Research Topics
Genomes and Genes
| Eero CastrenSummaryAffiliation: University of Helsinki Country: Finland Publications
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Detail Information
Publications
Neuronal plasticity and antidepressant actionsEero Castren
Neuroscience Center, University of Helsinki, P O Box 56, 00014 Helsinki, Finland Electronic address
Trends Neurosci 36:259-67. 2013..Increased variability together with competition-mediated selection facilitates normal function, such as pattern separation within the dentate gyrus and other mood-related circuits, thereby enhancing adaptability toward novel experiences...- Treatment of neurodevelopmental disorders in adulthoodEero Castren
Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland
J Neurosci 32:14074-9. 2012..Even though translation from animal experimentation to clinical practice is challenging, these results suggest a rational basis for treatment of neurodevelopmental disorders in adulthood... 
The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticityEero Castren
Sigrid Jusélius Laboratory, Neuroscience Center, University of Helsinki, Helsinki, Finland
Dev Neurobiol 70:289-97. 2010....- Role of brain-derived neurotrophic factor in the aetiology of depression: implications for pharmacological treatmentEero Castren
Sigrid Jusélius Laboratory, Neuroscience Center, University of Helsinki, Helsinki, Finland
CNS Drugs 24:1-7. 2010..This hypothesis suggests that antidepressant drugs should not be used alone but should always be combined with rehabilitation to guide the plastic networks within the brain... 
[On new mechanisms of action of centrally active drugs]Eero Castren
Helsingin yliopisto, Neurotieteen tutkimuskeskus PL 56, 00014 Helsingin yliopisto
Duodecim 119:1487-95. 2003- Role of neurotrophic factors in depressionEero Castren
Sigrid Jusélius Laboratory of Molecular Neuroscience, Neuroscience Center, University of Helsinki, PO Box 56, 00014 Helsinki, Finland
Curr Opin Pharmacol 7:18-21. 2007..Neurotrophic factors themselves do not control mood, but they act as necessary tools in the activity-dependent modulation of networks, the physiological function of which determines how a plastic change influences mood... - Neurotrophins as mediators of drug effects on mood, addiction, and neuroprotectionEero Castren
Neuroscience Center, University of Helsinki, P O Box 56, 00014 Helsinki, Finland
Mol Neurobiol 29:289-302. 2004.... - Is mood chemistry?Eero Castren
Neuroscience Center, University of Helsinki, Finland
Nat Rev Neurosci 6:241-6. 2005.... - Neurotrophic effects of antidepressant drugsEero Castren
Sigrid Jusélius professor of Neuroscience, Neuroscience Center, University of Helsinki, PO Box 56, 00014 Helsinki, Finland
Curr Opin Pharmacol 4:58-64. 2004.... - The antidepressant-like effects of glutamatergic drugs ketamine and AMPA receptor potentiator LY 451646 are preserved in bdnf⁺/⁻ heterozygous null miceJesse S O Lindholm
Neuroscience Center, University of Helsinki, Helsinki, Finland
Neuropharmacology 62:391-7. 2012..This article is part of a Special Issue entitled 'Anxiety and Depression'... - Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cgamma signaling pathways in mouse brainTomi Rantamäki
Neuroscience Center, University of Helsinki, PO Box 56, 00014 Helsinki, Finland
Neuropsychopharmacology 32:2152-62. 2007..In conclusion, our data suggest that rapid activation of the TrkB neurotrophin receptor and PLCgamma1 signaling is a common mechanism for all antidepressant drugs... - The responsiveness of TrkB to BDNF and antidepressant drugs is differentially regulated during mouse developmentAntonio Di Lieto
Sigrid Jusélius Laboratory, Neuroscience Center, University of Helsinki, Helsinki, Finland
PLoS ONE 7:e32869. 2012..When administered during early postnatal life, ADs produce long-lasting biochemical and behavioural alterations that are observed in adult animals... - BDNF and TrkB in neuronal differentiation of Fmr1-knockout mouseVerna Louhivuori
Department of Biomedicine Physiology, University of Helsinki, PO Box 63, FIN 00014 Helsinki, Finland
Neurobiol Dis 41:469-80. 2011..Altogether, the present data suggest that alterations in the BDNF/TrkB signaling modulate brain development and impair synaptic plasticity in FXS... - Long-lasting behavioural and molecular alterations induced by early postnatal fluoxetine exposure are restored by chronic fluoxetine treatment in adult miceNina N Karpova
Neuroscience Centre, University of Helsinki, 00014 Helsinki, Finland
Eur Neuropsychopharmacol 19:97-108. 2009..Our experiments show that behavioural and molecular changes induced by early postnatal fluoxetine administration are reversed by chronic fluoxetine treatment of adult mice to control levels... - Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampusHenri Autio
