Wael M Abdel-Rahman

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi request reprint The genetics of HNPCC: application to diagnosis and screening
    Wael M Abdel-Rahman
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Crit Rev Oncol Hematol 58:208-20. 2006
  2. ncbi request reprint Restoring mismatch repair does not stop the formation of reciprocal translocations in the colon cancer cell line HCA7 but further destabilizes chromosome number
    Wael M Abdel-Rahman
    Department of Medical Genetics, Helsinki University, Helsinki, Finland
    Oncogene 24:706-13. 2005
  3. ncbi request reprint Comprehensive characterization of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations
    Wael M Abdel-Rahman
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Oncogene 24:1542-51. 2005
  4. doi request reprint Somatic FGF9 mutations in colorectal and endometrial carcinomas associated with membranous beta-catenin
    Wael M Abdel-Rahman
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Hum Mutat 29:390-7. 2008
  5. ncbi request reprint HNPCC mutation MLH1 P648S makes the functional protein unstable, and homozygosity predisposes to mild neurofibromatosis type 1
    Tiina E Raevaara
    Department of Biosciences, Division of Genetics, University of Helsinki, Helsinki, Finland
    Genes Chromosomes Cancer 40:261-5. 2004
  6. ncbi request reprint Molecular analysis of familial endometrial carcinoma: a manifestation of hereditary nonpolyposis colorectal cancer or a separate syndrome?
    Miina Ollikainen
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    J Clin Oncol 23:4609-16. 2005
  7. ncbi request reprint Altered expression of MLH1, MSH2, and MSH6 in predisposition to hereditary nonpolyposis colorectal cancer
    Elise Renkonen
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    J Clin Oncol 21:3629-37. 2003
  8. doi request reprint Epigenetic signatures of familial cancer are characteristic of tumor type and family category
    Emmi I Joensuu
    Department of Medical Genetics, University of Helsinki, Finland
    Cancer Res 68:4597-605. 2008
  9. pmc Breast carcinoma and Lynch syndrome: molecular analysis of tumors arising in mutation carriers, non-carriers, and sporadic cases
    Johanna E Lotsari
    Department of Medical Genetics, Biomedicum Helsinki, P, O, Box 63 Haartmaninkatu 8, University of Helsinki, Helsinki, Finland, FIN 00014
    Breast Cancer Res 14:R90. 2012
  10. ncbi request reprint Adenomatous polyposis families that screen APC mutation-negative by conventional methods are genetically heterogeneous
    Elise T Renkonen
    Department of Medical Genetics, Institute of Dentistry, Biomedicum Helsinki, PO Box 63 Haartmaninkatu 8, FIN 00014 University of Helsinki, Helsinki, Finland
    J Clin Oncol 23:5651-9. 2005

