Affiliation: University of Helsinki
Savinko T, Morrison V, Uotila L, Wolff C, Alenius H, Fagerholm S. Functional Beta2-Integrins Restrict Skin Inflammation In Vivo. J Invest Dermatol. 2015;135:2249-2257 pubmed publisher
..Functional beta2-integrins also have a major role in restricting the immune response in the inflamed skin and lymph nodes in vivo, likely through effects on mast cell and dendritic cell numbers and activation. ..
Savinko T, Guenther C, Uotila L, Llort Asens M, Yao S, Tojkander S, et al
. Filamin A Is Required for Optimal T Cell Integrin-Mediated Force Transmission, Flow Adhesion, and T Cell Trafficking. J Immunol. 2018;200:3109-3116 pubmed publisher
..In addition, FlnA is not needed for T cell activation in vivo, which occurs in shear-free conditions in lymphoid organs. Our results therefore reveal a role of FlnA in integrin force transmission and T cell trafficking in vivo. ..
Fagerholm S, Morrice N, Gahmberg C, Cohen P. Phosphorylation of the cytoplasmic domain of the integrin CD18 chain by protein kinase C isoforms in leukocytes. J Biol Chem. 2002;277:1728-38 pubmed
..Thus, PKC-mediated phosphorylation of CD18 after cell stimulation could lead to the recruitment of 14-3-3 proteins to the activated integrin, which may play a role in regulating its adhesive state or ability to signal. ..
Morrison V, Uotila L, Llort Asens M, Savinko T, Fagerholm S. Optimal T Cell Activation and B Cell Antibody Responses In Vivo Require the Interaction between Leukocyte Function-Associated Antigen-1 and Kindlin-3. J Immunol. 2015;195:105-15 pubmed publisher
Uotila L, Guenther C, Savinko T, Lehti T, Fagerholm S. Filamin A Regulates Neutrophil Adhesion, Production of Reactive Oxygen Species, and Neutrophil Extracellular Trap Release. J Immunol. 2017;199:3644-3653 pubmed publisher
..Thus, FlnA is a negative regulator of ?2 integrin-dependent cell adhesion and reactive oxygen species production but is required for NET production in primary murine neutrophils. ..