Hans K Akerblom

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. pmc The Trial to Reduce IDDM in the Genetically at Risk (TRIGR) study: recruitment, intervention and follow-up
    H K Akerblom
    Hospital for Children and Adolescents, University of Helsinki, Biomedicum Helsinki 2 U, PO Box 20, 00014, Helsinki, Finland
    Diabetologia 54:627-33. 2011
  2. ncbi request reprint Environmental factors in the etiology of type 1 diabetes
    Hans K Akerblom
    University of Helsinki, Finland
    Am J Med Genet 115:18-29. 2002
  3. ncbi request reprint Dietary manipulation of beta cell autoimmunity in infants at increased risk of type 1 diabetes: a pilot study
    H K Akerblom
    Hospital for Children and Adolescents, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, PO Box 700, 00029 Helsinki, Finland
    Diabetologia 48:829-37. 2005
  4. ncbi request reprint Dietary intervention in infancy and later signs of beta-cell autoimmunity
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    N Engl J Med 363:1900-8. 2010
  5. doi request reprint Enhanced levels of cow's milk antibodies in infancy in children who develop type 1 diabetes later in childhood
    Kristiina Luopajarvi
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Pediatr Diabetes 9:434-41. 2008
  6. ncbi request reprint Hydrolyzed infant formula and early β-cell autoimmunity: a randomized clinical trial
    Mikael Knip
    University of Helsinki, Helsinki, Finland
    JAMA 311:2279-87. 2014
  7. ncbi request reprint Dietary insulin as an immunogen and tolerogen
    Minna Tiittanen
    Department of Viral Diseases and Immunology, Laboratory for Immunology, National Public Health Institute, Helsinki, Finland
    Pediatr Allergy Immunol 17:538-43. 2006
  8. pmc Early feeding and risk of type 1 diabetes: experiences from the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR)
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Am J Clin Nutr 94:1814S-1820S. 2011
  9. doi request reprint Infant feeding and the risk of type 1 diabetes
    Mikael Knip
    Hospital for Children and Adolescents and Folkhälsan Research Center, University of Helsinki, Finland
    Am J Clin Nutr 91:1506S-1513S. 2010
  10. ncbi request reprint Environmental triggers and determinants of type 1 diabetes
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, P O Box 281, FI 00029 Huch, Helsinki, Finland
    Diabetes 54:S125-36. 2005

Research Grants

Collaborators

Detail Information

Publications47

  1. pmc The Trial to Reduce IDDM in the Genetically at Risk (TRIGR) study: recruitment, intervention and follow-up
    H K Akerblom
    Hospital for Children and Adolescents, University of Helsinki, Biomedicum Helsinki 2 U, PO Box 20, 00014, Helsinki, Finland
    Diabetologia 54:627-33. 2011
    ..The Trial to Reduce IDDM in the Genetically at Risk (TRIGR) study was designed to establish whether weaning to a highly hydrolysed formula in infancy subsequently reduces the risk of type 1 diabetes...
  2. ncbi request reprint Environmental factors in the etiology of type 1 diabetes
    Hans K Akerblom
    University of Helsinki, Finland
    Am J Med Genet 115:18-29. 2002
    ..Among toxins, N-nitroso compounds are the main candidates. An interaction of genetic and environmental factors is important in evaluating the possible role of a certain environmental factor in the etiology of type 1 diabetes...
  3. ncbi request reprint Dietary manipulation of beta cell autoimmunity in infants at increased risk of type 1 diabetes: a pilot study
    H K Akerblom
    Hospital for Children and Adolescents, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, PO Box 700, 00029 Helsinki, Finland
    Diabetologia 48:829-37. 2005
    ....
  4. ncbi request reprint Dietary intervention in infancy and later signs of beta-cell autoimmunity
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    N Engl J Med 363:1900-8. 2010
    ..We tested the hypothesis that supplementing breast milk with highly hydrolyzed milk formula would decrease the cumulative incidence of diabetes-associated autoantibodies in such children...
  5. doi request reprint Enhanced levels of cow's milk antibodies in infancy in children who develop type 1 diabetes later in childhood
    Kristiina Luopajarvi
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Pediatr Diabetes 9:434-41. 2008
    ..Early exposure to cow's milk (CM) proteins have been implicated in the pathogenesis of type 1 diabetes (T1D)...
