H Adlercreutz

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi request reprint Plasma levels of enterolactone and percentage mammographic density among postmenopausal women
    Anne Stuedal
    Department of Nutrition, University of Oslo, Norway
    Cancer Epidemiol Biomarkers Prev 14:2154-9. 2005
  2. pmc The isoflavone metabolite 6-methoxyequol inhibits angiogenesis and suppresses tumor growth
    Sofia Bellou
    Department of Biomedical Research, Foundation of Research and Technology Hellas, Institute of Molecular Biology and Biotechnology, University Campus, 45110, Ioannina, Greece
    Mol Cancer 11:35. 2012
  3. pmc Androgen receptor expression in the rat prostate is down-regulated by dietary phytoestrogens
    Trent D Lund
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA
    Reprod Biol Endocrinol 2:5. 2004
  4. pmc Visual spatial memory is enhanced in female rats (but inhibited in males) by dietary soy phytoestrogens
    T D Lund
    The Neuroscience Center Brigham Young University, Provo, Utah 84602, USA
    BMC Neurosci 2:20. 2001
  5. ncbi request reprint An isotope dilution gas chromatographic-mass spectrometric method for the simultaneous assay of estrogens and phytoestrogens in urine
    Herman Adlercreutz
    Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, and Division of Clinical Chemistry, University of Helsinki, P O Box 63, FIN 00014 Helsinki, Finland
    J Steroid Biochem Mol Biol 92:399-411. 2004
  6. ncbi request reprint Lignans and human health
    Herman Adlercreutz
    Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, Finland
    Crit Rev Clin Lab Sci 44:483-525. 2007
  7. ncbi request reprint Phyto-oestrogens and cancer
    Herman Adlercreutz
    Institute for Preventive Medicine, Nutrition, and Cancer, Folkhalsan Research Center, Division of Clinical Chemistry, University of Helsinki, Helsinki, Finland
    Lancet Oncol 3:364-73. 2002
  8. ncbi request reprint Phyto-oestrogens and Western diseases
    H Adlercreutz
    Department of Clinical Chemistry, University of Helsinki, Meilahti Hospital, Finland
    Ann Med 29:95-120. 1997
  9. ncbi request reprint Phytoestrogens and breast cancer
    Herman Adlercreutz
    Institute for Preventive Medicine, Nutrition, and Cancer, Folkhalsan Research Center, and Division of Clinical Chemistry, University of Helsinki, PL 60, Helsinki FIN 00014, Finland
    J Steroid Biochem Mol Biol 83:113-8. 2002
  10. ncbi request reprint Phytoestrogens, cancer and coronary heart disease
    Herman Adlercreutz
    Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, and Division of Clinical Chemistry, Biomedicum, POB 63, 00014 University of Helsinki, Finland
    Biofactors 22:229-36. 2004

Detail Information

Publications96

  1. ncbi request reprint Plasma levels of enterolactone and percentage mammographic density among postmenopausal women
    Anne Stuedal
    Department of Nutrition, University of Oslo, Norway
    Cancer Epidemiol Biomarkers Prev 14:2154-9. 2005
    ..Enterolactone has been shown to have weak estrogenic and antiestrogenic properties. We decided to examine the association between plasma levels of enterolactone and mammographic density, a biomarker for breast cancer risk...
  2. pmc The isoflavone metabolite 6-methoxyequol inhibits angiogenesis and suppresses tumor growth
    Sofia Bellou
    Department of Biomedical Research, Foundation of Research and Technology Hellas, Institute of Molecular Biology and Biotechnology, University Campus, 45110, Ioannina, Greece
    Mol Cancer 11:35. 2012
    ..Identification of additional phytochemicals with potential antiangiogenic activity is important not only for understanding the mechanism of the preventive effect, but also for developing novel therapeutic interventions...
  3. pmc Androgen receptor expression in the rat prostate is down-regulated by dietary phytoestrogens
    Trent D Lund
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA
    Reprod Biol Endocrinol 2:5. 2004
    ..Proliferation of prostate cells is, at least in part, under control of estrogen receptor beta (ER-beta). Phytoestrogens bind ER-beta with high affinity and therefore may have antiproliferative effects in the prostate...
  4. pmc Visual spatial memory is enhanced in female rats (but inhibited in males) by dietary soy phytoestrogens
    T D Lund
    The Neuroscience Center Brigham Young University, Provo, Utah 84602, USA
    BMC Neurosci 2:20. 2001
    ..Additionally, brain phytoestrogen, calbindin (CALB), and cyclooxygenase-2 (COX-2) levels were determined...
  5. ncbi request reprint An isotope dilution gas chromatographic-mass spectrometric method for the simultaneous assay of estrogens and phytoestrogens in urine
    Herman Adlercreutz
    Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, and Division of Clinical Chemistry, University of Helsinki, P O Box 63, FIN 00014 Helsinki, Finland
    J Steroid Biochem Mol Biol 92:399-411. 2004
    ..It may also be used for animal (e.g. rat and mouse) urine using a minimum of 2 ml of usually pooled sample. Despite its complexity it was found to fulfill the reliability criteria, resulting in highly specific and accurate results...
  6. ncbi request reprint Lignans and human health
    Herman Adlercreutz
    Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, Finland
    Crit Rev Clin Lab Sci 44:483-525. 2007
    ..The source of the lignans seems to play a role because other factors in the food obviously participate in the protective effects. The results are promising, but much work is still needed in this area of medicine...
