J Tuomilehto

Summary

Affiliation: National Public Health Institute
Country: Finland

Publications

  1. ncbi The impact of diabetes on coronary heart disease differs from that on ischaemic stroke with regard to the gender
    Marjukka Hyvärinen
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Cardiovasc Diabetol 8:17. 2009
  2. ncbi A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland
    Qing Qiao
    Department of Public Health, University of Helsinki, Finland
    BMC Genet 8:84. 2007
  3. ncbi Increasing incidence of Type 1 diabetes--role for genes?
    Janne Pitkäniemi
    Department of Mathematics and Statistics, Rolf Nevanlinna Institute, P, O, Box 4 Yliopistonkatu 5, FIN 00014 University of Helsinki, Finland
    BMC Genet 5:5. 2004
  4. ncbi Impact of age on cardiovascular risk: implications for cardiovascular disease management
    Jaakko Tuomilehto
    National Public Health Institute, University of Helsinki, Mannerheiminite 166, 00300 Helsinki, Finland
    Atheroscler Suppl 5:9-17. 2004
  5. ncbi Glucose lowering and diabetes prevention: are they the same?
    Jaakko Tuomilehto
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Lancet 368:1218-9. 2006
  6. ncbi Point: a glucose tolerance test is important for clinical practice
    Jaakko Tuomilehto
    Department of Public Health, University of Helsinki, and the Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Helsinki, Finland
    Diabetes Care 25:1880-2. 2002
  7. ncbi Effect of ingesting sour milk fermented using Lactobacillus helveticus bacteria producing tripeptides on blood pressure in subjects with mild hypertension
    J Tuomilehto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    J Hum Hypertens 18:795-802. 2004
  8. ncbi [Difficulties to forecast the risk of stroke]
    Jaakko Tuomilehto
    Helsingin yliopisto, kansanterveystieteen laitos, Kansanterveyslaitos,
    Duodecim 118:2527-30. 2002
  9. ncbi Reducing coronary heart disease associated with type 2 diabetes: lifestyle intervention and treatment of dyslipidaemia
    Jaakko Tuomilehto
    Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    Diabetes Res Clin Pract 61:S27-34. 2003
  10. ncbi Low diastolic blood pressure and mortality in a population-based cohort of 16913 hypertensive patients in North Karelia, Finland
    J Tuomilehto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    J Hypertens 16:1235-42. 1998