  6. ncbi request reprint Hydrolyzed infant formula and early β-cell autoimmunity: a randomized clinical trial
    Mikael Knip
    University of Helsinki, Helsinki, Finland
    JAMA 311:2279-87. 2014
    ..Early exposure to complex dietary proteins may increase the risk of β-cell autoimmunity in children at genetic risk for type 1 diabetes. Extensively hydrolyzed formulas do not contain intact proteins...
  7. ncbi request reprint Dietary insulin as an immunogen and tolerogen
    Minna Tiittanen
    Department of Viral Diseases and Immunology, Laboratory for Immunology, National Public Health Institute, Helsinki, Finland
    Pediatr Allergy Immunol 17:538-43. 2006
    ..However, our results in infants who developed beta-cell autoimmunity suggest that in this subgroup of children breast milk insulin does not promote tolerance...
  8. pmc Early feeding and risk of type 1 diabetes: experiences from the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR)
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Am J Clin Nutr 94:1814S-1820S. 2011
    ..The overall retention rate over the first 5 y was 87%, and protocol compliance was 94%. The randomization code will be opened when the last recruited child turns 10 y of age (ie, in 2017)...
  9. doi request reprint Infant feeding and the risk of type 1 diabetes
    Mikael Knip
    Hospital for Children and Adolescents and Folkhälsan Research Center, University of Helsinki, Finland
    Am J Clin Nutr 91:1506S-1513S. 2010
    ..Additional work, which includes the application of modern approaches such as metabolomics and epigenomics, is needed to discern the contribution of dietary factors in infancy to the diabetic disease process...
  10. ncbi request reprint Environmental triggers and determinants of type 1 diabetes
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, P O Box 281, FI 00029 Huch, Helsinki, Finland
    Diabetes 54:S125-36. 2005
    ..Accordingly, progression to clinical type 1 diabetes typically requires the unfortunate combination of genetic disease susceptibility, a diabetogenic trigger, and a high exposure to a driving antigen...
  11. doi request reprint Expansion of CD4+CD25+FOXP3+ regulatory T cells in infants of mothers with type 1 diabetes
    Kristiina Luopajarvi
    Immune Response Unit, Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    Pediatr Diabetes 13:400-7. 2012
    ..Reduced risk for type 1 diabetes (T1D) has been reported in the offspring of mothers with T1D when compared with children of affected fathers...
  12. pmc Prediction of type 1 diabetes in the general population
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Diabetes Care 33:1206-12. 2010
    ..To evaluate the utility of GAD antibodies (GADAs) and islet antigen-2 antibodies (IA-2As) in prediction of type 1 diabetes over 27 years in the general population and to assess the 6-year rates of seroconversion...
  13. ncbi request reprint Maternal consumption of dairy products during pregnancy and lactation, and the development of cow's milk antibodies in the offspring
    Maijaliisa Erkkola
    Department of Epidemiology and Health Promotion, Nutrition Unit, National Public Health Institute, Helsinki, Finland
    Acta Paediatr 94:696-704. 2005
    ..To assess whether the maternal consumption of milk and milk products affects development of cow's milk (CM) antibodies in infants...
  14. ncbi request reprint Humoral beta-cell autoimmunity in relation to HLA-defined disease susceptibility in preclinical and clinical type 1 diabetes
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Finland
    Am J Med Genet 115:48-54. 2002
    ..In patients with newly diagnosed disease IA-2A may be a more specific marker of beta-cell damage, whereas GADA might reflect a propensity to autoimmunity in general...
  15. pmc Reduced CCR4, interleukin-13 and GATA-3 up-regulation in response to type 2 cytokines of cord blood T lymphocytes in infants at genetic risk of type 1 diabetes
    Kristiina Luopajarvi
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Immunology 121:189-96. 2007
    ....
  16. ncbi request reprint Does the secular increase in body mass in children contribute to the increasing incidence of type 1 diabetes?
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Pediatr Diabetes 9:46-9. 2008
    ..The incidence of type 1 diabetes in children has increased in most developed countries after World War II, and simultaneously, normal children have experienced accelerated weight gain and growth...
