Eero Castren

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. doi request reprint Neurotrophins and psychiatric disorders
    E Castren
    Neuroscience Center, University of Helsinki, 56, 00014, Helsinki, Finland
    Handb Exp Pharmacol 220:461-79. 2014
  2. pmc Neuronal plasticity and antidepressant actions
    Eero Castren
    Neuroscience Center, University of Helsinki, P O Box 56, 00014 Helsinki, Finland
    Trends Neurosci 36:259-67. 2013
  3. pmc Treatment of neurodevelopmental disorders in adulthood
    Eero Castren
    Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 32:14074-9. 2012
  4. doi request reprint The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity
    Eero Castren
    Sigrid Jusélius Laboratory, Neuroscience Center, University of Helsinki, Helsinki, Finland
    Dev Neurobiol 70:289-97. 2010
  5. doi request reprint Role of brain-derived neurotrophic factor in the aetiology of depression: implications for pharmacological treatment
    Eero Castren
    Sigrid Jusélius Laboratory, Neuroscience Center, University of Helsinki, Helsinki, Finland
    CNS Drugs 24:1-7. 2010
  6. ncbi request reprint Is mood chemistry?
    Eero Castren
    Neuroscience Center, University of Helsinki, Finland
    Nat Rev Neurosci 6:241-6. 2005
  7. ncbi request reprint Role of neurotrophic factors in depression
    Eero Castren
    Sigrid Jusélius Laboratory of Molecular Neuroscience, Neuroscience Center, University of Helsinki, PO Box 56, 00014 Helsinki, Finland
    Curr Opin Pharmacol 7:18-21. 2007
  8. ncbi request reprint [On new mechanisms of action of centrally active drugs]
    Eero Castren
    Helsingin yliopisto, Neurotieteen tutkimuskeskus PL 56, 00014 Helsingin yliopisto
    Duodecim 119:1487-95. 2003
  9. ncbi request reprint Neurotrophic effects of antidepressant drugs
    Eero Castren
    Sigrid Jusélius professor of Neuroscience, Neuroscience Center, University of Helsinki, PO Box 56, 00014 Helsinki, Finland
    Curr Opin Pharmacol 4:58-64. 2004
  10. ncbi request reprint Neurotrophins as mediators of drug effects on mood, addiction, and neuroprotection
    Eero Castren
    Neuroscience Center, University of Helsinki, P O Box 56, 00014 Helsinki, Finland
    Mol Neurobiol 29:289-302. 2004

Collaborators

Detail Information

Publications45

  1. doi request reprint Neurotrophins and psychiatric disorders
    E Castren
    Neuroscience Center, University of Helsinki, 56, 00014, Helsinki, Finland
    Handb Exp Pharmacol 220:461-79. 2014
    ....
  2. pmc Neuronal plasticity and antidepressant actions
    Eero Castren
    Neuroscience Center, University of Helsinki, P O Box 56, 00014 Helsinki, Finland
    Trends Neurosci 36:259-67. 2013
    ..Increased variability together with competition-mediated selection facilitates normal function, such as pattern separation within the dentate gyrus and other mood-related circuits, thereby enhancing adaptability toward novel experiences...
  3. pmc Treatment of neurodevelopmental disorders in adulthood
    Eero Castren
    Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 32:14074-9. 2012
    ..Even though translation from animal experimentation to clinical practice is challenging, these results suggest a rational basis for treatment of neurodevelopmental disorders in adulthood...
  4. doi request reprint The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity
    Eero Castren
    Sigrid Jusélius Laboratory, Neuroscience Center, University of Helsinki, Helsinki, Finland
    Dev Neurobiol 70:289-97. 2010
    ....
  5. doi request reprint Role of brain-derived neurotrophic factor in the aetiology of depression: implications for pharmacological treatment
    Eero Castren
    Sigrid Jusélius Laboratory, Neuroscience Center, University of Helsinki, Helsinki, Finland
    CNS Drugs 24:1-7. 2010
    ..This hypothesis suggests that antidepressant drugs should not be used alone but should always be combined with rehabilitation to guide the plastic networks within the brain...
