Irina Alafuzoff

Summary

Affiliation: University of Kuopio
Country: Finland

Publications

  1. ncbi beta-amyloid load is not influenced by the severity of cardiovascular disease in aged and demented patients
    A Irina
    Department of Neuroscience and Neurology, Kuopio University, Kuopio, Finland
    Stroke 30:613-8. 1999
  2. doi Assessment of alpha-synuclein pathology: a study of the BrainNet Europe Consortium
    Irina Alafuzoff
    Department of Neuroscience and Neurology, Kuopio University, Kuopio, Finland
    J Neuropathol Exp Neurol 67:125-43. 2008
  3. doi Inter-laboratory comparison of neuropathological assessments of beta-amyloid protein: a study of the BrainNet Europe consortium
    Irina Alafuzoff
    Department of Clinical Medicine, Unit of Neurology, Kuopio University, PO Box 1627, 70 211 Kuopio, Finland
    Acta Neuropathol 115:533-46. 2008
  4. doi Beta-amyloid deposition in brains of subjects with diabetes
    I Alafuzoff
    Unit of Neurology, Department of Clinical Medicine, Kuopio University and Kuopio University Hospital, Kuopio, Finland
    Neuropathol Appl Neurobiol 35:60-8. 2009
  5. pmc Staging of neurofibrillary pathology in Alzheimer's disease: a study of the BrainNet Europe Consortium
    Irina Alafuzoff
    Department of Neuroscience and Neurology, Kuopio University, Kuopio, Finland
    Brain Pathol 18:484-96. 2008
  6. pmc Assessment of beta-amyloid deposits in human brain: a study of the BrainNet Europe Consortium
    Irina Alafuzoff
    Department of Clinical Medicine, Kuopio University, Finland
    Acta Neuropathol 117:309-20. 2009
  7. ncbi Interlaboratory comparison of assessments of Alzheimer disease-related lesions: a study of the BrainNet Europe Consortium
    Irina Alafuzoff
    Department of Neuroscience and Neurology, Kuopio University, Kuopio University Hospital, Finland
    J Neuropathol Exp Neurol 65:740-57. 2006
  8. ncbi Selegiline treatment and the extent of degenerative changes in brain tissue of patients with Alzheimer's disease
    I Alafuzoff
    Department of Neuroscience and Neurology, Kuopio University, Finland
    Eur J Clin Pharmacol 55:815-9. 2000
  9. ncbi Severity of cardiovascular disease, apolipoprotein E genotype, and brain pathology in aging and dementia
    I Alafuzoff
    Department of Neuroscience and Neurology, Kuopio University, Finland
    Ann N Y Acad Sci 903:244-51. 2000
  10. doi APOE4 predicts amyloid-β in cortical brain biopsy but not idiopathic normal pressure hydrocephalus
    Okko T Pyykkö
    Neurosurgery of NeuroCentre, Kuopio University Hospital, P O Box 1777, 70211 Kuopio, Finland
    J Neurol Neurosurg Psychiatry 83:1119-24. 2012

Detail Information

Publications70

  1. ncbi beta-amyloid load is not influenced by the severity of cardiovascular disease in aged and demented patients
    A Irina
    Department of Neuroscience and Neurology, Kuopio University, Kuopio, Finland
    Stroke 30:613-8. 1999
    ....
  2. doi Assessment of alpha-synuclein pathology: a study of the BrainNet Europe Consortium
    Irina Alafuzoff
    Department of Neuroscience and Neurology, Kuopio University, Kuopio, Finland
    J Neuropathol Exp Neurol 67:125-43. 2008
    ..Moreover, the study demonstrates that there are limitations in the scoring of alphaS-IR structures...
  3. doi Inter-laboratory comparison of neuropathological assessments of beta-amyloid protein: a study of the BrainNet Europe consortium
    Irina Alafuzoff
    Department of Clinical Medicine, Unit of Neurology, Kuopio University, PO Box 1627, 70 211 Kuopio, Finland
    Acta Neuropathol 115:533-46. 2008
    ....
