Research Topics
Species | H AdlercreutzSummaryAffiliation: University of Helsinki Country: Finland Publications
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Detail Information
Publications
Plasma levels of enterolactone and percentage mammographic density among postmenopausal womenAnne Stuedal
Department of Nutrition, University of Oslo, Norway
Cancer Epidemiol Biomarkers Prev 14:2154-9. 2005..Enterolactone has been shown to have weak estrogenic and antiestrogenic properties. We decided to examine the association between plasma levels of enterolactone and mammographic density, a biomarker for breast cancer risk...
Androgen receptor expression in the rat prostate is down-regulated by dietary phytoestrogensTrent D Lund
Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA
Reprod Biol Endocrinol 2:5. 2004..Proliferation of prostate cells is, at least in part, under control of estrogen receptor beta (ER-beta). Phytoestrogens bind ER-beta with high affinity and therefore may have antiproliferative effects in the prostate...- Visual spatial memory is enhanced in female rats (but inhibited in males) by dietary soy phytoestrogensT D Lund
The Neuroscience Center Brigham Young University, Provo, Utah 84602, USA
BMC Neurosci 2:20. 2001..Additionally, brain phytoestrogen, calbindin (CALB), and cyclooxygenase-2 (COX-2) levels were determined... - Lignans and human healthHerman Adlercreutz
Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, Finland
Crit Rev Clin Lab Sci 44:483-525. 2007..The source of the lignans seems to play a role because other factors in the food obviously participate in the protective effects. The results are promising, but much work is still needed in this area of medicine... - Phytoestrogens and breast cancerHerman Adlercreutz
Institute for Preventive Medicine, Nutrition, and Cancer, Folkhalsan Research Center, and Division of Clinical Chemistry, University of Helsinki, PL 60, Helsinki FIN 00014, Finland
J Steroid Biochem Mol Biol 83:113-8. 2002..Whether the protective effect is caused by the phytoestrogens in the diet or whether they are only biomarkers of a healthy diet has not been established... - Phyto-oestrogens and cancerHerman Adlercreutz
Institute for Preventive Medicine, Nutrition, and Cancer, Folkhalsan Research Center, Division of Clinical Chemistry, University of Helsinki, Helsinki, Finland
Lancet Oncol 3:364-73. 2002..Whether these observed protective effects are caused by the presence of dietary phyto-oestrogens, or whether they are merely indicators of a healthy diet in general, has not been established... - An isotope dilution gas chromatographic-mass spectrometric method for the simultaneous assay of estrogens and phytoestrogens in urineHerman Adlercreutz
Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, and Division of Clinical Chemistry, University of Helsinki, P O Box 63, FIN 00014 Helsinki, Finland
J Steroid Biochem Mol Biol 92:399-411. 2004..It may also be used for animal (e.g. rat and mouse) urine using a minimum of 2 ml of usually pooled sample. Despite its complexity it was found to fulfill the reliability criteria, resulting in highly specific and accurate results... - Phytoestrogens, cancer and coronary heart diseaseHerman Adlercreutz
Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, and Division of Clinical Chemistry, Biomedicum, POB 63, 00014 University of Helsinki, Finland
Biofactors 22:229-36. 2004..In this short communication the possible mechanisms of disease prevention were not discussed... - Phyto-oestrogens and Western diseasesH Adlercreutz
Department of Clinical Chemistry, University of Helsinki, Meilahti Hospital, Finland
Ann Med 29:95-120. 1997..At present, however, no definite recommendations can be made as to the dietary amounts needed for prevention of disease. This review deals with all the above-mentioned aspects of phyto-oestrogens... - Diet and breast cancerH Adlercreutz
Dept. of Clinical Chemistry, University of Helsinki, Meilahti Hospital, Finland
Acta Oncol 31:175-81. 1992..However, the pattern observed was not entirely due to diet... - Changes in serum enterolactone, genistein, and daidzein in a dietary intervention study in FinlandK Stumpf
Folkhalsan Research Center, Institute of Preventive Medicine, Nutrition and Cancer, Department of Clinical Chemistry, University of Helsinki, Finland
Cancer Epidemiol Biomarkers Prev 9:1369-72. 2000..These major differences in serum enterolactone concentrations suggest that enterolactone may be used as a biomarker of a healthy diet containing plenty of vegetables, fruit, and berries... 
