Matti S Airaksinen

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi request reprint The GDNF family: signalling, biological functions and therapeutic value
    Matti S Airaksinen
    Programme of Molecular Neurobiology, Institute of Biotechnology, P O Box 56, Viikki Biocenter, FIN 00014, University of Helsinki, Finland
    Nat Rev Neurosci 3:383-94. 2002
  2. ncbi request reprint Evolution of the GDNF family ligands and receptors
    Matti S Airaksinen
    Neuroscience Center, University of Helsinki, Helsinki, Finland
    Brain Behav Evol 68:181-90. 2006
  3. ncbi request reprint A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2
    Pavel Uvarov
    Neuroscience Center, Viikinkaari 4, University of Helsinki, Finland
    J Biol Chem 282:30570-6. 2007
  4. ncbi request reprint KCC2 interacts with the dendritic cytoskeleton to promote spine development
    Hong Li
    Institute of Biotechnology, University of Helsinki, Viikinkaari 4, FIN 00014, Helsinki, Finland
    Neuron 56:1019-33. 2007
  5. doi request reprint Altered synaptic dynamics and hippocampal excitability but normal long-term plasticity in mice lacking hyperpolarizing GABA A receptor-mediated inhibition in CA1 pyramidal neurons
    Ruusu Riekki
    Neuroscience Center, University of Helsinki, Helsinki, Finland
    J Neurophysiol 99:3075-89. 2008
  6. ncbi request reprint KCC2-deficient mice show reduced sensitivity to diazepam, but normal alcohol-induced motor impairment, gaboxadol-induced sedation, and neurosteroid-induced hypnosis
    Janne Tornberg
    Neuroscience Center, University of Helsinki, Helsinki, Finland
    Neuropsychopharmacology 32:911-8. 2007
  7. doi request reprint Early growth response 4 mediates BDNF induction of potassium chloride cotransporter 2 transcription
    Anastasia Ludwig
    Institute of Biotechnology, University of Helsinki, Viikki Biocenter, Viikinkaari 9, FIN 00014, Helsinki, Finland
    J Neurosci 31:644-9. 2011
  8. pmc Neurturin evokes MAPK-dependent upregulation of Egr4 and KCC2 in developing neurons
    Anastasia Ludwig
    Neuroscience Center, University of Helsinki, Viikinkaari 4, 00014 Helsinki, Finland
    Neural Plast 2011:1-8. 2011
  9. ncbi request reprint Parasympathetic innervation and function of endocrine pancreas requires the glial cell line-derived factor family receptor alpha2 (GFRalpha2)
    Jari Rossi
    Neuroscience Center, P O Box 56 Viikinkaari 4, 00014 University of Helsinki, Finland
    Diabetes 54:1324-30. 2005
  10. pmc Coexpression and heteromerization of two neuronal K-Cl cotransporter isoforms in neonatal brain
    Pavel Uvarov
    Neuroscience Center, University of Helsinki, Viikinkaari 4, 00014 Helsinki, Finland
    J Biol Chem 284:13696-704. 2009

Collaborators

Detail Information

Publications32

  1. ncbi request reprint The GDNF family: signalling, biological functions and therapeutic value
    Matti S Airaksinen
    Programme of Molecular Neurobiology, Institute of Biotechnology, P O Box 56, Viikki Biocenter, FIN 00014, University of Helsinki, Finland
    Nat Rev Neurosci 3:383-94. 2002
    ..Although neurotrophins and GFLs activate common intracellular signalling pathways through their receptor tyrosine kinases, several clear differences exist between these families of trophic factors...
  2. ncbi request reprint Evolution of the GDNF family ligands and receptors
    Matti S Airaksinen
    Neuroscience Center, University of Helsinki, Helsinki, Finland
    Brain Behav Evol 68:181-90. 2006
    ..Loss of neurturin in frog and persephin in chicken suggests functional redundancy in early tetrapods. Functions of non-mammalian GFLs and prechordate RET and GFR-like proteins remain to be explored...
