S Alaluusua

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi request reprint Developmental dental toxicity of dioxin and related compounds--a review
    Satu Alaluusua
    Department of Pediatric and Preventive Dentistry, Institute of Dentistry, University of Helsinki, Finland
    Int Dent J 56:323-31. 2006
  2. pmc Developmental dental aberrations after the dioxin accident in Seveso
    Satu Alaluusua
    Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Helsinki, Finland
    Environ Health Perspect 112:1313-8. 2004
  3. ncbi request reprint Natal and neonatal teeth in relation to environmental toxicants
    Satu Alaluusua
    Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Finland
    Pediatr Res 52:652-5. 2002
  4. ncbi request reprint Aetiology of Molar-Incisor Hypomineralisation: A systematic review
    S Alaluusua
    Dept Pediatric and Preventive Dentistry, Institute of Dentistry, FI 00014 University of Helsinki, Helsinki, Finland
    Eur Arch Paediatr Dent 11:53-8. 2010
  5. ncbi request reprint Developmental dental defects associated with long breast feeding
    S Alaluusua
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    Eur J Oral Sci 104:493-7. 1996
  6. ncbi request reprint Arrest of rat molar tooth development by lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
    P L Lukinmaa
    Department of Oral Pathology, Institute of Dentistry, University of Helsinki, Helsinki, Finland
    Toxicol Appl Pharmacol 173:38-47. 2001
  7. ncbi request reprint Site-specific oral colonization of mutans streptococci detected by arbitrarily primed PCR fingerprinting
    L Gronroos
    Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Finland
    Caries Res 34:474-80. 2000
  8. ncbi request reprint Developmental dental defects in children who reside by a river polluted by dioxins and furans
    P Hölttä
    Institute of Dentistry, University of Helsinki, Hospital for Children and Adolescents, Helsinki University Central Hospital, Finland
    Arch Environ Health 56:522-8. 2001
  9. ncbi request reprint Dioxin alters gene expression in mouse embryonic tooth explants
    C Sahlberg
    Department of Pediatric and Preventive Dentistry, Institute of Dentistry, Biomedicum Helsinki, FIN 00014 University of Helsinki, Helsinki, Finland
    J Dent Res 86:600-5. 2007
  10. ncbi request reprint Lactational exposure of Han/Wistar rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin interferes with enamel maturation and retards dentin mineralization
    Y Gao
    Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Finland
    J Dent Res 83:139-44. 2004

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Developmental dental toxicity of dioxin and related compounds--a review
    Satu Alaluusua
    Department of Pediatric and Preventive Dentistry, Institute of Dentistry, University of Helsinki, Finland
    Int Dent J 56:323-31. 2006
    ..Even so, this is not the case after heavy exposure and little is known about the possible synergistic effects of these toxicants with other chemicals interfering with tooth development...
  2. pmc Developmental dental aberrations after the dioxin accident in Seveso
    Satu Alaluusua
    Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Helsinki, Finland
    Environ Health Perspect 112:1313-8. 2004
    ..The results support our hypothesis that dioxins can interfere with human organogenesis...
  3. ncbi request reprint Natal and neonatal teeth in relation to environmental toxicants
    Satu Alaluusua
    Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Finland
    Pediatr Res 52:652-5. 2002
    ..No association was found between pollutant levels and occurrence of natal and neonatal teeth, indicating that the prevailing levels of PCDD/Fs and PCBs are likely to be below the threshold to cause perinatal eruption of teeth...
  4. ncbi request reprint Aetiology of Molar-Incisor Hypomineralisation: A systematic review
    S Alaluusua
    Dept Pediatric and Preventive Dentistry, Institute of Dentistry, FI 00014 University of Helsinki, Helsinki, Finland
    Eur Arch Paediatr Dent 11:53-8. 2010
    ....
  5. ncbi request reprint Developmental dental defects associated with long breast feeding
    S Alaluusua
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    Eur J Oral Sci 104:493-7. 1996
    ..The result suggests that long breast feeding may increase the risk of mineralization defects in healthy children, possibly because of environmental contaminants that interfere with tooth development...
  6. ncbi request reprint Arrest of rat molar tooth development by lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
    P L Lukinmaa
    Department of Oral Pathology, Institute of Dentistry, University of Helsinki, Helsinki, Finland
    Toxicol Appl Pharmacol 173:38-47. 2001
    ....