Collaborators

Detail Information

Publications21

  1. ncbi request reprint The genetics of HNPCC: application to diagnosis and screening
    Wael M Abdel-Rahman
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Crit Rev Oncol Hematol 58:208-20. 2006
    ..This subset of tumors is the focus of current clinical and molecular research. This review addresses recent advances in the field of HNPCC research and their applications in the management of affected individuals and families...
  2. ncbi request reprint Restoring mismatch repair does not stop the formation of reciprocal translocations in the colon cancer cell line HCA7 but further destabilizes chromosome number
    Wael M Abdel-Rahman
    Department of Medical Genetics, Helsinki University, Helsinki, Finland
    Oncogene 24:706-13. 2005
    ..Thus, the accumulating data suggest that MMR defect may not be necessary for the development of reciprocal chromosomal translocations but might be permissive...
  3. ncbi request reprint Comprehensive characterization of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations
    Wael M Abdel-Rahman
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Oncogene 24:1542-51. 2005
    ..This feature distinguishes the MMR gene mutation negative families from both HNPCC families linked to MMR defects and sporadic cases, suggesting the involvement of novel predisposition genes and pathways in such families...
  4. doi request reprint Somatic FGF9 mutations in colorectal and endometrial carcinomas associated with membranous beta-catenin
    Wael M Abdel-Rahman
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Hum Mutat 29:390-7. 2008
    ..These data suggest that FGF9 plays a role in colorectal and endometrial carcinogenesis...
  5. ncbi request reprint HNPCC mutation MLH1 P648S makes the functional protein unstable, and homozygosity predisposes to mild neurofibromatosis type 1
    Tiina E Raevaara
    Department of Biosciences, Division of Genetics, University of Helsinki, Helsinki, Finland
    Genes Chromosomes Cancer 40:261-5. 2004
    ....
  6. ncbi request reprint Molecular analysis of familial endometrial carcinoma: a manifestation of hereditary nonpolyposis colorectal cancer or a separate syndrome?
    Miina Ollikainen
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    J Clin Oncol 23:4609-16. 2005
    ..Clustering of EC alone, termed as familial site-specific EC, may constitute a separate entity. Because its genetic basis is unknown, our purpose was to characterize such families molecularly...
  7. ncbi request reprint Altered expression of MLH1, MSH2, and MSH6 in predisposition to hereditary nonpolyposis colorectal cancer
    Elise Renkonen
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    J Clin Oncol 21:3629-37. 2003
    ..Our purpose was to address the genetic etiology of such families. Materials and..
  8. doi request reprint Epigenetic signatures of familial cancer are characteristic of tumor type and family category
    Emmi I Joensuu
    Department of Medical Genetics, University of Helsinki, Finland
    Cancer Res 68:4597-605. 2008
    ..Paired normal tissues or blood displayed negligible methylation arguing against a constitutional methylation abnormality in familial cases...
  9. pmc Breast carcinoma and Lynch syndrome: molecular analysis of tumors arising in mutation carriers, non-carriers, and sporadic cases
    Johanna E Lotsari
    Department of Medical Genetics, Biomedicum Helsinki, P, O, Box 63 Haartmaninkatu 8, University of Helsinki, Helsinki, Finland, FIN 00014
    Breast Cancer Res 14:R90. 2012
    ..This study aimed to settle the question as to whether breast carcinoma belongs to the LS tumor spectrum...
  10. ncbi request reprint Adenomatous polyposis families that screen APC mutation-negative by conventional methods are genetically heterogeneous
    Elise T Renkonen
    Department of Medical Genetics, Institute of Dentistry, Biomedicum Helsinki, PO Box 63 Haartmaninkatu 8, FIN 00014 University of Helsinki, Helsinki, Finland
    J Clin Oncol 23:5651-9. 2005
    ..Our purpose was to clarify the genetic basis of polyposis and genotype-phenotype correlations in such families...
  11. ncbi request reprint Pathogenicity of the hereditary colorectal cancer mutation hMLH1 del616 linked to shortage of the functional protein
    Tiina E Raevaara
    Division of Genetics, Department of Biosciences, University of Helsinki, Helsinki, Finland
    Gastroenterology 125:501-9. 2003
    ..Because the predicted coding change is a deletion of only 1 amino acid, the pathogenicity of the mutation was evaluated...
  12. ncbi request reprint Patterns of PIK3CA alterations in familial colorectal and endometrial carcinoma
    Miina Ollikainen
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Int J Cancer 121:915-20. 2007
    ..PIK3CA alterations frequently coexisted with PTEN or KRAS changes. Combined with published studies on sporadic tumors, our data broaden the understanding of the role for PI3K pathway genes in human tumorigenesis...
  13. ncbi request reprint APC and beta-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers
    Reetta Kariola
    Department of Biological and Environmental Sciences, Genetics, University of Helsinki, Viikinkaari 5, 00014 Helsinki, Finland
    Fam Cancer 4:187-90. 2005
    ..Here, we studied the involvement of APC and beta-catenin in hereditary nonpolyposis colorectal cancer (HNPCC)-related ECs, and compared the expression patterns to those in HNPCC-related CRCs...
  14. doi request reprint Distinct genetic and epigenetic signatures of colorectal cancers according to ethnic origin
    Taina T Nieminen
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Cancer Epidemiol Biomarkers Prev 21:202-11. 2012
    ..The outcome of colorectal cancer varies depending on ethnic origin. Egyptian colorectal carcinoma is surprisingly young-age disease with high proportion of rectal and advanced stage cancers...
  15. ncbi request reprint Truncation of MBD4 predisposes to reciprocal chromosomal translocations and alters the response to therapeutic agents in colon cancer cells
    Wael M Abdel-Rahman
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    DNA Repair (Amst) 7:321-8. 2008
    ..We also show that over-expression of MBD4(tru) in DLD1 alters the colony survival after exposure to cisplatin or etoposide. These data suggest a wide role for MBD4 in DNA damage response and maintaining chromosomal stability...
  16. ncbi request reprint Cutaneous T-cell lymphoma-associated lung cancers show chromosomal aberrations differing from primary lung cancer
    Sonja Hahtola
    Department of Dermatology and Allergology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Genes Chromosomes Cancer 47:107-17. 2008
    ..These preliminary observations warrant further prospective studies to identify the common underlying factors between CTCL and CTCL-associated lung cancer...
  17. doi request reprint Molecular analysis of endometrial tumorigenesis: importance of complex hyperplasia regardless of atypia
    Taina T Nieminen
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Clin Cancer Res 15:5772-83. 2009
    ..We characterized precursor lesions of endometrioid EC to identify markers of malignant transformation and tumor progression...
  18. doi request reprint Clinicopathological characterization and genomic aberrations in subcutaneous panniculitis-like T-cell lymphoma
    Sonja Hahtola
    Department of Dermatology and Allergology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    J Invest Dermatol 128:2304-9. 2008
    ....
  19. ncbi request reprint Molecular basis and diagnostics of hereditary colorectal cancers
    Wael M Abdel-Rahman
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Ann Med 36:379-88. 2004
    ..This review addresses the molecular basis of these syndromes with particular reference to the recent advances in this rapidly progressive field and the applications of such knowledge in diagnosis and management...
  20. ncbi request reprint Mutations of beta-catenin and KRAS in colorectal carcinomas
    Wael M Abdel-Rahman
    Dig Dis Sci 51:616-7. 2006
  21. ncbi request reprint Multiple reciprocal translocations in carcinomas
    Wael M Abdel-Rahman
    Cancer Genet Cytogenet 158:194-5. 2005