  6. ncbi request reprint Is mood chemistry?
    Eero Castren
    Neuroscience Center, University of Helsinki, Finland
    Nat Rev Neurosci 6:241-6. 2005
    ....
  7. ncbi request reprint Role of neurotrophic factors in depression
    Eero Castren
    Sigrid Jusélius Laboratory of Molecular Neuroscience, Neuroscience Center, University of Helsinki, PO Box 56, 00014 Helsinki, Finland
    Curr Opin Pharmacol 7:18-21. 2007
    ..Neurotrophic factors themselves do not control mood, but they act as necessary tools in the activity-dependent modulation of networks, the physiological function of which determines how a plastic change influences mood...
  8. ncbi request reprint [On new mechanisms of action of centrally active drugs]
    Eero Castren
    Helsingin yliopisto, Neurotieteen tutkimuskeskus PL 56, 00014 Helsingin yliopisto
    Duodecim 119:1487-95. 2003
  9. ncbi request reprint Neurotrophic effects of antidepressant drugs
    Eero Castren
    Sigrid Jusélius professor of Neuroscience, Neuroscience Center, University of Helsinki, PO Box 56, 00014 Helsinki, Finland
    Curr Opin Pharmacol 4:58-64. 2004
    ....
  10. ncbi request reprint Neurotrophins as mediators of drug effects on mood, addiction, and neuroprotection
    Eero Castren
    Neuroscience Center, University of Helsinki, P O Box 56, 00014 Helsinki, Finland
    Mol Neurobiol 29:289-302. 2004
    ....
  11. doi request reprint The antidepressant-like effects of glutamatergic drugs ketamine and AMPA receptor potentiator LY 451646 are preserved in bdnf⁺/⁻ heterozygous null mice
    Jesse S O Lindholm
    Neuroscience Center, University of Helsinki, Helsinki, Finland
    Neuropharmacology 62:391-7. 2012
    ..This article is part of a Special Issue entitled 'Anxiety and Depression'...
  12. ncbi request reprint Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cgamma signaling pathways in mouse brain
    Tomi Rantamäki
    Neuroscience Center, University of Helsinki, PO Box 56, 00014 Helsinki, Finland
    Neuropsychopharmacology 32:2152-62. 2007
    ..In conclusion, our data suggest that rapid activation of the TrkB neurotrophin receptor and PLCgamma1 signaling is a common mechanism for all antidepressant drugs...
  13. ncbi request reprint Overexpression of a truncated TrkB isoform increases the proliferation of neural progenitors
    Topi A Tervonen
    Neuroscience Center, University of Helsinki, PO Box 56, 00014 Helsinki, Finland
    Eur J Neurosci 24:1277-85. 2006
    ..The data indicate that changes in the relative expression levels of different TrkB isoforms influence the replicative capacity of neural progenitors...
  14. pmc The responsiveness of TrkB to BDNF and antidepressant drugs is differentially regulated during mouse development
    Antonio Di Lieto
    Sigrid Jusélius Laboratory, Neuroscience Center, University of Helsinki, Helsinki, Finland
    PLoS ONE 7:e32869. 2012
    ..When administered during early postnatal life, ADs produce long-lasting biochemical and behavioural alterations that are observed in adult animals...
  15. doi request reprint BDNF and TrkB in neuronal differentiation of Fmr1-knockout mouse
    Verna Louhivuori
    Department of Biomedicine Physiology, University of Helsinki, PO Box 63, FIN 00014 Helsinki, Finland
    Neurobiol Dis 41:469-80. 2011
    ..Altogether, the present data suggest that alterations in the BDNF/TrkB signaling modulate brain development and impair synaptic plasticity in FXS...
  16. pmc Gene expression patterns underlying the reinstatement of plasticity in the adult visual system
    Ettore Tiraboschi
    Neuroscience Centre, University of Helsinki, 00790 Helsinki, Finland
    Neural Plast 2013:605079. 2013
    ..Our findings reveal a key role for several molecules such as the metalloproteases Mmp2 and Mmp9 or the glycoprotein Reelin and open up new insights into the mechanisms underlying the reopening of the critical periods in the adult brain. ..
