Pekka Collin

Summary

Affiliation: University of Tampere
Country: Finland

Publications

  1. pmc Chronic gastritis in dermatitis herpetiformis: a controlled study
    Anna Alakoski
    Department of Dermatology, Tampere University Hospital, 33521 Tampere, Finland
    Clin Dev Immunol 2012:640630. 2012
  2. pmc Clinical benefit of gluten-free diet in screen-detected older celiac disease patients
    Anitta Vilppula
    Department of Neurology, Paijat Hame Central Hospital, Lahti, Finland
    BMC Gastroenterol 11:136. 2011
  3. doi request reprint Video capsule endoscopy in celiac disease: current clinical practice
    Pekka Collin
    Department of Gastroenterology and Alimentary Tract Surgery, Medical School, University of Tampere, Tampere, Finland
    J Dig Dis 13:94-9. 2012
  4. ncbi request reprint Should adults be screened for celiac disease? What are the benefits and harms of screening?
    Pekka Collin
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland
    Gastroenterology 128:S104-8. 2005
  5. ncbi request reprint Antiendomysial and antihuman recombinant tissue transglutaminase antibodies in the diagnosis of coeliac disease: a biopsy-proven European multicentre study
    Pekka Collin
    Tampere University Hospital and University of Tampere, Finland
    Eur J Gastroenterol Hepatol 17:85-91. 2005
  6. ncbi request reprint Should we screen reflux oesophagitis patients for coeliac disease?
    Pekka Collin
    Department of Medicine, Tampere University Hospital, University of Tampere, Finland
    Eur J Gastroenterol Hepatol 16:917-20. 2004
  7. ncbi request reprint The safe threshold for gluten contamination in gluten-free products. Can trace amounts be accepted in the treatment of coeliac disease?
    P Collin
    Department of Medicine, Tampere University Hospital, and Medical School, University of Tampere, Tampere, Finland
    Aliment Pharmacol Ther 19:1277-83. 2004
  8. ncbi request reprint Intraepithelial lymphocytes and coeliac disease
    Pekka Collin
    Tampere University Hospital and University of Tampere, University of Tampere, FIN 33014 Tampere, Finland
    Best Pract Res Clin Gastroenterol 19:341-50. 2005
  9. ncbi request reprint The hunt for coeliac disease in primary care
    P Collin
    Department of Internal Medicine, Tampere University Hospital, Finland
    QJM 95:75-7. 2002
  10. ncbi request reprint Endocrinological disorders and celiac disease
    Pekka Collin
    Department of Medicine, Tampere University Hospital and University of Tampere, 33014 Tampere, Finland
    Endocr Rev 23:464-83. 2002

Detail Information

Publications109 found, 100 shown here

  1. pmc Chronic gastritis in dermatitis herpetiformis: a controlled study
    Anna Alakoski
    Department of Dermatology, Tampere University Hospital, 33521 Tampere, Finland
    Clin Dev Immunol 2012:640630. 2012
    ..Previous small studies suggest that chronic atrophic gastritis is common in dermatitis herpetiformis (DH). We here examined the frequency and topography of chronic gastritis in 93 untreated DH subjects and in 186 controls with dyspepsia...
  2. pmc Clinical benefit of gluten-free diet in screen-detected older celiac disease patients
    Anitta Vilppula
    Department of Neurology, Paijat Hame Central Hospital, Lahti, Finland
    BMC Gastroenterol 11:136. 2011
    ..It remains obscure whether screening makes good or harm in subjects with long-standing gluten ingestion. We evaluated whether older subjects benefit from active detection and subsequent gluten free dietary treatment of celiac disease...
  3. doi request reprint Video capsule endoscopy in celiac disease: current clinical practice
    Pekka Collin
    Department of Gastroenterology and Alimentary Tract Surgery, Medical School, University of Tampere, Tampere, Finland
    J Dig Dis 13:94-9. 2012
    ..A complete examination of the small intestine is possible by video capsule endoscopy (VCE). The aim of this study was to evaluate current indications for performing VCE in celiac disease...
  4. ncbi request reprint Should adults be screened for celiac disease? What are the benefits and harms of screening?
    Pekka Collin
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland
    Gastroenterology 128:S104-8. 2005
    ..Evidence today does not support mass screening of celiac disease. Instead, increased alertness should be observed in patients at risk of the condition...
  5. ncbi request reprint Antiendomysial and antihuman recombinant tissue transglutaminase antibodies in the diagnosis of coeliac disease: a biopsy-proven European multicentre study
    Pekka Collin
    Tampere University Hospital and University of Tampere, Finland
    Eur J Gastroenterol Hepatol 17:85-91. 2005
    ..The setting allowed a further comparison between the antibody results and the conventional small-intestinal histology...
  6. ncbi request reprint Should we screen reflux oesophagitis patients for coeliac disease?
    Pekka Collin
    Department of Medicine, Tampere University Hospital, University of Tampere, Finland
    Eur J Gastroenterol Hepatol 16:917-20. 2004
    ..Oesophagitis and gastro-oesophageal reflux have been implicated recently in the manifestations of coeliac disease. The aim was to investigate this association in a primary-care setting...
  7. ncbi request reprint The safe threshold for gluten contamination in gluten-free products. Can trace amounts be accepted in the treatment of coeliac disease?
