Research Topics
Genomes and Genes | Irina AlafuzoffSummaryAffiliation: University of Kuopio Country: Finland Publications
| Collaborators
|
Detail Information
Publications
beta-amyloid load is not influenced by the severity of cardiovascular disease in aged and demented patientsA Irina
Department of Neuroscience and Neurology, Kuopio University, Kuopio, Finland
Stroke 30:613-8. 1999....
Assessment of alpha-synuclein pathology: a study of the BrainNet Europe ConsortiumIrina Alafuzoff
Department of Neuroscience and Neurology, Kuopio University, Kuopio, Finland
J Neuropathol Exp Neurol 67:125-43. 2008..Moreover, the study demonstrates that there are limitations in the scoring of alphaS-IR structures...- Inter-laboratory comparison of neuropathological assessments of beta-amyloid protein: a study of the BrainNet Europe consortiumIrina Alafuzoff
Department of Clinical Medicine, Unit of Neurology, Kuopio University, PO Box 1627, 70 211 Kuopio, Finland
Acta Neuropathol 115:533-46. 2008.... - Beta-amyloid deposition in brains of subjects with diabetesI Alafuzoff
Unit of Neurology, Department of Clinical Medicine, Kuopio University and Kuopio University Hospital, Kuopio, Finland
Neuropathol Appl Neurobiol 35:60-8. 2009..The objective of this study was to test the hypothesis that hyperinsulinaemia can elevate Abeta levels and thus contribute to AD pathology in humans... 
Staging of neurofibrillary pathology in Alzheimer's disease: a study of the BrainNet Europe ConsortiumIrina Alafuzoff
Department of Neuroscience and Neurology, Kuopio University, Kuopio, Finland
Brain Pathol 18:484-96. 2008..Thus, in a research setting when the extent of lesions is mild, it is strongly recommended that the assessment of lesions should be carried out by at least two independent observers...- Assessment of beta-amyloid deposits in human brain: a study of the BrainNet Europe ConsortiumIrina Alafuzoff
Department of Clinical Medicine, Kuopio University, Finland
Acta Neuropathol 117:309-20. 2009..Because most of these blocks are currently routinely sampled by the majority of laboratories, assessment of the A-beta phase in AD is feasible even in large scale retrospective studies... - Interlaboratory comparison of assessments of Alzheimer disease-related lesions: a study of the BrainNet Europe ConsortiumIrina Alafuzoff
Department of Neuroscience and Neurology, Kuopio University, Kuopio University Hospital, Finland
J Neuropathol Exp Neurol 65:740-57. 2006..Therefore, the IHC/HPtau methodology to visualize NFTs and neuropil threads should be considered as a method of choice in a future diagnostic protocol for Alzheimer disease... - Selegiline treatment and the extent of degenerative changes in brain tissue of patients with Alzheimer's diseaseI Alafuzoff
Department of Neuroscience and Neurology, Kuopio University, Finland
Eur J Clin Pharmacol 55:815-9. 2000..A beneficial effect of selegiline (L-deprenyl) in Alzheimer's disease (AD) has been reported in several clinical studies... - Severity of cardiovascular disease, apolipoprotein E genotype, and brain pathology in aging and dementiaI Alafuzoff
Department of Neuroscience and Neurology, Kuopio University, Finland
Ann N Y Acad Sci 903:244-51. 2000..The cardiovascular disease again seems to influence the extent of vascular lesions... - APOE4 predicts amyloid-β in cortical brain biopsy but not idiopathic normal pressure hydrocephalusOkko T Pyykkö
Neurosurgery of NeuroCentre, Kuopio University Hospital, P O Box 1777, 70211 Kuopio, Finland
J Neurol Neurosurg Psychiatry 83:1119-24. 2012.... - Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brainTero Tapiola
Department of Neuroscience and Neurology, Clinical Research Center Mediteknia, Kuopio University Hospital, University of Kuopio, Finland
Arch Neurol 66:382-9. 2009.... - Cortical brain biopsy in long-term prognostication of 468 patients with possible normal pressure hydrocephalusVille Leinonen
Department of Neurosurgery, Neurocenter, Kuopio University Hospital, Kuopio, Finland
Neurodegener Dis 10:166-9. 2012..Brain biopsy did not predict survival but may open a novel research window to study the pathobiology of neurodegeneration... - Expression of collagen XVII and ubiquitin-binding protein p62 in motor neuron diseaseAllan Seppänen
Department of Clinical Medicine, Neurology, University of Kuopio, FIN 70211 Kuopio, Finland
Brain Res 1247:171-7. 2009..Our study supports the re-definition of motor neuron disease as a multisystem disorder with a wide clinicopathological spectrum, and we advocate addressing psychiatric symptomology in future studies of motor neuron disease... - Cardiovascular diseases and hippocampal infarctsTuomas Rauramaa
Department of Pathology, Kuopio University Hospital, Finland