  4. doi Beta-amyloid deposition in brains of subjects with diabetes
    I Alafuzoff
    Unit of Neurology, Department of Clinical Medicine, Kuopio University and Kuopio University Hospital, Kuopio, Finland
    Neuropathol Appl Neurobiol 35:60-8. 2009
    ..The objective of this study was to test the hypothesis that hyperinsulinaemia can elevate Abeta levels and thus contribute to AD pathology in humans...
  5. pmc Staging of neurofibrillary pathology in Alzheimer's disease: a study of the BrainNet Europe Consortium
    Irina Alafuzoff
    Department of Neuroscience and Neurology, Kuopio University, Kuopio, Finland
    Brain Pathol 18:484-96. 2008
    ..Thus, in a research setting when the extent of lesions is mild, it is strongly recommended that the assessment of lesions should be carried out by at least two independent observers...
  6. pmc Assessment of beta-amyloid deposits in human brain: a study of the BrainNet Europe Consortium
    Irina Alafuzoff
    Department of Clinical Medicine, Kuopio University, Finland
    Acta Neuropathol 117:309-20. 2009
    ..Because most of these blocks are currently routinely sampled by the majority of laboratories, assessment of the A-beta phase in AD is feasible even in large scale retrospective studies...
  7. ncbi Interlaboratory comparison of assessments of Alzheimer disease-related lesions: a study of the BrainNet Europe Consortium
    Irina Alafuzoff
    Department of Neuroscience and Neurology, Kuopio University, Kuopio University Hospital, Finland
    J Neuropathol Exp Neurol 65:740-57. 2006
    ..Therefore, the IHC/HPtau methodology to visualize NFTs and neuropil threads should be considered as a method of choice in a future diagnostic protocol for Alzheimer disease...
  8. ncbi Selegiline treatment and the extent of degenerative changes in brain tissue of patients with Alzheimer's disease
    I Alafuzoff
    Department of Neuroscience and Neurology, Kuopio University, Finland
    Eur J Clin Pharmacol 55:815-9. 2000
    ..A beneficial effect of selegiline (L-deprenyl) in Alzheimer's disease (AD) has been reported in several clinical studies...
  9. ncbi Severity of cardiovascular disease, apolipoprotein E genotype, and brain pathology in aging and dementia
    I Alafuzoff
    Department of Neuroscience and Neurology, Kuopio University, Finland
    Ann N Y Acad Sci 903:244-51. 2000
    ..The cardiovascular disease again seems to influence the extent of vascular lesions...
  10. doi APOE4 predicts amyloid-β in cortical brain biopsy but not idiopathic normal pressure hydrocephalus
    Okko T Pyykkö
    Neurosurgery of NeuroCentre, Kuopio University Hospital, P O Box 1777, 70211 Kuopio, Finland
    J Neurol Neurosurg Psychiatry 83:1119-24. 2012
    ....
  11. doi Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain
    Tero Tapiola
    Department of Neuroscience and Neurology, Clinical Research Center Mediteknia, Kuopio University Hospital, University of Kuopio, Finland
    Arch Neurol 66:382-9. 2009
    ....
  12. doi Cortical brain biopsy in long-term prognostication of 468 patients with possible normal pressure hydrocephalus
    Ville Leinonen
    Department of Neurosurgery, Neurocenter, Kuopio University Hospital, Kuopio, Finland
    Neurodegener Dis 10:166-9. 2012
    ..Brain biopsy did not predict survival but may open a novel research window to study the pathobiology of neurodegeneration...
  13. doi Expression of collagen XVII and ubiquitin-binding protein p62 in motor neuron disease
    Allan Seppänen
    Department of Clinical Medicine, Neurology, University of Kuopio, FIN 70211 Kuopio, Finland
    Brain Res 1247:171-7. 2009
    ..Our study supports the re-definition of motor neuron disease as a multisystem disorder with a wide clinicopathological spectrum, and we advocate addressing psychiatric symptomology in future studies of motor neuron disease...
  14. doi Cardiovascular diseases and hippocampal infarcts
    Tuomas Rauramaa
    Department of Pathology, Kuopio University Hospital, Finland
    Hippocampus 21:281-7. 2011
    ..Furthermore it should be noted that the size of the hippocampal tissue damage, i.e., small vs. large cystic infarcts is of significance regarding clinical alterations...