    P Collin
    Department of Medicine, Tampere University Hospital, and Medical School, University of Tampere, Tampere, Finland
    Aliment Pharmacol Ther 19:1277-83. 2004
    ..Gluten contamination in gluten-free products cannot totally be avoided. The safe threshold for gluten remains obscure...
  8. ncbi request reprint Intraepithelial lymphocytes and coeliac disease
    Pekka Collin
    Tampere University Hospital and University of Tampere, University of Tampere, FIN 33014 Tampere, Finland
    Best Pract Res Clin Gastroenterol 19:341-50. 2005
    ....
  9. ncbi request reprint The hunt for coeliac disease in primary care
    P Collin
    Department of Internal Medicine, Tampere University Hospital, Finland
    QJM 95:75-7. 2002
    ..Serological screening suggests that most coeliac disease goes undetected...
  10. ncbi request reprint Endocrinological disorders and celiac disease
    Pekka Collin
    Department of Medicine, Tampere University Hospital and University of Tampere, 33014 Tampere, Finland
    Endocr Rev 23:464-83. 2002
    ..Celiac disease will be increasingly detected provided the close association with autoimmune endocrinological diseases is recognized...
  11. doi request reprint Psychoneurotic symptoms and alexithymia in coeliac disease
    Pekka Collin
    Department of Gastroenterology and Alimentary Tract Surgery, Medical School, Tampere University Hospital, Tampere, Finland
    Scand J Gastroenterol 43:1329-33. 2008
    ..The aim of this study was to evaluate whether patients with coeliac disease suffer from psychoneurotic symptoms or alexithymia, and whether a gluten-free diet has an impact on the symptoms...
  12. ncbi request reprint Serologic screening for coeliac disease in risk groups: is once in the lifetime enough?
    P Collin
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, PO Box 2000, FIN 33521 Tampere, Finland
    Dig Liver Dis 40:101-3. 2008
  13. ncbi request reprint Clinical features of celiac disease today
    P Collin
    Departments of Medicine and Paediatrics, Tampere University Hospital, Medical School and Institute of Medical Technology, University of Tampere, Finland
    Dig Dis 17:100-6. 1999
    ..The term latent celiac disease is applied in situations where the patient has normal villous architecture while on a gluten-containing diet, but later develops small bowel villous atrophy compatible with celiac disease...
  14. ncbi request reprint New diagnostic findings in coeliac disease
    P Collin
    Department of Medicine, Tampere University Hospital, and Medical School, University of Tampere, Finland
    Ann Med 31:399-405. 1999
    ....
  15. ncbi request reprint Diagnosis of celiac disease in clinical practice: physician's alertness to the condition essential
    Pekka Collin
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Medical School, Tampere, Finland
    J Clin Gastroenterol 41:152-6. 2007
    ..The aim was to establish whether this approach would offer an alternative to population screening, which has yielded a prevalence of 1% in Finland...
  16. ncbi request reprint Autoimmune hypopituitarism in patients with coeliac disease: symptoms confusingly similar
    P Collin
    Dept of Medicine, Tampere University Hospital, Finland
    Scand J Gastroenterol 36:558-60. 2001
    ..None had a pituitary mass, suggesting that hypopituitarism was of autoimmune origin. Overall condition improved only after replacement therapy for the underlying hormone deficiency; this association should thus be recognized...
  17. ncbi request reprint Recognition and management of the cutaneous manifestations of celiac disease: a guide for dermatologists
    Pekka Collin
    Departments of Medicine and Dermatology, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland
    Am J Clin Dermatol 4:13-20. 2003
    ..By contrast, the reported association of celiac disease with psoriasis seems to be coincidental...
  18. ncbi request reprint Antibodies against deamidated gliadin peptides in early-stage celiac disease
    Kalle Kurppa
    Pediatric Research Centre, University of Tampere, Helsinki, Finland
    J Clin Gastroenterol 45:673-8. 2011
    ..We hypothesized that the antibodies against deamidated gliadin peptides (DGP-AGA) might appear before the other antibodies and would thus be useful in the diagnosis and follow-up of patients with early-stage celiac disease...
  19. doi request reprint Persistently positive gliadin antibodies without transglutaminase antibodies in the elderly: gluten intolerance beyond coeliac disease
    Anitta Ruuskanen
    Department of Neurology, Päijät Häme Central Hospital in Lahti, Finland
    Dig Liver Dis 43:772-8. 2011
    ..The specificity of the conventional gliadin antibody test is considered low...
  20. pmc Serological responses to microbial antigens in celiac disease patients during a gluten-free diet
    Sara Ashorn
    Paediatric Research Centre and Medical School, University of Tampere and Tampere University Hospital, Tampere, Finland
    J Clin Immunol 29:190-5. 2009
    ..Further, we wanted to evaluate whether these serologic specificities could provide new tools for the follow-up of CD patients...
  21. doi request reprint Serodiagnostic assays for celiac disease based on the open or closed conformation of the autoantigen, transglutaminase 2
    Katri Lindfors
    Pediatric Research Center, University of Tampere and Tampere University Hospital, Tampere, Finland
    J Clin Immunol 31:436-42. 2011
    ..It thus offers a promising tool in the diagnostics and follow-up of celiac disease...