  3. ncbi request reprint A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2
    Pavel Uvarov
    Neuroscience Center, Viikinkaari 4, University of Helsinki, Finland
    J Biol Chem 282:30570-6. 2007
    ....
  4. ncbi request reprint KCC2 interacts with the dendritic cytoskeleton to promote spine development
    Hong Li
    Institute of Biotechnology, University of Helsinki, Viikinkaari 4, FIN 00014, Helsinki, Finland
    Neuron 56:1019-33. 2007
    ..1N may play an important role. A more general conclusion based on our data is that KCC2 acts as a synchronizing factor in the functional development of glutamatergic and GABAergic synapses in cortical neurons and networks...
  5. doi request reprint Altered synaptic dynamics and hippocampal excitability but normal long-term plasticity in mice lacking hyperpolarizing GABA A receptor-mediated inhibition in CA1 pyramidal neurons
    Ruusu Riekki
    Neuroscience Center, University of Helsinki, Helsinki, Finland
    J Neurophysiol 99:3075-89. 2008
    ..Moreover, our data demonstrate a novel, unexpected role for the KCC2, namely the modulation of properties of glutamatergic transmission during repetitious afferent activity...
  6. ncbi request reprint KCC2-deficient mice show reduced sensitivity to diazepam, but normal alcohol-induced motor impairment, gaboxadol-induced sedation, and neurosteroid-induced hypnosis
    Janne Tornberg
    Neuroscience Center, University of Helsinki, Helsinki, Finland
    Neuropsychopharmacology 32:911-8. 2007
    ..Electrophysiological recordings show that the tonic conductance is not affected. The results suggest that KCC2 activity is more critical for behaviors dependent on phasic than tonic GABAergic inhibition...
  7. doi request reprint Early growth response 4 mediates BDNF induction of potassium chloride cotransporter 2 transcription
    Anastasia Ludwig
    Institute of Biotechnology, University of Helsinki, Viikki Biocenter, Viikinkaari 9, FIN 00014, Helsinki, Finland
    J Neurosci 31:644-9. 2011
    ..These results indicate that Egr4 is an important component in the mechanism of BDNF-dependent KCC2 gene regulation via the ERK1/2 pathway in immature neurons...
  8. pmc Neurturin evokes MAPK-dependent upregulation of Egr4 and KCC2 in developing neurons
    Anastasia Ludwig
    Neuroscience Center, University of Helsinki, Viikinkaari 4, 00014 Helsinki, Finland
    Neural Plast 2011:1-8. 2011
    ..These results show that Egr4 is an important component in the mechanism for trophic factor-mediated upregulation of KCC2 in immature neurons involving the activation of specific intracellular pathways common to BDNF and Neurturin...
  9. ncbi request reprint Parasympathetic innervation and function of endocrine pancreas requires the glial cell line-derived factor family receptor alpha2 (GFRalpha2)
    Jari Rossi
    Neuroscience Center, P O Box 56 Viikinkaari 4, 00014 University of Helsinki, Finland
    Diabetes 54:1324-30. 2005
    ..The GFRalpha2-KO mouse represents a useful model to study the role of parasympathetic innervation of the endocrine pancreas in glucose homeostasis...
  10. pmc Coexpression and heteromerization of two neuronal K-Cl cotransporter isoforms in neonatal brain
    Pavel Uvarov
    Neuroscience Center, University of Helsinki, Viikinkaari 4, 00014 Helsinki, Finland
    J Biol Chem 284:13696-704. 2009
    ..Consistent with this, native gel analysis shows that a substantial part of endogenous KCC2 isoforms in the neonatal brain constitute dimers...
  11. ncbi request reprint Ablation of persephin receptor glial cell line-derived neurotrophic factor family receptor alpha4 impairs thyroid calcitonin production in young mice
    Päivi H Lindfors
    Neuroscience Center, University of Helsinki, Finland
    Endocrinology 147:2237-44. 2006
    ..In conclusion, this study indicates a novel role for endogenous GFRalpha4 signaling in regulating calcitonin production in thyroid C cells of young mice...