Effect of soybean phytoestrogen intake on low density lipoprotein oxidation resistanceM J Tikkanen
Department of Medicine, University of Helsinki, 00290 Helsinki, Finland
Proc Natl Acad Sci U S A 95:3106-10. 1998..As only very small amounts of these substances were detected in purified LDL, modified LDL particles may have been produced in vivo by circulating isoflavonoids promoting resistance to oxidation ex vivo...- Serum enterolactone concentration is not associated with breast cancer risk in a nested case-control studyAnnamari Kilkkinen
Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
Int J Cancer 108:277-80. 2004..67 (95% CI 0.95-2.95), 1.71 (95% CI 0.96-3.06) and 1.30 (95% CI 0.73-2.31), and p for trend was 0.48. Our findings do not support the hypothesis that high serum enterolactone concentration is associated with reduced risk of breast cancer... 
The effect of high-fiber rye bread enriched with nonesterified plant sterols on major serum lipids and apolipoproteins in normocholesterolemic individualsP P Söderholm
Folkhalsan Research Center, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, Helsinki, Finland
Nutr Metab Cardiovasc Dis 22:575-82. 2012....- Sensitive high-performance liquid chromatographic method for profiling phytoestrogens using coulometric electrode array detection: application to plasma analysisT Nurmi
Institute for Preventive Medicine, Folkhälsan Research Center and Clinical Chemistry Division, University of Helsinki, Finland
Anal Biochem 274:110-7. 1999..Intraassay precision CVs ranged from 1.5% (enterolactone, 12.4 nmol/liter) to 14% (genistein, 245 nmol/liter) and interassay precision CVs ranged from 9.9% (daidzein, 67.4 nmol/liter) to 44% (enterodiol, 1.20 nmol/liter)... - A randomized placebo-controlled crossover trial with phytoestrogens in treatment of menopause in breast cancer patientsEini Nikander
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
Obstet Gynecol 101:1213-20. 2003..We studied the effects of daily use of isoflavonoids on climacteric symptoms and quality of life in patients with a history of breast cancer... - Phytoestrogens: epidemiology and a possible role in cancer protectionH Adlercreutz
Department of Clinical Chemistry, University of Helsinki, Finland
Environ Health Perspect 103:103-12. 1995..This report is a review on recent results suggesting that the diphenolic isoflavonoids and lignans are natural cancer-protective compounds... - Determinants of serum enterolactone concentrationA Kilkkinen
National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
Am J Clin Nutr 73:1094-100. 2001..The lignan enterolactone, which is produced by the intestinal microflora from dietary precursors, may protect against hormone-dependent cancers and cardiovascular diseases... - Alcohol intake, androgen and glucocorticoid steroids in premenopausal women using oral contraceptives: an interventional studyT Sarkola
Department of Mental Health and Alcohol Research, National Public Health Institute, POB 719, FIN 00101, Helsinki, Finland
J Steroid Biochem Mol Biol 78:157-65. 2001..The present results may be of relevance in the development of disturbances in the glucocorticoid as well as sex steroid balance among heavy female drinkers... - Quantification of alkylresorcinol metabolites in urine by HPLC with coulometric electrode array detectionAnja Koskela
Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center and Division of Clinical Chemistry, University of Helsinki, Helsinki, Finland
Clin Chem 53:1380-3. 2007..Two recently identified urinary AR metabolites, 3,5-dihydroxyphenylbenzoic acid (DHBA) and 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), may be useful as biomarkers of intake of whole-grain rye and wheat... - No effect on adenoma formation in Min mice after moderate amount of flaxseedS Oikarinen
Dept of Applied Chemistry and Microbiology Nutrition, University of Helsinki, 6600014, Helsinki, Finland
Eur J Nutr 44:273-80. 2005..The present work aims to evaluate the effect of flaxseed on tumour formation in multiple intestinal neoplasia (Min) mice, a model for colon tumorigenesis... - Plasma and prostate phytoestrogen concentrations in prostate cancer patients after oral phytoestogen supplementationAntti Rannikko
Department of Urology, Helsinki University Central Hospital, Helsinki, Finland
Prostate 66:82-7. 2006..Phytoestrogens have been suggested to reduce the risk of prostate cancer (CaP), but no data exists on how oral phytoestrogen supplementation influences phytoestrogen concentrations in prostate tissue... - Rye bread intake improves oxidation resistance of LDL in healthy humansP P Söderholm
Folkhalsan Research Center, Biomedicum C315a, PO Box 63, FI 00014 University of Helsinki, Helsinki, Finland