  15. doi Poor cognitive outcome in shunt-responsive idiopathic normal pressure hydrocephalus
    Anne M Koivisto
    Unit of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Neurosurgery 72:1-8;discussion 8. 2013
    ..Idiopathic normal pressure hydrocephalus (iNPH) causes cognitive decline that can be alleviated by shunting, but long-term outcome studies are scarce...
  16. doi Staging/typing of Lewy body related alpha-synuclein pathology: a study of the BrainNet Europe Consortium
    Irina Alafuzoff
    Department of Neuroscience and Neurology, Kuopio University, Kuopio, Finland
    Acta Neuropathol 117:635-52. 2009
    ....
  17. doi The effect of prolonged fixation time on immunohistochemical staining of common neurodegenerative disease markers
    Maria Pikkarainen
    Department of Clinical Medicine, Unit of Neurology, Section of Neuropathology, Kuopio University, Kuopio, Finland
    J Neuropathol Exp Neurol 69:40-52. 2010
    ..alpha-Synuclein-immunoreactive structures were visualized up to 14 years but only by the use of Syn42-Ab after formic acid AR or after a combination of heat and formic acid methods...
  18. doi Heavy alcohol consumption and neuropathological lesions: a post-mortem human study
    Leena Aho
    Department of Clinical Medicine, Unit of Neurology, Kuopio University, Kuopio, Finland
    J Neurosci Res 87:2786-92. 2009
    ..Our results indicate that alcohol-related dementia differs from VCI, AD, and DLB; i.e., it has a different etiology and pathogenesis...
  19. doi Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11-labeled Pittsburgh Compound B
    Ville Leinonen
    Department of Neurosurgery, Kuopio University Hospital, PO Box 1777, 70211 Kuopio, Finland
    Arch Neurol 65:1304-9. 2008
    ..To compare carbon 11-labeled Pittsburgh Compound B ([11C]PiB) positron emission tomography (PET) findings in patients with and without Alzheimer disease lesions in frontal cortical biopsy specimens...
  20. doi Hyperphosphorylated tau in the occipital cortex in aged nondemented subjects
    Maria Pikkarainen
    From the Department of Clinical Medicine, Unit of Neurology, Section of Neuropathology, Kuopio University, Kuopio, Finland
    J Neuropathol Exp Neurol 68:653-60. 2009
    ..Further systematic clinicopathologic studies are needed for an understanding of regional susceptibility to neurodegeneration and the significance of scattered HPtau-IR brain lesions...
  21. ncbi Increased expression of caspase 2 in experimental and human temporal lobe epilepsy
    Susanna Narkilahti
    A I Virtanen Institute for Molecular Sciences, University of Kuopio, and Department of Neurology, Kuopio University Hospital, Finland
    Neuromolecular Med 9:129-44. 2007
    ..Our data suggest that caspase 2-mediated programmed cell death participates in the seizure-induced degenerative process in experimental and human TLE...
  22. doi Systematic appraisal using immunohistochemistry of brain pathology in aged and demented subjects
    Leena Aho
    Department of Clinical Medicine, Unit of Neurology, Section of Neuropathology, Kuopio University, Kuopio, Finland
    Dement Geriatr Cogn Disord 25:423-32. 2008
    ..Abnormal processing of hyperphosphorylated tau (HPtau), amyloid-beta (Abeta) and alpha-synuclein (alphaS) proteins is considered as causative with regard to the clinical symptoms in age-related neurodegenerative diseases...
  23. pmc Increased γ-Secretase Activity in Idiopathic Normal Pressure Hydrocephalus Patients with β-Amyloid Pathology
    Tiina Laiterä
    Institute of Clinical Medicine Neurosurgery, University of Eastern Finland, Kuopio, Finland Neurosurgery of NeuroCenter, Kuopio University Hospital, Kuopio, Finland
    PLoS ONE 9:e93717. 2014
    ..Despite the resemblances in the Aβ pathology, iNPH and AD patients appear to have marked differences in the cellular mechanisms responsible for the production of Aβ. ..