  7. ncbi request reprint Phyto-oestrogens and cancer
    Herman Adlercreutz
    Institute for Preventive Medicine, Nutrition, and Cancer, Folkhalsan Research Center, Division of Clinical Chemistry, University of Helsinki, Helsinki, Finland
    Lancet Oncol 3:364-73. 2002
    ..Whether these observed protective effects are caused by the presence of dietary phyto-oestrogens, or whether they are merely indicators of a healthy diet in general, has not been established...
  8. ncbi request reprint Phyto-oestrogens and Western diseases
    H Adlercreutz
    Department of Clinical Chemistry, University of Helsinki, Meilahti Hospital, Finland
    Ann Med 29:95-120. 1997
    ..At present, however, no definite recommendations can be made as to the dietary amounts needed for prevention of disease. This review deals with all the above-mentioned aspects of phyto-oestrogens...
  9. ncbi request reprint Phytoestrogens and breast cancer
    Herman Adlercreutz
    Institute for Preventive Medicine, Nutrition, and Cancer, Folkhalsan Research Center, and Division of Clinical Chemistry, University of Helsinki, PL 60, Helsinki FIN 00014, Finland
    J Steroid Biochem Mol Biol 83:113-8. 2002
    ..Whether the protective effect is caused by the phytoestrogens in the diet or whether they are only biomarkers of a healthy diet has not been established...
  10. ncbi request reprint Phytoestrogens, cancer and coronary heart disease
    Herman Adlercreutz
    Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, and Division of Clinical Chemistry, Biomedicum, POB 63, 00014 University of Helsinki, Finland
    Biofactors 22:229-36. 2004
    ..In this short communication the possible mechanisms of disease prevention were not discussed...
  11. ncbi request reprint Changes in serum enterolactone, genistein, and daidzein in a dietary intervention study in Finland
    K Stumpf
    Folkhalsan Research Center, Institute of Preventive Medicine, Nutrition and Cancer, Department of Clinical Chemistry, University of Helsinki, Finland
    Cancer Epidemiol Biomarkers Prev 9:1369-72. 2000
    ..These major differences in serum enterolactone concentrations suggest that enterolactone may be used as a biomarker of a healthy diet containing plenty of vegetables, fruit, and berries...
  12. ncbi request reprint Diet and breast cancer
    H Adlercreutz
    Dept. of Clinical Chemistry, University of Helsinki, Meilahti Hospital, Finland
    Acta Oncol 31:175-81. 1992
    ..However, the pattern observed was not entirely due to diet...
  13. pmc Effect of soybean phytoestrogen intake on low density lipoprotein oxidation resistance
    M J Tikkanen
    Department of Medicine, University of Helsinki, 00290 Helsinki, Finland
    Proc Natl Acad Sci U S A 95:3106-10. 1998
    ..As only very small amounts of these substances were detected in purified LDL, modified LDL particles may have been produced in vivo by circulating isoflavonoids promoting resistance to oxidation ex vivo...
  14. ncbi request reprint Serum enterolactone concentration is not associated with breast cancer risk in a nested case-control study
    Annamari Kilkkinen
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Int J Cancer 108:277-80. 2004
    ..67 (95% CI 0.95-2.95), 1.71 (95% CI 0.96-3.06) and 1.30 (95% CI 0.73-2.31), and p for trend was 0.48. Our findings do not support the hypothesis that high serum enterolactone concentration is associated with reduced risk of breast cancer...
  15. doi request reprint The effect of high-fiber rye bread enriched with nonesterified plant sterols on major serum lipids and apolipoproteins in normocholesterolemic individuals
    P P Söderholm
    Folkhalsan Research Center, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, Helsinki, Finland
    Nutr Metab Cardiovasc Dis 22:575-82. 2012
    ....
  16. ncbi request reprint Sensitive high-performance liquid chromatographic method for profiling phytoestrogens using coulometric electrode array detection: application to plasma analysis
    T Nurmi
    Institute for Preventive Medicine, Folkhälsan Research Center and Clinical Chemistry Division, University of Helsinki, Finland
    Anal Biochem 274:110-7. 1999
    ..Intraassay precision CVs ranged from 1.5% (enterolactone, 12.4 nmol/liter) to 14% (genistein, 245 nmol/liter) and interassay precision CVs ranged from 9.9% (daidzein, 67.4 nmol/liter) to 44% (enterodiol, 1.20 nmol/liter)...
  17. ncbi request reprint A randomized placebo-controlled crossover trial with phytoestrogens in treatment of menopause in breast cancer patients
    Eini Nikander
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Obstet Gynecol 101:1213-20. 2003
    ..We studied the effects of daily use of isoflavonoids on climacteric symptoms and quality of life in patients with a history of breast cancer...
  18. pmc Phytoestrogens: epidemiology and a possible role in cancer protection
    H Adlercreutz
    Department of Clinical Chemistry, University of Helsinki, Finland
    Environ Health Perspect 103:103-12. 1995
    ..This report is a review on recent results suggesting that the diphenolic isoflavonoids and lignans are natural cancer-protective compounds...
  19. ncbi request reprint Determinants of serum enterolactone concentration
    A Kilkkinen
    National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
    Am J Clin Nutr 73:1094-100. 2001
    ..The lignan enterolactone, which is produced by the intestinal microflora from dietary precursors, may protect against hormone-dependent cancers and cardiovascular diseases...
