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Genomes and Genes
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Publications
Pulmonary blood volume in mitral regurgitation in Cavalier King Charles spanielsA Eriksson
Minerva Institute for Medical Research, University of Helsinki, Helsinki, Finland
J Vet Intern Med 24:1393-9. 2010..However, little is known about pulmonary blood volume (PBV), blood pulmonary transit time (PTT), and the regulation of these...- Human influence on distribution and extinctions of the late Pleistocene Eurasian megafaunaDiana Pushkina
Department of Geology, University of Helsinki, Finland
J Hum Evol 54:769-82. 2008.... - Modulation of epithelial cell fate of the root in vitroM Tummers
Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, PO Box 56, FIN 00014, Helsinki, Finland
J Dent Res 86:1063-7. 2007..We conclude that the fate of the epithelium is regulated by external cues influenced by culture conditions, and that the molar has the intrinsic capacity to grow continuously... - Species-level selection reduces selfishness through competitive exclusionD J Rankin
Laboratory of Ecological and Evolutionary Dynamics, Department of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland
J Evol Biol 20:1459-68. 2007..Our results suggest that species-level selection and community dynamics play an important role in regulating the intensity of conflicts in natural populations... - Monocyte CD14 and soluble CD14 in predicting mortality of patients with severe community acquired infectionHannele Aalto
Department of Bacteriology and Immunology, The Haartman Institute, University of Helsinki, Finland
Scand J Infect Dis 39:596-603. 2007..In conclusion, low monocyte mCD14 level, unlike the concurrent sCD14 level, predicts 28-d mortality in patients with community acquired infections... - Distal myopathy caused by homozygous missense mutations in the nebulin geneCarina Wallgren-Pettersson
Department of Medical Genetics, University of Helsinki, Helsinki, Finland
Brain 130:1465-76. 2007..We conclude that homozygous missense mutations in NEB cause a novel distal myopathy, predominantly involving lower leg extensor muscles, finger extensors and neck flexors... - The effect of emergency department delay on outcome in critically ill medical patients: evaluation using hospital mortality and quality of life at 6 monthsK A Saukkonen
Emergency Care, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
J Intern Med 260:586-91. 2006..The 15D is a generic, 15-dimensional, standardized measure of HRQoL. We hypothesized that prolonged stay in the ED is related to worse outcome... - Sense of coherence and its determinants: a comparative study of the Finnish-speaking majority and the Swedish-speaking minority in FinlandSalla Maarit Volanen
Department of Public Health, University of Turku, Finland
Scand J Public Health 34:515-25. 2006..This study investigated (1) the level of sense of coherence (SOC), (2) the structure of generalized resistance resources (GRRs), and (3) associations of GRRs with SOC among Finnish- and Swedish-speaking Finns... - Novel function of the skin in calcium metabolism in female and male chickens (Gallus domesticus)Liisa M Peltonen
Department of Biomedicine, Physiology, Biomedicum Helsinki, 00014 University of Helsinki, Finland
Comp Biochem Physiol B Biochem Mol Biol 144:432-41. 2006..Possible functions of the skin as a dynamic calcium source balancing the free circulating Ca2+ levels and, also, as an excretory organ for Ca2+ are discussed... - Extracellular matrix-induced changes in expression of cell cycle-related proteins and proteasome components in endometrial adenocarcinoma cellsHannu Koistinen
Department of Clinical Chemistry, Helsinki University Central Hospital, Biomedicum Helsinki, PO Box 700, 00029 HUS, Finland
Gynecol Oncol 102:546-51. 2006..The purpose of this study was to investigate these changes... - Effect of diet and tylosin on chronic diarrhea in beaglesElias Westermarck
Department of Clinical Veterinary Sciences, Faculty of Veterinary Medicine, Hämeentie 57, 00014 University of Helsinki, Finland
J Vet Intern Med 19:822-7. 2005..The feces then became significantly firmer and remained so throughout a 3-month follow-up. We conclude that the combination of diet and tylosin was more effective than either agent alone in control of chronic diarrhea... - GABA(A) receptor subtypes as targets for neuropsychiatric drug developmentEsa R Korpi
Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, P O Box 63 Haartmaninkatu 8, FI 00014 University of Helsinki, Finland
Pharmacol Ther 109:12-32. 2006.... - Detection of human picornaviruses by multiplex reverse transcription-PCR and liquid hybridizationPia Jokela