  24. doi Amyloid and tau proteins in cortical brain biopsy and Alzheimer's disease
    Ville Leinonen
    Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland
    Ann Neurol 68:446-53. 2010
    ..Amyloid-β(Aβ) aggregates are presumed to be found in the brain at an early stage of Alzheimer's disease (AD) but have seldom been assessed by brain biopsy during life in often elderly patients...
  25. doi Immunohistochemical visualization of amyloid-beta protein precursor and amyloid-beta in extra- and intracellular compartments in the human brain
    Leena Aho
    Department of Clinical Medicine, Unit of Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 20:1015-28. 2010
    ..The staining results and conclusions depended strongly on the chosen antibody and the pretreatment strategy and thus multiple antibodies must be used when assessing the intracellular accumulation of Abeta...
  26. doi Long-term epilepsy surgery outcomes in patients with MRI-negative temporal lobe epilepsy
    Arto Immonen
    Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland
    Epilepsia 51:2260-9. 2010
    ..The purpose of this study was to determine the long-term outcomes of consecutive true MRI-negative TLE patients who all underwent standardized preoperative evaluation with intracranial electroencephalography (EEG) electrodes...
  27. ncbi Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease
    Teemu Natunen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 37:217-32. 2013
    ..While the present study indicates that GGA3 is involved in the cellular processes relevant for AD pathogenesis, the genetic data do not support the idea that common GGA3 polymorphisms would contribute to AD risk. ..
  28. pmc Effects of NR1H3 genetic variation on the expression of liver X receptor α and the progression of Alzheimer's disease
    Teemu Natunen
    Institute of Clinical Medicine Neurology, University of Eastern Finland and Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    PLoS ONE 8:e80700. 2013
    ..These results suggest that genetic variation in NR1H3 modulates the expression of LXRα and the levels of soluble Aβ42. ..
  29. doi GRN variant rs5848 reduces plasma and brain levels of granulin in Alzheimer's disease patients
    Anna Kämäläinen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 33:23-7. 2013
    ..Our findings suggest that the A allele of rs5848 is functionally relevant by reducing the expression of granulin...
  30. pmc Applicability of current staging/categorization of alpha-synuclein pathology and their clinical relevance
    Laura Parkkinen
    Department of Clinical Medicine, Unit of Neurology, Section of Neuropathology, Kuopio University, Yliopistonranta 1 C, P O Box 1627, 70211, Kuopio, Finland
    Acta Neuropathol 115:399-407. 2008
    ..However, finding that around half of the subjects with abundant alphaS pathology remain neurologically intact is intriguing and raises the question whether we do assess the actual disease process...
  31. ncbi Human brain tissue microarrays as a platform to investigate diseases of the nervous system
    Paula Martikainen
    Department of Neuroscience and Neurology, University of Kuopio, and Kuopio University Hospital, Finland
    Brain Res 1089:33-43. 2006
    ....
  32. pmc Cerebrospinal fluid biomarker and brain biopsy findings in idiopathic normal pressure hydrocephalus
    Okko T Pyykkö
    Neurosurgery of Neurocenter, Kuopio University Hospital, Kuopio, Finland
    PLoS ONE 9:e91974. 2014
    ..The significance of amyloid precursor protein (APP) and neuroinflammation in idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's disease (AD) is unknown...
  33. doi Distribution and pattern of pathology in subjects with familial or sporadic late-onset cerebellar ataxia as assessed by p62/sequestosome immunohistochemistry
    Maria Pikkarainen
    Department of Clinical Medicine, Unit of Neurology, University of Eastern Finland, Kuopio, Finland
    Cerebellum 10:720-31. 2011
    ..Based on a literature search, it is apparent that there is a need for clinico-pathologic-genetical studies of LOCA, especially to obtain a deeper understanding of the regional distribution and progression of pathology...
  34. doi Unusual clinical presentation and neuropathology in two subjects with fused-in sarcoma (FUS) positive inclusions
    Päivi H Hartikainen
    Department of Neurology, Kuopio University Hospital, Finland
    Neuropathology 32:60-8. 2012
    ..We conclude that clinical phenotypes of FUS pathologies also include elderly patients and are more variable with motor and speech disorders than previously reported...
