Markku Seppala

Summary

Country: Finland

Publications

  1. ncbi Glycodelin: a major lipocalin protein of the reproductive axis with diverse actions in cell recognition and differentiation
    Markku Seppala
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Haartmaninkatu 2, 00029 HUS, Helsinki, Finland
    Endocr Rev 23:401-30. 2002
  2. ncbi The role of glycodelin in cell differentiation and tumor growth
    Hannu Koistinen
    Department of Clinical Chemistry, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
    Scand J Clin Lab Invest 69:452-9. 2009
  3. ncbi Glycodelin reduces breast cancer xenograft growth in vivo
    Laura C Hautala
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Int J Cancer 123:2279-84. 2008
  4. ncbi Extracellular matrix-induced changes in expression of cell cycle-related proteins and proteasome components in endometrial adenocarcinoma cells
    Hannu Koistinen
    Department of Clinical Chemistry, Helsinki University Central Hospital, Biomedicum Helsinki, PO Box 700, 00029 HUS, Finland
    Gynecol Oncol 102:546-51. 2006
  5. ncbi Maternal serum glycodelin in premature rupture of membranes
    Mikko Loukovaara
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    J Perinat Med 30:480-2. 2002
  6. ncbi Glycodelin reduces carcinoma-associated gene expression in endometrial adenocarcinoma cells
    Hannu Koistinen
    Department of Clinical Chemistry, Helsinki University Central Hospital, Biomedicum, Helsinki, Finland
    Am J Obstet Gynecol 193:1955-60. 2005
  7. ncbi Differences in glycosylation and sperm-egg binding inhibition of pregnancy-related glycodelin
    Hannu Koistinen
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, 00029 HUS, Finland
    Biol Reprod 69:1545-51. 2003
  8. ncbi Serum insulin-like growth factor (IGF)-I and IGF-binding protein-1 in elderly people: relationships with cardiovascular risk factors, body composition, size at birth, and childhood growth
    Eero Kajantie
    Hospital for Children and Adolescents, Helsinki University Central Hospital, 00029 HUS, Helsinki, Finland
    J Clin Endocrinol Metab 88:1059-65. 2003
  9. ncbi Serum insulin-like growth factor-I and insulin-like growth factor binding protein-3 in premature rupture of membranes
    Mikko Loukovaara
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
    Acta Obstet Gynecol Scand 81:905-8. 2002
  10. ncbi IGF-I, IGF binding protein (IGFBP)-3, phosphoisoforms of IGFBP-1, and postnatal growth in very low birth weight infants
    Eero Kajantie
    Hospital for Children and Adolescents, Helsinki University Central Hospital, 00029 HUS, Helsinki, Finland
    J Clin Endocrinol Metab 87:2171-9. 2002

Detail Information

Publications11

  1. ncbi Glycodelin: a major lipocalin protein of the reproductive axis with diverse actions in cell recognition and differentiation
    Markku Seppala
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Haartmaninkatu 2, 00029 HUS, Helsinki, Finland
    Endocr Rev 23:401-30. 2002
    ..These various properties, as well as the chemistry, biology, and clinical aspects of glycodelin, continue to be areas of active investigation reviewed in this communication...
  2. ncbi The role of glycodelin in cell differentiation and tumor growth
    Hannu Koistinen
    Department of Clinical Chemistry, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
    Scand J Clin Lab Invest 69:452-9. 2009
    ..This research has therefore introduced a novel mechanism to control cancer cell growth. In this communication we review the differentiation-related effects of glycodelin...
  3. ncbi Glycodelin reduces breast cancer xenograft growth in vivo
    Laura C Hautala
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Int J Cancer 123:2279-84. 2008
    ..Our results suggest that glycodelin acts as a tumor suppressor in breast cancer. This may explain its reported association with a more favorable prognosis in some cancers...
  4. ncbi Extracellular matrix-induced changes in expression of cell cycle-related proteins and proteasome components in endometrial adenocarcinoma cells
    Hannu Koistinen
    Department of Clinical Chemistry, Helsinki University Central Hospital, Biomedicum Helsinki, PO Box 700, 00029 HUS, Finland
    Gynecol Oncol 102:546-51. 2006
    ..The purpose of this study was to investigate these changes...
  5. ncbi Maternal serum glycodelin in premature rupture of membranes
    Mikko Loukovaara
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    J Perinat Med 30:480-2. 2002
    ..Glycodelin is produced by epithelial cells of pregnancy decidua. We investigated whether serum glycodelin concentrations are altered in premature rupture of membranes (PROM)...
  6. ncbi Glycodelin reduces carcinoma-associated gene expression in endometrial adenocarcinoma cells
    Hannu Koistinen
    Department of Clinical Chemistry, Helsinki University Central Hospital, Biomedicum, Helsinki, Finland
    Am J Obstet Gynecol 193:1955-60. 2005
    ..We aimed to elucidate its role in growth and gene expression of endometrial adenocarcinoma cells, and hypothesized that glycodelin affects cell growth and tumor-associated gene expression...
  7. ncbi Differences in glycosylation and sperm-egg binding inhibition of pregnancy-related glycodelin
    Hannu Koistinen
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, 00029 HUS, Finland
    Biol Reprod 69:1545-51. 2003
    ..However, these glycodelins exhibit quantitative physicochemical and functional differences between different sources and individuals...
  8. ncbi Serum insulin-like growth factor (IGF)-I and IGF-binding protein-1 in elderly people: relationships with cardiovascular risk factors, body composition, size at birth, and childhood growth
    Eero Kajantie
    Hospital for Children and Adolescents, Helsinki University Central Hospital, 00029 HUS, Helsinki, Finland
    J Clin Endocrinol Metab 88:1059-65. 2003
    ..Prospective studies should address whether this group is susceptible to type 2 diabetes, coronary heart disease, and osteoporosis...
  9. ncbi Serum insulin-like growth factor-I and insulin-like growth factor binding protein-3 in premature rupture of membranes
    Mikko Loukovaara
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
    Acta Obstet Gynecol Scand 81:905-8. 2002
    ..The aim of the study was to evaluate whether the circulating levels of insulin-like growth factor-I (IGF-I) and its major circulating binding protein, IGFBP-3, are affected in premature rupture of membranes (PROM) and preterm delivery...
  10. ncbi IGF-I, IGF binding protein (IGFBP)-3, phosphoisoforms of IGFBP-1, and postnatal growth in very low birth weight infants
    Eero Kajantie
    Hospital for Children and Adolescents, Helsinki University Central Hospital, 00029 HUS, Helsinki, Finland
    J Clin Endocrinol Metab 87:2171-9. 2002
    ..Finally, the regulation of IGFBP-1 by glucocorticoids may be divergent in situations with a high or low insulin concentration...
  11. ncbi Monoclonal antibodies, immunofluorometric assay, and detection of human semenogelin in male reproductive tract: no association with in vitro fertilizing capacity of sperm
    Hannu Koistinen
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, 00290 Helsinki, Finland
    Biol Reprod 66:624-8. 2002
    ..The levels of semenogelin appear to bear no relationship to the in vitro fertilization capacity of the spermatozoa...