Atherosclerosis 221:583-6. 2012..The capacity of LDL to resist oxidation can be determined ex vivo by exposing isolated LDL particles to copper ions and measuring the formation of conjugated dienes by spectrophotometry... - Isoflavone content of the soy based supplementsT Nurmi
Department of Clinical Chemistry, Folkhalsan Research Center, University of Helsinki, PO Box 63, FIN 00014 Helsinki, Finland
J Pharm Biomed Anal 28:1-11. 2002..Measured amounts of isoflavones in aglycones after the hydrolysis were in general lower than the values in the product labels. Product data were often confusing and the concrete amount of isoflavones was difficult to find out... - Dietary soy-derived isoflavone phytoestrogens. Could they have a role in coronary heart disease prevention?M J Tikkanen
Department of Medicine, Helsinki University Central Hospital, 00290 Helsinki, Finland
Biochem Pharmacol 60:1-5. 2000..Further studies are needed to assess to what extent analogous effects could be produced in vivo and whether such substances have a role in hormone replacement and coronary heart disease prevention in postmenopausal women... - Plasma enterolactone or intestinal Bifidobacterium levels do not explain adenoma formation in multiple intestinal neoplasia (Min) mice fed with two different types of rye-bran fractionsS Oikarinen
Department of Applied Chemistry and Microbiology, Division of Nutrition, PO Box 27, FIN 00014 University of Helsinki, Finland
Br J Nutr 90:119-25. 2003..In conclusion, rye bran and rye fractions influence adenoma formation in Min mice to a varying degree but plasma enterolactone levels or the production of bifidogenic bacteria do not mediate the effect... - Determination of lignans in human plasma by liquid chromatography with coulometric electrode array detectionJosé L Peñalvo
Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, and Division of Clinical Chemistry, University of Helsinki, Biomedicum, P O Box 63, 00014, Helsinki, Finland
Anal Biochem 332:384-93. 2004.... - Quantification of lignans in food using isotope dilution gas chromatography/mass spectrometryJosé L Peñalvo
Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, and Division of Clinical Chemistry, University of Helsinki, Biomedicum, Helsinki, Finland
J Agric Food Chem 53:9342-7. 2005.... - Plasma and urinary alkylresorcinol metabolites as potential biomarkers of breast cancer risk in Finnish women: a pilot studyMylene Aubertin-Leheudre
Folkhalsan Research Center, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, Helsinki, Finland
Nutr Cancer 62:759-64. 2010..This novel approach will likely also facilitate studies of associations between rye and whole-grain wheat cereal fiber intake and other diseases. Our findings should, however, be confirmed with larger subject populations... - Whole-grain rye and wheat alkylresorcinols are incorporated into human erythrocyte membranesAnna Maria Linko
Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center and Division of Clinical Chemistry, P O Box 63, University of Helsinki, FIN 00014, Helsinki, Finland
Br J Nutr 93:11-3. 2005..Long-chain AR were incorporated into erythrocyte membranes in a higher proportion compared to shorter-chain AR. This preliminary study shows that AR are incorporated into human erythrocyte membranes in vivo... - Identification of urinary metabolites of the red clover isoflavones formononetin and biochanin A in human subjectsSatu Maarit Heinonen
Folkhälsan Research Center and Department of Clinical Chemistry, University of Helsinki, Finland
J Agric Food Chem 52:6802-9. 2004..Possible metabolic pathways are presented for the red clover isoflavones formononetin and biochanin A... - Metabolism of the soy isoflavones daidzein, genistein and glycitein in human subjects. Identification of new metabolites having an intact isoflavonoid skeletonSatu Maarit Heinonen
Department of Clinical Chemistry, Biomedicum, Folkhälsan Research Centre, University of Helsinki, P O Box 63, FIN 00014 Helsinki, Finland
J Steroid Biochem Mol Biol 87:285-99. 2003..The metabolic pathways of daidzein, genistein and glycitein are presented on the basis of the identification of the metabolites in human urine after soy supplementation... - Effects of a flaxseed mixture and plant oils rich in alpha-linolenic acid on the adenoma formation in multiple intestinal neoplasia (Min) miceSeija I Oikarinen
Department of Applied Chemistry and Microbiology Nutrition, PO Box 66, FIN 00014 University of Helsinki, Finland
Br J Nutr 94:510-8. 2005.... - Studies of the in vitro intestinal metabolism of isoflavones aid in the identification of their urinary metabolitesSatu Maarit Heinonen
Folkhälsan Research Center and Department of Clinical Chemistry, Biomedicum, P O Box 63, FIN 00014 University of Helsinki, Helsinki, Finland
