M Viluksela

Summary

Affiliation: National Public Health Institute
Country: Finland

Publications

  1. ncbi request reprint Cytotoxicity of macrolide antibiotics in a cultured human liver cell line
    M Viluksela
    Department of Pharmacology and Toxicology, University of Helsinki, Finland
    J Antimicrob Chemother 38:465-73. 1996
  2. ncbi request reprint Tissue-specific effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the activity of 5'-deiodinases I and II in rats
    Matti Viluksela
    Laboratory of Toxicology, National Public Health Institute, FIN 70701 Kuopio, Finland
    Toxicol Lett 147:133-42. 2004
  3. ncbi request reprint Liver tumor-promoting activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in TCDD-sensitive and TCDD-resistant rat strains
    M Viluksela
    Laboratory of Toxicology, National Public Health Institute, Kuopio, Finland
    Cancer Res 60:6911-20. 2000
  4. ncbi request reprint Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on liver phosphoenolpyruvate carboxykinase (PEPCK) activity, glucose homeostasis and plasma amino acid concentrations in the most TCDD-susceptible and the most TCDD-resistant rat strains
    M Viluksela
    National Public Health Institute, Laboratory of Toxicology, P O Box 95, FIN 70701 Kuopio, Finland
    Arch Toxicol 73:323-36. 1999
  5. ncbi request reprint Structure-activity relationships and dose responses of polychlorinated dibenzo-p-dioxins for short-term effects in 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant and -sensitive rat strains
    Ulla Simanainen
    Department of Environmental Health, National Public Health Institute, Kuopio, Finland
    Toxicol Appl Pharmacol 181:38-47. 2002
  6. ncbi request reprint Comparison of acute toxicities of indolo[3,2-b]carbazole (ICZ) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in TCDD-sensitive rats
    R Pohjanvirta
    National Public Health Institute, Laboratory of Toxicology, PO Box 95, FIN 70701 Kuopio, Finland
    Food Chem Toxicol 40:1023-32. 2002
  7. ncbi request reprint Effect of in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on rat molar development: the role of exposure time
    Hanna M Miettinen
    National Public Health Institute, Department of Environmental Health, P O Box 95, FIN 70701 Kuopio, Finland
    Toxicol Appl Pharmacol 184:57-66. 2002
  8. ncbi request reprint In utero/lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure impairs molar tooth development in rats
    H Kattainen
    Department of Environmental Health, National Public Health Institute, Kuopio, FIN-70701, Finland
    Toxicol Appl Pharmacol 174:216-24. 2001
  9. ncbi request reprint Adult 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure and effects on male reproductive organs in three differentially TCDD-susceptible rat lines
    Ulla Simanainen
    National Public Health Institute, Department of Environmental Health, P O Box 95, FIN 70701 Kuopio, Finland
    Toxicol Sci 81:401-7. 2004
  10. ncbi request reprint The effect of perinatal TCDD exposure on caries susceptibility in rats
    Hanna M Miettinen
    Laboratory of Toxicology, Department of Environmental Health, National Public Health Institute, Kuopio, Finland
    Toxicol Sci 91:568-75. 2006