  17. doi request reprint Long-lasting behavioural and molecular alterations induced by early postnatal fluoxetine exposure are restored by chronic fluoxetine treatment in adult mice
    Nina N Karpova
    Neuroscience Centre, University of Helsinki, 00014 Helsinki, Finland
    Eur Neuropsychopharmacol 19:97-108. 2009
    ..Our experiments show that behavioural and molecular changes induced by early postnatal fluoxetine administration are reversed by chronic fluoxetine treatment of adult mice to control levels...
  18. doi request reprint Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus
    Henri Autio
    Neuroscience Center, University of Helsinki, P O Box 56, 00790 Helsinki, Finland
    Neuropharmacology 61:1291-6. 2011
    ..Our findings show that acetylcholinesterase inhibitors are capable of rapidly activating hippocampal neurotrophin signaling and thus suggest that therapies targeting Trk signaling may already be in clinical use in the treatment of AD...
  19. doi request reprint Fear erasure in mice requires synergy between antidepressant drugs and extinction training
    Nina N Karpova
    Sigrid Jusélius Laboratory, Neuroscience Center, University of Helsinki, Helsinki, Finland
    Science 334:1731-4. 2011
    ..Thus, the pharmacological effects of antidepressants need to be combined with psychological rehabilitation to reorganize networks rendered more plastic by the drug treatment...
  20. pmc Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons
    Satu Massinen
    Research Program s Unit, Molecular Medicine and Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    PLoS ONE 6:e20580. 2011
    ..Moreover, DCDC2 overexpression in C. elegans causes an abnormal neuronal phenotype that can only be seen in ciliated neurons. Together our results suggest a potential role for DCDC2 in the structure and function of primary cilia...
  21. doi request reprint Brain-derived neurotrophic factor controls activity-dependent maturation of CA1 synapses by downregulating tonic activation of presynaptic kainate receptors
    Marko Sallert
    Neuroscience Center, University of Helsinki, FI 00014 Helsinki, Finland
    J Neurosci 29:11294-303. 2009
    ....
  22. doi request reprint Aberrant differentiation of glutamatergic cells in neocortex of mouse model for fragile X syndrome
    Topi A Tervonen
    Neuroscience Center, University of Helsinki, P O Box 56, 00014 Helsinki, Finland
    Neurobiol Dis 33:250-9. 2009
    ..These abnormalities were associated with an increased density of pyramidal cells of the layer V in the early postnatal neocortex suggesting a role for FMRP in the regulation of the differentiation of neocortical glutamatergic neurons...
  23. pmc The aromatase gene CYP19A1: several genetic and functional lines of evidence supporting a role in reading, speech and language
    Heidi Anthoni
    Department of Medical Genetics, Biomedicum, University of Helsinki, 00014, Helsinki, Finland
    Behav Genet 42:509-27. 2012
    ..An aromatase inhibitor reduced dendritic growth in cultured rat neurons. From this broad set of evidence, we propose CYP19A1 as a candidate gene for human cognitive functions implicated in reading, speech and language...
  24. doi request reprint Regulation of brain-derived neurotrophic factor (BDNF) and cerebral dopamine neurotrophic factor (CDNF) by anti-parkinsonian drug therapy in vivo
    Tobias Gyárfás
    Neuroscience Center, University of Helsinki, Viikinkaari 4, 00014, Helsinki, Finland
    Cell Mol Neurobiol 30:361-8. 2010
    ....
  25. doi request reprint Chronic fluoxetine treatment increases expression of synaptic proteins in the hippocampus of the ovariectomized rat: role of BDNF signalling
    Olivia F O'Leary
    Neuroscience Centre, University of Helsinki, Finland
    Psychoneuroendocrinology 34:367-81. 2009
    ..Moreover, these effects were only observed in ovariectomized animals, thus suggesting that fluoxetine-induced increases in synaptic protein levels might only occur or become detectable when hippocampal synaptic connectivity is perturbed...