  17. ncbi request reprint Models for predicting type 1 diabetes in siblings of affected children
    Samy Mrena
    Hospital for Children and Adolescents, University of Helsinki, P O Box 281, FI 00029 Huch, Helsinki, Finland
    Diabetes Care 29:662-7. 2006
    ..To generate predictive models for the assessment of risk of type 1 diabetes and age at diagnosis in siblings of children with newly diagnosed type 1 diabetes...
  18. ncbi request reprint Intestinal permeability to mannitol and lactulose in children with type 1 diabetes with the HLA-DQB1*02 allele
    Mikael Kuitunen
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Autoimmunity 35:365-8. 2002
    ..The higher permeability of patients with the HLA-DQB1*02 allele suggests that these patients may be more prone to develop abnormal immune responses to food antigens...
  19. ncbi request reprint Early nutrition and later diabetes risk
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, P O Box 281, FI 00029 Huch, Helsinki, Finland
    Adv Exp Med Biol 569:142-50. 2005
    ....
  20. ncbi request reprint Effect of cow's milk exposure and maternal type 1 diabetes on cellular and humoral immunization to dietary insulin in infants at genetic risk for type 1 diabetes. Finnish Trial to Reduce IDDM in the Genetically at Risk Study Group
    J Paronen
    Hospital for Children and Adolescents, University of Helsinki, Finland
    Diabetes 49:1657-65. 2000
    ..The priming of insulin-specific humoral and T-cell immunity occurs in early infancy by dietary insulin, and this phenomenon is influenced by maternal type 1 diabetes...
  21. pmc Jejuna of patients with insulin-dependent diabetes mellitus (IDDM) show signs of immune activation
    E Savilahti
    Hospital for Children and Adolescents, University of Helsinki, Finland
    Clin Exp Immunol 116:70-7. 1999
    ..These findings reflect a stage of inflammation in the structurally normal intestines of patients with IDDM and suggest secretion of inflammatory Th1-type cytokines in the intestine...
  22. ncbi request reprint Experience of severe hypoglycaemia may influence both patient's and physician's subsequent treatment policy of insulin-dependent diabetes mellitus
    S Tupola
    Aurora Hospital, Helsinki, Finland
    Eur J Pediatr 157:625-7. 1998
    ..3+/-1.5% vs 9.1+/-1.8%, P< 0.001, respectively). Physicians decreased the insulin dose even in 14 of the 33 patients with a preventable cause for their hypoglycaemia other than erroneous excess of insulin...
  23. ncbi request reprint Breastfeeding patterns of mothers with type 1 diabetes: results from an infant feeding trial
    Susa Sorkio
    Nutrition Unit, National Institute for Health and Welfare, Helsinki, Finland
    Diabetes Metab Res Rev 26:206-11. 2010
    ..The aim of this study was to prospectively examine the breastfeeding patterns among mothers with and without T1D participating in a large international randomized infant feeding trial (TRIGR)...
  24. ncbi request reprint Prevalence of coeliac disease in siblings of patients with Type I diabetes is related to the prevalence of DQB1*02 allele
    T Saukkonen
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Diabetologia 44:1051-3. 2001
    ..Our aim was to find out if coeliac disease is more common among siblings of children with Type I diabetes than in the normal population...
  25. ncbi request reprint Immune response to glycated and oxidized LDL in IDDM patients with and without renal disease
    E Korpinen
    Children s Hospital, University of Helsinki, Finland
    Diabetes Care 20:1168-71. 1997
    ..To study autoantibodies to oxidized and glycated LDL in IDDM patients with and without diabetic nephropathy and in nephropathy-related macroangiopathy..
  26. ncbi request reprint Genetic modification of risk assessment based on staging of preclinical type 1 diabetes in siblings of affected children
    S Mrena
    Hospital for Children and Adolescents, University of Helsinki, FIN 00029 Helsinki, Finland
    J Clin Endocrinol Metab 88:2682-9. 2003
    ..Genetic susceptibility has an impact on both the initiation and progression of the autoimmune process leading to clinical diabetes in siblings of affected children...
  27. ncbi request reprint Prediction of type 1 diabetes among siblings of affected children and in the general population
    H T Siljander
    Hospital for Children and Adolescents, University of Helsinki, P O Box 22 Stenbäckinkatu 11, 00014 Helsinki, Finland
    Diabetologia 50:2272-5. 2007
    ..To compare the predictive characteristics of autoantibodies to GAD (GADA) and islet antigen 2 (IA-2A) for type 1 diabetes between siblings of affected children and children from the general population...
