Research Topics
Genomes and Genes
| Matti S AiraksinenSummaryAffiliation: University of Helsinki Country: Finland Publications
| Collaborators
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Detail Information
Publications
The GDNF family: signalling, biological functions and therapeutic valueMatti S Airaksinen
Programme of Molecular Neurobiology, Institute of Biotechnology, P O Box 56, Viikki Biocenter, FIN 00014, University of Helsinki, Finland
Nat Rev Neurosci 3:383-94. 2002..Although neurotrophins and GFLs activate common intracellular signalling pathways through their receptor tyrosine kinases, several clear differences exist between these families of trophic factors...- Evolution of the GDNF family ligands and receptorsMatti S Airaksinen
Neuroscience Center, University of Helsinki, Helsinki, Finland
Brain Behav Evol 68:181-90. 2006..Loss of neurturin in frog and persephin in chicken suggests functional redundancy in early tetrapods. Functions of non-mammalian GFLs and prechordate RET and GFR-like proteins remain to be explored... - A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2Pavel Uvarov
Neuroscience Center, Viikinkaari 4, University of Helsinki, Finland
J Biol Chem 282:30570-6. 2007.... - KCC2-deficient mice show reduced sensitivity to diazepam, but normal alcohol-induced motor impairment, gaboxadol-induced sedation, and neurosteroid-induced hypnosisJanne Tornberg
Neuroscience Center, University of Helsinki, Helsinki, Finland
Neuropsychopharmacology 32:911-8. 2007..Electrophysiological recordings show that the tonic conductance is not affected. The results suggest that KCC2 activity is more critical for behaviors dependent on phasic than tonic GABAergic inhibition... - KCC2 interacts with the dendritic cytoskeleton to promote spine developmentHong Li
Institute of Biotechnology, University of Helsinki, Viikinkaari 4, FIN 00014, Helsinki, Finland
Neuron 56:1019-33. 2007..1N may play an important role. A more general conclusion based on our data is that KCC2 acts as a synchronizing factor in the functional development of glutamatergic and GABAergic synapses in cortical neurons and networks... 
Altered synaptic dynamics and hippocampal excitability but normal long-term plasticity in mice lacking hyperpolarizing GABA A receptor-mediated inhibition in CA1 pyramidal neuronsRuusu Riekki
Neuroscience Center, University of Helsinki, Helsinki, Finland
J Neurophysiol 99:3075-89. 2008..Moreover, our data demonstrate a novel, unexpected role for the KCC2, namely the modulation of properties of glutamatergic transmission during repetitious afferent activity...- Early growth response 4 mediates BDNF induction of potassium chloride cotransporter 2 transcriptionAnastasia Ludwig
Institute of Biotechnology, University of Helsinki, Viikki Biocenter, Viikinkaari 9, FIN 00014, Helsinki, Finland
J Neurosci 31:644-9. 2011..These results indicate that Egr4 is an important component in the mechanism of BDNF-dependent KCC2 gene regulation via the ERK1/2 pathway in immature neurons... 