  7. ncbi request reprint Site-specific oral colonization of mutans streptococci detected by arbitrarily primed PCR fingerprinting
    L Gronroos
    Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Finland
    Caries Res 34:474-80. 2000
    ..mutans differed depending on tooth site (chi-square test for heterogeneity, p<0.001), suggesting that mutans streptococcal clones may selectively colonize specific hard-tissue sites...
  8. ncbi request reprint Developmental dental defects in children who reside by a river polluted by dioxins and furans
    P Hölttä
    Institute of Dentistry, University of Helsinki, Hospital for Children and Adolescents, Helsinki University Central Hospital, Finland
    Arch Environ Health 56:522-8. 2001
    ..Compared with the figures reported earlier in Finland, neither the prevalence of dental lesions nor the levels of dioxins and furans in human milk were increased in riverside residents...
  9. ncbi request reprint Dioxin alters gene expression in mouse embryonic tooth explants
    C Sahlberg
    Department of Pediatric and Preventive Dentistry, Institute of Dentistry, Biomedicum Helsinki, FIN 00014 University of Helsinki, Helsinki, Finland
    J Dent Res 86:600-5. 2007
    ..Incomplete tooth morphogenesis caused by TCDD may thus result from modified expression of developmentally regulated genes...
  10. ncbi request reprint Lactational exposure of Han/Wistar rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin interferes with enamel maturation and retards dentin mineralization
    Y Gao
    Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Finland
    J Dent Res 83:139-44. 2004
    ..Extinction of AhR may lead to abolition of CYP1A1 expression as a sign of impaired dental cell function...
  11. ncbi request reprint Molar-incisor hypomineralization (MIH) in a group of school-aged children in Benghazi, Libya
    D Fteita
    Pediatric and Preventive Dentistry, Institute of Dentistry, University of Helsinki, Helsinki, Finland
    Eur Arch Paediatr Dent 7:92-5. 2006
    ..The aim of the present study was to assess developmental enamel defects with an emphasis to MIH in children from four primary schools in Benghazi, Libya...
  12. ncbi request reprint Transmission of oral Prevotella melaninogenica between a mother and her young child
    E Kononen
    Department of Periodontology, Institute of Dentistry, University of Helsinki, Finland
    Oral Microbiol Immunol 9:310-4. 1994
    ..melaninogenica between the mother and her child, probably via maternal saliva. However, the unique ribotypes found in these children also indicate that other sources besides the mother influence the oral colonization of young children...
  13. ncbi request reprint Periodontal findings in Cohen syndrome with chronic neutropenia
    S Alaluusua
    Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Finland
    J Periodontol 68:473-8. 1997
    ..001) more often than the controls. We conclude that subjects with Cohen syndrome have increased susceptibility to early periodontal breakdown which is likely to be associated with neutropenia...
  14. pmc Mutacin production by Streptococcus mutans may promote transmission of bacteria from mother to child
    L Gronroos
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    Infect Immun 66:2595-600. 1998
    ..In conclusion, the mutacin activity of clinical isolates is reasonably stable, and this virulence factor seems to be of clinical importance in early colonization by S. mutans...
  15. ncbi request reprint Mutans streptococcal serotypes in children with gastroesophageal reflux disease
    P Hölttä
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    ASDC J Dent Child 64:201-4, 228. 1997
    ..The data do not suggest that the acid regurgitation would have an influence on the prevalence of Streptococcus sobrinus...
  16. ncbi request reprint Response of the incisor tooth to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a dioxin-resistant and a dioxin-sensitive rat strain
    Anu Kiukkonen
    Department of Pedodontics and Orthodontics, Institute of Dentistry, Mannerheimintie 172, FIN 00014 University of Helsinki, Finland
    Toxicol Sci 69:482-9. 2002
    ..Similar responses in both strains implied that the impaired formation of the incisor tooth, at least of its mesenchymal elements, is not associated with the differential resistance of H/W and L-E rats to TCDD acute lethality...
  17. ncbi request reprint 7,12-dimethylbenz[a]anthracene interferes with the development of cultured mouse mandibular molars
    Eija Peltonen
    Department of Pediatric and Preventive Dentistry and Department of Oral Pathology, Institute of Dentistry, 00014 University of Helsinki, Fl 00014 Helsinki, Finland
    Toxicol Sci 92:279-85. 2006
    ..Cusps were thin and sharp. In line with the finding that maternal smoking during pregnancy has an adverse effect on child's tooth development, this study shows the toxic influence of PAHs on tooth development in vitro...