  20. ncbi request reprint Alcohol intake, androgen and glucocorticoid steroids in premenopausal women using oral contraceptives: an interventional study
    T Sarkola
    Department of Mental Health and Alcohol Research, National Public Health Institute, POB 719, FIN 00101, Helsinki, Finland
    J Steroid Biochem Mol Biol 78:157-65. 2001
    ..The present results may be of relevance in the development of disturbances in the glucocorticoid as well as sex steroid balance among heavy female drinkers...
  21. ncbi request reprint Quantification of alkylresorcinol metabolites in urine by HPLC with coulometric electrode array detection
    Anja Koskela
    Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center and Division of Clinical Chemistry, University of Helsinki, Helsinki, Finland
    Clin Chem 53:1380-3. 2007
    ..Two recently identified urinary AR metabolites, 3,5-dihydroxyphenylbenzoic acid (DHBA) and 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), may be useful as biomarkers of intake of whole-grain rye and wheat...
  22. ncbi request reprint No effect on adenoma formation in Min mice after moderate amount of flaxseed
    S Oikarinen
    Dept of Applied Chemistry and Microbiology Nutrition, University of Helsinki, 6600014, Helsinki, Finland
    Eur J Nutr 44:273-80. 2005
    ..The present work aims to evaluate the effect of flaxseed on tumour formation in multiple intestinal neoplasia (Min) mice, a model for colon tumorigenesis...
  23. ncbi request reprint Plasma and prostate phytoestrogen concentrations in prostate cancer patients after oral phytoestogen supplementation
    Antti Rannikko
    Department of Urology, Helsinki University Central Hospital, Helsinki, Finland
    Prostate 66:82-7. 2006
    ..Phytoestrogens have been suggested to reduce the risk of prostate cancer (CaP), but no data exists on how oral phytoestrogen supplementation influences phytoestrogen concentrations in prostate tissue...
  24. doi request reprint Rye bread intake improves oxidation resistance of LDL in healthy humans
    P P Söderholm
    Folkhalsan Research Center, Biomedicum C315a, PO Box 63, FI 00014 University of Helsinki, Helsinki, Finland
    Atherosclerosis 221:583-6. 2012
    ..The capacity of LDL to resist oxidation can be determined ex vivo by exposing isolated LDL particles to copper ions and measuring the formation of conjugated dienes by spectrophotometry...
  25. ncbi request reprint Isoflavone content of the soy based supplements
    T Nurmi
    Department of Clinical Chemistry, Folkhalsan Research Center, University of Helsinki, PO Box 63, FIN 00014 Helsinki, Finland
    J Pharm Biomed Anal 28:1-11. 2002
    ..Measured amounts of isoflavones in aglycones after the hydrolysis were in general lower than the values in the product labels. Product data were often confusing and the concrete amount of isoflavones was difficult to find out...
  26. ncbi request reprint Dietary soy-derived isoflavone phytoestrogens. Could they have a role in coronary heart disease prevention?
    M J Tikkanen
    Department of Medicine, Helsinki University Central Hospital, 00290 Helsinki, Finland
    Biochem Pharmacol 60:1-5. 2000
    ..Further studies are needed to assess to what extent analogous effects could be produced in vivo and whether such substances have a role in hormone replacement and coronary heart disease prevention in postmenopausal women...
  27. ncbi request reprint Plasma enterolactone or intestinal Bifidobacterium levels do not explain adenoma formation in multiple intestinal neoplasia (Min) mice fed with two different types of rye-bran fractions
    S Oikarinen
    Department of Applied Chemistry and Microbiology, Division of Nutrition, PO Box 27, FIN 00014 University of Helsinki, Finland
    Br J Nutr 90:119-25. 2003
    ..In conclusion, rye bran and rye fractions influence adenoma formation in Min mice to a varying degree but plasma enterolactone levels or the production of bifidogenic bacteria do not mediate the effect...
  28. doi request reprint Lignan content of selected foods from Japan
    José L Peñalvo
    Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center and Division of Clinical Chemistry, University of Helsinki, 00014 Helsinki, Finland
    J Agric Food Chem 56:401-9. 2008
    ..These data will complement the previous databases and most importantly expand the knowledge of occurrence of lignans in food to Eastern diets...
  29. ncbi request reprint Identification of urinary metabolites of the red clover isoflavones formononetin and biochanin A in human subjects
    Satu Maarit Heinonen
    Folkhälsan Research Center and Department of Clinical Chemistry, University of Helsinki, Finland
    J Agric Food Chem 52:6802-9. 2004
    ..Possible metabolic pathways are presented for the red clover isoflavones formononetin and biochanin A...
  30. ncbi request reprint Determination of lignans in human plasma by liquid chromatography with coulometric electrode array detection
    José L Peñalvo
    Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, and Division of Clinical Chemistry, University of Helsinki, Biomedicum, P O Box 63, 00014, Helsinki, Finland
    Anal Biochem 332:384-93. 2004
    ....
  31. doi request reprint Plasma and urinary alkylresorcinol metabolites as potential biomarkers of breast cancer risk in Finnish women: a pilot study
    Mylene Aubertin-Leheudre
    Folkhalsan Research Center, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, Helsinki, Finland
    Nutr Cancer 62:759-64. 2010
    ..This novel approach will likely also facilitate studies of associations between rye and whole-grain wheat cereal fiber intake and other diseases. Our findings should, however, be confirmed with larger subject populations...
  32. ncbi request reprint Effects of a flaxseed mixture and plant oils rich in alpha-linolenic acid on the adenoma formation in multiple intestinal neoplasia (Min) mice
    Seija I Oikarinen
    Department of Applied Chemistry and Microbiology Nutrition, PO Box 66, FIN 00014 University of Helsinki, Finland
    Br J Nutr 94:510-8. 2005
    ....