J Agric Food Chem 52:2640-6. 2004..Four novel isoflavone metabolites were identified in human urine collected after soy supplementation: 3' '-OH-O-desmethylangolensin, 3',4',7-trihydroxyisoflavanone, 4',7,8-trihydroxyisoflavanone, and 4',6,7-trihydroxyisoflavanone... - Whole-grain rye bread consumption by women correlates with plasma alkylresorcinols and increases their concentration compared with low-fiber wheat breadAnna Maria Linko
Institute for Preventive Medicine, Nutrition and Cancer, Folkhälsan Research Center and Department of Clinical Chemistry, University of Helsinki, FIN 00014, Helsinki, Finland
J Nutr 135:580-3. 2005..08) bread diet periods (P < 0.001). These data strongly suggest that plasma ARs could be used as specific biomarkers for whole-grain rye intake, and their homologue pattern could be used as an indicator of the bread type consumed... - Plant lignans in soy-based health supplementsJosé L Peñalvo
Department of Clinical Chemistry, University of Helsinki, Biomedicum, PO Box 63, 00014 Helsinki, Finland
J Agric Food Chem 52:4133-8. 2004..Additional quantification of plant lignans and isoflavones in soybeans has been carried out, and results are provided to allow the comparison of the average levels in soybeans and soy-based supplements... - Determination of plasma genistein fatty acid esters following administration of genistein or genistein 4'7-O-dioleate in monkeysMaija Badeau
Department of Medicine, University of Helsinki, Helsinki 00014, Finland
Biochim Biophys Acta 1738:115-20. 2005..The results suggest that it may be possible to introduce intact genistein ester molecules into plasma by parenteral but not oral administration... - Dietary sesamin is converted to enterolactone in humansJosé L Peñalvo
Institute for Preventive Medicine, Nutrition, and Cancer, Folkhalsan Research Center, and Division of Clinical Chemistry, University of Helsinki, Helsinki, Finland
J Nutr 135:1056-62. 2005..Enterolactone was the major metabolite of sesamin both in vivo and in vitro. The abundance of sesamin in sesame seeds indicates that they are a major food source of enterolactone precursors... - Quantification of alkylresorcinol metabolites in plasma by high-performance liquid chromatography with coulometric electrode array detectionAnja Koskela
Institute for Preventive Medicine, Nutrition, and Cancer, Folkhalsan Research Center and Division of Clinical Chemistry, P O Box 63, FIN 00014 University of Helsinki, Finland
J Agric Food Chem 56:7678-81. 2008..Additional investigation is needed to clarify whether the two plasma AR metabolites are useful as biomarkers of whole-grain intake and helpful in the exploration of the association between whole-grain cereal intake and human diseases... - Kinetics of the appearance of cereal alkylresorcinols in pig plasmaAnna Maria Linko
Nestle Research Centre, Lausanne 26, CH 1000, Switzerland
Br J Nutr 95:282-7. 2006..AR concentrations in pig plasma increase rapidly after a meal containing AR, and persist in plasma for at least 5 d, indicating that AR may be a useful biomarker of wholegrain wheat and rye intake... - Serum enterolactone concentration is not associated with prostate cancer risk in a nested case-control studyAnnamari Kilkkinen
National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
Cancer Epidemiol Biomarkers Prev 12:1209-12. 2003..00 (referent), 0.72 [95% confidence interval (CI), 0.43-1.23], 0.98 (95% CI, 0.58-1.68), and 0.71 (95% CI, 0.42-1.21). Our findings do not support the hypothesis that enterolactone is involved in the development of prostate cancer... - Plasma alkylresorcinols and urinary alkylresorcinol metabolites as biomarkers of cereal fiber intake in Finnish womenMylene Aubertin-Leheudre
Folkhalsan Research Center, University of Helsinki, Helsinki, Finland
Cancer Epidemiol Biomarkers Prev 17:2244-8. 2008..These results indicate that assay of plasma ARs or urinary AR metabolites may be used as biomarkers in epidemiologic studies in free-living populations to evaluate the role of cereal fiber intake in various diseases... - Lignan content of selected foods from JapanJosé L Peñalvo
Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center and Division of Clinical Chemistry, University of Helsinki, 00014 Helsinki, Finland
J Agric Food Chem 56:401-9. 2008..These data will complement the previous databases and most importantly expand the knowledge of occurrence of lignans in food to Eastern diets... - Plasma alkylresorcinol metabolites as potential biomarkers of whole-grain wheat and rye cereal fibre intakes in womenMylene Aubertin-Leheudre
Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, and Division of Clinical Chemistry, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, PO Box 63, BP 63, Room C315a, FIN 00014 Helsinki, Finland
Br J Nutr 103:339-43. 2010..Thus, sum of plasma AR metabolites and more specifically plasma DHPPA seems to be good and specific biomarkers of cereal fibre intake... - Relationship between animal protein intake and muscle mass index in healthy womenMylene Aubertin-Leheudre