Neurturin evokes MAPK-dependent upregulation of Egr4 and KCC2 in developing neuronsAnastasia Ludwig
Neuroscience Center, University of Helsinki, Viikinkaari 4, 00014 Helsinki, Finland
Neural Plast 2011:1-8. 2011..These results show that Egr4 is an important component in the mechanism for trophic factor-mediated upregulation of KCC2 in immature neurons involving the activation of specific intracellular pathways common to BDNF and Neurturin...- Parasympathetic innervation and function of endocrine pancreas requires the glial cell line-derived factor family receptor alpha2 (GFRalpha2)Jari Rossi
Neuroscience Center, P O Box 56 Viikinkaari 4, 00014 University of Helsinki, Finland
Diabetes 54:1324-30. 2005..The GFRalpha2-KO mouse represents a useful model to study the role of parasympathetic innervation of the endocrine pancreas in glucose homeostasis... - Coexpression and heteromerization of two neuronal K-Cl cotransporter isoforms in neonatal brainPavel Uvarov
Neuroscience Center, University of Helsinki, Viikinkaari 4, 00014 Helsinki, Finland
J Biol Chem 284:13696-704. 2009..Consistent with this, native gel analysis shows that a substantial part of endogenous KCC2 isoforms in the neonatal brain constitute dimers... - Ablation of persephin receptor glial cell line-derived neurotrophic factor family receptor alpha4 impairs thyroid calcitonin production in young micePäivi H Lindfors
Neuroscience Center, University of Helsinki, Finland
Endocrinology 147:2237-44. 2006..In conclusion, this study indicates a novel role for endogenous GFRalpha4 signaling in regulating calcitonin production in thyroid C cells of young mice... - Cation-chloride cotransporters and neuronal functionPeter Blaesse
Department of Biological and Environmental Sciences, University of Helsinki, Viikinkaari 1, FIN 00014, Helsinki, Finland
Neuron 61:820-38. 2009..The rapidly expanding work on CCCs promotes our understanding of fundamental mechanisms that control brain development and functions under normal and pathophysiological conditions... - Two novel mammalian Nogo receptor homologs differentially expressed in the central and peripheral nervous systemsJuha Lauren
Program in Molecular Neurobiology, Institute of Biotechnology, University of Helsinki, P O Box 56 Viikinkaari 9, FIN 00014, University of Helsinki, Helsinki, Finland
Mol Cell Neurosci 24:581-94. 2003..We also show that all four members of the reticulon family, including Nogo-A, are widely expressed in the nervous system, and therefore are possible ligands for the NgRLs... - GDNF family ligands activate multiple events during axonal growth in mature sensory neuronsMikhail Paveliev
Program for Molecular Neurobiology, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Helsinki FIN 00014, Finland
Mol Cell Neurosci 25:453-9. 2004..We also show that neurturin and GDNF induce extensive lamellipodia formation on neuronal somata and growth cones. GDNF, when applied after the time of axonal initiation in culture, also promotes axonal elongation... - Neuronal K+/Cl- co-transporter (KCC2) transgenes lacking neurone restrictive silencer element recapitulate CNS neurone-specific expression and developmental up-regulation of endogenous KCC2 genePavel Uvarov
Neuroscience Centre, 00014 University of Helsinki, Helsinki, Finland
J Neurochem 95:1144-55. 2005..Thus, developmental up-regulation of the KCC2 gene does not require NRSE(KCC2) and the 1.4-kb KCC2 promoter is largely sufficient for neurone-specific expression of KCC2... - Upregulation of the neuron-specific K+/Cl- cotransporter expression by transcription factor early growth response 4Pavel Uvarov
Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland
J Neurosci 26:13463-73. 2006..Together, the results indicate an important role for Egr4 in the developmental upregulation of KCC2 gene expression... - Role of upstream stimulating factors in the transcriptional regulation of the neuron-specific K-Cl cotransporter KCC2Marika Markkanen
Neuroscience Center, Viikinkaari 4, 00014 University of Helsinki, Finland
Brain Res 1236:8-15. 2008..The results suggest that binding of USF proteins to the E-boxKCC2b may contribute to the upregulation of KCC2b gene expression in developing brain... - Patterns of cation-chloride cotransporter expression during embryonic rodent CNS developmentHong Li
Institute of Biotechnology, PO Box 56, Viikinkaari 9C, FIN-00014 University of Helsinki, Finland