  33. ncbi request reprint Studies of the in vitro intestinal metabolism of isoflavones aid in the identification of their urinary metabolites
    Satu Maarit Heinonen
    Folkhälsan Research Center and Department of Clinical Chemistry, Biomedicum, P O Box 63, FIN 00014 University of Helsinki, Helsinki, Finland
    J Agric Food Chem 52:2640-6. 2004
    ..Four novel isoflavone metabolites were identified in human urine collected after soy supplementation: 3' '-OH-O-desmethylangolensin, 3',4',7-trihydroxyisoflavanone, 4',7,8-trihydroxyisoflavanone, and 4',6,7-trihydroxyisoflavanone...
  34. ncbi request reprint Whole-grain rye and wheat alkylresorcinols are incorporated into human erythrocyte membranes
    Anna Maria Linko
    Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center and Division of Clinical Chemistry, P O Box 63, University of Helsinki, FIN 00014, Helsinki, Finland
    Br J Nutr 93:11-3. 2005
    ..Long-chain AR were incorporated into erythrocyte membranes in a higher proportion compared to shorter-chain AR. This preliminary study shows that AR are incorporated into human erythrocyte membranes in vivo...
  35. ncbi request reprint Whole-grain rye bread consumption by women correlates with plasma alkylresorcinols and increases their concentration compared with low-fiber wheat bread
    Anna Maria Linko
    Institute for Preventive Medicine, Nutrition and Cancer, Folkhälsan Research Center and Department of Clinical Chemistry, University of Helsinki, FIN 00014, Helsinki, Finland
    J Nutr 135:580-3. 2005
    ..08) bread diet periods (P < 0.001). These data strongly suggest that plasma ARs could be used as specific biomarkers for whole-grain rye intake, and their homologue pattern could be used as an indicator of the bread type consumed...
  36. doi request reprint Plasma alkylresorcinol metabolites as potential biomarkers of whole-grain wheat and rye cereal fibre intakes in women
    Mylene Aubertin-Leheudre
    Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, and Division of Clinical Chemistry, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, PO Box 63, BP 63, Room C315a, FIN 00014 Helsinki, Finland
    Br J Nutr 103:339-43. 2010
    ..Thus, sum of plasma AR metabolites and more specifically plasma DHPPA seems to be good and specific biomarkers of cereal fibre intake...
  37. doi request reprint Relationship between animal protein intake and muscle mass index in healthy women
    Mylene Aubertin-Leheudre
    Institute for Preventive Medicine, Nutrition and Cancer, Division of Clinical Chemistry, University of Helsinki, Helsinki, Finland
    Br J Nutr 102:1803-10. 2009
    ..42). Thus, a vegetarian diet is associated with a lower muscle mass index than is an omnivorous diet at the same protein intake. A good indicator of muscle mass index in women seems to be animal protein intake...
  38. ncbi request reprint Quantification of lignans in food using isotope dilution gas chromatography/mass spectrometry
    José L Peñalvo
    Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, and Division of Clinical Chemistry, University of Helsinki, Biomedicum, Helsinki, Finland
    J Agric Food Chem 53:9342-7. 2005
    ....
  39. ncbi request reprint Determination of plasma genistein fatty acid esters following administration of genistein or genistein 4'7-O-dioleate in monkeys
    Maija Badeau
    Department of Medicine, University of Helsinki, Helsinki 00014, Finland
    Biochim Biophys Acta 1738:115-20. 2005
    ..The results suggest that it may be possible to introduce intact genistein ester molecules into plasma by parenteral but not oral administration...
  40. ncbi request reprint Kinetics of the appearance of cereal alkylresorcinols in pig plasma
    Anna Maria Linko
    Nestle Research Centre, Lausanne 26, CH 1000, Switzerland
    Br J Nutr 95:282-7. 2006
    ..AR concentrations in pig plasma increase rapidly after a meal containing AR, and persist in plasma for at least 5 d, indicating that AR may be a useful biomarker of wholegrain wheat and rye intake...
  41. ncbi request reprint Alkylresorcinols from whole-grain wheat and rye are transported in human plasma lipoproteins
    Anna Maria Linko-Parvinen
    Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, Division of Clinical Chemistry, University of Helsinki, FIN 00014 Helsinki, Finland
    J Nutr 137:1137-42. 2007
    ..The plasma alkylresorcinol C17:0 to C21:0 ratio reflects intake of whole-grain wheat and rye, and the plasma total alkylresorcinol concentration appears to be a useful biomarker of whole-grain cereal intake...
  42. doi request reprint Plasma alkylresorcinols and urinary alkylresorcinol metabolites as biomarkers of cereal fiber intake in Finnish women
    Mylene Aubertin-Leheudre
    Folkhalsan Research Center, University of Helsinki, Helsinki, Finland
    Cancer Epidemiol Biomarkers Prev 17:2244-8. 2008
    ..These results indicate that assay of plasma ARs or urinary AR metabolites may be used as biomarkers in epidemiologic studies in free-living populations to evaluate the role of cereal fiber intake in various diseases...
  43. ncbi request reprint Dietary sesamin is converted to enterolactone in humans
    José L Peñalvo
    Institute for Preventive Medicine, Nutrition, and Cancer, Folkhalsan Research Center, and Division of Clinical Chemistry, University of Helsinki, Helsinki, Finland
    J Nutr 135:1056-62. 2005
    ..Enterolactone was the major metabolite of sesamin both in vivo and in vitro. The abundance of sesamin in sesame seeds indicates that they are a major food source of enterolactone precursors...