  12. ncbi request reprint Two novel mammalian Nogo receptor homologs differentially expressed in the central and peripheral nervous systems
    Juha Lauren
    Program in Molecular Neurobiology, Institute of Biotechnology, University of Helsinki, P O Box 56 Viikinkaari 9, FIN 00014, University of Helsinki, Helsinki, Finland
    Mol Cell Neurosci 24:581-94. 2003
    ..We also show that all four members of the reticulon family, including Nogo-A, are widely expressed in the nervous system, and therefore are possible ligands for the NgRLs...
  13. doi request reprint Cation-chloride cotransporters and neuronal function
    Peter Blaesse
    Department of Biological and Environmental Sciences, University of Helsinki, Viikinkaari 1, FIN 00014, Helsinki, Finland
    Neuron 61:820-38. 2009
    ..The rapidly expanding work on CCCs promotes our understanding of fundamental mechanisms that control brain development and functions under normal and pathophysiological conditions...
  14. doi request reprint Role of upstream stimulating factors in the transcriptional regulation of the neuron-specific K-Cl cotransporter KCC2
    Marika Markkanen
    Neuroscience Center, Viikinkaari 4, 00014 University of Helsinki, Finland
    Brain Res 1236:8-15. 2008
    ..The results suggest that binding of USF proteins to the E-boxKCC2b may contribute to the upregulation of KCC2b gene expression in developing brain...
  15. ncbi request reprint Neuronal K+/Cl- co-transporter (KCC2) transgenes lacking neurone restrictive silencer element recapitulate CNS neurone-specific expression and developmental up-regulation of endogenous KCC2 gene
    Pavel Uvarov
    Neuroscience Centre, 00014 University of Helsinki, Helsinki, Finland
    J Neurochem 95:1144-55. 2005
    ..Thus, developmental up-regulation of the KCC2 gene does not require NRSE(KCC2) and the 1.4-kb KCC2 promoter is largely sufficient for neurone-specific expression of KCC2...
  16. ncbi request reprint Upregulation of the neuron-specific K+/Cl- cotransporter expression by transcription factor early growth response 4
    Pavel Uvarov
    Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 26:13463-73. 2006
    ..Together, the results indicate an important role for Egr4 in the developmental upregulation of KCC2 gene expression...
  17. ncbi request reprint GDNF family ligands activate multiple events during axonal growth in mature sensory neurons
    Mikhail Paveliev
    Program for Molecular Neurobiology, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Helsinki FIN 00014, Finland
    Mol Cell Neurosci 25:453-9. 2004
    ..We also show that neurturin and GDNF induce extensive lamellipodia formation on neuronal somata and growth cones. GDNF, when applied after the time of axonal initiation in culture, also promotes axonal elongation...
  18. doi request reprint LRRTM3 is dispensable for amyloid-β production in mice
    Tiina Laakso
    Neuroscience Center, University of Helsinki, Helsinki, Finland Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    J Alzheimers Dis 31:759-64. 2012
    ..Moreover, Aβ levels in primary cortical neurons were similar between the genotypes, indicating that LRRTM3 is not required for Aβ generation in developing mice...
  19. ncbi request reprint Patterns of cation-chloride cotransporter expression during embryonic rodent CNS development
    Hong Li
    Institute of Biotechnology, PO Box 56, Viikinkaari 9C, FIN 00014 University of Helsinki, Finland
    Eur J Neurosci 16:2358-70. 2002
    ..These unique spatiotemporal expression patterns of distinct CCCs during embryonic development suggests that Cl- regulatory mechanisms are critically involved in the control of neuronal development...
  20. ncbi request reprint Behavioural phenotypes of hypomorphic KCC2-deficient mice
    Janne Tornberg
    Neuroscience Center, PO Box 56, Viikinkaari 4, FIN 00014 University of Helsinki, Finland
    Eur J Neurosci 21:1327-37. 2005
    ....
  21. ncbi request reprint Sympathetic cholinergic target innervation requires GDNF family receptor GFR alpha 2
    Päivi H Hiltunen
    Neuroscience Center, 00014 University of Helsinki, Finland
    Mol Cell Neurosci 26:450-7. 2004
    ..Thus, neurturin may be a general target-derived innervation factor for postganglionic cholinergic neurons in all parts of the autonomic nervous system...