Institute for Preventive Medicine, Nutrition and Cancer, Division of Clinical Chemistry, University of Helsinki, Helsinki, Finland
Br J Nutr 102:1803-10. 2009..42). Thus, a vegetarian diet is associated with a lower muscle mass index than is an omnivorous diet at the same protein intake. A good indicator of muscle mass index in women seems to be animal protein intake... - Alkylresorcinols from whole-grain wheat and rye are transported in human plasma lipoproteinsAnna Maria Linko-Parvinen
Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, Division of Clinical Chemistry, University of Helsinki, FIN 00014 Helsinki, Finland
J Nutr 137:1137-42. 2007..The plasma alkylresorcinol C17:0 to C21:0 ratio reflects intake of whole-grain wheat and rye, and the plasma total alkylresorcinol concentration appears to be a useful biomarker of whole-grain cereal intake... - Gas chromatographic-mass spectrometric method for the determination of alkylresorcinols in human plasmaAnna Maria Linko
Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, Department of Clinical Chemistry, University of Helsinki, Finland
Anal Biochem 308:307-13. 2002..The alkylresorcinols were in the unconjugated form. The total amounts of alkylresorcinols in two plasma samples analyzed here were 333 and 381nmol/L... - Short-term variations in enterolactone in serum, 24-hour urine, and spot urine and relationship with enterolactone concentrationsKatariina Stumpf
, Institute for Preventive Medicine, Nutrition and Cancer, Biomedicum, PB 63, University of Helsinki, FIN-00014 Helsinki, Finland
Clin Chem 49:178-81. 2003 - Synthesis of novel mammalian metabolites of the isoflavonoid phytoestrogens daidzein and genisteinK Wahala
Department of Chemistry, University of Helsinki, Finland
Proc Soc Exp Biol Med 217:293-9. 1998.... - The effect of flaxseed supplementation in processed foods on serum fatty acids and enterolactoneS Tarpila
Department of Internal Medicine, The Mehiläinen Hospital, Helsinki, Finland
Eur J Clin Nutr 56:157-65. 2002..The purpose was to study the effects of flaxseed supplementation as a part of daily diet on serum lipids, fatty acids and plasma enterolactone... - Accumulation of genistein and lipophilic genistein derivatives in lipoproteins during incubation with human plasma in vitroMaija Kaamanen
Department of Medicine, University of Helsinki, Helsinki 00014, Finland
Biochim Biophys Acta 1631:147-52. 2003..A smaller part of the latter were genistein monoesters, while part remained unidentified. Our results suggest an explanation for the increased oxidation resistance of isolated LDL during intake of soybean isoflavones... - Time-resolved fluoroimmunoassay of plasma and urine O-desmethylangolensinElke Brouwers
Division of Clinical Chemistry and Institute for Preventive Medicine, Nutrition and Cancer, , University of Helsinki, PB 60, Finland
J Steroid Biochem Mol Biol 81:353-61. 2002..8-7.7 and 3.0-6.0%, respectively and the inter-assay CVs varied 3.8-8.9 and 4.4-6.6%, respectively. The working range of the plasma and urine O-DMA assays was 0.5-512 nmol/l... - Intake of lignans is associated with serum enterolactone concentration in Finnish men and womenAnnamari Kilkkinen
Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
J Nutr 133:1830-3. 2003..2 mg). The main dietary sources of lignans, i.e., whole grain, vegetables and fruits, are foods commonly associated with lower risk of cardiovascular diseases and cancer. Serum EL concentration is a feasible biomarker of lignan intake... - Associations between pituitary-adrenocortical function and abdominal obesity, hyperinsulinaemia and dyslipidaemia in normotensive malesA Hautanen
Department of Clinical Chemistry, University of Helsinki, Finland
J Intern Med 241:451-61. 1997..To examine the relationships between pituitary-adrenal cortical (PA) function, abdominal obesity, hyperinsulinaemia, and dyslipidaemia... - The effects of short-term oral phytoestrogen supplementation on the hypothalamic-pituitary-testicular axis in prostate cancer patientsAntti Rannikko
Department of Urology, Helsinki University Central Hospital, Helsinki, Finland
Prostate 66:1086-91. 2006..Here we evaluate the effects of oral phytoestrogen supplementation on hypothalamic-pituitary-testicular (HPT) axis in CaP patients... - Effect of sesamin on serum cholesterol and triglycerides levels in LDL receptor-deficient miceJosé L Peñalvo
Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center and Division of Clinical Chemistry, University of Helsinki, Finland
Eur J Nutr 45:439-44. 2006.... - Time-resolved fluoroimmunoassay for equol in plasma and urineElke Brouwers
, Division of Clinical Chemistry, Institute for Preventive Medicine, Nutrition and Cancer, P.O. Box 63, University of Helsinki, FIN-00014 Helsinki, Finland