Neuroscience Center, University of Helsinki, P O Box 56, 00790 Helsinki, Finland
Neuropharmacology 61:1291-6. 2011..Our findings show that acetylcholinesterase inhibitors are capable of rapidly activating hippocampal neurotrophin signaling and thus suggest that therapies targeting Trk signaling may already be in clinical use in the treatment of AD... - Fear erasure in mice requires synergy between antidepressant drugs and extinction trainingNina N Karpova
Sigrid Jusélius Laboratory, Neuroscience Center, University of Helsinki, Helsinki, Finland
Science 334:1731-4. 2011..Thus, the pharmacological effects of antidepressants need to be combined with psychological rehabilitation to reorganize networks rendered more plastic by the drug treatment... - Brain-derived neurotrophic factor controls activity-dependent maturation of CA1 synapses by downregulating tonic activation of presynaptic kainate receptorsMarko Sallert
Neuroscience Center, University of Helsinki, FI 00014 Helsinki, Finland
J Neurosci 29:11294-303. 2009.... - Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neuronsSatu Massinen
Research Program s Unit, Molecular Medicine and Department of Medical Genetics, University of Helsinki, Helsinki, Finland
PLoS ONE 6:e20580. 2011..Moreover, DCDC2 overexpression in C. elegans causes an abnormal neuronal phenotype that can only be seen in ciliated neurons. Together our results suggest a potential role for DCDC2 in the structure and function of primary cilia... - Aberrant differentiation of glutamatergic cells in neocortex of mouse model for fragile X syndromeTopi A Tervonen
Neuroscience Center, University of Helsinki, P O Box 56, 00014 Helsinki, Finland
Neurobiol Dis 33:250-9. 2009..These abnormalities were associated with an increased density of pyramidal cells of the layer V in the early postnatal neocortex suggesting a role for FMRP in the regulation of the differentiation of neocortical glutamatergic neurons... - The aromatase gene CYP19A1: several genetic and functional lines of evidence supporting a role in reading, speech and languageHeidi Anthoni
Department of Medical Genetics, Biomedicum, University of Helsinki, 00014, Helsinki, Finland
Behav Genet 42:509-27. 2012..An aromatase inhibitor reduced dendritic growth in cultured rat neurons. From this broad set of evidence, we propose CYP19A1 as a candidate gene for human cognitive functions implicated in reading, speech and language... - Regulation of brain-derived neurotrophic factor (BDNF) and cerebral dopamine neurotrophic factor (CDNF) by anti-parkinsonian drug therapy in vivoTobias Gyárfás
Neuroscience Center, University of Helsinki, Viikinkaari 4, 00014, Helsinki, Finland
Cell Mol Neurobiol 30:361-8. 2010.... - Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockadeTomi Rantamäki
Sigrid Jusélius Laboratory, Neuroscience Center, University of Helsinki, Helsinki, Finland
PLoS ONE 6:e20567. 2011..However, recent findings demonstrate that Trk receptors can be transactivated independently of their neurotrophin ligands... - Chronic fluoxetine treatment increases expression of synaptic proteins in the hippocampus of the ovariectomized rat: role of BDNF signallingOlivia F O'Leary
Neuroscience Centre, University of Helsinki, Finland
Psychoneuroendocrinology 34:367-81. 2009..Moreover, these effects were only observed in ovariectomized animals, thus suggesting that fluoxetine-induced increases in synaptic protein levels might only occur or become detectable when hippocampal synaptic connectivity is perturbed... - Neurotrophins in depression and antidepressant effectsEero Castren
Neuroscience Center, University of Helsinki, PO Box 56, 00014 Helsinki, Finland
Novartis Found Symp 289:43-52; discussion 53-9, 87-93. 2008..Antidepressant treatments may, through enhanced BDNF signalling, improve the ability of critical brain circuits to respond optimally to environmental demands, a process that may be critical in the recovery from depression... - Targeting TrkB neurotrophin receptor to treat depressionTomi Rantamäki
University of Helsinki, Neuroscience Center, P O Box 56, Helsinki, Finland
Expert Opin Ther Targets 12:705-15. 2008..Therefore, targeting TrkB receptors might be a rational strategy to develop novel antidepressant drugs... - Darkness reduces BDNF expression in the visual cortex and induces repressive chromatin remodeling at the BDNF gene in both hippocampus and visual cortexNina N Karpova
Sigrid Jusélius Laboratory, Neuroscience Center, University of Helsinki, Helsinki, Finland
Cell Mol Neurobiol 30:1117-23. 2010..These data highlight the spatial differences in signaling pathways that lead to the BDNF expression in response to diminished ambient light... - Phosphoproteomic analysis of neurotrophin receptor TrkB signaling pathways in mouse brainArtour Semenov