  22. ncbi request reprint Burden of illness and use of health care services before and after celiac disease diagnosis in children
    Eeva Mattila
    School of Medicine, University of Tampere, Tampere, Finland
    J Pediatr Gastroenterol Nutr 57:53-6. 2013
    ..We investigated these issues prospectively in newly detected patients with celiac disease before and after diagnosis in a large nationwide cohort of children...
  23. pmc Predictors of persistent symptoms and reduced quality of life in treated coeliac disease patients: a large cross-sectional study
    Pilvi Paarlahti
    Tampere Centre for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland
    BMC Gastroenterol 13:75. 2013
    ..We aimed to find predictors for these continuous health concerns in long-term treated adult coeliac patients...
  24. doi request reprint Utility of the new ESPGHAN criteria for the diagnosis of celiac disease in at-risk groups
    Kalle Kurppa
    University of Tampere, Tampere, Finland
    J Pediatr Gastroenterol Nutr 54:387-91. 2012
    ..The utility of these new criteria was evaluated by applying the human red blood cell TG2 antibody test (RBC-TG2ab) to a large cohort of children and adults belonging to at-risk groups...
  25. ncbi request reprint Diagnosing mild enteropathy celiac disease: a randomized, controlled clinical study
    Kalle Kurppa
    Paediatric Research Centre, University of Tampere and Tampere University Hospital, Tampere, Finland
    Gastroenterology 136:816-23. 2009
    ..We hypothesized that patients with mild enteropathy but positive endomysial antibodies benefit from a gluten-free diet (GFD) similarly to patients with more severe enteropathy...
  26. doi request reprint Degree of damage to the small bowel and serum antibody titers correlate with clinical presentation of patients with celiac disease
    Juha Taavela
    Pediatric Research Centre, University of Tampere and Tampere University Hospital, Tampere, Finland
    Clin Gastroenterol Hepatol 11:166-71.e1. 2013
    ..We investigated whether the degree of mucosal damage to the small bowel correlates with clinical presentation and serum markers of celiac disease...
  27. ncbi request reprint Burden of illness in screen-detected children with celiac disease and their families
    Sampsa Kinos
    School of Medicine, University of Tampere, Tampere, Finland
    J Pediatr Gastroenterol Nutr 55:412-6. 2012
    ..We assessed health and well-being and the effect of a 1-year gluten-free diet in a nationwide cohort of children with celiac disease detected by screening in at-risk groups...
  28. pmc Endomysial antibodies predict celiac disease irrespective of the titers or clinical presentation
    Kalle Kurppa
    Pediatric Research Centre, University of Tampere and Tampere University Hospital, FIN 33014, Tampere, Finland
    World J Gastroenterol 18:2511-6. 2012
    ..To investigate the association between serum antibody levels and a subsequent celiac disease diagnosis in a large series of children and adults...
  29. doi request reprint IgA-class autoantibodies against neuronal transglutaminase, TG6 in celiac disease: no evidence for gluten dependency
    Katri Lindfors
    Pediatric Research Center, University of Tampere and Tampere University Hospital, Tampere, Finland
    Clin Chim Acta 412:1187-90. 2011
    ..We here investigated whether TG6-targeted autoantibodies are a characteristic feature of celiac patients, especially those with neurological symptoms, and further, whether such antibodies are gluten-dependent...
  30. doi request reprint Gluten-dependent small bowel mucosal transglutaminase 2-specific IgA deposits in overt and mild enteropathy coeliac disease
    Outi Koskinen
    Pediatric Research Centre, University of Tampere, Finland
    J Pediatr Gastroenterol Nutr 47:436-42. 2008
    ..We evaluated the gluten dependency of these deposits in overt and mild enteropathy coeliac disease...
  31. doi request reprint Usefulness of small-bowel mucosal transglutaminase-2 specific autoantibody deposits in the diagnosis and follow-up of celiac disease
    Outi Koskinen
    Pediatric Research Center, University of Tampere, Tampere, Finland
    J Clin Gastroenterol 44:483-8. 2010
    ..Furthermore, as the often compromised quality of biopsy specimens renders diagnosis difficult, new diagnostic tools are warranted...
  32. doi request reprint Intestinal transglutaminase 2 specific antibody deposits in non-responsive coeliac disease
    Outi Koskinen
    Pediatric Research Center and Medical School, University of Tampere, FIN 33014 Tampere, Finland
    Dig Liver Dis 42:692-7. 2010
    ..We investigated whether small-bowel mucosal transglutaminase-2 specific autoantibody deposits distinguish non-responsive coeliac disease from other enteropathies...
  33. ncbi request reprint The risk of colorectal cancer in patients with inflammatory bowel diseases in Finland: a follow-up of 20 years
    Pia Manninen
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Finland Tampere Medical School, University of Tampere, Tampere, Finland Electronic address
    J Crohns Colitis 7:e551-7. 2013
    ..To prevent the development of cancer, endoscopic facilities should be targeted correctly. We report here the results of a 20-year follow-up in Finland and evaluate the efficacy of endoscopic surveillance in cancer prevention...
