O Niemela

Summary

Country: Finland

Publications

  1. pmc Individual and Joint Impacts of Ethanol Use, BMI, Age and Gender on Serum Gamma-Glutamyltransferase Levels in Healthy Volunteers
    Joanna Danielsson
    Department of Laboratory Medicine and Medical Research Unit, Seinajoki Central Hospital, and University of Tampere, Seinajoki 60220, Finland
    Int J Mol Sci 14:11929-41. 2013
  2. doi request reprint Dose- and gender-dependent interactions between coffee consumption and serum GGT activity in alcohol consumers
    Joanna Danielsson
    Department of Laboratory Medicine and Medical Research Unit, Seinäjoki Central Hospital and University of Tampere, Hanneksenrinne 7, 60220 Seinajoki, Finland
    Alcohol Alcohol 48:303-7. 2013
  3. doi request reprint Effect of age and gender on the relationship between alcohol consumption and serum GGT: time to recalibrate goals for normal ranges
    Joanna Tynjälä
    Department of Laboratory Medicine and Medical Research Unit, Seinajoki Central Hospital, University of Tampere, Seinäjoki FIN 60220, Finland
    Alcohol Alcohol 47:558-62. 2012
  4. pmc Modification of carbonic anhydrase II with acetaldehyde, the first metabolite of ethanol, leads to decreased enzyme activity
    Fatemeh Bootorabi
    Institute of Medical Technology, Tampere University Hospital, 33520 Tampere, Finland
    BMC Biochem 9:32. 2008
  5. doi request reprint Biomarkers of alcohol consumption and related liver disease
    Onni Niemela
    Department of Laboratory Medicine and Medical Research Unit, Seinäjoki Central Hospital and University of Tampere, Seinajoki, Finland
    Scand J Clin Lab Invest 70:305-12. 2010
  6. ncbi request reprint Biomarkers in alcoholism
    Onni Niemela
    Department of Laboratory Medicine and Medical Research Unit, Seinäjoki Central Hospital and University of Tampere, FIN 60220 Seinäjoki, Finland
    Clin Chim Acta 377:39-49. 2007
  7. ncbi request reprint Serum gamma-glutamyl transferase in alcoholics, moderate drinkers and abstainers: effect on gt reference intervals at population level
    Johanna Hietala
    Department of Laboratory Medicine and Medical Research Unit, Seinajoki Central Hospital, and University of Tampere, FIN 60220 Seinäjoki, Finland
    Alcohol Alcohol 40:511-4. 2005
  8. ncbi request reprint Alcoholic macrocytosis--is there a role for acetaldehyde and adducts?
    Onni Niemela
    EP Central Hospital, Laboratory and the Department of Clinical Chemistry, and Institute of Medical Technology, University of Tampere, Finland
    Addict Biol 9:3-10. 2004
  9. ncbi request reprint Generation of aldehyde-derived protein modifications in ethanol-exposed heart
    Onni Niemela
    Etela Pohjanmaa Central Hospital Laboratory, Department of Clinical Chemistry and Institute of Medical Technology, University of Tampere, Finland
    Alcohol Clin Exp Res 27:1987-92. 2003
  10. ncbi request reprint Effect of Kupffer cell inactivation on ethanol-induced protein adducts in the liver
    Onni Niemela
    Laboratory Medicine, EP Central Hospital, Seinajoki, Finland
    Free Radic Biol Med 33:350-5. 2002

Collaborators

  • Seppo Parkkila
  • Mauri Aalto
  • Yuji Iimuro
  • Päivikki Alatalo
  • Joanna Danielsson
  • Tiina Laatikainen
  • Päivikki Kangastupa
  • Joanna Tynjälä
  • Fatemeh Bootorabi
  • K Puukka
  • Johanna Hietala
  • Janne Jänis
  • Abdul Waheed
  • Sari Isoniemi
  • Jarkko Valjakka
  • Daniela Vullo
  • Claudiu T Supuran
  • Pirjo Vainiotalo
  • William S Sly
  • P Anttila
  • R Bloigu
  • H Koivisto
  • J Hietala
  • Katri Puukka
  • Petra Anttila
  • Heidi Koivisto

