signaling...
  49. pmc A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin
    Valeria V Orlova
    Experimental Immunology Branch, NCI, NIH, Bethesda, MD 20892, USA
    EMBO J 26:1129-39. 2007
    ..Together, a novel HMGB1-dependent pathway for inflammatory cell recruitment and activation that requires the functional interplay between Mac-1 and RAGE is described here...
  50. ncbi request reprint Lipoprotein(a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac-1 integrin
    Sotirios N Sotiriou
    Experimental Immunology Branch, NCI, NIH, Bethesda, Maryland 20892, USA
    FASEB J 20:559-61. 2006
    ..These observations suggest a novel mechanism for the atherogenic properties of Lp(a)...
  51. pmc Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins
    Eun Young Choi
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 111:3607-14. 2008
    ..In conclusion, Cbl-b deficiency activates LFA-1 and LFA-1-mediated inflammatory cell recruitment by stimulating the interaction between the LFA-1 beta-chain and 14-3-3 proteins...
  52. ncbi request reprint P-selectin glycoprotein ligand 1 and beta2-integrins cooperate in the adhesion of leukocytes to von Willebrand factor
    Ronan Pendu
    INSERM U 770, 80 rue du General Leclerc, 94276 Le Kremlin Bicetre Cedex, France
    Blood 108:3746-52. 2006
    ..VWF is unique in its intrinsic capacity to combine the rolling and the stable adhesion step in the interaction with leukocytes...
  53. ncbi request reprint Beta2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding
    Heikki Takala
    Department of Biological and Environmental Science and Nanoscience Center, University of Jyvaskyla, Jyvaskyla, Finland
    Blood 112:1853-62. 2008
    ..Our results suggest that the phosphorylation of beta2 integrins on Thr758 acts as a molecular switch to inhibit filamin binding and allow 14-3-3 protein binding to the integrin cytoplasmic domain, thereby modulating T-cell adhesion...
  54. ncbi request reprint DC-SIGN binds ICAM-3 isolated from peripheral human leukocytes through Lewis x residues
    Valentina Bogoevska
    Institut fur Klinische Chemie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, D 20251 Hamburg, Germany
    Glycobiology 17:324-33. 2007
    ..The results suggest that ICAM-3 assists in the interaction of granulocytes with DC-SIGN of DCs...