  26. pmc Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade
    Tomi Rantamäki
    Sigrid Jusélius Laboratory, Neuroscience Center, University of Helsinki, Helsinki, Finland
    PLoS ONE 6:e20567. 2011
    ..However, recent findings demonstrate that Trk receptors can be transactivated independently of their neurotrophin ligands...
  27. doi request reprint Utilization of in situ ELISA method for examining Trk receptor phosphorylation in cultured cells
    Hanna Antila
    Neuroscience Center, P O Box 56, Viikinkaari 4, FI 00014 University of Helsinki, Finland
    J Neurosci Methods 222:142-6. 2014
    ..However, methods allowing simple and large-scale Trk phosphorylation analyses in cultured cells are lacking...
  28. ncbi request reprint Neurotrophins in depression and antidepressant effects
    Eero Castren
    Neuroscience Center, University of Helsinki, PO Box 56, 00014 Helsinki, Finland
    Novartis Found Symp 289:43-52; discussion 53-9, 87-93. 2008
    ..Antidepressant treatments may, through enhanced BDNF signalling, improve the ability of critical brain circuits to respond optimally to environmental demands, a process that may be critical in the recovery from depression...
  29. pmc The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease
    Tomi Rantamäki
    Neuroscience Center, University of Helsinki, Helsinki, Finland
    PLoS ONE 8:e68722. 2013
    ..If similar BDNF accumulation happens in human AD brains, it would suggest that functional BDNF levels in the AD brains are even lower than reported, which could partially contribute to learning and memory problems of AD patients. ..
  30. doi request reprint Co-treatment with diazepam prevents the effects of fluoxetine on the proliferation and survival of hippocampal dentate granule cells
    Xuefei Wu
    Neuroscience Center, University of Helsinki, Helsinki, Finland
    Biol Psychiatry 66:5-8. 2009
    ..Selective serotonin reuptake inhibitors increase proliferation of neuronal progenitors in rodent hippocampus after a delay of approximately 2 weeks...
  31. doi request reprint Darkness reduces BDNF expression in the visual cortex and induces repressive chromatin remodeling at the BDNF gene in both hippocampus and visual cortex
    Nina N Karpova
    Sigrid Jusélius Laboratory, Neuroscience Center, University of Helsinki, Helsinki, Finland
    Cell Mol Neurobiol 30:1117-23. 2010
    ..These data highlight the spatial differences in signaling pathways that lead to the BDNF expression in response to diminished ambient light...
  32. ncbi request reprint The effects of acute and long-term lithium treatments on trkB neurotrophin receptor activation in the mouse hippocampus and anterior cingulate cortex
    Tomi Rantamäki
    Neuroscience Center, University of Helsinki, Finland
    Neuropharmacology 50:421-7. 2006
    ..The present results suggest that acute and long-term lithium treatment induces trkB activation in the AC but not in the HC. The activation of CREB is, however, significantly reduced in the HC after acute LiCl treatment...
  33. ncbi request reprint Phosphoproteomic analysis of neurotrophin receptor TrkB signaling pathways in mouse brain
    Artour Semenov
    Neuroscience Center, University of Helsinki, P O Box 56, 00014, Helsinki, Finland
    Cell Mol Neurobiol 26:163-75. 2006
    ..Furthermore, we found that beta-actin was tyrosine phosphorylated in the brain of the transgenic mice. 5. Our results demonstrate that phosphoproteomics is a sensitive approach to investigate signaling pathways activated in mouse brain...
  34. ncbi request reprint Targeting TrkB neurotrophin receptor to treat depression
    Tomi Rantamäki
    University of Helsinki, Neuroscience Center, P O Box 56, Helsinki, Finland
    Expert Opin Ther Targets 12:705-15. 2008
    ..Therefore, targeting TrkB receptors might be a rational strategy to develop novel antidepressant drugs...
  35. doi request reprint Neuronal network plasticity and recovery from depression
    Eero Castren
    Neuroscience Center, University of Helsinki, Helsinki, Finland
    JAMA Psychiatry 70:983-9. 2013
    ..The network hypothesis of antidepressant action presented here proposes that recovery from depression and related mood disorders is a gradual process that develops slowly and is facilitated by structured guidance and rehabilitation. ..