  28. ncbi request reprint Coeliac disease in children and adolescents with type 1 diabetes: a study of growth, glycaemic control, and experiences of families
    T Saukkonen
    Hospital for Children and Adolescents, University of Helsinki, Finland
    Acta Paediatr 91:297-302. 2002
    ..3+/-18.1 to 8.2+/-15.4% deviation from population median, p = 0.02). This increase in weight-for-height was inversely correlated with changes in GHbA1 (r = -0.574, p = 0.02)...
  29. ncbi request reprint Natural course of preclinical type 1 diabetes in siblings of affected children
    S Mrena
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Acta Paediatr 92:1403-10. 2003
    ..To define the dynamics of preclinical type 1 diabetes in siblings of affected children and to characterize the siblings experiencing a progressive process...
  30. ncbi request reprint Relation between T-cell responses to glutamate decarboxylase and coxsackievirus B4 in patients with insulin-dependent diabetes mellitus
    P Klemetti
    Department of Biochemistry, National Public Health Institute, and Hospital for Children and Adolescents, University of Helsinki, Finland
    J Clin Virol 14:95-105. 1999
    ..A possible connection between glutamate decarboxylase (GAD) autoimmunity and enterovirus infections in IDDM has been suggested to be based on a homology region between GAD and the non-structural protein 2C of coxsackievirus B4 (CVB4)...
  31. ncbi request reprint Increased secretion of TGF-beta1 by peripheral blood mononuclear cells from patients with Type 1 diabetes mellitus with diabetic nephropathy
    E Korpinen
    Hospital for Children and Adolescents, University of Helsinki, Finland
    Diabet Med 18:121-5. 2001
    ..To study transforming growth factor (TGF)-beta1 secretion by peripheral blood mononuclear cells (PBMC) from Type 1 diabetic patients with and without nephropathy...
  32. ncbi request reprint Urinary transforming growth factor-beta1 and alpha1-microglobulin in children and adolescents with type 1 diabetes
    E Korpinen
    Hospital for Children and Adolescents, University of Helsinki, Finland
    Diabetes Care 23:664-8. 2000
    ..Urinary TGF-beta1 reflects TGF-beta1 production in the kidney, and alpha1-microglobulin tubular dysfunction. These 2 markers were studied in the early phases of type 1 diabetes...
  33. ncbi request reprint N-acetyltransferase-2 polymorphism, smoking and type 1 diabetic nephropathy
    E Korpinen
    Hospital for Children and Adolescents, University of Helsinki, Finland
    Pharmacogenetics 9:627-33. 1999
    ..09]. Smoking is a strong confounding factor in relation to NAT2 analyses and diabetic nephropathy. According to our data, in nonsmoking type 1 diabetic patients fast NAT2 genotype implies an increased risk for diabetic nephropathy...
  34. ncbi request reprint Cardiovascular Risk in Young Finns Study: general outline and recent developments
    H K Akerblom
    Hospital for Children and Adolescents, University of Helsinki, Finland
    Ann Med 31:45-54. 1999
    ..26 in 1980 to 0.39 in 1992, with no significant changes in the total energy derived from fat. 'Hard-driving' was found to be the psychological risk factor most consistently related to the CHD risk factor level...
  35. ncbi request reprint From pathomechanisms to prediction, prevention and improved care of insulin-dependent diabetes mellitus in children
    H K Akerblom
    Children s Hospital, University of Helsinki, Finland
    Ann Med 29:383-5. 1997
    ....
  36. ncbi request reprint Early programming of diabetes risk--an introduction
    H K Akerblom
    Biomedicum Helsinki and Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Adv Exp Med Biol 569:139-41. 2005
  37. ncbi request reprint IA-2 antibody epitopes and isotypes during the prediabetic process in siblings of children with type 1 diabetes
    Sanna Hoppu
    Pediatric Research Center, University of Tampere, and Tampere University Hospital, Tampere, Finland
    J Autoimmun 23:361-70. 2004
    ..This study demonstrates that JM-reactive IA-2 antibodies are associated with an increased risk of progression to overt T1D, whereas an IgE response to IA-2 confers relative protection against clinical disease...