  34. doi request reprint Factors associated with dietary adherence in celiac disease: a nationwide study
    Kalle Kurppa
    Pediatric Research Center, University of Tampere and Tampere University Hospital, Tampere, Finland
    Digestion 86:309-14. 2012
    ..In order to establish whether this has affected the success of treatment, and to identify predictors for dietary non-adherence, we carried out a study in a nationwide cohort of treated celiac patients...
  35. ncbi request reprint Celiac disease: from inflammation to atrophy: a long-term follow-up study
    Marja Leena Lähdeaho
    Department of Pediatrics and Internal Medicine, Tampere University Hospital and Medical School, University of Tampere, Finland
    J Pediatr Gastroenterol Nutr 41:44-8. 2005
    ..The aim of this study was to evaluate the role of intraepithelial lymphocytosis and marginally decreased villous height/crypt depth ratio in the development of overt villous atrophy in a long-term follow-up...
  36. doi request reprint Positive serum antigliadin antibodies without celiac disease in the elderly population: does it matter?
    Anitta Ruuskanen
    Department of Neurology, Päijät Häme Central Hospital in Lahti, Finland
    Scand J Gastroenterol 45:1197-202. 2010
    ..However, data suggest that AGA positivity might be related to distinct disease entities such as allergy and gluten ataxia. Our aim here is to explore the clinical relevance of positive AGA in the elderly population...
  37. pmc Use of health care services and pharmaceutical agents in coeliac disease: a prospective nationwide study
    Anniina Ukkola
    School of Medicine, FinnMedi3, University of Tampere, FIN 33014, Tampere, Finland
    BMC Gastroenterol 12:136. 2012
    ..Unexplained symptoms may lead to incremented medical consultations and productivity losses. The aim here was to estimate the possible concealed burden of untreated coeliac disease and the effects of a gluten-free diet...
  38. ncbi request reprint Gastrointestinal symptoms and quality of life in screen-detected celiac disease
    Aku Paavola
    School of Medicine, University of Tampere, Tampere, Finland
    Dig Liver Dis 44:814-8. 2012
    ..The effects of a long-term gluten-free diet on possible gastrointestinal symptoms and psychological well-being in screen-detected patients have nevertheless remained obscure...
  39. doi request reprint Symptom-detected and screen-detected celiac disease and adult height: a large cohort study
    Aleksi Pärnänen
    Pediatric Research Centre, Tampere University Hospital, Tampere, Finland
    Eur J Gastroenterol Hepatol 24:1066-70. 2012
    ..We aimed to assess the final height in a large cohort of symptom-detected and screen-detected patients with celiac disease diagnosed in adulthood...
  40. ncbi request reprint Resurrection of gliadin antibodies in coeliac disease. Deamidated gliadin peptide antibody test provides additional diagnostic benefit
    Katri Kaukinen
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Finland
    Scand J Gastroenterol 42:1428-33. 2007
    ..The purpose of this study was to compare these serological tests with a new test recognizing antibodies against deamidated and defined gliadin peptides...
  41. ncbi request reprint Coeliac disease, autoimmune diseases and gluten exposure
    Mervi Viljamaa
    Department of Internal Medicine, Tampere University Hospital, Finland
    Scand J Gastroenterol 40:437-43. 2005
    ..The aim here was to investigate the occurrence of autoimmune disorders in relation to gluten intake in coeliac patients in a well-defined area...
  42. pmc Long-term consumption of oats in adult celiac disease patients
    Katri Kaukinen
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere FIN 33521, Finland
    Nutrients 5:4380-9. 2013
    ..Oat-consumers had a significantly higher daily intake of fiber than those who did not use oats. Two thirds of celiac disease patients preferred to use oats in their daily diet. Even long-term ingestion of oats had no harmful effects. ..
  43. pmc Increasing prevalence and high incidence of celiac disease in elderly people: a population-based study
    Anitta Vilppula
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    BMC Gastroenterol 9:49. 2009
    ....
  44. doi request reprint Gastrointestinal symptoms, quality of life and bone mineral density in mild enteropathic coeliac disease: a prospective clinical trial
    Kalle Kurppa
    Paediatric Research Centre, University of Tampere and Tampere University Hospital, Tampere, Finland
    Scand J Gastroenterol 45:305-14. 2010
    ..The aim of this study was to evaluate gastrointestinal symptoms, quality of life and bone mineral density in patients with mild enteropathy, and the effect of a gluten-free diet...
  45. ncbi request reprint IgA-class transglutaminase antibodies in evaluating the efficacy of gluten-free diet in coeliac disease
    Katri Kaukinen
    Department of Internal Medicine, University of Tampere, Tampere, Finland
    Eur J Gastroenterol Hepatol 14:311-5. 2002
    ..We investigated whether the tissue transglutaminase antibody test could substitute biopsy in this respect, and whether the test is better than the endomysial antibody test in follow-up...
  46. doi request reprint Gluten-sensitive hypertransaminasemia in celiac disease: an infrequent and often subclinical finding
    Satu Korpimäki
    Pediatric Research Center, University of Tampere and Tampere University Hospital, Tampere, Finland
    Am J Gastroenterol 106:1689-96. 2011
    ..We investigated the prevalence and gluten dependency of hypertransaminasemia in celiac patients also diagnosed with minor or atypical symptoms...