  18. ncbi request reprint Splicing site mutations in dentin sialophosphoprotein causing dentinogenesis imperfecta type II
    Heidi Holappa
    Institute of Dentistry, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Eur J Oral Sci 114:381-4. 2006
    ..1194C>A (IVS2-3) transversion. Bioinformatic analysis of known DSPP mutations suggests that DGI type II is usually caused by aberration of normal splicing...
  19. ncbi request reprint Interference by 2,3,7,8-tetrachlorodibenzo-p-dioxin with cultured mouse submandibular gland branching morphogenesis involves reduced epidermal growth factor receptor signaling
    Anu Kiukkonen
    Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Helsinki, Finland
    Toxicol Appl Pharmacol 212:200-11. 2006
    ..Together with the failure of EGF and FN at morphogenesis-stimulating concentrations to compensate for the effect of TCDD this implies that TCDD toxicity to developing salivary gland involves reduced EGF receptor signaling...
  20. doi request reprint Frameshift mutations in dentin phosphoprotein and dependence of dentin disease phenotype on mutation location
    Pekka Nieminen
    Institute of Dentistry, Biomedicum, University of Helsinki, Helsinki, Finland
    J Bone Miner Res 26:873-80. 2011
    ..Furthermore, we propose that the location of the mutation is reflected in the phenotypic features as a gradient from DD-II to more severe disease that does not conform to the classic definitions of DI-II...
  21. ncbi request reprint Disturbed root development of permanent teeth after pediatric stem cell transplantation. Dental root development after SCT
    Päivi Hölttä
    Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Helsinki, Finland
    Cancer 103:1484-93. 2005
    ..Deficient dental root development has been reported after conventional pediatric anticancer therapy, but less information is available on stem cell transplantation (SCT) recipients...
  22. ncbi request reprint Agenesis and microdontia of permanent teeth as late adverse effects after stem cell transplantation in young children
    Päivi Hölttä
    Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Helsinki, Finland
    Cancer 103:181-90. 2005
    ..The objective of the current study was to examine the occurrence of tooth agenesis and microdontia in pediatric stem cell transplantation (SCT) recipients...
  23. ncbi request reprint Developmental toxicity of dioxin to mouse embryonic teeth in vitro: arrest of tooth morphogenesis involves stimulation of apoptotic program in the dental epithelium
    Anna Maija Partanen
    Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, FIN 00014 Helsinki, Finland
    Toxicol Appl Pharmacol 194:24-33. 2004
    ..TCDD interferes with tooth development by stimulating apoptosis in those cells of the dental epithelium, which are predetermined to undergo apoptosis during normal development...
  24. doi request reprint Tributyltin impairs dentin mineralization and enamel formation in cultured mouse embryonic molar teeth
    Eija Salmela
    Department of Pediatric and Preventive Dentistry, Institute of Dentistry, 00014 University of Helsinki, Helsinki, Finland
    Toxicol Sci 106:214-22. 2008
    ..The effects depend on the stage of tooth development at the start of exposure and may involve epithelial-mesenchymal interactions...
  25. ncbi request reprint Expression of the mediators of dioxin toxicity, aryl hydrocarbon receptor (AHR) and the AHR nuclear translocator (ARNT), is developmentally regulated in mouse teeth
    Carin Sahlberg
    Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Finland
    Int J Dev Biol 46:295-300. 2002
    ..The coexpression of AHR and ARNT during early tooth development as well as during the information and mineralization of the dental matrices is suggestive of the AHR-ARNT pathway as a mediator of dental toxicity of TCDD...
  26. ncbi request reprint 2,3,7,8-tetrachlorodibenzo-p-dioxin specifically reduces mRNA for the mineralization-related dentin sialophosphoprotein in cultured mouse embryonic molar teeth
    Anu Kiukkonen
    Department of Pediatric and Preventive Dentistry, Institute of Dentistry, University of Helsinki, and Department of Pathology, Helsinki University Central Hospital, Finland
    Toxicol Appl Pharmacol 216:399-406. 2006
    ..The results suggest that the retardation of dentin mineralization by TCDD in mouse molar teeth involves specific interference with Dspp expression...