Detail Information

Publications15

  1. pmc Individual and Joint Impacts of Ethanol Use, BMI, Age and Gender on Serum Gamma-Glutamyltransferase Levels in Healthy Volunteers
    Joanna Danielsson
    Department of Laboratory Medicine and Medical Research Unit, Seinajoki Central Hospital, and University of Tampere, Seinajoki 60220, Finland
    Int J Mol Sci 14:11929-41. 2013
    ..In light of the ability of GGT enzyme to modulate crucial redox-sensitive functions, the present findings also support the use of GGT as a biomarker of oxidative stress...
  2. doi request reprint Dose- and gender-dependent interactions between coffee consumption and serum GGT activity in alcohol consumers
    Joanna Danielsson
    Department of Laboratory Medicine and Medical Research Unit, Seinäjoki Central Hospital and University of Tampere, Hanneksenrinne 7, 60220 Seinajoki, Finland
    Alcohol Alcohol 48:303-7. 2013
    ..To explore the relationship and dose response, we assessed the impacts of coffee and alcohol intake on serum GGT activity in apparently healthy men and women with varying levels of coffee and alcohol consumption...
  3. doi request reprint Effect of age and gender on the relationship between alcohol consumption and serum GGT: time to recalibrate goals for normal ranges
    Joanna Tynjälä
    Department of Laboratory Medicine and Medical Research Unit, Seinajoki Central Hospital, University of Tampere, Seinäjoki FIN 60220, Finland
    Alcohol Alcohol 47:558-62. 2012
    ..Therefore, further information on the associations between ethanol intake and GGT activities in apparently healthy individuals appears warranted...
  4. pmc Modification of carbonic anhydrase II with acetaldehyde, the first metabolite of ethanol, leads to decreased enzyme activity
    Fatemeh Bootorabi
    Institute of Medical Technology, Tampere University Hospital, 33520 Tampere, Finland
    BMC Biochem 9:32. 2008
    ....
  5. doi request reprint Biomarkers of alcohol consumption and related liver disease
    Onni Niemela
    Department of Laboratory Medicine and Medical Research Unit, Seinäjoki Central Hospital and University of Tampere, Seinajoki, Finland
    Scand J Clin Lab Invest 70:305-12. 2010
    ....
  6. ncbi request reprint Biomarkers in alcoholism
    Onni Niemela
    Department of Laboratory Medicine and Medical Research Unit, Seinäjoki Central Hospital and University of Tampere, FIN 60220 Seinäjoki, Finland
    Clin Chim Acta 377:39-49. 2007
    ....
  7. ncbi request reprint Serum gamma-glutamyl transferase in alcoholics, moderate drinkers and abstainers: effect on gt reference intervals at population level
    Johanna Hietala
    Department of Laboratory Medicine and Medical Research Unit, Seinajoki Central Hospital, and University of Tampere, FIN 60220 Seinäjoki, Finland
    Alcohol Alcohol 40:511-4. 2005
    ..To clarify in the association between amount of ethanol consumption and serum gamma-glutamyl transferase (GT) levels...
  8. ncbi request reprint Alcoholic macrocytosis--is there a role for acetaldehyde and adducts?
    Onni Niemela
    EP Central Hospital, Laboratory and the Department of Clinical Chemistry, and Institute of Medical Technology, University of Tampere, Finland
    Addict Biol 9:3-10. 2004
    ..Elevated adduct levels have been found from the erythrocytes of alcohol abusers, which may also be associated with ethanol-induced effects in haematopoiesis and adverse consequences in cellular functions...
  9. ncbi request reprint Generation of aldehyde-derived protein modifications in ethanol-exposed heart
    Onni Niemela
    Etela Pohjanmaa Central Hospital Laboratory, Department of Clinical Chemistry and Institute of Medical Technology, University of Tampere, Finland
    Alcohol Clin Exp Res 27:1987-92. 2003
    ..We hypothesized that posttranslational covalent binding of reactive molecular species to proteins occurs in the heart in response to acute ethanol exposure...
  10. ncbi request reprint Effect of Kupffer cell inactivation on ethanol-induced protein adducts in the liver
    Onni Niemela
    Laboratory Medicine, EP Central Hospital, Seinajoki, Finland
    Free Radic Biol Med 33:350-5. 2002
    ..The data indicates that Kupffer cells are involved in the generation of protein adducts with both acetaldehyde and ethanol-induced lipid peroxidation products in alcoholic liver disease...
  11. ncbi request reprint Distribution of ethanol-induced protein adducts in vivo: relationship to tissue injury
    O Niemela
    EP Central Hospital Laboratory, Seinajoki, Finland
    Free Radic Biol Med 31:1533-8. 2001
    ..Elevated adduct levels also occur in erythrocytes of alcoholics, which may be related to ethanol-induced morphological aberrations in hematopoiesis...
  12. ncbi request reprint Induction of cytochrome P450 enzymes and generation of protein-aldehyde adducts are associated with sex-dependent sensitivity to alcohol-induced liver disease in micropigs
    O Niemela
    Department of Clinical Chemistry, University of Oulu, Helsinki, Finland
    Hepatology 30:1011-7. 1999
    ..It appears that the premature, juvenile, metabolic phenotype, as induced by castration, favors liver damage. The present findings should be implicated in studies on the gender differences on the adverse effects of ethanol in the liver...
  13. ncbi request reprint Aldehyde-protein adducts in the liver as a result of ethanol-induced oxidative stress
    O Niemela
    Department of Clinical Chemistry, University of Oulu, FIN 90220 Oulu, and EP Central Hospital Laboratory, Seinajoki, Finland
    Front Biosci 4:D506-13. 1999
    ..Dietary supplementation with fat and/or iron strikingly increases the amount of aldehyde-derived epitopes in the liver together with promotion of fibrogenesis...
  14. ncbi request reprint Obesity and the clinical use of serum GGT activity as a marker of heavy drinking
    K Puukka
    Department of Laboratory Medicine and Medical Research Unit, Seinajoki Central Hospital, Seinajoki, Finland
    Scand J Clin Lab Invest 67:480-8. 2007
    ..However, although obesity may also elevate serum GGT activities, the effects of overweight on the interpretation of GGT testing have remained poorly defined...
  15. ncbi request reprint HFE mutations do not account for transfusional iron overload in patients with acute myeloid leukemia
    S Parkkila
    Department of Anatomy, University of Oulu, Oulu, Finland
    Transfusion 41:828-31. 2001
    ..This would identify C282Y homozygotes, who have a high risk of developing severe iron overload...