  47. ncbi request reprint Small Bowel Transglutaminase 2-specific IgA Deposits in Dermatitis Herpetiformis
    Teea T Salmi
    Department of Dermatology, Tampere University Hospital, FIN 33521 Tampere, Finland
    Acta Derm Venereol 94:393-7. 2014
    ..The results show that the majority of untreated DH patients have similar gluten-dependent TG2-specific IgA deposits the small bowel mucosa as coeliac disease patients. ..
  48. pmc Validation of morphometric analyses of small-intestinal biopsy readouts in celiac disease
    Juha Taavela
    Tampere Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland
    PLoS ONE 8:e76163. 2013
    ..g. Marsh groups), but this is often too imprecise and ignores minor but significant changes in the mucosa. Consequently, there is a need for validated continuous variables in everyday practice and in academic and pharmacological research...
  49. ncbi request reprint Oats can diversify a gluten-free diet in celiac disease and dermatitis herpetiformis
    Markku Peräaho
    Department of Medicine, Tampere University Hospital, Tampere, Finland
    J Am Diet Assoc 104:1148-50. 2004
    ..There is a market demand for oats, and celiac societies and dietitians should make efforts to promote the development of products free of wheat contamination...
  50. ncbi request reprint Intraepithelial lymphocytes in celiac disease
    Teea T Järvinen
    Department of Internal Medicine, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland
    Am J Gastroenterol 98:1332-7. 2003
    ..The aim of this study was to investigate the value of immunohistochemical characterization of different intraepithelial lymphocytes (IELs) in the diagnostic workup of celiac disease (CD)...
  51. ncbi request reprint Comparison of a novel whole blood transglutaminase-based ELISA with a whole blood rapid antibody test and established conventional serological celiac disease assays
    Tiina Raivio
    Paediatric Research Centre, University of Tampere, Finland
    J Pediatr Gastroenterol Nutr 47:562-7. 2008
    ..We assessed the value of this new test in celiac disease antibody detection...
  52. doi request reprint Future treatment strategies for celiac disease
    Katri Lindfors
    University of Tampere and Tampere University Hospital, School of Medicine, Pediatric Research Center, Finn Medi 3, FIN 33014, Tampere, Finland
    Expert Opin Ther Targets 16:665-75. 2012
    ..Currently, the only effective treatment is a strict life-long gluten-free diet excluding all gluten-containing food products. In view of the extremely restricted nature of the diet, new treatment options would clearly be desirable...
  53. doi request reprint Changes in body mass index on a gluten-free diet in coeliac disease: a nationwide study
    Anniina Ukkola
    School of Medicine, University of Tampere, Tampere, Finland
    Eur J Intern Med 23:384-8. 2012
    ..The aim of the study was to evaluate the impact of a GFD on the body mass index (BMI) in a nationwide cohort of coeliac patients and to determine variables predictive of favourable or unfavourable BMI changes...
  54. ncbi request reprint Patients' experiences and perceptions of living with coeliac disease - implications for optimizing care
    Anniina Ukkola
    School of Medicine, University of Tampere and Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Finland
    J Gastrointestin Liver Dis 21:17-22. 2012
    ..Little is known regarding the impact of coeliac disease on daily living from patients' own viewpoints. The aim of the study was to investigate patients' perceptions of their disease, dietary treatment and self-rated healthcare needs...
  55. doi request reprint The diagnostic value of video capsule endoscopy
    Heidi Niemenmaa
    Tampere University Hospital, Department of Gastroenterology and Alimentary Tract Surgery and University of Tampere, Tampere, Finland
    Eur J Intern Med 21:383-5. 2010
    ..Video capsule endoscopy (VCE) offers the best means of studying small bowel, but is expensive. We investigated how physicians appraise the value of VCE...
  56. ncbi request reprint HLA-DQ typing in the diagnosis of celiac disease
    Katri Kaukinen
    Department of Internal Medicine, Tampere University Hospital, Finland
    Am J Gastroenterol 97:695-9. 2002
    ..Our aim was to investigate whether HLA-DQ2 and -DQ8 typing is helpful when diagnosis is uncertain because of the absence of unequivocal small bowel villous atrophy...
  57. doi request reprint Galactosylation of serum IgA1 O-glycans in celiac disease
    Katri Lindfors
    Pediatric Research Center, University of Tampere and Tampere University Hospital, Finn Medi 3, FIN 33014 Tampere, Finland
    J Clin Immunol 31:74-9. 2011
    ..Thus, the undergalactosylated IgA1 molecules are not pathognomonic for celiac disease, but galactose deficiency in IgA1 could be an aggravating factor...
  58. ncbi request reprint Age, symptoms and upper gastrointestinal malignancy in primary care endoscopy
    Maarit Salo
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Scand J Gastroenterol 43:122-7. 2008
    ..Upper gastrointestinal complaints are common in the general population. The aim of this study was to establish whether age and occurrence of alarm symptoms are predictors of malignancy in primary care open-access endoscopy...
  59. pmc Latent coeliac disease or coeliac disease beyond villous atrophy?
    Katri Kaukinen
    Medical School, University of Tampere, Finland
    Gut 56:1339-40. 2007
  60. doi request reprint Diet improves perception of health and well-being in symptomatic, but not asymptomatic, patients with celiac disease
    Anniina Ukkola
    Medical School, University of Tampere, Tampere, Finland
    Clin Gastroenterol Hepatol 9:118-23. 2011
    ..We investigated the impact of a gluten-free diet on self-perceived health and well-being in symptomatic and asymptomatic patients with celiac disease...