  44. ncbi request reprint Metabolism of the soy isoflavones daidzein, genistein and glycitein in human subjects. Identification of new metabolites having an intact isoflavonoid skeleton
    Satu Maarit Heinonen
    Department of Clinical Chemistry, Biomedicum, Folkhälsan Research Centre, University of Helsinki, P O Box 63, FIN 00014 Helsinki, Finland
    J Steroid Biochem Mol Biol 87:285-99. 2003
    ..The metabolic pathways of daidzein, genistein and glycitein are presented on the basis of the identification of the metabolites in human urine after soy supplementation...
  45. ncbi request reprint Gas chromatographic-mass spectrometric method for the determination of alkylresorcinols in human plasma
    Anna Maria Linko
    Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, Department of Clinical Chemistry, University of Helsinki, Finland
    Anal Biochem 308:307-13. 2002
    ..The alkylresorcinols were in the unconjugated form. The total amounts of alkylresorcinols in two plasma samples analyzed here were 333 and 381nmol/L...
  46. ncbi request reprint Serum enterolactone concentration is not associated with prostate cancer risk in a nested case-control study
    Annamari Kilkkinen
    National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
    Cancer Epidemiol Biomarkers Prev 12:1209-12. 2003
    ..00 (referent), 0.72 [95% confidence interval (CI), 0.43-1.23], 0.98 (95% CI, 0.58-1.68), and 0.71 (95% CI, 0.42-1.21). Our findings do not support the hypothesis that enterolactone is involved in the development of prostate cancer...
  47. doi request reprint Quantification of alkylresorcinol metabolites in plasma by high-performance liquid chromatography with coulometric electrode array detection
    Anja Koskela
    Institute for Preventive Medicine, Nutrition, and Cancer, Folkhalsan Research Center and Division of Clinical Chemistry, P O Box 63, FIN 00014 University of Helsinki, Finland
    J Agric Food Chem 56:7678-81. 2008
    ..Additional investigation is needed to clarify whether the two plasma AR metabolites are useful as biomarkers of whole-grain intake and helpful in the exploration of the association between whole-grain cereal intake and human diseases...
  48. ncbi request reprint Plant lignans in soy-based health supplements
    José L Peñalvo
    Department of Clinical Chemistry, University of Helsinki, Biomedicum, PO Box 63, 00014 Helsinki, Finland
    J Agric Food Chem 52:4133-8. 2004
    ..Additional quantification of plant lignans and isoflavones in soybeans has been carried out, and results are provided to allow the comparison of the average levels in soybeans and soy-based supplements...
  49. ncbi request reprint Short-term variations in enterolactone in serum, 24-hour urine, and spot urine and relationship with enterolactone concentrations
    Katariina Stumpf
    Folkhalsan Research Center, Institute for Preventive Medicine, Nutrition and Cancer, Biomedicum, PB 63, University of Helsinki, FIN 00014 Helsinki, Finland
    Clin Chem 49:178-81. 2003
  50. ncbi request reprint Synthesis of novel mammalian metabolites of the isoflavonoid phytoestrogens daidzein and genistein
    K Wahala
    Department of Chemistry, University of Helsinki, Finland
    Proc Soc Exp Biol Med 217:293-9. 1998
    ....
  51. ncbi request reprint The effect of flaxseed supplementation in processed foods on serum fatty acids and enterolactone
    S Tarpila
    Department of Internal Medicine, The Mehiläinen Hospital, Helsinki, Finland
    Eur J Clin Nutr 56:157-65. 2002
    ..The purpose was to study the effects of flaxseed supplementation as a part of daily diet on serum lipids, fatty acids and plasma enterolactone...
  52. ncbi request reprint Accumulation of genistein and lipophilic genistein derivatives in lipoproteins during incubation with human plasma in vitro
    Maija Kaamanen
    Department of Medicine, University of Helsinki, Helsinki 00014, Finland
    Biochim Biophys Acta 1631:147-52. 2003
    ..A smaller part of the latter were genistein monoesters, while part remained unidentified. Our results suggest an explanation for the increased oxidation resistance of isolated LDL during intake of soybean isoflavones...
  53. ncbi request reprint Intake of lignans is associated with serum enterolactone concentration in Finnish men and women
    Annamari Kilkkinen
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    J Nutr 133:1830-3. 2003
    ..2 mg). The main dietary sources of lignans, i.e., whole grain, vegetables and fruits, are foods commonly associated with lower risk of cardiovascular diseases and cancer. Serum EL concentration is a feasible biomarker of lignan intake...
  54. ncbi request reprint Time-resolved fluoroimmunoassay of plasma and urine O-desmethylangolensin
    Rafaëlla L'homme
    Division of Clinical Chemistry and Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, University of Helsinki, PB 60, Finland
    J Steroid Biochem Mol Biol 81:353-61. 2002
    ..8-7.7 and 3.0-6.0%, respectively and the inter-assay CVs varied 3.8-8.9 and 4.4-6.6%, respectively. The working range of the plasma and urine O-DMA assays was 0.5-512 nmol/l...
  55. ncbi request reprint Associations between pituitary-adrenocortical function and abdominal obesity, hyperinsulinaemia and dyslipidaemia in normotensive males
    A Hautanen
    Department of Clinical Chemistry, University of Helsinki, Finland
    J Intern Med 241:451-61. 1997
    ..To examine the relationships between pituitary-adrenal cortical (PA) function, abdominal obesity, hyperinsulinaemia, and dyslipidaemia...