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Cytotoxicity of macrolide antibiotics in a cultured human liver cell line
    M Viluksela
    Department of Pharmacology and Toxicology, University of Helsinki, Finland
    J Antimicrob Chemother 38:465-73. 1996
    ..In view of the low level of hepatotoxicity of macrolides hitherto reported in humans, the results do not suggest any substantial risk for hepatic disorders related to the use of azithromycin, clarithromycin and roxithromycin...
  2. ncbi request reprint Tissue-specific effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the activity of 5'-deiodinases I and II in rats
    Matti Viluksela
    Laboratory of Toxicology, National Public Health Institute, FIN 70701 Kuopio, Finland
    Toxicol Lett 147:133-42. 2004
    ..Thyroid and kidney 5'-DI activities as well as circulating T3 levels were not affected. The results suggest that altered 5'-DI or 5'-DII activities do not significantly influence the circulating levels of T4 or T3 in TCDD-treated rats...
  3. ncbi request reprint Liver tumor-promoting activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in TCDD-sensitive and TCDD-resistant rat strains
    M Viluksela
    Laboratory of Toxicology, National Public Health Institute, Kuopio, Finland
    Cancer Res 60:6911-20. 2000
    ..Understanding the role of transactivation domain of the aryl hydrocarbon receptor in carcinogenesis is therefore likely to improve dioxin risk assessment...
  4. ncbi request reprint Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on liver phosphoenolpyruvate carboxykinase (PEPCK) activity, glucose homeostasis and plasma amino acid concentrations in the most TCDD-susceptible and the most TCDD-resistant rat strains
    M Viluksela
    National Public Health Institute, Laboratory of Toxicology, P O Box 95, FIN 70701 Kuopio, Finland
    Arch Toxicol 73:323-36. 1999
    ....
  5. ncbi request reprint Structure-activity relationships and dose responses of polychlorinated dibenzo-p-dioxins for short-term effects in 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant and -sensitive rat strains
    Ulla Simanainen
    Department of Environmental Health, National Public Health Institute, Kuopio, Finland
    Toxicol Appl Pharmacol 181:38-47. 2002
    ..Type I effects are similar in both strains, and type II effects show decreased efficacy of toxic response in relation with the altered H/W-type AHR...
  6. ncbi request reprint Comparison of acute toxicities of indolo[3,2-b]carbazole (ICZ) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in TCDD-sensitive rats
    R Pohjanvirta
    National Public Health Institute, Laboratory of Toxicology, PO Box 95, FIN 70701 Kuopio, Finland
    Food Chem Toxicol 40:1023-32. 2002
    ..Thus, the present study does not support the view that dietary exposure to ICZ would present a hazard of AHR-mediated adverse health effects to humans...
  7. ncbi request reprint Effect of in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on rat molar development: the role of exposure time
    Hanna M Miettinen
    National Public Health Institute, Department of Environmental Health, P O Box 95, FIN 70701 Kuopio, Finland
    Toxicol Appl Pharmacol 184:57-66. 2002
    ..Response to TCDD was increased if the exposure was started several days before this critical window of sensitivity or if it was continued thereafter. Dental epithelium is the likely target of TCDD...
  8. ncbi request reprint In utero/lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure impairs molar tooth development in rats
    H Kattainen
    Department of Environmental Health, National Public Health Institute, Kuopio, FIN-70701, Finland
    Toxicol Appl Pharmacol 174:216-24. 2001
    ..03 microg/kg in line A and at 0.1 microg/kg in lines B and C. The results indicate that impaired tooth development is one of the most sensitive endpoints of TCDD-induced toxicity...
  9. ncbi request reprint Adult 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure and effects on male reproductive organs in three differentially TCDD-susceptible rat lines
    Ulla Simanainen
    National Public Health Institute, Department of Environmental Health, P O Box 95, FIN 70701 Kuopio, Finland
    Toxicol Sci 81:401-7. 2004
    ..The fact that the influence of resistance alleles on spermatogenesis is different from that on androgenic status indicates that the effect of TCDD on sperm numbers is not fully related to decreased serum testosterone...
  10. ncbi request reprint The effect of perinatal TCDD exposure on caries susceptibility in rats
    Hanna M Miettinen
    Laboratory of Toxicology, Department of Environmental Health, National Public Health Institute, Kuopio, Finland
    Toxicol Sci 91:568-75. 2006
    ..In conclusion, perinatal TCDD exposure can render rat molars more susceptible to caries...
  11. ncbi request reprint Pattern of male reproductive system effects after in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure in three differentially TCDD-sensitive rat lines
    Ulla Simanainen
    National Public Health Institute, Department of Environmental Health, Kuopio, Finland
    Toxicol Sci 80:101-8. 2004
    ..Thus, the intraspecies genetic differences in C-terminal transactivation domain of AHR appear to modify the sensitivity to only certain dioxin-induced male reproductive effects...
  12. ncbi request reprint Postnatal development of resistance to short-term high-dose toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in TCDD-resistant and -semiresistant rats
    Ulla Simanainen
    Laboratory of Toxicology, Department of Environmental Health, National Public Health Institute, FIN 70701 Kuopio, Finland
    Toxicol Appl Pharmacol 196:11-9. 2004
    ..This difference in the time course of resistance development suggests that there are basic differences in pathways mediating resistance in lines A and B rats...
  13. ncbi request reprint Dose-response analysis of short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in three differentially susceptible rat lines
    Ulla Simanainen