Hippocampus 21:281-7. 2011..Furthermore it should be noted that the size of the hippocampal tissue damage, i.e., small vs. large cystic infarcts is of significance regarding clinical alterations... - Staging/typing of Lewy body related alpha-synuclein pathology: a study of the BrainNet Europe ConsortiumIrina Alafuzoff
Department of Neuroscience and Neurology, Kuopio University, Kuopio, Finland
Acta Neuropathol 117:635-52. 2009.... - Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11-labeled Pittsburgh Compound BVille Leinonen
Department of Neurosurgery, Kuopio University Hospital, PO Box 1777, 70211 Kuopio, Finland
Arch Neurol 65:1304-9. 2008..To compare carbon 11-labeled Pittsburgh Compound B ([11C]PiB) positron emission tomography (PET) findings in patients with and without Alzheimer disease lesions in frontal cortical biopsy specimens... - The effect of prolonged fixation time on immunohistochemical staining of common neurodegenerative disease markersMaria Pikkarainen
Department of Clinical Medicine, Unit of Neurology, Section of Neuropathology, Kuopio University, Kuopio, Finland
J Neuropathol Exp Neurol 69:40-52. 2010..alpha-Synuclein-immunoreactive structures were visualized up to 14 years but only by the use of Syn42-Ab after formic acid AR or after a combination of heat and formic acid methods... - Heavy alcohol consumption and neuropathological lesions: a post-mortem human studyLeena Aho
Department of Clinical Medicine, Unit of Neurology, Kuopio University, Kuopio, Finland
J Neurosci Res 87:2786-92. 2009..Our results indicate that alcohol-related dementia differs from VCI, AD, and DLB; i.e., it has a different etiology and pathogenesis... - Systematic appraisal using immunohistochemistry of brain pathology in aged and demented subjectsLeena Aho
Department of Clinical Medicine, Unit of Neurology, Section of Neuropathology, Kuopio University, Kuopio, Finland
Dement Geriatr Cogn Disord 25:423-32. 2008..Abnormal processing of hyperphosphorylated tau (HPtau), amyloid-beta (Abeta) and alpha-synuclein (alphaS) proteins is considered as causative with regard to the clinical symptoms in age-related neurodegenerative diseases... - Hyperphosphorylated tau in the occipital cortex in aged nondemented subjectsMaria Pikkarainen
From the Department of Clinical Medicine, Unit of Neurology, Section of Neuropathology, Kuopio University, Kuopio, Finland
J Neuropathol Exp Neurol 68:653-60. 2009..Further systematic clinicopathologic studies are needed for an understanding of regional susceptibility to neurodegeneration and the significance of scattered HPtau-IR brain lesions... - Increased expression of caspase 2 in experimental and human temporal lobe epilepsySusanna Narkilahti
A I Virtanen Institute for Molecular Sciences, University of Kuopio, and Department of Neurology, Kuopio University Hospital, Finland
Neuromolecular Med 9:129-44. 2007..Our data suggest that caspase 2-mediated programmed cell death participates in the seizure-induced degenerative process in experimental and human TLE... - Long-term epilepsy surgery outcomes in patients with MRI-negative temporal lobe epilepsyArto Immonen
Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland
Epilepsia 51:2260-9. 2010..The purpose of this study was to determine the long-term outcomes of consecutive true MRI-negative TLE patients who all underwent standardized preoperative evaluation with intracranial electroencephalography (EEG) electrodes... - Amyloid and tau proteins in cortical brain biopsy and Alzheimer's diseaseVille Leinonen
Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland
Ann Neurol 68:446-53. 2010..Amyloid-β(Aβ) aggregates are presumed to be found in the brain at an early stage of Alzheimer's disease (AD) but have seldom been assessed by brain biopsy during life in often elderly patients... - Immunohistochemical visualization of amyloid-beta protein precursor and amyloid-beta in extra- and intracellular compartments in the human brainLeena Aho
Department of Clinical Medicine, Unit of Neurology, University of Eastern Finland, Kuopio, Finland
J Alzheimers Dis 20:1015-28. 2010..The staining results and conclusions depended strongly on the chosen antibody and the pretreatment strategy and thus multiple antibodies must be used when assessing the intracellular accumulation of Abeta... - Poor cognitive outcome in shunt-responsive idiopathic normal pressure hydrocephalusAnne M Koivisto
Unit of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
Neurosurgery 72:1-8;discussion 8. 2013..Idiopathic normal pressure hydrocephalus (iNPH) causes cognitive decline that can be alleviated by shunting, but long-term outcome studies are scarce... - Applicability of current staging/categorization of alpha-synuclein pathology and their clinical relevanceLaura Parkkinen
Department of Clinical Medicine, Unit of Neurology, Section of Neuropathology, Kuopio University, Yliopistonranta 1 C, P O Box 1627, 70211, Kuopio, Finland
