Shannon Healy

Summary

Affiliation: Tampere University of Technology
Country: Finland

Publications

  1. doi Biotin is not a natural histone modification
    Shannon Healy
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Biochim Biophys Acta 1789:719-33. 2009
  2. ncbi Structural impact of human and Escherichia coli biotin carboxyl carrier proteins on biotin attachment
    Shannon Healy
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Biochemistry 49:4687-94. 2010
  3. pmc Nonenzymatic biotinylation of histone H2A
    Shannon Healy
    Department of Biochemistry and Molecular Biology, University of Calgary, Alberta, Canada
    Protein Sci 18:314-28. 2009
  4. doi Dynamical effects of transcriptional pause-prone sites
    Andre S Ribeiro
    Computational Systems Biology Research Group, Dept of Signal Processing, Tampere University of Technology, Finland
    Comput Biol Chem 34:143-8. 2010
  5. doi Genome wide study of NF-Y type CCAAT boxes in unidirectional and bidirectional promoters in human and mouse
    Antti Häkkinen
    Laboratory of Biosystem Dynamics, Department of Signal Processing, Tampere University of Technology, Finland
    J Theor Biol 281:74-83. 2011
  6. pmc Cell-to-cell diversity in protein levels of a gene driven by a tetracycline inducible promoter
    Olli Pekka Smolander
    Department of Signal Processing, Tampere University of Technology, Finland
    BMC Mol Biol 12:21. 2011

Collaborators

Detail Information

Publications6

  1. doi Biotin is not a natural histone modification
    Shannon Healy
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Biochim Biophys Acta 1789:719-33. 2009
    ..We conclude that biotin is absent in native histones to a sensitivity of at least one part per 100,000, suggesting that the regulatory impact of biotin on gene expression must be through alternate mechanisms...
  2. ncbi Structural impact of human and Escherichia coli biotin carboxyl carrier proteins on biotin attachment
    Shannon Healy
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Biochemistry 49:4687-94. 2010
    ..While the function of the thumb loop remains unknown, these results indicate a constraint on specificity of the bacterial substrate for biotin attachment that is not itself a feature of BirA...
  3. pmc Nonenzymatic biotinylation of histone H2A
    Shannon Healy
    Department of Biochemistry and Molecular Biology, University of Calgary, Alberta, Canada
    Protein Sci 18:314-28. 2009
    ..None of the lysine sites within H2A resembles the biotin attachment consensus sequence seen in carboxylases, suggesting a novel mechanism for histone biotinylation...
  4. doi Dynamical effects of transcriptional pause-prone sites
    Andre S Ribeiro
    Computational Systems Biology Research Group, Dept of Signal Processing, Tampere University of Technology, Finland
    Comput Biol Chem 34:143-8. 2010
    ..This regulatory mechanism of noise and bursting, being evolvable, may partially explain how different genes exhibit a wide spectrum of different behaviors. The results might assist the engineering of genes with a desired degree of noise...
  5. doi Genome wide study of NF-Y type CCAAT boxes in unidirectional and bidirectional promoters in human and mouse
    Antti Häkkinen
    Laboratory of Biosystem Dynamics, Department of Signal Processing, Tampere University of Technology, Finland
    J Theor Biol 281:74-83. 2011
    ..We conclude that bidirectional and unidirectional promoters, while sharing some similarities, appear to possess distinct regulatory mechanisms at the sequence level...
  6. pmc Cell-to-cell diversity in protein levels of a gene driven by a tetracycline inducible promoter
    Olli Pekka Smolander
    Department of Signal Processing, Tampere University of Technology, Finland
    BMC Mol Biol 12:21. 2011
    ..Also, we measured the transcriptional activity of a tetracycline inducible promoter controlling the transcription of a RNA with 96 binding sites for MS2-GFP...