J Steroid Biochem Mol Biol 84:577-88. 2003..5-6.5 and 3.4-6.9, respectively. The inter-assay CV% varies between 5.4-9.7 and 7.4-7.7, respectively. The working ranges of the plasma and urine assay are 1.27-512 and 1.9-512nmol/l, respectively... - Preliminary antiproliferative effects of some species of Terminalia, Combretum and Pteleopsis collected in Tanzania on some human cancer cell linesP Fyhrquist
Division of Clinical Chemistry and Folkhälsan Research Center, Institute for Preventive Nutrition, Medicine and Cancer, Biomedicum, P O Box 63, FIN 00014 University of Helsinki, Finland
Fitoterapia 77:358-66. 2006.... - Does antibacterial treatment for urinary tract infection contribute to the risk of breast cancer?P Knekt
National Public Health Institute, Helsinki, Finland
Br J Cancer 82:1107-10. 2000..The results are, however, still inconclusive and the hypothesis needs to be tested by other studies... - Accumulation of high-density lipoprotein-derived estradiol-17beta fatty acid esters in low-density lipoprotein particlesH Helisten
Department of Medicine, University of Helsinki, 00014 Helsinki, Finland
J Clin Endocrinol Metab 86:1294-300. 2001.... - The role of the liver in the acute effect of alcohol on androgens in womenT Sarkola
Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
J Clin Endocrinol Metab 86:1981-5. 2001..Our results suggests that the liver should be included as a major site in the acute endocrinological effects of alcohol on steroid hormones in women... - Estrogen A-ring structure and antioxidative effect on lipoproteinsMaija Badeau
Department of Medicine, University of Helsinki, 00014 Helsinki, Finland
J Steroid Biochem Mol Biol 96:271-8. 2005..Accordingly, both the presence of unsubstituted hydroxyl groups and adjacent substituents, as well as the lipophilicity of the derivatives determine the antioxidant activity of estrogen derivatives in aqueous lipoprotein solutions... - Fat/fiber intakes and sex hormones in healthy premenopausal women in USAMylene Aubertin-Leheudre
Folkhalsan Research Center, Institute of Preventive Medicine, Nutrition and Cancer, Division of Clinical Chemistry, University of Helsinki, Finland
J Steroid Biochem Mol Biol 112:32-9. 2008..Our results suggest that fat affects estrogen metabolism more than does fiber and that one mechanism resulting in high estrogen values is an increased reabsorption of biliary estrogens... - Phytoestrogens and vitamin D metabolism: a new concept for the prevention and therapy of colorectal, prostate, and mammary carcinomasHeide S Cross
Department of Pathophysiology, University of Vienna Medical School, Austria
J Nutr 134:1207S-1212S. 2004..We suggest that nutritional soy or genistein can optimize extrarenal 1,25-D3 synthesis, which could result in growth control and, conceivably, in inhibition of tumor progression... - Dietary fiber intake and endogenous serum hormone levels in naturally postmenopausal Mexican American women: the Multiethnic Cohort StudyKristine R Monroe
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
Nutr Cancer 58:127-35. 2007..The suggestive findings relating increased estrogen levels to avocado and grapefruit intakes need confirmation... - Effects of soy-derived isoflavones and a high-fat diet on spontaneous mammary tumor development in Tg.NK (MMTV/c-neu) miceMirjam Luijten
Laboratory of Toxicology, Pathology and Genetics, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
Nutr Cancer 50:46-54. 2004..This study shows that breast cancer-modulating effects of phytoestrogens are dependent both on the background diet and on the timing of exposure in the life cycle... - Isoflavonoids inhibit catabolism of vitamin D in prostate cancer cellsHesso Farhan
Institute of Pathophysiology, University of Vienna Medical School, AKH, , Vienna, Austria
J Chromatogr B Analyt Technol Biomed Life Sci 777:261-8. 2002..High levels of CYP24 frequently found in prostate cancer cells may thus degrade the active metabolite. This could be prevented by ingestion of genistein-containing food such as soybeans... - Mammalian lignan formation in rats fed a wheat bran dietCatherine Nicolle
Laboratoire des Maladies Métaboliques et Micronutriments, INRA, 63122 Saint Genes Champanelle, France
J Agric Food Chem 50:6222-6. 2002..These results show that the formation of lignans from wheat bran is influenced by the diet, possibly because of an adaptation of the colonic microflora... - Monoclonal antibody-based time-resolved fluorescence immunoassays for daidzein, genistein, and equol in blood and urine: application to the Isoheart intervention studyDuncan C S Talbot
Unilever Corporate Research, Sharnbrook, United Kingdom
Clin Chem 53:748-56. 2007.... - An incident case-referent study on plasma enterolactone and breast cancer riskKerstin Hultén