Neuroscience Center, University of Helsinki, P O Box 56, 00014, Helsinki, Finland
Cell Mol Neurobiol 26:163-75. 2006..Furthermore, we found that beta-actin was tyrosine phosphorylated in the brain of the transgenic mice. 5. Our results demonstrate that phosphoproteomics is a sensitive approach to investigate signaling pathways activated in mouse brain... - Co-treatment with diazepam prevents the effects of fluoxetine on the proliferation and survival of hippocampal dentate granule cellsXuefei Wu
Neuroscience Center, University of Helsinki, Helsinki, Finland
Biol Psychiatry 66:5-8. 2009..Selective serotonin reuptake inhibitors increase proliferation of neuronal progenitors in rodent hippocampus after a delay of approximately 2 weeks... - The effects of acute and long-term lithium treatments on trkB neurotrophin receptor activation in the mouse hippocampus and anterior cingulate cortexTomi Rantamäki
Neuroscience Center, University of Helsinki, Finland
Neuropharmacology 50:421-7. 2006..The present results suggest that acute and long-term lithium treatment induces trkB activation in the AC but not in the HC. The activation of CREB is, however, significantly reduced in the HC after acute LiCl treatment... - Altered differentiation of neural stem cells in fragile X syndromeMaija Castrén
Neuroscience Center, University of Helsinki, P O Box 56, 00014 Helsinki, Finland
Proc Natl Acad Sci U S A 102:17834-9. 2005..These results demonstrate substantial alterations in the early maturation of FMRP-deficient neural stem cells in fragile X syndrome and in the fmr1-KO mice... - Neurotrophins and dementia--keeping in touchEero Castren
Sigrid Jusélius Laboratory of Molecular Neuroscience, Neuroscience Center, University of Helsinki, 00014, Helsinki, Finland
Neuron 51:1-3. 2006..Two papers in this issue of Neuron show that reduced retrograde transport or signaling of the neurotrophins NGF or BDNF, respectively, may account for the neuronal pathology in mouse models of Down's syndrome... - The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neuronsAnastasia Shulga
Institute of Biotechnology, University of Helsinki, FI 00014 Helsinki, Finland
J Neurosci 32:1757-70. 2012..Thus, application of bumetanide prevents p75(NTR) upregulation and neuronal death in the injured areas with reduced levels of endogenous BDNF... - Experience-dependent expression of NPAS4 regulates plasticity in adult visual cortexJosé Fernando Maya-Vetencourt
Scuola Normale Superiore, Neurobiology Laboratory, Piazza dei Cavalieri Pisa 56100 Italy
J Physiol 590:4777-87. 2012..Our findings lead the way to the identification of novel therapeutic targets for pathological conditions where reorganization of neuronal networks would be beneficial in adult life... - Alterations in BDNF and phospho-CREB levels following chronic oral nicotine treatment and its withdrawal in dopaminergic brain areas of miceTanja Kivinummi
Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, P O Box 56, FIN 00014 Helsinki, Finland
Neurosci Lett 491:108-12. 2011..In conclusion, the current results suggest the involvement of BDNF- and CREB-related neuronal processes in nicotine-induced neurochemical, behavioural, and neuroplastic changes in dopaminergic neurocircuits... - Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrusMikko Sairanen
Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland
J Neurosci 25:1089-94. 2005..These data suggest that antidepressants increase turnover of hippocampal neurons rather than neurogenesis per se and that BDNF signaling is required for the long-term survival of newborn neurons in mouse hippocampus... - Brain-derived neurotrophic factor expression after acute administration of ethanolNoora Raivio
Department of Alcohol, Drugs and Addiction, National Institute for Health and Welfare, Helsinki, Finland
Eur J Pharmacol 687:9-13. 2012..These data suggest that BDNF is involved in the acute effects of ethanol, but separate brain areas may be differentially engaged in the mediation of these effects... - Physiology, pathology and relatedness of human tissues from gene expression meta-analysisDario Greco
Institute of Biotechnology, University of Helsinki, Helsinki, Finland
PLoS ONE 3:e1880. 2008.... - Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexiaSatu Massinen
Department of Medical Genetics, University of Helsinki and Folkhälsan Institute of Genetics, Helsinki, Finland
Hum Mol Genet 18:2802-12. 2009..These findings provide novel insights into the function of DYX1C1 and link neuronal migration and developmental dyslexia to the estrogen-signaling effects in the brain...