Acta Neuropathol 115:399-407. 2008..However, finding that around half of the subjects with abundant alphaS pathology remain neurologically intact is intriguing and raises the question whether we do assess the actual disease process... - Human brain tissue microarrays as a platform to investigate diseases of the nervous systemPaula Martikainen
Department of Neuroscience and Neurology, University of Kuopio, and Kuopio University Hospital, Finland
Brain Res 1089:33-43. 2006.... - Distribution and pattern of pathology in subjects with familial or sporadic late-onset cerebellar ataxia as assessed by p62/sequestosome immunohistochemistryMaria Pikkarainen
Department of Clinical Medicine, Unit of Neurology, University of Eastern Finland, Kuopio, Finland
Cerebellum 10:720-31. 2011..Based on a literature search, it is apparent that there is a need for clinico-pathologic-genetical studies of LOCA, especially to obtain a deeper understanding of the regional distribution and progression of pathology... - Unusual clinical presentation and neuropathology in two subjects with fused-in sarcoma (FUS) positive inclusionsPäivi H Hartikainen
Department of Neurology, Kuopio University Hospital, Finland
Neuropathology 32:60-8. 2012..We conclude that clinical phenotypes of FUS pathologies also include elderly patients and are more variable with motor and speech disorders than previously reported... - Oxidative modification of proteins in the frontal cortex of Alzheimer's disease brainMinna A Korolainen
Department of Neuroscience and Neurology, University of Kuopio, and Department of Neurology, Kuopio University Hospital, Kuopio, Finland
Neurobiol Aging 27:42-53. 2006..These results do not contradict the hypothesis of increased oxidative stress in AD but may represent co-existing compensatory changes in response to oxidative stress... - Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions visualized with ubiquitin-binding protein p62 immunohistochemistryMaria Pikkarainen
Department of Clinical Medicine, Unit of Neurology, Section of Neuropathology, Kuopio University Hospital, Kuopio, Finland
J Neuropathol Exp Neurol 67:280-98. 2008.... - Heparan sulfate proteoglycan 2 polymorphism in Alzheimer's disease and correlation with neuropathologySusan Iivonen
Department of Neuroscience and Neurology, University Hospital and University of Kuopio, P O Box 1627, 70211, Kuopio, Finland
Neurosci Lett 352:146-50. 2003..In conclusion, HSPG2 A allele may possess an additive risk effect among the APOE epsilon4 carriers in AD... - Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62Erkki Kuusisto
Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
J Neuropathol Exp Neurol 62:1241-53. 2003..The results also point at dissimilarities in the formation of perikaryal vs intraneuritic inclusions... - TAR-DNA binding protein-43 and alterations in the hippocampusTuomas Rauramaa
Department of Pathology, Kuopio University Hospital, Kuopio, Finland
J Neural Transm 118:683-9. 2011..Our findings justify assessment of TDP43 pathology in every case where a pathological alteration is observed in the hippocampus using a routine stain... - Alpha-synuclein pathology does not predict extrapyramidal symptoms or dementiaLaura Parkkinen
Department of Neuroscience and Neurology, Kuopio University, 70211 Kuopio, Finland
Ann Neurol 57:82-91. 2005..Some neurologically unimpaired cases had a reasonable burden of alpha-synuclein pathology in both brainstem and cortical areas, suggesting that alpha-synuclein-positive structures are not definite markers of neuronal dysfunction... - Regional distribution of alpha-synuclein pathology in unimpaired aging and Alzheimer diseaseLaura Parkkinen
Department of Neuroscience, Kuopio University, P O Box 1627, FIN 70211 Kuopio, Finland
J Neuropathol Exp Neurol 62:363-7. 2003..However, this was not inevitably associated with AD pathology, but was related to cognitive decline. Incidental LBs in the SN were described in the occasional subjects, with no alphaS pathology in the lower brainstem... - Widespread and abundant alpha-synuclein pathology in a neurologically unimpaired subjectLaura Parkkinen
Department of Neuroscience and Neurology, Kuopio University, Kuopio, Finland
Neuropathology 25:304-14. 2005..The alphaS-positive inclusions may well represent detoxified reserves that cells can tolerate for years, and thus prevention of their development could actually accelerate the diseases process... - Does protein expression predict recurrence of benign World Health Organization grade I meningioma?Vesa Kärjä
Department of Clinical Pathology, Kuopio University Hospital, 70211 Kuopio, Finland
Hum Pathol 41:199-207. 2010.... - Beta-amyloid aggregation in human brains with cerebrovascular lesionsLeena Aho