Epidemiology Department of Public Health and Clinical Medicine, Umea University, Sweden
Eur J Nutr 41:168-76. 2002..Using a nested case-referent design, we evaluated the relationship between plasma levels of the lignan enterolactone and the risk of developing breast cancer... - Whole grain food intake elevates serum enterolactoneDavid R Jacobs
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, USA
Br J Nutr 88:111-6. 2002..Serum enterolactone concentrations can be raised by eating a diet rich in whole grains... - Dietary phytoestrogens are not associated with risk of overall breast cancer but diets rich in coumestrol are inversely associated with risk of estrogen receptor and progesterone receptor negative breast tumors in Swedish womenMaria Hedelin
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
J Nutr 138:938-45. 2008..Our results of a decreased risk of ER-PR- tumors in women with intermediate intake of coumestrol could be due to chance because of the low intake. The results should be confirmed in other studies... - A combination of dietary fructooligosaccharides and isoflavone conjugates increases femoral bone mineral density and equol production in ovariectomized miceAtsutane Ohta
Bioscience Laboratories, Meiji Seika Kaisha, Ltd, Sakado City, Saitama 350 0289, Japan
J Nutr 132:2048-54. 2002..These results suggest that FOS increase the bioavailability of isoflavones, leading to cooperative effects in the prevention of osteopenia in OVX mice... - Circulating enterolactone and prostate cancer risk: a Nordic nested case-control studyPar Stattin
Department of Urology, Umea University Hospital, Umea, Sweden
Int J Cancer 99:124-9. 2002..21 (95% CI = 0.91-1.60), 1.02 (95% CI = 0.59-1.76) and 0.87 (95% CI = 0.45-1.67), respectively. No support for the hypothesis that high circulating enterolactone is protective against prostate cancer was found... - Use of oral antimicrobials decreases serum enterolactone concentrationAnnamari Kilkkinen
Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
Am J Epidemiol 155:472-7. 2002..Furthermore, recent use of antimicrobials should be considered when the association between serum enterolactone concentration and risk of chronic diseases is studied... - Neurobehavioral effects of dietary soy phytoestrogensEdwin D Lephart
Neuroscience Center, 633 WIDB, Brigham Young University, Provo, UT 86402, USA
Neurotoxicol Teratol 24:5-16. 2002.... - Human plasma kinetics and relative bioavailability of alkylresorcinols after intake of rye branRikard Landberg
Department of Food Science, Swedish University of Agriculture Science SLU, Uppsala, Sweden
J Nutr 136:2760-5. 2006..The apparent half-lives were rather short, approximately 5 h for all homologs, which suggests that the AR concentration in plasma could be used as a short- to medium-term biomarker of regular intake of whole-grain wheat and rye... - Phytoestrogens regulate vitamin D metabolism in the mouse colon: relevance for colon tumor prevention and therapyEnikö Kállay
Department of Pathophysiology, University of Vienna Medical School, Vienna, Austria
J Nutr 132:3490S-3493S. 2002..Our data therefore suggest that an inverse correlation of soy product consumption with colon tumor incidence may be consequent to enhanced colonic synthesis of the antimitotic hormone 1,25-dihydroxyvitamin D3... - Secoisolariciresinol and matairesinol of sea buckthorn (Hippophaë rhamnoides L.) berries of different subspecies and harvesting timesBaoru Yang
Department of Biochemistry and Food Chemistry, University of Turku, FIN-20014 Turku, Finland
J Agric Food Chem 54:8065-70. 2006..Harvesting dates had a significant influence on the content of the two lignans in seeds, fruit pulp/peel, and whole berries. This is the first report of lignans in sea buckthorn... - Anticancer effects of a plant lignan 7-hydroxymatairesinol on a prostate cancer model in vivoAnnika Bylund
University of Turku, Functional Foods Forum, FI-20014 Turku, Finland
Exp Biol Med (Maywood) 230:217-23. 2005..30% HMR diet compared with mice receiving the control diet. Our results suggest that dietary HMR started at the early phase of the tumor development inhibits the growth of the LNCaP human prostate cancer xenografts in athymic male mice... - Phytoestrogen tissue levels in benign prostatic hyperplasia and prostate cancer and their association with prostatic diseasesClemens Brossner
Department of Urology and Andrology, Danube Hospital, Vienna, Austria
Urology 64:707-11. 2004..To compare phytoestrogen tissue levels in men with small-volume benign prostatic hyperplasia (BPH), large-volume BPH, and prostate cancer (PCa)... - The effect of soy consumption on the urinary 2:16-hydroxyestrone ratio in postmenopausal women depends on equol production status but is not influenced by probiotic consumptionJennifer A Nettleton
Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USA
J Nutr 135:603-8. 2005..These results are consistent with studies that found lower urine 2:16OHE(1) ratios in women with breast cancer and suggest that soy consumption increases this ratio only in women who are equol producers... - Prospective study of plasma enterolactone and prostate cancer risk (Sweden)Par Stattin
Department of Surgery and Perioperative Sciences, Urology and Andrology, Umed University Hospital, Sweden
Cancer Causes Control 15:1095-102. 2004..We studied the association between plasma enterolactone and risk of prostate cancer... - Plasma phytoestrogens are not altered by probiotic consumption in postmenopausal women with and without a history of breast cancerJennifer A Nettleton
Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USA
J Nutr 134:1998-2003. 2004.... - Dietary lignins are precursors of mammalian lignans in ratsAynun Nahar Begum
Unite des Maladies Metaboliques et Micronutrients, INRA Theix, 63122 Saint-Genes-Champanelle, France
J Nutr 134:120-7. 2004..The detection of deuterated ENL by LC-tandem MS in urine (20 nmol/d) clearly confirms the conversion of lignin into mammalian lignans. More research is warranted to determine the bioavailability of lignins in the human diet... - Lignan precursors from flaxseed or rye bran do not protect against the development of intestinal neoplasia in ApcMin miceHenk J van Kranen
Laboratory of Health Effects Research, Department of Carcinogenesis, Mutagenesis and Genetics, Laboratory of Pathology, National Institute of Public Health and Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
Nutr Cancer 45:203-10. 2003.... - Rye, lignans and human healthGoran Hallmans
Departments of Public Health and Clinical Medicine, University of Umea, Umea, Sweden
Proc Nutr Soc 62:193-9. 2003..It seems reasonable to assume that these protective effects are associated with one or more factors in the dietary fibre complex... - Short-term soy and probiotic supplementation does not markedly affect concentrations of reproductive hormones in postmenopausal women with and without histories of breast cancerJennifer A Nettleton
Department of Food Science and Nutrition, University of Minnesota, St Paul, MN 55108, USA
J Altern Complement Med 11:1067-74. 2005..Because intestinal bacteria metabolize isoflavones, it was hypothesized that consumption of probiotic bacteria would enhance the biologic effects of isoflavones, including effects on endogenous hormones... - Dietary phytoestrogen, serum enterolactone and risk of prostate cancer: the cancer prostate Sweden study (Sweden)Maria Hedelin
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE 171 77, Stockholm, Sweden
Cancer Causes Control 17:169-80. 2006..Based on evidence that phytoestrogens may protect against prostate cancer, we evaluated the associations between serum enterolactone concentration or dietary phytoestrogen intake and risk of prostate cancer... - Rye bread in the diet of pigs enhances the formation of enterolactone and increases its levels in plasma, urine and fecesKnud Erik Bach Knudsen
Department of Animal Nutrition and Physiology, Danish Institute of Agricultural Sciences, Research Centre Foulum, Tjele, Denmark
J Nutr 133:1368-75. 2003.... - Phyto-oestrogen database of foods and average intake in FinlandLiisa M Valsta
National Public Health Institute KTL, Department of Epidemiology and Health Promotion, Nutrition Unit, Mannerheimintie 166, FIN 00300, Finland
Br J Nutr 89:S31-8. 2003..The average intake of lignans and isoflavones in Finland seems to be low, but intake varies throughout the population... - Phyto-oestrogen intake and plasma concentrations in South Asian and native British women resident in EnglandDee Bhakta
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Br J Nutr 95:1150-8. 2006..The present study does not support the hypothesis that differences in phytoestrogen intake, or in circulating levels, could explain differences in hormone-related cancer risks between these two populations... - Soy isoflavones: a safety reviewIan C Munro
Cantox Health Sciences International
Nutr Rev 61:1-33. 2003..Whereas results in some studies are limited or conflicting, when viewed in its entirety, the current literature supports the safety of isoflavones as typically consumed in diets based on soy or containing soy products... - Dietary fiber intake and risk of postmenopausal breast cancer defined by estrogen and progesterone receptor status--a prospective cohort study among Swedish womenReiko Suzuki
The National Institute of Environmental Medicine, Division of Nutritional Epidemiology, Karolinska Institutet, Stockholm, Sweden
Int J Cancer 122:403-12. 2008..Our results suggest that dietary fiber intake from fruit and cereal may play a role in reducing breast cancer risk...