  35. ncbi Oxidative modification of proteins in the frontal cortex of Alzheimer's disease brain
    Minna A Korolainen
    Department of Neuroscience and Neurology, University of Kuopio, and Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    Neurobiol Aging 27:42-53. 2006
    ..These results do not contradict the hypothesis of increased oxidative stress in AD but may represent co-existing compensatory changes in response to oxidative stress...
  36. doi Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions visualized with ubiquitin-binding protein p62 immunohistochemistry
    Maria Pikkarainen
    Department of Clinical Medicine, Unit of Neurology, Section of Neuropathology, Kuopio University Hospital, Kuopio, Finland
    J Neuropathol Exp Neurol 67:280-98. 2008
    ....
  37. ncbi Heparan sulfate proteoglycan 2 polymorphism in Alzheimer's disease and correlation with neuropathology
    Susan Iivonen
    Department of Neuroscience and Neurology, University Hospital and University of Kuopio, P O Box 1627, 70211, Kuopio, Finland
    Neurosci Lett 352:146-50. 2003
    ..In conclusion, HSPG2 A allele may possess an additive risk effect among the APOE epsilon4 carriers in AD...
  38. ncbi Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62
    Erkki Kuusisto
    Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
    J Neuropathol Exp Neurol 62:1241-53. 2003
    ..The results also point at dissimilarities in the formation of perikaryal vs intraneuritic inclusions...
  39. doi TAR-DNA binding protein-43 and alterations in the hippocampus
    Tuomas Rauramaa
    Department of Pathology, Kuopio University Hospital, Kuopio, Finland
    J Neural Transm 118:683-9. 2011
    ..Our findings justify assessment of TDP43 pathology in every case where a pathological alteration is observed in the hippocampus using a routine stain...
  40. ncbi Regional distribution of alpha-synuclein pathology in unimpaired aging and Alzheimer disease
    Laura Parkkinen
    Department of Neuroscience, Kuopio University, P O Box 1627, FIN 70211 Kuopio, Finland
    J Neuropathol Exp Neurol 62:363-7. 2003
    ..However, this was not inevitably associated with AD pathology, but was related to cognitive decline. Incidental LBs in the SN were described in the occasional subjects, with no alphaS pathology in the lower brainstem...
  41. ncbi Alpha-synuclein pathology does not predict extrapyramidal symptoms or dementia
    Laura Parkkinen
    Department of Neuroscience and Neurology, Kuopio University, 70211 Kuopio, Finland
    Ann Neurol 57:82-91. 2005
    ..Some neurologically unimpaired cases had a reasonable burden of alpha-synuclein pathology in both brainstem and cortical areas, suggesting that alpha-synuclein-positive structures are not definite markers of neuronal dysfunction...
  42. doi Does protein expression predict recurrence of benign World Health Organization grade I meningioma?
    Vesa Kärjä
    Department of Clinical Pathology, Kuopio University Hospital, 70211 Kuopio, Finland
    Hum Pathol 41:199-207. 2010
    ....
  43. ncbi Human postmortem brain tissue and 2-mm tissue microarrays
    Tarja Kauppinen
    Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
    Appl Immunohistochem Mol Morphol 14:353-9. 2006
    ..Thus, the applications of this brain TMA block in neurologic research by scientists with different skill bases remain to be determined...
  44. ncbi Widespread and abundant alpha-synuclein pathology in a neurologically unimpaired subject
    Laura Parkkinen
    Department of Neuroscience and Neurology, Kuopio University, Kuopio, Finland
    Neuropathology 25:304-14. 2005
    ..The alphaS-positive inclusions may well represent detoxified reserves that cells can tolerate for years, and thus prevention of their development could actually accelerate the diseases process...
  45. ncbi Beta-amyloid aggregation in human brains with cerebrovascular lesions
    Leena Aho
    Department of Clinical Medicine, Neurology, Kuopio University, P O B 1647, Harjulantie 1, Kuopio, Finland
    Stroke 37:2940-5. 2006
    ....
  46. ncbi Case report: central neurocytoma with concomitant cerebral involvement by acute lymphatic leukemia
    Jan Böhm
    Department of Pathology and Forensic Medicine, University of Kuopio and Kuopio University Hospital, Finland
    Hum Pathol 37:488-92. 2006
    ..These two entities might be problematic to differentiate from each other without proper histopathological examination...