Department of Clinical Medicine, Neurology, Kuopio University, P O B 1647, Harjulantie 1, Kuopio, Finland
Stroke 37:2940-5. 2006.... - Human postmortem brain tissue and 2-mm tissue microarraysTarja Kauppinen
Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
Appl Immunohistochem Mol Morphol 14:353-9. 2006..Thus, the applications of this brain TMA block in neurologic research by scientists with different skill bases remain to be determined... - Case report: central neurocytoma with concomitant cerebral involvement by acute lymphatic leukemiaJan Böhm
Department of Pathology and Forensic Medicine, University of Kuopio and Kuopio University Hospital, Finland
Hum Pathol 37:488-92. 2006..These two entities might be problematic to differentiate from each other without proper histopathological examination... - Interleukin 1 alpha gene polymorphism as a susceptibility factor in Alzheimer's disease and its influence on the extent of histopathological hallmark lesions of Alzheimer's diseaseMia Pirskanen
Department of Clinical Genetics, University Hospital of Kuopio, Finland
Dement Geriatr Cogn Disord 14:123-7. 2002..However, the IL1A C/C genotype might be associated with the progression of SPs/NPs in AD patients, but the effect is weak and obscured by the APOE epsilon4 allele... - GRN variant rs5848 reduces plasma and brain levels of granulin in Alzheimer's disease patientsAnna Kämäläinen
Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
J Alzheimers Dis 33:23-7. 2013..Our findings suggest that the A allele of rs5848 is functionally relevant by reducing the expression of granulin... - Cystatin C expression is associated with granule cell dispersion in epilepsyTerhi J Pirttilä
A I Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
Ann Neurol 58:211-23. 2005.... - Expression of interleukin-18 is increased in the brains of Alzheimer's disease patientsJohanna Ojala
Department of Neuroscience and Neurology, University of Kuopio, Canthia, P O Box 1627, FIN 70211 Kuopio, Finland
Neurobiol Aging 30:198-209. 2009..Plasma levels of IL-18 showed no correlation with the disease. In conclusion, amyloid-beta may induce the synthesis of IL-18, and IL-18 kinases involved in tau phosphorylation as a part of the amyloid-associated inflammatory reaction... - Proteomic analysis of glial fibrillary acidic protein in Alzheimer's disease and aging brainMinna A Korolainen
Department of Neuroscience and Neurology, University of Kuopio, Harjulantie 1D, P O Box 1627, FIN 70211 Kuopio, Finland
Neurobiol Dis 20:858-70. 2005..Mechanisms, structures and functional consequences of modification of GFAP isoforms remain to be clarified... - Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's diseaseAntero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
Prog Neurobiol 96:87-95. 2012..We will review here the molecular and functional characteristics of p62 protein and outline its potential role in the regulation of Alzheimer's pathogenesis... - Distribution of collagen XVII in the human brainAllan Seppänen
Department of Clinical Medicine, Neurology, University of Kuopio, Finland
Brain Res 1158:50-6. 2007..Many neurodegenerative disorders display a specific pattern of neuroanatomical involvement, thus the regionally variable expression of collagen XVII offers new prospects for research... - Malignant giant cell tumor in the posterior fossa of a neonatePetros N Karamanakos
Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland
J Neurosurg Pediatr 5:277-82. 2010..In addition, the extremely high growth rate of the tumor in the postoperative period renders this case the most aggressive primary malignant GCT of the cranium described so far... - Proteomic analysis of protein oxidation in Alzheimer's disease brainMinna A Korolainen
Department of Neuroscience and Neurology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Finland
Electrophoresis 23:3428-33. 2002..Two proteins showed a significant decrease in the degree of oxidation in AD. Our results suggest that the balance of protein oxidation and degradation is altered in AD... - Postmortem examination of vascular lesions in cognitive impairment: a survey among neuropathological servicesLeonardo Pantoni
Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
Stroke 37:1005-9. 2006..We aimed at surveying the postmortem neuropathological procedures used in different centers in examining brain lesions of presumable or possible vascular origin in cognitively impaired patients... - No correlation between CSF tau protein phosphorylated at threonine 181 with neocortical neurofibrillary pathology in Alzheimer's diseaseKatharina Buerger
Brain 130:e82. 2007 - Reelin-immunoreactive Cajal-Retzius cells: the entorhinal cortex in normal aging and Alzheimer's diseaseAnett Riedel
Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany
Acta Neuropathol 106:291-302. 2003..Nevertheless, CR cells seem to be partially affected by the formation of paired helical filaments, indicating subtle changes that are suggested to be a result rather than a cause of the pathogenetic cascade of AD... - Absence of association between an intercellular adhesion molecule 1 gene E469K polymorphism and Alzheimer's disease in Finnish patientsKari M Mattila
Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, Finland
Neurosci Lett 337:61-3. 2003..We therefore conclude that the E469K polymorphism of ICAM1 is not a risk factor for AD or PD... - CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's diseaseKatharina Buerger
Dementia Research Section and Memory Clinic, Alzheimer Memorial Center, Department of Psychiatry, Ludwig Maximilian University Munich, Germany
Brain 129:3035-41. 2006..There was a correlation between P-tau231P in CSF and brain homogenates. These findings indicate that CSF P-tau231P may serve as an in vivo surrogate biomarker of neurofibrillary pathology in Alzheimer's disease... - Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brainsXin-wen Zhou
Karolinska Institutet, Department of Neurotec, Geriatric-lab, Novum Plan 5, S-14157, Huddinge, Sweden
Neurobiol Dis 22:657-68. 2006..Assessments of levels of these abnormal proteins by dot blots may serve as a useful complement to the morphological evaluations in diagnosis of AD... - Role of protein kinase B in Alzheimer's neurofibrillary pathologyJin Jing Pei
Neurotec, Section for Experimental Geriatrics, Novum, Karolinska Institutet, KFC Plan 4, 141 86 Huddinge, Sweden
Acta Neuropathol 105:381-92. 2003..These studies suggest the involvement of PKB/GSK-3 signaling in Alzheimer neurofibrillary degeneration... - Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's diseaseWen Lin An
Division of Experimental Geriatrics, Karolinska Institutet, Neurotec, Novum, Huddinge, Sweden
Am J Pathol 163:591-607. 2003..A p70 S6 kinase modulated up-regulation of tau translation might contribute to PHF-tau accumulation in neurons with neurofibrillary changes... - Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markersKhalid Iqbal
New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
Ann Neurol 58:748-57. 2005..These subgroups, which can be identified by CSF analysis, might benefit differently from different therapeutic drugs... - Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brainXu Li
Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institutet, Huddinge, Sweden
FEBS J 272:4211-20. 2005.... - Glycosylation changes in Alzheimer's disease as revealed by a proteomic approachKatja Kanninen
Department of Neurobiology, A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, Neulaniementie 2, P.O. Box 1627, FIN-70211 Kuopio, Finland
Neurosci Lett 367:235-40. 2004..CRMP-2 regulates the assembly and polymerization of microtubules and is associated with neurofibrillary tangles in AD. Aberrant glycosylations in AD may help understand the mechanisms of neurodegenerative diseases... - Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistryHeiko Braak
Institute for Clinical Neuroanatomy, J W Goethe University Clinic, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
Acta Neuropathol 112:389-404. 2006..It is anticipated that this revised methodological protocol will enable a more uniform application of the staging procedure... - Collagen XVII is expressed in human CNS neuronsAllan Seppänen
Department of Neurology, University of Oulu and Clinical Research Center, Oulu University Hospital, FIN 90014 Oulu, Finland
Matrix Biol 25:185-8. 2006..We propose that collagen XVII may be involved in the pathogenesis of various disorders affecting neuronal migration or synaptic plasticity... - Management of a twenty-first century brain bank: experience in the BrainNet Europe consortiumJeanne E Bell
Department of Pathology Neuropathology, University of Edinburgh, Wilkie Building, Teviot Place, Edinburgh, UK
Acta Neuropathol 115:497-507. 2008.... - Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brainXu Li
Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institutet, KFC Plan 4, Novum, S 141 86 Huddinge, Sweden
Neuroreport 15:2237-40. 2004..Level of eIF4E phosphorylation is significantly correlated with total- and Alzheimer hyperphosphorylated taus. These data suggest that the increase of eIF4E phosphorylation is involved in formation of Alzheimer neurofibrillary changes... - The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristaeCamilla A Hansson Petersen
Karolinska Institutet Dainippon Sumitomo Pharma Alzheimer Center, NVS, Novum, 141 57 Huddinge, Sweden
Proc Natl Acad Sci U S A 105:13145-50. 2008..Together, these results provide further insight into the mitochondrial uptake of Abeta, a peptide considered to be of major significance in Alzheimer's disease...