  36. ncbi request reprint Effects of antidepressant drug imipramine on gene expression in rat prefrontal cortex
    Juha E A Knuuttila
    Neuroscience Center, University of Helsinki, Helsinki, Finland
    Neurochem Res 29:1235-44. 2004
    ..Our data suggest that cAMP metabolism, synaptic function, and protein processing by serine proteases may be important targets of antidepressant treatment and potential objects for antidepressant drug development...
  37. pmc Altered differentiation of neural stem cells in fragile X syndrome
    Maija Castrén
    Neuroscience Center, University of Helsinki, P O Box 56, 00014 Helsinki, Finland
    Proc Natl Acad Sci U S A 102:17834-9. 2005
    ..These results demonstrate substantial alterations in the early maturation of FMRP-deficient neural stem cells in fragile X syndrome and in the fmr1-KO mice...
  38. doi request reprint The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons
    Anastasia Shulga
    Institute of Biotechnology, University of Helsinki, FI 00014 Helsinki, Finland
    J Neurosci 32:1757-70. 2012
    ..Thus, application of bumetanide prevents p75(NTR) upregulation and neuronal death in the injured areas with reduced levels of endogenous BDNF...
  39. ncbi request reprint Neurotrophins and dementia--keeping in touch
    Eero Castren
    Sigrid Jusélius Laboratory of Molecular Neuroscience, Neuroscience Center, University of Helsinki, 00014, Helsinki, Finland
    Neuron 51:1-3. 2006
    ..Two papers in this issue of Neuron show that reduced retrograde transport or signaling of the neurotrophins NGF or BDNF, respectively, may account for the neuronal pathology in mouse models of Down's syndrome...
  40. pmc Experience-dependent expression of NPAS4 regulates plasticity in adult visual cortex
    José Fernando Maya-Vetencourt
    Scuola Normale Superiore, Neurobiology Laboratory, Piazza dei Cavalieri Pisa 56100 Italy
    J Physiol 590:4777-87. 2012
    ..Our findings lead the way to the identification of novel therapeutic targets for pathological conditions where reorganization of neuronal networks would be beneficial in adult life...
  41. ncbi request reprint Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus
    Mikko Sairanen
    Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 25:1089-94. 2005
    ..These data suggest that antidepressants increase turnover of hippocampal neurons rather than neurogenesis per se and that BDNF signaling is required for the long-term survival of newborn neurons in mouse hippocampus...
  42. doi request reprint Alterations in BDNF and phospho-CREB levels following chronic oral nicotine treatment and its withdrawal in dopaminergic brain areas of mice
    Tanja Kivinummi
    Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, P O Box 56, FIN 00014 Helsinki, Finland
    Neurosci Lett 491:108-12. 2011
    ..In conclusion, the current results suggest the involvement of BDNF- and CREB-related neuronal processes in nicotine-induced neurochemical, behavioural, and neuroplastic changes in dopaminergic neurocircuits...
  43. doi request reprint Brain-derived neurotrophic factor expression after acute administration of ethanol
    Noora Raivio
    Department of Alcohol, Drugs and Addiction, National Institute for Health and Welfare, Helsinki, Finland
    Eur J Pharmacol 687:9-13. 2012
    ..These data suggest that BDNF is involved in the acute effects of ethanol, but separate brain areas may be differentially engaged in the mediation of these effects...
  44. doi request reprint Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia
    Satu Massinen
    Department of Medical Genetics, University of Helsinki and Folkhälsan Institute of Genetics, Helsinki, Finland
    Hum Mol Genet 18:2802-12. 2009
    ..These findings provide novel insights into the function of DYX1C1 and link neuronal migration and developmental dyslexia to the estrogen-signaling effects in the brain...
  45. pmc Physiology, pathology and relatedness of human tissues from gene expression meta-analysis
    Dario Greco
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    PLoS ONE 3:e1880. 2008
    ....