  61. doi request reprint Mortality in ulcerative colitis and Crohn's disease. A population-based study in Finland
    Pia Manninen
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    J Crohns Colitis 6:524-8. 2012
    ..We evaluated the long-term mortality risk of patients with inflammatory bowel diseases (IBD) in a well-defined population...
  62. doi request reprint Gluten-free diet and autoimmune thyroiditis in patients with celiac disease. A prospective controlled study
    Saara Metso
    Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
    Scand J Gastroenterol 47:43-8. 2012
    ..We investigated the course of autoimmune thyroid diseases in newly diagnosed celiac disease patients before and after gluten-free dietary treatment...
  63. ncbi request reprint Gluten-free diet and quality of life in patients with screen-detected celiac disease
    Kirsi Mustalahti
    Department of Pediatrics, Tampere University Hospital, Finland
    Eff Clin Pract 5:105-13. 2002
    ..Although pathologic changes of celiac disease resolve on a gluten-free diet, how a gluten-free diet affects the quality of life for patients with screen-detected celiac disease is unclear...
  64. pmc Elevated serum anti-Saccharomyces cerevisiae, anti-I2 and anti-OmpW antibody levels in patients with suspicion of celiac disease
    Sara Ashorn
    Paediatric Research Centre and Medical School, University of Tampere and Tampere University Hospital, Tampere, Finland
    J Clin Immunol 28:486-94. 2008
    ....
  65. doi request reprint The prevalence of celiac disease in Europe: results of a centralized, international mass screening project
    Kirsi Mustalahti
    Paediatric Research Centre, University of Tampere and Department of Paediatrics, Tampere University Hospital, Tampere, Finland
    Ann Med 42:587-95. 2010
    ....
  66. doi request reprint Coeliac disease--a diagnostic and therapeutic challenge
    Katri Kaukinen
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Clin Chem Lab Med 48:1205-16. 2010
    ..Currently, the only effective treatment for the condition is a life-long strict gluten-free diet. Long-term regular follow-up of patients is recommended in order to maintain good adherence to the diet...
  67. pmc Type 1 diabetes is associated with enterovirus infection in gut mucosa
    Maarit Oikarinen
    Department of Virology, School of Medicine, University of Tampere, Tampere, Finland
    Diabetes 61:687-91. 2012
    ..This finding opens new opportunities for studying the viral etiology of type 1 diabetes...
  68. ncbi request reprint Coeliac disease presenting with neurological disorders
    L Luostarinen
    Department of Neurology, Tampere University Hospital, Kuopio, Finland
    Eur Neurol 42:132-5. 1999
    ..In these patient groups screening for coeliac disease with serological antibody tests helps to find patients who may suffer from this disease...
  69. ncbi request reprint Immunoglobulin A autoantibodies against transglutaminase 2 in the small intestinal mucosa predict forthcoming coeliac disease
    T T Salmi
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Aliment Pharmacol Ther 24:541-52. 2006
    ..Reliable markers of early developing coeliac diseases are needed. Coeliac autoantibodies in the serum or Marsh I inflammation may be indicators of subsequent coeliac disease...
  70. doi request reprint The duodenal microbiota composition of adult celiac disease patients is associated with the clinical manifestation of the disease
    Pirjo Wacklin
    Finnish Red Cross Blood Service, Helsinki, Finland
    Inflamm Bowel Dis 19:934-41. 2013
    ..In this study, the role of duodenal microbiota in the celiac disease outcome was studied by analyzing mucosa-associated microbiota in celiac disease patients with a variety of intestinal and extraintestinal symptoms...
  71. doi request reprint The epidemiology of inflammatory bowel diseases in Finland
    Pia Manninen
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Scand J Gastroenterol 45:1063-7. 2010
    ..We here conducted an epidemiological survey using a population-based register in a well-defined area representative of the whole Finnish population...
  72. doi request reprint Celiac disease and health-related quality of life
    Kalle Kurppa
    Paediatric Research Center, University of Tampere and Tampere University Hospital, FIN 33014, Finland
    Expert Rev Gastroenterol Hepatol 5:83-90. 2011
    ..This article highlights the studies of health-related quality of life and celiac disease conducted to date. Particular attention is paid to the extraintestinal and atypical forms of the disorder...
  73. ncbi request reprint Antibodies in relation to gluten intake
    M Maki
    Institute of Medical Technology, University of Tampere, Tampere, Finland
    Dig Dis 16:330-2. 1998
    ..However, slight dietary transgressions and minor mucosal damages cannot always be revealed with the serological tests. Therefore, small-bowel mucosal biopsy remains the most sensitive method to monitor the effect of a gluten-free diet...
  74. doi request reprint Diagnostic methods beyond conventional histology in coeliac disease diagnosis
    T T Salmi
    Department of Dermatology, Tampere University Hospital, Medical School, University of Tampere, Tampere, Finland
    Dig Liver Dis 42:28-32. 2010
    ..Coeliac disease diagnostic criteria currently require the detection of small bowel mucosal villous atrophy and crypt hyperplasia...