    National Public Health Institute, Department of Environmental Health, P O Box 95, FIN 70701 Kuopio, Finland
    Toxicol Appl Pharmacol 187:128-36. 2003
    ..Both H/W-type resistance alleles also decreased the potency of TCDD. However, the potency differences in short-term toxicity seem not to explain, at least alone, the differences seen in acute lethality among the rat lines...
  14. ncbi request reprint 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced accumulation of biliverdin and hepatic peliosis in rats
    Marjo Niittynen
    Department of Environmental Health, Laboratory of Toxicology, National Public Health Institute, Box 95, FIN 70701 Kuopio, Finland
    Toxicol Sci 71:112-23. 2003
    ....
  15. ncbi request reprint Differences in acute toxicity syndromes of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 1,2,3,4,7,8-hexachlorodibenzo-p-dioxin in rats
    Marjo Niittynen
    Department of Environmental Health, National Public Health Institute, PO Box 95, FI 70701 Kuopio, Finland
    Toxicology 235:39-51. 2007
    ....
  16. ncbi request reprint Effects of in utero and lactational TCDD exposure on bone development in differentially sensitive rat lines
    Hanna M Miettinen
    National Public Health Institute, Department of Environmental Health, FIN 70701 Kuopio, Finland
    Toxicol Sci 85:1003-12. 2005
    ..The dioxin-resistance alleles, Ahr(hw) and B(hw) increase the resistance to these defects...
  17. pmc Associations between congenital cryptorchidism in newborn boys and levels of dioxins and PCBs in placenta
    H E Virtanen
    Departments of Physiology and Paediatrics, University of Turku, Turku, Finland
    Int J Androl 35:283-93. 2012
    ..In conclusion, no association between placenta levels of dioxins or PCBs and congenital cryptorchidism was found. Significant country differences in chemical levels were observed...
  18. ncbi request reprint Dioxin exposure in contaminated sawmill area: the use of molar teeth and bone of bank vole (Clethrionomys glareolus) and field vole (Microtus agrestis) as biomarkers
    Mari Murtomaa
    National Public Health Institute, Department of Environmental Health, Kuopio, Finland
    Chemosphere 68:951-7. 2007
    ..In conclusion, the size of molar teeth seems to be a sensitive and robust biomarker for PCDD/F exposure in wild bank vole populations and thus worth of further studies...
  19. doi request reprint Dioxins interfere with differentiation of osteoblasts and osteoclasts
    Merja Korkalainen
    National Institute for Health and Welfare, Department of Environmental Health, P O Box 95, FI 70701 Kuopio, Finland
    Bone 44:1134-42. 2009
    ..Disrupting effects in osteoblastic cells, in addition to disturbed osteoclastogenesis, may thus play a role in adverse effects on bone quality in TCDD exposed animals...
  20. ncbi request reprint TCDD activates Mdm2 and attenuates the p53 response to DNA damaging agents
    Gerd Pääjärvi
    Institute of Environmental Medicine, Karolinska Institutet, Box 210, 17177 Stockholm, Sweden
    Carcinogenesis 26:201-8. 2005
    ..In summary, TCDD is a potent inhibitor of p53 that may influence the liver's ability to handle genotoxic agents in a safe way, and may play a role in TCDD-induced carcinogenesis...
  21. ncbi request reprint Response of the incisor tooth to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a dioxin-resistant and a dioxin-sensitive rat strain
    Anu Kiukkonen
    Department of Pedodontics and Orthodontics, Institute of Dentistry, Mannerheimintie 172, FIN 00014 University of Helsinki, Finland
    Toxicol Sci 69:482-9. 2002
    ..Similar responses in both strains implied that the impaired formation of the incisor tooth, at least of its mesenchymal elements, is not associated with the differential resistance of H/W and L-E rats to TCDD acute lethality...
  22. ncbi request reprint Effects of in utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on rat follicular steroidogenesis
    Sari A Pesonen
    Department of Biology, Laboratory of Animal Physiology, University of Turku, 20014 Turku, Finland
    Reprod Toxicol 22:521-8. 2006
    ..Furthermore, TCDD had no direct effect on immature rat ovarian steroidogenesis in vitro suggesting that the follicle culture method is not a sensitive method to study the mechanisms of TCDD action...
  23. ncbi request reprint Differential expression profiling of the hepatic proteome in a rat model of dioxin resistance: correlation with genomic and transcriptomic analyses
    Roberta Pastorelli
    Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    Mol Cell Proteomics 5:882-94. 2006
    ..As such, our work is expected to lead to new insights into the mechanism of TCDD toxicity and resistance...
  24. ncbi request reprint Bone resorption by aryl hydrocarbon receptor-expressing osteoclasts is not disturbed by TCDD in short-term cultures
    Joanna Ilvesaro
    Department of Anatomy and Cell Biology, FIN 90014 University of Oulu, Finland
    Life Sci 77:1351-66. 2005
    ..These data indicate that even though TCDD-treated bones show decreased mechanical strength and size, this is not a direct result from increased osteoclastic bone resorption...
  25. ncbi request reprint Altered retinoid metabolism in female Long-Evans and Han/Wistar rats following long-term 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treatment
    Nick Fletcher
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Toxicol Sci 86:264-72. 2005
    ..Furthermore, 9-cis-4-oxo-13,14-dihydro-RA was identified as a novel and sensitive indicator of TCDD exposure, in a resistant and sensitive rat strain, thereby extending the database of low-dose TCDD effects...
  26. ncbi request reprint Simultaneous exposure of rats to dioxin and carbon monoxide reduces the xenobiotic but not the hypoxic response
    Thomas Hofer
    Institute of Veterinary Physiology, University of Zurich, CH 8057 Zurich, Switzerland
    Biol Chem 385:291-4. 2004
    ..We found that exposure to CO inhibited the xenobiotic response while dioxin application had no significant negative impact on hypoxia-mediated gene transcription...