Eur J Neurosci 16:2358-70. 2002..These unique spatiotemporal expression patterns of distinct CCCs during embryonic development suggests that Cl- regulatory mechanisms are critically involved in the control of neuronal development... - Behavioural phenotypes of hypomorphic KCC2-deficient miceJanne Tornberg
Neuroscience Center, PO Box 56, Viikinkaari 4, FIN 00014 University of Helsinki, Finland
Eur J Neurosci 21:1327-37. 2005.... - Sympathetic cholinergic target innervation requires GDNF family receptor GFR alpha 2Päivi H Hiltunen
Neuroscience Center, 00014 University of Helsinki, Finland
Mol Cell Neurosci 26:450-7. 2004..Thus, neurturin may be a general target-derived innervation factor for postganglionic cholinergic neurons in all parts of the autonomic nervous system... - Deficient nonpeptidergic epidermis innervation and reduced inflammatory pain in glial cell line-derived neurotrophic factor family receptor alpha2 knock-out micePäivi H Lindfors
Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland
J Neurosci 26:1953-60. 2006..Overall, our results indicate a critical role for endogenous GFRalpha2 signaling in maintaining the size and terminal innervation of the nonpeptidergic class of cutaneous nociceptors in vivo... - Alimentary tract innervation deficits and dysfunction in mice lacking GDNF family receptor alpha2Jari Rossi
Program in Molecular Neurobiology, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
J Clin Invest 112:707-16. 2003..Taken together, the results suggest that the growth retardation in mice lacking GFRalpha2 is largely due to impaired salivary and pancreatic secretion and intestinal dysmotility... - Increased apoptosis of parasympathetic but not enteric neurons in mice lacking GFRalpha2Meri Lähteenmäki
Neuroscience Center, Viikinkaari 4, 00014 University of Helsinki, Helsinki, Finland
Dev Biol 305:325-32. 2007.... - Impaired behavioural flexibility and memory in mice lacking GDNF family receptor alpha2Vootele Voikar
Department of Biosciences, PO Box 56, Viikinkaari 4, FIN 00014 University of Helsinki, Finland
Eur J Neurosci 20:308-12. 2004..The results suggest that GFRalpha2 signalling plays a role in the development or maintenance of cognitive abilities that help in solving complex learning tasks... - Loss of neurturin in frog--comparative genomics study of GDNF family ligand-receptor pairsTuomas Hätinen
Institute of Biotechnology, 00014 University of Helsinki, Finland
Mol Cell Neurosci 34:155-67. 2007..Evolutionary trace analysis and protein structure homology modeling points at GDNF as the endogenous ligand of frog GFRalpha2... - GDNF family signalling in exocrine tissues: distinct roles for GDNF and neurturin in parasympathetic neuron developmentJari Rossi
Program in Molecular Neurobiology, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
Adv Exp Med Biol 506:19-26. 2002 - LRRTM3 is dispensable for amyloid-β production in miceTiina Laakso
Neuroscience Center, University of Helsinki, Helsinki, Finland Institute of Biomedicine, University of Helsinki, Helsinki, Finland
J Alzheimers Dis 31:759-64. 2012..Moreover, Aβ levels in primary cortical neurons were similar between the genotypes, indicating that LRRTM3 is not required for Aβ generation in developing mice... - A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous systemJuha Lauren
Program in Molecular Neurobiology, Institute of Biotechnology, University of Helsinki, P O Box 56 Viikinkaari 9, FIN 00014 Helsinki, Finland
Genomics 81:411-21. 2003..The structure and expression profile of LRRTM mRNAs suggest that they may have a role in the development and maintenance of the vertebrate nervous system... 
BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusionClaudio Rivera
Department of Biosciences, Division of Animal Physiology, Institute of Biotechnology, University of Helsinki, Finland
J Cell Biol 159:747-52. 2002....- Characterization of myelin ligand complexes with neuronal Nogo-66 receptor family membersJuha Lauren
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Biol Chem 282:5715-25. 2007..This detailed knowledge of the molecular interactions between NgR1 and its ligands is imperative when assessing options for development of NgR1-based therapeutics for central nervous system injuries... - GFR alpha2/neurturin signalling regulates noxious heat transduction in isolectin B4-binding mouse sensory neuronsCheryl L Stucky
Growth Factors and Regeneration Group, Department of Neuroscience, Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, Berlin D 13092, Germany
J Physiol 545:43-50. 2002..Our data are the first to indicate a transduction-function role for GFR alpha2/neurturin signalling in a specific class of sensory neurons...