  75. ncbi request reprint Coeliac disease among healthy members of multiple case coeliac disease families
    K Mustalahti
    Medical School, Paediatric Research Center, University of Tampere, Finland
    Scand J Gastroenterol 37:161-5. 2002
    ..The correlation of endomysial and tissue transglutaminase antibodies and the correlation of endomysial antibodies to the HLA typical for coeliac disease was determined...
  76. pmc Blisters in the small intestinal mucosa of coeliac patients contain T cells positive for cyclooxygenase 2
    H Kainulainen
    Institute of Medical Technology, University of Tampere, Tampere, Finland
    Gut 50:84-9. 2002
    ..We have investigated expression of COX-2 in the coeliac disease affected small intestinal mucosa where it may be an indicator of either disease induction or mucosal restoration processes...
  77. ncbi request reprint Performance of a new rapid whole blood coeliac test in adult patients with low prevalence of endomysial antibodies
    T Raivio
    Paediatric Research Centre, University of Tampere, Tampere, Finland
    Dig Liver Dis 39:1057-63. 2007
    ..In coeliac disease endomysial and transglutaminase autoantibodies are directed against the human autoantigen, transglutaminase. The conventional coeliac antibody tests are performed from serum samples in centralized laboratories...
  78. ncbi request reprint cDNA microarray analysis of gene expression in coeliac disease jejunal biopsy samples
    K Juuti-Uusitalo
    Paediatric Research Centre, Tampere University Hospital, University of Tampere, FIN 33014 Tampere, Finland
    J Autoimmun 22:249-65. 2004
    ..The method holds promise in exploring the pathogenetic mechanisms in the small bowel and may reveal new target genes for the therapy of coeliac disease...
  79. pmc Endomysial antibody-negative coeliac disease: clinical characteristics and intestinal autoantibody deposits
    T T Salmi
    Medical School, University of Tampere, Finland 33014
    Gut 55:1746-53. 2006
    ..Some patients with untreated coeliac disease are negative for serum endomysial autoantibodies (EmA) targeted against transglutaminase 2 (TG2)...
  80. ncbi request reprint Celiac disease in patients with severe liver disease: gluten-free diet may reverse hepatic failure
    Katri Kaukinen
    Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
    Gastroenterology 122:881-8. 2002
    ..Mild liver abnormalities are common in patients with celiac disease and usually resolve with a gluten-free diet. We investigated the occurrence of celiac disease in patients with severe liver failure...
  81. ncbi request reprint Lymphoma in patients with dermatitis herpetiformis and their first-degree relatives
    K Hervonen
    Department of Dermatology, Tampere University Hospital, PO Box 2000, FIN 33521 Tampere, Finland
    Br J Dermatol 152:82-6. 2005
    ..The risk for lymphoma is increased in both dermatitis herpetiformis (DH) and in coeliac disease. The lymphoma most associated with coeliac disease is enteropathy-associated T-cell lymphoma...
  82. ncbi request reprint Wheat-starch-based gluten-free products in the treatment of newly detected coeliac disease: prospective and randomized study
    M Peräaho
    Department of Medicine, Tampere University Hospital, Tampere, Finland
    Aliment Pharmacol Ther 17:587-94. 2003
    ..The safety of wheat-starch-based gluten-free products in the treatment of coeliac disease is debatable. Prospective studies are lacking...
  83. doi request reprint Clinical trial: gluten microchallenge with wheat-based starch hydrolysates in coeliac disease patients - a randomized, double-blind, placebo-controlled study to evaluate safety
    K Kaukinen
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, and Medical School, University of Tampere, Tampere, Finland
    Aliment Pharmacol Ther 28:1240-8. 2008
    ..These products contain low amounts of residual gluten and it has been questioned whether they are safe for coeliac disease patients...
  84. doi request reprint Ascites: aetiology, mortality and the prevalence of spontaneous bacterial peritonitis
    Jahangir Khan
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland
    Scand J Gastroenterol 44:970-4. 2009
    ..The validity of an elevated (>11 g/l) serum-ascites albumin gradient (SAAG) in the diagnostic work-up was evaluated. Mortality trends were observed over two periods of time...
  85. ncbi request reprint Small bowel cyclooxygenase 2 (COX-2) expression in patients with IgA nephropathy
    Teemu Honkanen
    Department of Pathology, Tampere University Hospital, Tampere, Finland
    Kidney Int 67:2187-95. 2005
    ..An intestinal inflammation has also been described. We hypothesized that the intestinal inflammation should manifest itself as an increase in inflammatory cells and mucosal cyclooxygenase 2 (COX-2) expression...
  86. ncbi request reprint Small bowel T cells, HLA class II antigen DR, and GroEL stress protein in IgA nephropathy
    I Rantala
    Pathology Unit, Department of Internal Medicine, Tampere University Hospital, Finland
    Kidney Int 55:2274-80. 1999
    ..To further clarify this involvement, we investigated whether or not IgAN patients have small bowel mucosal findings suggestive of inflammation and stress...
  87. ncbi request reprint Persistent small bowel mucosal villous atrophy without symptoms in coeliac disease
    K Kaukinen
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Aliment Pharmacol Ther 25:1237-45. 2007
    ..Refractory sprue with malabsorption carries a risk of lymphoma...