  38. ncbi request reprint Maternal antibodies in breast milk protect the child from enterovirus infections
    Karita Sadeharju
    Department of Virology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Pediatrics 119:941-6. 2007
    ..We set out to assess whether breastfeeding can protect against these infections and whether such an effect is related to maternal antibodies in breast milk or in the peripheral circulation of the infant...
  39. ncbi request reprint Autoantibodies to GAD, IA-2 and insulin in ICA-positive first-degree relatives of children with type 1 diabetes: a comparison between parents and siblings
    Sari Korhonen
    Department of Pediatrics, University of Oulu, Oulu, Finland
    Diabetes Metab Res Rev 18:43-8. 2002
    ....
  40. ncbi request reprint A linkage study of 12 IDDM susceptibility loci in the Finnish population
    Antti Pekka Laine
    JDRF Centre for Prevention of Type 1 Diabetes in Finland, Department of Virology, University of Turku, Turku, Finland
    Diabetes Metab Res Rev 20:144-9. 2004
    ..Genome scans and candidate gene studies have generated several chromosomal candidate regions that may have a role in T1D development...
  41. pmc Two insulin gene single nucleotide polymorphisms associated with type 1 diabetes risk in the Finnish and Swedish populations
    Antti Pekka Laine
    Immunogenetics Laboratory, University of Turku, Turku, Finland
    Dis Markers 23:139-45. 2007
    ..These observations suggest that heterogeneity between the protective IDDM2 lineages could exist, and analyzing both -23HphI and -2221MspI would thus potentially enhance the sensitivity and specificity of type 1 diabetes risk estimation...
  42. ncbi request reprint Serum alpha-tocopherol concentrations and risk of type 1 diabetes mellitus: a cohort study in siblings of affected children
    Liisa Uusitalo
    Tampere School of Public Health, University of Tampere, Finland
    J Pediatr Endocrinol Metab 18:1409-16. 2005
    ..08 and 0.09, respectively). Although the results did not reach statistical significance, they support the hypothesis that high alpha-tocopherol levels may protect against DM1...
  43. ncbi request reprint Geographic origin as a determinant of carotid artery intima-media thickness and brachial artery flow-mediated dilation: the Cardiovascular Risk in Young Finns study
    Markus Juonala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Arterioscler Thromb Vasc Biol 25:392-8. 2005
    ..Whether this is because of genetic or environmental factors is unknown. We examined the effect of geographic family origin on subclinical atherosclerosis among young Finns...
  44. ncbi request reprint Relative validity of a dietary interview for assessing infant diet and compliance in a dietary intervention trial
    Liisa Vähätalo
    Nutrition Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Mannerhemintie 166, FI 00300 Helsinki, Finland
    Matern Child Nutr 2:181-7. 2006
    ..As a conclusion, the interview was found to be a useful tool for assessing diet and compliance in a dietary intervention for infants...
  45. ncbi request reprint Human leukocyte antigen non-class II determinants for type 1 diabetes in the Finnish population
    Zsofia Gombos
    Immunogenetics Laboratory, University of Turku, Turku, Finland
    Hum Immunol 67:714-21. 2006
    ..Another locus close to D6S273 may also have an effect. For the first time we report that a locus near the C143 marker appear to affect disease association of the DRB1*08-DQB1*04 haplotype...
  46. ncbi request reprint Estimation of genetic risk for type 1 diabetes
    Jorma Ilonen
    Institute of Microbiology and Pathology, University of Turku, Finland
    Am J Med Genet 115:30-6. 2002
    ..The efficiency of the procedure has also been tested in Finnish and Greek populations...
  47. ncbi request reprint Increased frequency of islet cell antibodies in unaffected brothers of children with type 1 diabetes
    Vesa Eskola
    University of Tampere Medical School and Department of Paediatrics, Tampere University Hospital, Tampere, Finland
    Horm Res 59:195-200. 2003
    ..To assess the relation between islet cell antibody (ICA) positivity and demographic characteristics in an extensive series of first-degree relatives of children with type 1 diabetes (T1D)...

Research Grants1

  1. Trial to Reduce IDDM in the Genetically at Risk- study
    HANS AKERBLOM; Fiscal Year: 2007
    ..If our intervention is effective in delaying autoimmunity or its progression to diabetes, this first ever primary prevention study of T1D, will have far-reaching impact for individuals and the global society. ..