Department of Virology, Haartman Institute, University of Helsinki, P O Box 21, FIN 00014 Helsinki, Finland
J Clin Microbiol 43:1239-45. 2005.... - Helicobacter pylori and specific immunoglobulin E antibodies to food allergens in childrenKaija Leena Kolho
Hospital for Children and Adolescents, University of Helsinki, Stenbackinkatu 11, FIN 00029 HUS
J Pediatr Gastroenterol Nutr 40:180-3. 2005..We assessed the presence of food-specific immunoglobulin (Ig)E antibodies in H. pylori positive children and controls... - Mannose-binding lectin variant associated with severe malaria in young African childrenVille Holmberg
Institute of Tropical Medicine and International Health, Charite University Medicine Berlin, Spandauer Damm 130, 14050 Berlin, Germany
Microbes Infect 10:342-8. 2008..falciparum infection and manifestation of severe malaria, particularly in young children in whom specific immune responses are weak or absent... - How to derive biological information from the value of the normalization constant in allometric equationsPekka Kaitaniemi
Hyytiälä Forestry Field Station, University of Helsinki, Korkeakoski, Finland
PLoS ONE 3:e1932. 2008..The results show how the value of b can be used as a source of valuable biological information if an appropriate regression model is selected... - Glycosaminoglycan-resistant and pH-sensitive lipid-coated DNA complexes produced by detergent removal methodJulia Lehtinen
Centre for Drug Research, University of Helsinki, P O Box 56, 00014 University of Helsinki, Finland
J Control Release 131:145-9. 2008..PEGylation of the coated complexes increased their cellular uptake but reduced the pH-sensitivity. Detergent removal was thus a superior method for the production of stable, but acid activatable, lipid-coated DNA complexes... - Seasonal fluctuations in leaf phenolic composition under UV manipulations reflect contrasting strategies of alder and birch treesTitta Kotilainen
Department of Biological and Environmental Sciences, P O Box 35, FIN 40014, University of Jyvaskyla, Jyvaskyla, Finland
Physiol Plant 140:297-309. 2010..Moreover, our results highlight differences in responses of the two tree species, which are taken to indicate differences in their ecological niche differentiation... - Lignin biosynthesis studies in plant tissue culturesAnna Kärkönen
Department of Applied Biology, University of Helsinki, Helsinki, Finland
J Integr Plant Biol 52:176-85. 2010..This review focuses on studies where the use of plant tissue cultures has been advantageous in structural and biosynthesis studies of lignin, and discusses the validity of tissue cultures as models for lignin biosynthesis... - Infant feeding and the risk of type 1 diabetesMikael Knip
Hospital for Children and Adolescents and Folkhälsan Research Center, University of Helsinki, Finland
Am J Clin Nutr 91:1506S-1513S. 2010..Additional work, which includes the application of modern approaches such as metabolomics and epigenomics, is needed to discern the contribution of dietary factors in infancy to the diabetic disease process... - Wide variety of bioserotypes of enteropathogenic Yersinia in tonsils of English pigs at slaughterPilar Ortiz Martínez
Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, P O Box 66, Fi 00014 Helsinki University, Finland
Int J Food Microbiol 139:64-9. 2010..The high prevalence of Y. enterocolitica bioserotypes 2/O:9 and 2/O:5 found in this study suggests that English pigs are an important reservoir of these bioserotypes whereas in other European countries bioserotype 4/O:3 predominates... - Metabolomics in angiotensin II-induced cardiac hypertrophyEero Mervaala
Institute of Biomedicine, University of Helsinki, Helsinki, Finland
Hypertension 55:508-15. 2010..The finding underscores the importance of Ang II in the regulation of mitochondrial biogenesis and cardiac metabolomics, even in healthy hearts... - Operative treatment of fractures in children is increasing. A population-based study from FinlandIlkka Helenius
Section of Pediatric Surgery, Turku Children s Hospital, Turku University Central Hospital, P O Box 499, FIN 20521, Turku, Finland
J Bone Joint Surg Am 91:2612-6. 2009..Our aim was to determine the incidence of in-hospital-treated fractures and of the surgical treatment of these fractures in children and adolescents... - Differences in the nemosis response of normal and cancer-associated fibroblasts from patients with oral squamous cell carcinomaKati Räsänen
Haartman Institute, University of Helsinki, Helsinki, Finland
PLoS ONE 4:e6879. 2009..Here we used paired normal skin fibroblasts and cancer-associated fibroblasts (CAF) and primary and recurrent oral squamous cell carcinoma (SCC) cells to study the nemosis response... - Population dynamics in a cyclic environment: consequences of cyclic food abundance on tawny owl reproduction and survivalPatrik Karell