  88. ncbi request reprint Malignancies and mortality in patients with coeliac disease and dermatitis herpetiformis: 30-year population-based study
    M Viljamaa
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, P O Box 2000, FIN 33521 Tampere, Finland
    Dig Liver Dis 38:374-80. 2006
    ..The risks have probably been overestimated, as patients with subtle forms have earlier remained undetected...
  89. ncbi request reprint Selective IgA deficiency and coeliac disease
    P Collin
    Dept of Clinical Sciences, University of Tampere, Finland
    Scand J Gastroenterol 27:367-71. 1992
    ..Patients with IgA deficiency also had other concomitant diseases, especially autoimmune diseases. Patients with selective IgA deficiency have at least a tenfold risk of coeliac disease compared with the population in general...
  90. ncbi request reprint Villous tip intraepithelial lymphocytes as markers of early-stage coeliac disease
    T T Järvinen
    Dept of Internal Medicine, Tampere University Hospital, Medical School, University of Tampere, Tampere, Finland
    Scand J Gastroenterol 39:428-33. 2004
    ..An investigation was conducted to determine whether the density of small-intestinal villous tip intraepithelial lymphocytes would be of value in clinical practice in uncovering early-stage coeliac disease...
  91. pmc Neuromuscular and sensory disturbances in patients with well treated coeliac disease
    L Luostarinen
    Department of Neurology, Tampere University Hospital and Medical School, University of Tampere, Lahti, Finland
    J Neurol Neurosurg Psychiatry 74:490-4. 2003
    ..The aim of this study was to assess in a controlled study whether patients with treated coeliac disease carry an increased risk for neuropathy and characterise the type of possible neuropathy...
  92. ncbi request reprint The occurrence of type 1 diabetes in patients with dermatitis herpetiformis and their first-degree relatives
    K Hervonen
    Department of Dermatology, Tampere University Hospital and Medical School, University of Tampere, PO Box 2000, FIN 33531, Tampere, Finland
    Br J Dermatol 150:136-8. 2004
    ..The increased prevalence of type 1 diabetes (T1D) is well documented in patients with coeliac disease, whereas evidence is scanty in patients with dermatitis herpetiformis (DH)...
  93. ncbi request reprint First-degree relatives are frequently affected in coeliac disease and dermatitis herpetiformis
    K Hervonen
    Dept of Dermatology, Tampere University Hospital and University of Tampere, Finland
    Scand J Gastroenterol 37:51-5. 2002
    ..Coeliac disease is known to cluster in families, whereas there is little evidence for dermatitis herpetiformis and for the occurrence of both diseases in the same families...
  94. ncbi request reprint Clinical and subclinical autoimmune thyroid disease in adult celiac disease
    M Hakanen
    Department of Medicine, Tampere University Hospital, Medical School, Finland
    Dig Dis Sci 46:2631-5. 2001
    ..In conclusion, the occurrence of both clinical and subclinical autoimmune thyroid disease was increased in celiac disease; subclinical thyroid disease indicates regular surveillance...
  95. ncbi request reprint Is coeliac disease screening in risk groups justified? A fourteen-year follow-up with special focus on compliance and quality of life
    M Viljamaa
    Department of Gastroenterology, Tampere University Hospital, UKK Institute for Health Promotion Research, School of Public Health, Medical School, University of Tampere, Finland
    Aliment Pharmacol Ther 22:317-24. 2005
    ..The benefits of serologic screening for coeliac disease in asymptomatic individuals are debatable...
  96. ncbi request reprint Self transglutaminase-based rapid coeliac disease antibody detection by a lateral flow method
    T Raivio
    Paediatric Research Centre, University of Tampere, Finland
    Aliment Pharmacol Ther 24:147-54. 2006
    ..The conventional coeliac disease antibody tests require patient's sera, and are laborious and time-consuming...
  97. ncbi request reprint Increasing prevalence of coeliac disease over time
    S Lohi
    Paediatric Research Center, Medical School, University of Tampere, Tampere, Finland
    Aliment Pharmacol Ther 26:1217-25. 2007
    ..The number of coeliac disease diagnoses has increased in the recent past and according to screening studies, the total prevalence of the disorder is around 1%...
  98. ncbi request reprint Association between coeliac disease, epilepsy and brain atrophy
    L Luostarinen
    Department of Neurology, Tampere University Hospital and Institute of Medical Technology, University of Tampere, Finland
    Eur Neurol 46:187-91. 2001
    ..Prevalence of CD was increased among patients with epilepsy of unknown aetiology, but the combination of CD, epilepsy and intracranial posterior calcifications was rare in Finnish adult epilepsy population...
  99. ncbi request reprint Celiac disease without villous atrophy: revision of criteria called for
    K Kaukinen
    Department of Internal Medicine, Tampere University Hospital, University of Tampere, Finland
    Dig Dis Sci 46:879-87. 2001
    ..Our patients showed a clinical, histological, and serological recovery on diet; risk of osteopenia speaks in favor of dietary treatment...
  100. ncbi request reprint Complete small intestine mucosal recovery is obtainable in the treatment of celiac disease
    Pekka Collin
    Gastrointest Endosc 59:158-9; author reply 159-60. 2004