Henrik Edgren

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. pmc Identification of fusion genes in breast cancer by paired-end RNA-sequencing
    Henrik Edgren
    Institute for Molecular Medicine Finland, Tukholmankatu 8, Helsinki, 00290, Finland
    Genome Biol 12:R6. 2011
  2. pmc Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues
    Sami Kilpinen
    Medical Biotechnology, VTT Technical Research Centre and University of Turku, Itäinen Pitkäkatu 4C, Turku, Finland
    Genome Biol 9:R139. 2008
  3. pmc Data integration from two microarray platforms identifies bi-allelic genetic inactivation of RIC8A in a breast cancer cell line
    Aslaug Aamodt Muggerud
    Department of Genetics, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway
    BMC Med Genomics 2:26. 2009
  4. pmc A new look towards BAC-based array CGH through a comprehensive comparison with oligo-based array CGH
    Nicolas Wicker
    Laboratoire de Bioinformatique et de Génomique lntégratives, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch Cedex, France
    BMC Genomics 8:84. 2007
  5. pmc Reanalysis of RNA-sequencing data reveals several additional fusion genes with multiple isoforms
    Sara Kangaspeska
    Institute for Molecular Medicine Finland, Helsinki, Finland
    PLoS ONE 7:e48745. 2012
  6. pmc Array-based gene expression, CGH and tissue data defines a 12q24 gain in neuroblastic tumors with prognostic implication
    Maija Wolf
    Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland
    BMC Cancer 10:181. 2010
  7. doi request reprint KRAS oncogene rearrangements and gene fusions: unexpected rare encounters in late-stage prostate cancers
    Henrik Edgren
    Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
    Cancer Discov 1:12-3. 2011

Collaborators

Detail Information

Publications7

  1. pmc Identification of fusion genes in breast cancer by paired-end RNA-sequencing
    Henrik Edgren
    Institute for Molecular Medicine Finland, Tukholmankatu 8, Helsinki, 00290, Finland
    Genome Biol 12:R6. 2011
    ..Next-generation sequencing technologies provide an opportunity for systematic characterization of cancer cell transcriptomes, including the discovery of expressed fusion genes resulting from underlying genomic rearrangements...
  2. pmc Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues
    Sami Kilpinen
    Medical Biotechnology, VTT Technical Research Centre and University of Turku, Itäinen Pitkäkatu 4C, Turku, Finland
    Genome Biol 9:R139. 2008
    ..This database of gene expression patterns in normal human tissues and pathological conditions covers 113 million datapoints and is available from the GeneSapiens website...
  3. pmc Data integration from two microarray platforms identifies bi-allelic genetic inactivation of RIC8A in a breast cancer cell line
    Aslaug Aamodt Muggerud
    Department of Genetics, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway
    BMC Med Genomics 2:26. 2009
    ....
  4. pmc A new look towards BAC-based array CGH through a comprehensive comparison with oligo-based array CGH
    Nicolas Wicker
    Laboratoire de Bioinformatique et de Génomique lntégratives, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch Cedex, France
    BMC Genomics 8:84. 2007
    ..The correlation as well as the discriminative power of these platforms has never been compared statistically on a significant set of human patient samples...
  5. pmc Reanalysis of RNA-sequencing data reveals several additional fusion genes with multiple isoforms
    Sara Kangaspeska
    Institute for Molecular Medicine Finland, Helsinki, Finland
    PLoS ONE 7:e48745. 2012
    ..This illustrates the importance of reanalyzing sequencing data as gene definitions change and bioinformatic methods improve, and highlights the previously unforeseen isoform diversity among fusion transcripts...
  6. pmc Array-based gene expression, CGH and tissue data defines a 12q24 gain in neuroblastic tumors with prognostic implication
    Maija Wolf
    Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland
    BMC Cancer 10:181. 2010
    ..Here, we present a framework, which integrates DNA, RNA and tissue data to identify and prioritize genetic events that represent clinically relevant new therapeutic targets and prognostic biomarkers for neuroblastoma...
  7. doi request reprint KRAS oncogene rearrangements and gene fusions: unexpected rare encounters in late-stage prostate cancers
    Henrik Edgren
    Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
    Cancer Discov 1:12-3. 2011
    ..Wang and colleagues identify a fusion between UBE2L3 and KRAS in a subset of metastatic prostate cancers...