Bird Ecology Unit, Department of Biological and Environmental Sciences, University of Helsinki, Finland
J Anim Ecol 78:1050-62. 2009.... - Nonmarital cohabitation among older Finnish men and women: socioeconomic characteristics and forms of union dissolutionHeta Moustgaard
Population Research Unit, Department of Sociology, University of Helsinki, PO Box 18, Helsinki FIN 00014, Finland
J Gerontol B Psychol Sci Soc Sci 64:507-16. 2009..Nonmarital cohabitation has increased substantially among older adults. Our objective was to enhance understanding of cohabitation by comparing elderly cohabiters with the married according to socioeconomic status and union dissolution... - Clustering of fibroblasts induces proinflammatory chemokine secretion promoting leukocyte migrationAnna Enzerink
Haartman Institute, University of Helsinki, P O Box 21, FIN 00014 Helsinki, Finland
Mol Immunol 46:1787-95. 2009.... - Postpartum oral health parameters in women with preterm birthAura Heimonen
Institute of Dentistry, University of Helsinki, and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland
Acta Odontol Scand 66:334-41. 2008.... - Body composition in psychotic disorders: a general population surveyS E Saarni
National Public Health Institute, Department for Mental Health and Alcohol Research, Mannerheimintie 166, 00300 Helsinki, Finland
Psychol Med 39:801-10. 2009..We examined the detailed body composition of people with different psychotic disorders in a large population-based sample... - Probe-based negative selection for underrepresented phylotypes in large environmental clone librariesJenni Hultman
Institute of Biotechnology, Viikinkaari 4, University of Helsinki, Finland
J Microbiol Methods 75:457-63. 2008..The method is especially suitable for samples with a few dominating sequence types... - Pearling barley and rye to produce phytosterol-rich fractionsAnna Maija Lampi
Department of Applied Chemistry and Microbiology, University of Helsinki, Finland
Lipids 39:783-7. 2004..Pearling fines of hulless barley and rye contained >2 mg/g phytosterol compounds, which makes them a good source of phytosterols and thus valuable raw materials for health-promoting foods... - Malignancy in pheochromocytomasKaisa Salmenkivi
Department of Pathology, Haartman Institute, University of Helsinki and HUCH Laboratory Diagnostics, Helsinki University Central Hospital, Helsinki, Finland
APMIS 112:551-9. 2004..In this overview of malignancy in pheochromocytomas, different steps of the tumorigenesis and several markers associated with them are discussed... - Cardiorespiratory responses to exercise in acute hypoxia, hyperoxia and normoxiaJ E Peltonen
Unit for Sports and Exercise Medicine, Institute of Clinical Medicine, University of Helsinski, Finland
Eur J Appl Physiol 85:82-8. 2001.... - Paenibacillus borealis sp. nov., a nitrogen-fixing species isolated from spruce forest humus in FinlandS Elo
Department of Biosciences, Viikki Biocenter, University of Helsinki, Finland
Int J Syst Evol Microbiol 51:535-45. 2001..Based on phylogenetic inference and phenotypic and chemotaxonomic characteristics, these isolates are proposed as a new species, Paenibacillus borealis sp. nov., the type strain of which is KK19T (= DSM 13188T = CCUG 43137T)... - Attempt to model laboratory-scale diffusion and retardation dataP Hölttä
Laboratory of Radiochemistry, Department of Chemistry, University of Helsinki, PO Box 55, Helsinki 00014 Finland
J Contam Hydrol 47:139-48. 2001..Kd values obtained from fracture column experiments were one order of magnitude lower than Kd values from batch experiments... - Fats, lipids and blood coagulationM Mutanen
Department of Applied Chemistry and Microbiology Nutrition, University of Helsinki, Helsinki, Finland
Curr Opin Lipidol 12:25-9. 2001.... - Changes in serum enterolactone, genistein, and daidzein in a dietary intervention study in FinlandK Stumpf
Folkhalsan Research Center, Institute of Preventive Medicine, Nutrition and Cancer, Department of Clinical Chemistry, University of Helsinki, Finland
Cancer Epidemiol Biomarkers Prev 9:1369-72. 2000..These major differences in serum enterolactone concentrations suggest that enterolactone may be used as a biomarker of a healthy diet containing plenty of vegetables, fruit, and berries... - Nitric oxide synthase immunoreactivity in the rat hippocampus after status epilepticus induced by perforant pathway stimulationA Lumme
Department of Anatomy, Institute of Biomedicine, P O Box 9, 00014 University of Helsinki, Helsinki, Finland