  22. ncbi request reprint Deficient nonpeptidergic epidermis innervation and reduced inflammatory pain in glial cell line-derived neurotrophic factor family receptor alpha2 knock-out mice
    Päivi H Lindfors
    Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 26:1953-60. 2006
    ..Overall, our results indicate a critical role for endogenous GFRalpha2 signaling in maintaining the size and terminal innervation of the nonpeptidergic class of cutaneous nociceptors in vivo...
  23. pmc Lack of cholinergic innervation in gastric mucosa does not affect gastrin secretion or basal acid output in neurturin receptor GFRα2 deficient mice
    Jussi Kupari
    Institute of Biomedicine, Anatomy, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    J Physiol 591:2175-88. 2013
    ..Basal acid secretion in the KO mice appears to be, at least partly, facilitated by constitutive activity of muscarinic receptors...
  24. ncbi request reprint Increased apoptosis of parasympathetic but not enteric neurons in mice lacking GFRalpha2
    Meri Lähteenmäki
    Neuroscience Center, Viikinkaari 4, 00014 University of Helsinki, Helsinki, Finland
    Dev Biol 305:325-32. 2007
    ....
  25. pmc Alimentary tract innervation deficits and dysfunction in mice lacking GDNF family receptor alpha2
    Jari Rossi
    Program in Molecular Neurobiology, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    J Clin Invest 112:707-16. 2003
    ..Taken together, the results suggest that the growth retardation in mice lacking GFRalpha2 is largely due to impaired salivary and pancreatic secretion and intestinal dysmotility...
  26. ncbi request reprint Impaired behavioural flexibility and memory in mice lacking GDNF family receptor alpha2
    Vootele Voikar
    Department of Biosciences, PO Box 56, Viikinkaari 4, FIN 00014 University of Helsinki, Finland
    Eur J Neurosci 20:308-12. 2004
    ..The results suggest that GFRalpha2 signalling plays a role in the development or maintenance of cognitive abilities that help in solving complex learning tasks...
  27. ncbi request reprint Loss of neurturin in frog--comparative genomics study of GDNF family ligand-receptor pairs
    Tuomas Hätinen
    Institute of Biotechnology, 00014 University of Helsinki, Finland
    Mol Cell Neurosci 34:155-67. 2007
    ..Evolutionary trace analysis and protein structure homology modeling points at GDNF as the endogenous ligand of frog GFRalpha2...
  28. ncbi request reprint GDNF family signalling in exocrine tissues: distinct roles for GDNF and neurturin in parasympathetic neuron development
    Jari Rossi
    Program in Molecular Neurobiology, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Adv Exp Med Biol 506:19-26. 2002
  29. ncbi request reprint A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system
    Juha Lauren
    Program in Molecular Neurobiology, Institute of Biotechnology, University of Helsinki, P O Box 56 Viikinkaari 9, FIN 00014 Helsinki, Finland
    Genomics 81:411-21. 2003
    ..The structure and expression profile of LRRTM mRNAs suggest that they may have a role in the development and maintenance of the vertebrate nervous system...
  30. pmc BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion
    Claudio Rivera
    Department of Biosciences, Division of Animal Physiology, Institute of Biotechnology, University of Helsinki, Finland
    J Cell Biol 159:747-52. 2002
    ....
  31. pmc GFR alpha2/neurturin signalling regulates noxious heat transduction in isolectin B4-binding mouse sensory neurons
    Cheryl L Stucky
    Growth Factors and Regeneration Group, Department of Neuroscience, Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, Berlin D 13092, Germany
    J Physiol 545:43-50. 2002
    ..Our data are the first to indicate a transduction-function role for GFR alpha2/neurturin signalling in a specific class of sensory neurons...
  32. pmc Characterization of myelin ligand complexes with neuronal Nogo-66 receptor family members
    Juha Lauren
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 282:5715-25. 2007
    ..This detailed knowledge of the molecular interactions between NgR1 and its ligands is imperative when assessing options for development of NgR1-based therapeutics for central nervous system injuries...