  56. pmc Effect of sesamin on serum cholesterol and triglycerides levels in LDL receptor-deficient mice
    José L Peñalvo
    Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center and Division of Clinical Chemistry, University of Helsinki, Finland
    Eur J Nutr 45:439-44. 2006
    ....
  57. ncbi request reprint The effects of short-term oral phytoestrogen supplementation on the hypothalamic-pituitary-testicular axis in prostate cancer patients
    Antti Rannikko
    Department of Urology, Helsinki University Central Hospital, Helsinki, Finland
    Prostate 66:1086-91. 2006
    ..Here we evaluate the effects of oral phytoestrogen supplementation on hypothalamic-pituitary-testicular (HPT) axis in CaP patients...
  58. ncbi request reprint Time-resolved fluoroimmunoassay for equol in plasma and urine
    Elke Brouwers
    Folkhalsan Research Center, Division of Clinical Chemistry, Institute for Preventive Medicine, Nutrition and Cancer, P O Box 63, University of Helsinki, FIN 00014 Helsinki, Finland
    J Steroid Biochem Mol Biol 84:577-88. 2003
    ..5-6.5 and 3.4-6.9, respectively. The inter-assay CV% varies between 5.4-9.7 and 7.4-7.7, respectively. The working ranges of the plasma and urine assay are 1.27-512 and 1.9-512nmol/l, respectively...
  59. pmc Does antibacterial treatment for urinary tract infection contribute to the risk of breast cancer?
    P Knekt
    National Public Health Institute, Helsinki, Finland
    Br J Cancer 82:1107-10. 2000
    ..The results are, however, still inconclusive and the hypothesis needs to be tested by other studies...
  60. ncbi request reprint Accumulation of high-density lipoprotein-derived estradiol-17beta fatty acid esters in low-density lipoprotein particles
    H Helisten
    Department of Medicine, University of Helsinki, 00014 Helsinki, Finland
    J Clin Endocrinol Metab 86:1294-300. 2001
    ....
  61. ncbi request reprint Preliminary antiproliferative effects of some species of Terminalia, Combretum and Pteleopsis collected in Tanzania on some human cancer cell lines
    P Fyhrquist
    Division of Clinical Chemistry and Folkhälsan Research Center, Institute for Preventive Nutrition, Medicine and Cancer, Biomedicum, P O Box 63, FIN 00014 University of Helsinki, Finland
    Fitoterapia 77:358-66. 2006
    ....
  62. ncbi request reprint The role of the liver in the acute effect of alcohol on androgens in women
    T Sarkola
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    J Clin Endocrinol Metab 86:1981-5. 2001
    ..Our results suggests that the liver should be included as a major site in the acute endocrinological effects of alcohol on steroid hormones in women...
  63. pmc Fat/fiber intakes and sex hormones in healthy premenopausal women in USA
    Mylene Aubertin-Leheudre
    Folkhalsan Research Center, Institute of Preventive Medicine, Nutrition and Cancer, Division of Clinical Chemistry, University of Helsinki, Finland
    J Steroid Biochem Mol Biol 112:32-9. 2008
    ..Our results suggest that fat affects estrogen metabolism more than does fiber and that one mechanism resulting in high estrogen values is an increased reabsorption of biliary estrogens...
  64. ncbi request reprint Estrogen A-ring structure and antioxidative effect on lipoproteins
    Maija Badeau
    Department of Medicine, University of Helsinki, 00014 Helsinki, Finland
    J Steroid Biochem Mol Biol 96:271-8. 2005
    ..Accordingly, both the presence of unsubstituted hydroxyl groups and adjacent substituents, as well as the lipophilicity of the derivatives determine the antioxidant activity of estrogen derivatives in aqueous lipoprotein solutions...
  65. ncbi request reprint Mammalian lignan formation in rats fed a wheat bran diet
    Catherine Nicolle
    Laboratoire des Maladies Métaboliques et Micronutriments, INRA, 63122 Saint Genes Champanelle, France
    J Agric Food Chem 50:6222-6. 2002
    ..These results show that the formation of lignans from wheat bran is influenced by the diet, possibly because of an adaptation of the colonic microflora...
  66. ncbi request reprint Monoclonal antibody-based time-resolved fluorescence immunoassays for daidzein, genistein, and equol in blood and urine: application to the Isoheart intervention study
    Duncan C S Talbot
    Unilever Corporate Research, Sharnbrook, United Kingdom
    Clin Chem 53:748-56. 2007
    ....
  67. ncbi request reprint Dietary fiber intake and endogenous serum hormone levels in naturally postmenopausal Mexican American women: the Multiethnic Cohort Study
    Kristine R Monroe
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Nutr Cancer 58:127-35. 2007
    ..The suggestive findings relating increased estrogen levels to avocado and grapefruit intakes need confirmation...
  68. ncbi request reprint A combination of dietary fructooligosaccharides and isoflavone conjugates increases femoral bone mineral density and equol production in ovariectomized mice
    Atsutane Ohta
    Bioscience Laboratories, Meiji Seika Kaisha, Ltd, Sakado City, Saitama 350 0289, Japan
    J Nutr 132:2048-54. 2002
    ..These results suggest that FOS increase the bioavailability of isoflavones, leading to cooperative effects in the prevention of osteopenia in OVX mice...
  69. ncbi request reprint Use of oral antimicrobials decreases serum enterolactone concentration
    Annamari Kilkkinen
    Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Am J Epidemiol 155:472-7. 2002
    ..Furthermore, recent use of antimicrobials should be considered when the association between serum enterolactone concentration and risk of chronic diseases is studied...