Brain Res 871:303-10. 2000..Our results suggest that status epilepticus provokes a de novo expression of nNOS protein, and the nNOS expressing neurons may be selectively resistant to epileptic brain injury... - Mismatch negativity (MMN): perspectives for applicationR Naatanen
Cognitive Brain Research Unit, P O Box 13 Meritullinkatu 1, 00014 University of Helsinki and the Academy of Finland, Helsinki, Finland
Int J Psychophysiol 37:3-10. 2000..The MMN can be measured in the absence of attention and without any task requirements, which makes it particularly suitable for testing different clinical populations and infants... - Noncholesterol sterols and cholesterol lowering by long-term simvastatin treatment in coronary patients: relation to basal serum cholestanolT A Miettinen
Department of Medicine, University of Helsinki, Helsinki, Finland
Arterioscler Thromb Vasc Biol 20:1340-6. 2000..Subjects with high cholesterol absorption and low synthesis may need a combination therapy to lower more effectively their serum cholesterol levels and prevent an increase in the levels of plant sterols... - Insertion of Alu element responsible for acute intermittent porphyriaS Mustajoki
Department of Medicine, Helsinki University Central Hospital, Finland
Hum Mutat 13:431-8. 1999..The mutated construct expressed no enzyme activity comparable to that of the wild-type PBGD; furthermore, no mutant protein could be detected by Western blot analysis... - Susceptibility of oral Candida species to calcium hydroxide in vitroT M Waltimo
Department of Cariology, Institute of Dentistry, University of Helsinki, Finland
Int Endod J 32:94-8. 1999..The susceptibility of common oral Candida species to saturated aqueous calcium hydroxide solution was studied... - The synchronization of electrodermal activity and heart rate and its relationship to energetic arousal: a time series approachJ Kettunen
Department of Psychology, University of Helsinki, Finland
Biol Psychol 48:209-25. 1998..It is suggested that within-subjects analysis of physiological time series data can further our understanding of the individual differences in ANS function and on the correlates of effector organ synchronization... - Leukocyte adhesion: CD11/CD18 integrins and intercellular adhesion moleculesC G Gahmberg
Department of Biosciences, University of Helsinki, Finland
Curr Opin Cell Biol 9:643-50. 1997..Furthermore, much progress has been made in the study of integrin activation and the role of leukocyte adhesion molecules in disease... - The musical brain: brain waves reveal the neurophysiological basis of musicality in human subjectsM Tervaniemi
Department of Psychology, University of Helsinki, Finland
Neurosci Lett 226:1-4. 1997.... - Working memory in spelling: evidence from backward typingE Service
University of Helsinki, Finland
Memory 9:395-421. 2001..For short words the task seems to rely on non-phonological modes of coding, whereas longer words appear to require the use of a phonological code, possibly for keeping track of progress through the word... - Pulmonary prostacyclin is associated with less severe respiratory distress in preterm infantsPatrik Lassus
Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland
Early Hum Dev 67:11-8. 2002..Aims: To examine in small preterm infants, the relationship between pulmonary PGI(2) and TxA(2) and respiratory distress during the early postnatal period... - Portfolios as a learning tool in obstetrics and gynaecology undergraduate trainingK Lonka
Development and Research Unit, Faculty of Medicine, University of Helsinki, Finland
Med Educ 35:1125-30. 2001..The main objective was to support the learning process of the students. We also wanted feedback information to enhance teaching... - Oral health, atherosclerosis, and cardiovascular diseaseJukka H Meurman
Institute of Dentistry, University of Helsinki, and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, PB 41, FIN 00014 Helsinki, Finland
Crit Rev Oral Biol Med 15:403-13. 2004..41 (CI 1.12-1.77) and 2.27 (CI 1.32-3.90), respectively. Overall, it appears that periodontal disease may indeed contribute to the pathogenesis of cardiovascular disease, although the statistical effect size is small... - [Genes behind humanity, rage, peace and the brain of apes]Hannu Sariola
, Biomedicum Helsinki, Helsingin yliopisto
Duodecim 120:1836-7. 2004 - Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactionsUlla Pirvola
Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
Dev Biol 273:350-60. 2004..Together, these data show that Fgf9 signaling is required for inner ear morphogenesis... - Microvascular loops and networks in uveal melanomaTero Kivela
Ocular Oncology Service and Ophthalmic Pathology Laboratory, Department of Ophthalmology, Helsinki University Central Hospital, Helsinki, Finland