  27. ncbi request reprint The prevalence of Molar Incisor Hypomineralisation (MIH) in a group of Italian school children
    P C Calderara
    Department of Paediatric and Preventive Dentistry, Institute of Dentistry, University of Helsinki, Finland
    Eur J Paediatr Dent 6:79-83. 2005
    ..This epidemiological study in a group of Italian children was undertaken in order to increase our knowledge of the prevalence of Molar Incisor Hypomineralisation (MIH) in different European countries...
  28. ncbi request reprint Root-crown ratios of permanent teeth in a healthy Finnish population assessed from panoramic radiographs
    P Hölttä
    Department of Pedodontics and Orthodontics, Institute of Dentistry, Hospital for Children and Adolescents, University of Helsinki, Finland
    Eur J Orthod 26:491-7. 2004
    ..The Finnish R/C data reported here for all teeth except third molars could be used for comparison with other populations, patient groups or individuals where crown-root aberrations are suspected...
  29. ncbi request reprint Early plaque accumulation--a sign for caries risk in young children
    S Alaluusua
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    Community Dent Oral Epidemiol 22:273-6. 1994
    ..The results suggest that visible plaque on the labial surfaces of maxillary incisors of a young child is a sign of caries risk...
  30. ncbi request reprint Dental health of young children prenatally exposed to buprenorphine. A concern of child neglect?
    K Kivistö
    Department of Social Pediatrics, Hospital for Children and Adolescents, Helsinki University Central Hospital, University of Helsinki, P O Box 280, 00029 HUS, Helsinki, Finland
    Eur Arch Paediatr Dent 15:197-202. 2014
    ..To study the oral health and dental neglect of prenatally buprenorphine-exposed 3-year-old children...
  31. ncbi request reprint Long-term adverse effects on dentition in children with poor-risk neuroblastoma treated with high-dose chemotherapy and autologous stem cell transplantation with or without total body irradiation
    P Hölttä
    Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Helsinki, Finland
    Bone Marrow Transplant 29:121-7. 2002
    ..Disturbances in dental development may compromise occlusal function in poor-risk NBL patients after ASCT, especially when TBI is included in the conditioning regimen. Long-term dental follow-up and rehabilitation is required...
  32. ncbi request reprint Identification of a nonsense mutation in the PAX9 gene in molar oligodontia
    P Nieminen
    Institute of Biotechnology, University of Helsinki, Finland
    Eur J Hum Genet 9:743-6. 2001
    ..The phenotype is presumably a consequence of haploinsufficiency of PAX9. In another Finnish family with molar tooth agenesis, we could not find similar sequence changes in PAX9...
  33. ncbi request reprint The effect of perinatal TCDD exposure on caries susceptibility in rats
    Hanna M Miettinen
    Laboratory of Toxicology, Department of Environmental Health, National Public Health Institute, Kuopio, Finland
    Toxicol Sci 91:568-75. 2006
    ..In conclusion, perinatal TCDD exposure can render rat molars more susceptible to caries...
  34. ncbi request reprint Severely hypoplastic amelogenesis imperfecta with taurodontism
    Alenka Pavlic
    Department of Paediatric and Preventive Dentistry, University of Ljubljana, Ljubljana, Slovenia
    Int J Paediatr Dent 17:259-66. 2007
    ..The prominent dental feature of a boy was severely hypoplastic enamel in both primary and permanent teeth...
  35. ncbi request reprint Effect of in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on rat molar development: the role of exposure time
    Hanna M Miettinen
    National Public Health Institute, Department of Environmental Health, P O Box 95, FIN 70701 Kuopio, Finland
    Toxicol Appl Pharmacol 184:57-66. 2002
    ..Response to TCDD was increased if the exposure was started several days before this critical window of sensitivity or if it was continued thereafter. Dental epithelium is the likely target of TCDD...
  36. pmc Streptococcus mutans clonal variation revealed by multilocus sequence typing
    Kazuhiko Nakano
    Departments of Pediatric Dentistry, Osaka University Graduate School of Dentistry, 1 8 Yamada oka, Suita, Osaka 565 0871, Japan
    J Clin Microbiol 45:2616-25. 2007
    ..In conclusion, the superior discriminatory capacity of this MLST scheme for S. mutans may have important practical implications...
  37. ncbi request reprint [Amoxicillin may be a cause of enamel hypomineralization]
    Satu Alaluusua
    Duodecim 122:491-2. 2006