  70. ncbi request reprint Whole grain food intake elevates serum enterolactone
    David R Jacobs
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, USA
    Br J Nutr 88:111-6. 2002
    ..Serum enterolactone concentrations can be raised by eating a diet rich in whole grains...
  71. ncbi request reprint An incident case-referent study on plasma enterolactone and breast cancer risk
    Kerstin Hultén
    Epidemiology Department of Public Health and Clinical Medicine, Umea University, Sweden
    Eur J Nutr 41:168-76. 2002
    ..Using a nested case-referent design, we evaluated the relationship between plasma levels of the lignan enterolactone and the risk of developing breast cancer...
  72. ncbi request reprint Phytoestrogens regulate vitamin D metabolism in the mouse colon: relevance for colon tumor prevention and therapy
    Enikö Kállay
    Department of Pathophysiology, University of Vienna Medical School, Vienna, Austria
    J Nutr 132:3490S-3493S. 2002
    ..Our data therefore suggest that an inverse correlation of soy product consumption with colon tumor incidence may be consequent to enhanced colonic synthesis of the antimitotic hormone 1,25-dihydroxyvitamin D3...
  73. ncbi request reprint Dietary phytoestrogens are not associated with risk of overall breast cancer but diets rich in coumestrol are inversely associated with risk of estrogen receptor and progesterone receptor negative breast tumors in Swedish women
    Maria Hedelin
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Nutr 138:938-45. 2008
    ..Our results of a decreased risk of ER-PR- tumors in women with intermediate intake of coumestrol could be due to chance because of the low intake. The results should be confirmed in other studies...
  74. ncbi request reprint Isoflavonoids inhibit catabolism of vitamin D in prostate cancer cells
    Hesso Farhan
    Institute of Pathophysiology, University of Vienna Medical School, AKH, Währingergürtel 18 20 A 1090, Vienna, Austria
    J Chromatogr B Analyt Technol Biomed Life Sci 777:261-8. 2002
    ..High levels of CYP24 frequently found in prostate cancer cells may thus degrade the active metabolite. This could be prevented by ingestion of genistein-containing food such as soybeans...
  75. ncbi request reprint Dietary fiber intake and risk of postmenopausal breast cancer defined by estrogen and progesterone receptor status--a prospective cohort study among Swedish women
    Reiko Suzuki
    The National Institute of Environmental Medicine, Division of Nutritional Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 122:403-12. 2008
    ..Our results suggest that dietary fiber intake from fruit and cereal may play a role in reducing breast cancer risk...
  76. ncbi request reprint Human plasma kinetics and relative bioavailability of alkylresorcinols after intake of rye bran
    Rikard Landberg
    Department of Food Science, Swedish University of Agriculture Science SLU, Uppsala, Sweden
    J Nutr 136:2760-5. 2006
    ..The apparent half-lives were rather short, approximately 5 h for all homologs, which suggests that the AR concentration in plasma could be used as a short- to medium-term biomarker of regular intake of whole-grain wheat and rye...
  77. ncbi request reprint Dietary phytoestrogen, serum enterolactone and risk of prostate cancer: the cancer prostate Sweden study (Sweden)
    Maria Hedelin
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE 171 77, Stockholm, Sweden
    Cancer Causes Control 17:169-80. 2006
    ..Based on evidence that phytoestrogens may protect against prostate cancer, we evaluated the associations between serum enterolactone concentration or dietary phytoestrogen intake and risk of prostate cancer...
  78. ncbi request reprint Secoisolariciresinol and matairesinol of sea buckthorn (Hippophaë rhamnoides L.) berries of different subspecies and harvesting times
    Baoru Yang
    Department of Biochemistry and Food Chemistry, University of Turku, FIN 20014 Turku, Finland
    J Agric Food Chem 54:8065-70. 2006
    ..Harvesting dates had a significant influence on the content of the two lignans in seeds, fruit pulp/peel, and whole berries. This is the first report of lignans in sea buckthorn...
  79. ncbi request reprint Neurobehavioral effects of dietary soy phytoestrogens
    Edwin D Lephart
    Neuroscience Center, 633 WIDB, Brigham Young University, Provo, UT 86402, USA
    Neurotoxicol Teratol 24:5-16. 2002
    ....
  80. ncbi request reprint Phytoestrogens and vitamin D metabolism: a new concept for the prevention and therapy of colorectal, prostate, and mammary carcinomas
    Heide S Cross
    Department of Pathophysiology, University of Vienna Medical School, Austria
    J Nutr 134:1207S-1212S. 2004
    ..We suggest that nutritional soy or genistein can optimize extrarenal 1,25-D3 synthesis, which could result in growth control and, conceivably, in inhibition of tumor progression...
  81. ncbi request reprint Lignan precursors from flaxseed or rye bran do not protect against the development of intestinal neoplasia in ApcMin mice
    Henk J van Kranen
    Laboratory of Health Effects Research, Department of Carcinogenesis, Mutagenesis and Genetics, Laboratory of Pathology, National Institute of Public Health and Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Nutr Cancer 45:203-10. 2003
    ....
  82. ncbi request reprint Circulating enterolactone and prostate cancer risk: a Nordic nested case-control study
    Par Stattin
    Department of Urology, Umea University Hospital, Umea, Sweden
    Int J Cancer 99:124-9. 2002
    ..21 (95% CI = 0.91-1.60), 1.02 (95% CI = 0.59-1.76) and 0.87 (95% CI = 0.45-1.67), respectively. No support for the hypothesis that high circulating enterolactone is protective against prostate cancer was found...