  47. ncbi Interleukin 1 alpha gene polymorphism as a susceptibility factor in Alzheimer's disease and its influence on the extent of histopathological hallmark lesions of Alzheimer's disease
    Mia Pirskanen
    Department of Clinical Genetics, University Hospital of Kuopio, Finland
    Dement Geriatr Cogn Disord 14:123-7. 2002
    ..However, the IL1A C/C genotype might be associated with the progression of SPs/NPs in AD patients, but the effect is weak and obscured by the APOE epsilon4 allele...
  48. ncbi Proteomic analysis of glial fibrillary acidic protein in Alzheimer's disease and aging brain
    Minna A Korolainen
    Department of Neuroscience and Neurology, University of Kuopio, Harjulantie 1D, P O Box 1627, FIN 70211 Kuopio, Finland
    Neurobiol Dis 20:858-70. 2005
    ..Mechanisms, structures and functional consequences of modification of GFAP isoforms remain to be clarified...
  49. ncbi Cystatin C expression is associated with granule cell dispersion in epilepsy
    Terhi J Pirttilä
    A I Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
    Ann Neurol 58:211-23. 2005
    ....
  50. ncbi Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients
    Johanna Ojala
    Department of Neuroscience and Neurology, University of Kuopio, Canthia, P O Box 1627, FIN 70211 Kuopio, Finland
    Neurobiol Aging 30:198-209. 2009
    ..Plasma levels of IL-18 showed no correlation with the disease. In conclusion, amyloid-beta may induce the synthesis of IL-18, and IL-18 kinases involved in tau phosphorylation as a part of the amyloid-associated inflammatory reaction...
  51. doi Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Prog Neurobiol 96:87-95. 2012
    ..We will review here the molecular and functional characteristics of p62 protein and outline its potential role in the regulation of Alzheimer's pathogenesis...
  52. ncbi Distribution of collagen XVII in the human brain
    Allan Seppänen
    Department of Clinical Medicine, Neurology, University of Kuopio, Finland
    Brain Res 1158:50-6. 2007
    ..Many neurodegenerative disorders display a specific pattern of neuroanatomical involvement, thus the regionally variable expression of collagen XVII offers new prospects for research...
  53. doi Malignant giant cell tumor in the posterior fossa of a neonate
    Petros N Karamanakos
    Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland
    J Neurosurg Pediatr 5:277-82. 2010
    ..In addition, the extremely high growth rate of the tumor in the postoperative period renders this case the most aggressive primary malignant GCT of the cranium described so far...
  54. ncbi Proteomic analysis of protein oxidation in Alzheimer's disease brain
    Minna A Korolainen
    Department of Neuroscience and Neurology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Finland
    Electrophoresis 23:3428-33. 2002
    ..Two proteins showed a significant decrease in the degree of oxidation in AD. Our results suggest that the balance of protein oxidation and degradation is altered in AD...
  55. ncbi Role of protein kinase B in Alzheimer's neurofibrillary pathology
    Jin Jing Pei
    Neurotec, Section for Experimental Geriatrics, Novum, Karolinska Institutet, KFC Plan 4, 141 86 Huddinge, Sweden
    Acta Neuropathol 105:381-92. 2003
    ..These studies suggest the involvement of PKB/GSK-3 signaling in Alzheimer neurofibrillary degeneration...
  56. pdf Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry
    Heiko Braak
    Institute for Clinical Neuroanatomy, J W Goethe University Clinic, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Acta Neuropathol 112:389-404. 2006
    ..It is anticipated that this revised methodological protocol will enable a more uniform application of the staging procedure...
  57. ncbi Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains
    Xin Wen Zhou
    Karolinska Institutet, Department of Neurotec, Geriatric lab, Novum Plan 5, S 14157, Huddinge, Sweden
    Neurobiol Dis 22:657-68. 2006
    ..Assessments of levels of these abnormal proteins by dot blots may serve as a useful complement to the morphological evaluations in diagnosis of AD...