Can J Ophthalmol 39:409-21. 2004.... - The effects of regional characteristics on alcohol-related mortality-a register-based multilevel analysis of 1.1 million menJenni Blomgren
Department of Sociology, University of Helsinki, Finland
Soc Sci Med 58:2523-35. 2004..Fuller understanding of the mechanisms underlying the effects of area measures of social structure and cohesion on risky alcohol consumption and alcohol-related mortality is needed... - Dehydration studies using a novel multichamber microscale fluid bed dryer with in-line near-infrared measurementEetu Räsänen
Pharmaceutical Technology Division, Department of Pharmacy, P O Box 56, FIN 00014 University of Helsinki, Finland
J Pharm Sci 92:2074-81. 2003..The presented setup is a material and cost-saving approach for studying the influence of different process parameters on dehydration behavior during pharmaceutical processing... - Do viruses form lineages across different domains of life?Dennis H Bamford
Department of Biosciences and Institute of Biotechnology, P O Box 56 Viikinkaari 5, 00014 University of Helsinki, Helsinki, Finland
Res Microbiol 154:231-6. 2003..This hypothesis has a few consequences. All viruses are old, maybe preceding cellular life, and virus origins are polyphyletic, as opposed to the idea of a monophyletic origin of cellular life... - Efficacy of intramammary treatment with procaine penicillin G vs. procaine penicillin G plus neomycin in bovine clinical mastitis caused by penicillin-susceptible, gram-positive bacteria--a double blind field studyS Taponen
Faculty of Veterinary Medicine, Department of Clinical Veterinary Sciences, University of Helsinki, Saarentaus, Finland
J Vet Pharmacol Ther 26:193-8. 2003.... - Phylogeny of bipolar Cladonia arbuscula and Cladonia mitis (Lecanorales, Euascomycetes)Leena Myllys
Department of Biology, University of Turku, Turku FIN 20014, Finland
Mol Phylogenet Evol 27:58-69. 2003.... - Context modulates processing of speech sounds in the right auditory cortex of human subjectsAnu Kujala
Cognitive Brain Research Unit, Department of Psychology, PO Box 13, University of Helsinki, FIN 00014, Helsinki, Finland
Neurosci Lett 331:91-4. 2002..This facilitation thus was insensitive to the phonetic and semantic features of the context but might nevertheless reflect the participation of the right hemisphere in speech perception... - Diabetes contributes to cholesterol metabolism regardless of obesityPiia P Simonen
Department of Medicine, Division of Internal Medicine, University of Helsinki, Finland
Diabetes Care 25:1511-5. 2002..To investigate cholesterol metabolism in obesity with and without diabetes... - No pain, no gain: clinical excellence and scientific rigour--lessons learned from IA morphineEija Kalso
Pain Clinic, Department of Anaesthesia and Intensive Care, Helsinki University Hospital, P O Box 340, Helsinki, FIN 00029 HUS, Finland
Pain 98:269-75. 2002..A minimum of 30% of the maximum possible pain intensity is needed for an analgesic effect to be detected in a study... - Those magnificent molecular machines: logistics in dsRNA virus transcriptionDennis H Bamford
Department of Biosciences and Institute of Biotechnology, PO Box 56 (Viikinkaari 5, FIN-00014 University of Helsinki, Finland
EMBO Rep 3:317-8. 2002 - mRNAS for one, two or three members of trk receptor family are expressed in single rat trigeminal ganglion neuronsM Moshnyakov
Program of Molecular Neurobiology, University of Helsinki, Finland
Brain Res Mol Brain Res 43:141-8. 1996..There were also neurons containing neither trk receptors nor p75. We provide here first direct evidence that single sensory neurons can simultaneously express three or even four neurotrophin receptors...
Research Grants
- PREDISPOSING/MODIFYING GENES IN HEREDITARY COLON CANCERPaivi Peltomaki; Fiscal Year: 2001..The aim is to identify genes that might modify the clinical phenotype of HNPCC, taking advantage of association and linkage-based approaches in these genetically homogeneous subsets of HNPCC patients. ..
- Control of lymphatic endothelial differentiation programKari Alitalo; Fiscal Year: 2006..They should also identify molecular markers distinguishing superficial and visceral lymphatic vessels, which could then be used to develop targeted drug delivery to these vessels. ..
- Trial to Reduce IDDM in the Genetically at Risk- studyHANS AKERBLOM; Fiscal Year: 2007..If our intervention is effective in delaying autoimmunity or its progression to diabetes, this first ever primary prevention study of T1D, will have far-reaching impact for individuals and the global society. ..
- Identification of Biomarkers of Autoimmunity in T1D by Novel ToolsMikael Knip; Fiscal Year: 2007....