  83. ncbi request reprint Phytoestrogen tissue levels in benign prostatic hyperplasia and prostate cancer and their association with prostatic diseases
    Clemens Brossner
    Department of Urology and Andrology, Danube Hospital, Vienna, Austria
    Urology 64:707-11. 2004
    ..To compare phytoestrogen tissue levels in men with small-volume benign prostatic hyperplasia (BPH), large-volume BPH, and prostate cancer (PCa)...
  84. ncbi request reprint Effects of soy-derived isoflavones and a high-fat diet on spontaneous mammary tumor development in Tg.NK (MMTV/c-neu) mice
    Mirjam Luijten
    Laboratory of Toxicology, Pathology and Genetics, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Nutr Cancer 50:46-54. 2004
    ..This study shows that breast cancer-modulating effects of phytoestrogens are dependent both on the background diet and on the timing of exposure in the life cycle...
  85. ncbi request reprint Rye, lignans and human health
    Goran Hallmans
    Departments of Public Health and Clinical Medicine, University of Umea, Umea, Sweden
    Proc Nutr Soc 62:193-9. 2003
    ..It seems reasonable to assume that these protective effects are associated with one or more factors in the dietary fibre complex...
  86. ncbi request reprint Rye bread in the diet of pigs enhances the formation of enterolactone and increases its levels in plasma, urine and feces
    Knud Erik Bach Knudsen
    Department of Animal Nutrition and Physiology, Danish Institute of Agricultural Sciences, Research Centre Foulum, Tjele, Denmark
    J Nutr 133:1368-75. 2003
    ....
  87. ncbi request reprint Anticancer effects of a plant lignan 7-hydroxymatairesinol on a prostate cancer model in vivo
    Annika Bylund
    University of Turku, Functional Foods Forum, FI 20014 Turku, Finland
    Exp Biol Med (Maywood) 230:217-23. 2005
    ..30% HMR diet compared with mice receiving the control diet. Our results suggest that dietary HMR started at the early phase of the tumor development inhibits the growth of the LNCaP human prostate cancer xenografts in athymic male mice...
  88. ncbi request reprint Phyto-oestrogen database of foods and average intake in Finland
    Liisa M Valsta
    National Public Health Institute KTL, Department of Epidemiology and Health Promotion, Nutrition Unit, Mannerheimintie 166, FIN 00300, Finland
    Br J Nutr 89:S31-8. 2003
    ..The average intake of lignans and isoflavones in Finland seems to be low, but intake varies throughout the population...
  89. ncbi request reprint The effect of soy consumption on the urinary 2:16-hydroxyestrone ratio in postmenopausal women depends on equol production status but is not influenced by probiotic consumption
    Jennifer A Nettleton
    Department of Food Science and Nutrition, University of Minnesota, St Paul, MN 55108, USA
    J Nutr 135:603-8. 2005
    ..These results are consistent with studies that found lower urine 2:16OHE(1) ratios in women with breast cancer and suggest that soy consumption increases this ratio only in women who are equol producers...
  90. ncbi request reprint Prospective study of plasma enterolactone and prostate cancer risk (Sweden)
    Par Stattin
    Department of Surgery and Perioperative Sciences, Urology and Andrology, Umed University Hospital, Sweden
    Cancer Causes Control 15:1095-102. 2004
    ..We studied the association between plasma enterolactone and risk of prostate cancer...
  91. ncbi request reprint Soy isoflavones: a safety review
    Ian C Munro
    Cantox Health Sciences International
    Nutr Rev 61:1-33. 2003
    ..Whereas results in some studies are limited or conflicting, when viewed in its entirety, the current literature supports the safety of isoflavones as typically consumed in diets based on soy or containing soy products...
  92. ncbi request reprint Short-term soy and probiotic supplementation does not markedly affect concentrations of reproductive hormones in postmenopausal women with and without histories of breast cancer
    Jennifer A Nettleton
    Department of Food Science and Nutrition, University of Minnesota, St Paul, MN 55108, USA
    J Altern Complement Med 11:1067-74. 2005
    ..Because intestinal bacteria metabolize isoflavones, it was hypothesized that consumption of probiotic bacteria would enhance the biologic effects of isoflavones, including effects on endogenous hormones...
  93. ncbi request reprint Plasma phytoestrogens are not altered by probiotic consumption in postmenopausal women with and without a history of breast cancer
    Jennifer A Nettleton
    Department of Food Science and Nutrition, University of Minnesota, St Paul, MN 55108, USA
    J Nutr 134:1998-2003. 2004
    ....
  94. ncbi request reprint Phyto-oestrogen intake and plasma concentrations in South Asian and native British women resident in England
    Dee Bhakta
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Br J Nutr 95:1150-8. 2006
    ..The present study does not support the hypothesis that differences in phytoestrogen intake, or in circulating levels, could explain differences in hormone-related cancer risks between these two populations...
  95. ncbi request reprint Dietary lignins are precursors of mammalian lignans in rats
    Aynun Nahar Begum
    Unite des Maladies Metaboliques et Micronutrients, INRA Theix, 63122 Saint Genes Champanelle, France
    J Nutr 134:120-7. 2004
    ..The detection of deuterated ENL by LC-tandem MS in urine (20 nmol/d) clearly confirms the conversion of lignin into mammalian lignans. More research is warranted to determine the bioavailability of lignins in the human diet...