  58. ncbi Reelin-immunoreactive Cajal-Retzius cells: the entorhinal cortex in normal aging and Alzheimer's disease
    Anett Riedel
    Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    Acta Neuropathol 106:291-302. 2003
    ..Nevertheless, CR cells seem to be partially affected by the formation of paired helical filaments, indicating subtle changes that are suggested to be a result rather than a cause of the pathogenetic cascade of AD...
  59. ncbi Absence of association between an intercellular adhesion molecule 1 gene E469K polymorphism and Alzheimer's disease in Finnish patients
    Kari M Mattila
    Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, Finland
    Neurosci Lett 337:61-3. 2003
    ..We therefore conclude that the E469K polymorphism of ICAM1 is not a risk factor for AD or PD...
  60. ncbi Glycosylation changes in Alzheimer's disease as revealed by a proteomic approach
    Katja Kanninen
    Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Neulaniementie 2, P O Box 1627, FIN 70211 Kuopio, Finland
    Neurosci Lett 367:235-40. 2004
    ..CRMP-2 regulates the assembly and polymerization of microtubules and is associated with neurofibrillary tangles in AD. Aberrant glycosylations in AD may help understand the mechanisms of neurodegenerative diseases...
  61. ncbi Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain
    Xu Li
    Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institutet, Huddinge, Sweden
    FEBS J 272:4211-20. 2005
    ....
  62. ncbi CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease
    Katharina Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center, Department of Psychiatry, Ludwig Maximilian University Munich, Germany
    Brain 129:3035-41. 2006
    ..There was a correlation between P-tau231P in CSF and brain homogenates. These findings indicate that CSF P-tau231P may serve as an in vivo surrogate biomarker of neurofibrillary pathology in Alzheimer's disease...
  63. ncbi Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers
    Khalid Iqbal
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Ann Neurol 58:748-57. 2005
    ..These subgroups, which can be identified by CSF analysis, might benefit differently from different therapeutic drugs...
  64. pmc Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease
    Wen Lin An
    Division of Experimental Geriatrics, Karolinska Institutet, Neurotec, Novum, Huddinge, Sweden
    Am J Pathol 163:591-607. 2003
    ..A p70 S6 kinase modulated up-regulation of tau translation might contribute to PHF-tau accumulation in neurons with neurofibrillary changes...
  65. ncbi Postmortem examination of vascular lesions in cognitive impairment: a survey among neuropathological services
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Stroke 37:1005-9. 2006
    ..We aimed at surveying the postmortem neuropathological procedures used in different centers in examining brain lesions of presumable or possible vascular origin in cognitively impaired patients...
  66. ncbi No correlation between CSF tau protein phosphorylated at threonine 181 with neocortical neurofibrillary pathology in Alzheimer's disease
    Katharina Buerger
    Brain 130:e82. 2007
  67. ncbi Collagen XVII is expressed in human CNS neurons
    Allan Seppänen
    Department of Neurology, University of Oulu and Clinical Research Center, Oulu University Hospital, FIN 90014 Oulu, Finland
    Matrix Biol 25:185-8. 2006
    ..We propose that collagen XVII may be involved in the pathogenesis of various disorders affecting neuronal migration or synaptic plasticity...
  68. doi Management of a twenty-first century brain bank: experience in the BrainNet Europe consortium
    Jeanne E Bell
    Department of Pathology Neuropathology, University of Edinburgh, Wilkie Building, Teviot Place, Edinburgh, UK
    Acta Neuropathol 115:497-507. 2008
    ....
  69. ncbi Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain
    Xu Li
    Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institutet, KFC Plan 4, Novum, S 141 86 Huddinge, Sweden
    Neuroreport 15:2237-40. 2004
    ..Level of eIF4E phosphorylation is significantly correlated with total- and Alzheimer hyperphosphorylated taus. These data suggest that the increase of eIF4E phosphorylation is involved in formation of Alzheimer neurofibrillary changes...
  70. pmc The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae
    Camilla A Hansson Petersen
    Karolinska Institutet Dainippon Sumitomo Pharma Alzheimer Center, NVS, Novum, 141 57 Huddinge, Sweden
    Proc Natl Acad Sci U S A 105:13145-50. 2008
    ..Together, these results provide further insight into the mitochondrial uptake of Abeta, a peptide considered to be of major significance in Alzheimer's disease...