Research Grants

  1. Risk of Type 1 and Type 2 Diabetes among Young Finns
    Jaakko Tuomilehto; Fiscal Year: 2005

Collaborators

Detail Information

Publications190 found, 100 shown here

  1. ncbi The impact of diabetes on coronary heart disease differs from that on ischaemic stroke with regard to the gender
    Marjukka Hyvärinen
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Cardiovasc Diabetol 8:17. 2009
    ..To study the diabetes related CVD risk between men and women of different ages...
  2. ncbi A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland
    Qing Qiao
    Department of Public Health, University of Helsinki, Finland
    BMC Genet 8:84. 2007
    ....
  3. ncbi Increasing incidence of Type 1 diabetes--role for genes?
    Janne Pitkäniemi
    Department of Mathematics and Statistics, Rolf Nevanlinna Institute, P, O, Box 4 Yliopistonkatu 5, FIN 00014 University of Helsinki, Finland
    BMC Genet 5:5. 2004
    ..After the introduction of insulin treatment in 1930s, an increase in the pool of genetically susceptible individuals has been suggested to contribute to the increase in the incidence of Type 1 diabetes...
  4. ncbi Impact of age on cardiovascular risk: implications for cardiovascular disease management
    Jaakko Tuomilehto
    National Public Health Institute, University of Helsinki, Mannerheiminite 166, 00300 Helsinki, Finland
    Atheroscler Suppl 5:9-17. 2004
    ..This review also focuses on how these conditions can be optimally managed and whether treatment outcomes are affected by age. The current status of research is assessed and issues which remain to be resolved are highlighted...
  5. ncbi Glucose lowering and diabetes prevention: are they the same?
    Jaakko Tuomilehto
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Lancet 368:1218-9. 2006
  6. ncbi Point: a glucose tolerance test is important for clinical practice
    Jaakko Tuomilehto
    Department of Public Health, University of Helsinki, and the Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Helsinki, Finland
    Diabetes Care 25:1880-2. 2002
  7. ncbi Effect of ingesting sour milk fermented using Lactobacillus helveticus bacteria producing tripeptides on blood pressure in subjects with mild hypertension
    J Tuomilehto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    J Hum Hypertens 18:795-802. 2004
    ..0+/-8.3 mmHg between the two test products was not significant either (P=0.4431). In conclusion, the ingestion of sour milk fermented by L. helveticus bacteria and that containing ACE inhibitory tripeptides seems to lower BP modestly...
  8. ncbi [Difficulties to forecast the risk of stroke]
    Jaakko Tuomilehto
    Helsingin yliopisto, kansanterveystieteen laitos, Kansanterveyslaitos,
    Duodecim 118:2527-30. 2002
  9. ncbi Reducing coronary heart disease associated with type 2 diabetes: lifestyle intervention and treatment of dyslipidaemia
    Jaakko Tuomilehto
    Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    Diabetes Res Clin Pract 61:S27-34. 2003
    ..Combination therapies for dyslipidaemia may be the key to optimizing CHD risk reduction in type 2 diabetes...
  10. ncbi Low diastolic blood pressure and mortality in a population-based cohort of 16913 hypertensive patients in North Karelia, Finland
    J Tuomilehto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    J Hypertens 16:1235-42. 1998
    ..To examine the relationship between mortality and diastolic blood pressure during treatment...
  11. ncbi Ultrasonographic manifestations of carotid atherosclerosis and glucose intolerance in elderly eastern Finnish men
    J Tuomilehto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Diabetes Care 21:1349-52. 1998
    ..To study the association of ultrasonographic manifestations of common carotid atherosclerosis with glucose intolerance in survivors of the cohort of men born in 1900-1919 in eastern Finland...
  12. ncbi Coffee consumption and risk of type 2 diabetes mellitus among middle-aged Finnish men and women
    Jaakko Tuomilehto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    JAMA 291:1213-9. 2004
    ..Only a few studies of coffee consumption and diabetes mellitus (DM) have been reported, even though coffee is the most consumed beverage in the world...
  13. ncbi Urinary sodium excretion and cardiovascular mortality in Finland: a prospective study
    J Tuomilehto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Lancet 357:848-51. 2001
    ..We aimed to find out whether salt intake, measured by 24 h urinary sodium excretion, is an independent risk factor for cardiovascular disease frequency and mortality, and all-cause mortality...
  14. ncbi The major diabetes prevention trials
    Jaakko Tuomilehto
    National Public Health Institute, Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, Mannerheimintie 166, Helsinki 00300, Finland
    Curr Diab Rep 3:115-22. 2003
    ..Thus, the prevention of T2D is possible in most high-risk subjects, but how to achieve this at the population level remains a major challenge...
  15. ncbi Counterpoint: Evidence-based prevention of type 2 diabetes: the power of lifestyle management
    Jaakko Tuomilehto
    Department of Public Health, University of Helsinki, Mannerheimintie 172, 00300 Helsinki, Finland
    Diabetes Care 30:435-8. 2007
  16. ncbi The unchanging incidence of hospitalization for diabetic nephropathy in a population-based cohort of IDDM patients in Finland
    J Tuomilehto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Diabetes Care 20:1081-6. 1997
    ....
  17. ncbi Cardiovascular risk: prevention and treatment of the metabolic syndrome
    Jaakko Tuomilehto
    University of Helsinki and National Public Health Institute, Mannerheimintie 166, Helsinki FIN 00300, Finland
    Diabetes Res Clin Pract 68:S28-35. 2005
    ....
  18. ncbi Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    J Tuomilehto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    N Engl J Med 344:1343-50. 2001
    ..Whether type 2 diabetes can be prevented by interventions that affect the lifestyles of subjects at high risk for the disease is not known...
  19. ncbi Ethnic comparison of the association of undiagnosed diabetes with obesity
    R Nyamdorj
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Int J Obes (Lond) 34:332-9. 2010
    ..The aim of the study was to investigate the crude prevalence and estimated probability of undiagnosed diabetes in different ethnic groups, given the same level of obesity...
  20. ncbi Decline of coronary heart disease mortality in Finland during 1983 to 1992: roles of incidence, recurrence, and case-fatality. The FINMONICA MI Register Study
    V Salomaa
    National Public Health Institute, Helsinki, Finland
    Circulation 94:3130-7. 1996
    ..The aim of the present study was to examine the contributions of incidence, recurrence, and case fatality of coronary events to the trends in CHD mortality in three areas of Finland...
  21. ncbi Relationship of socioeconomic status to the incidence and prehospital, 28-day, and 1-year mortality rates of acute coronary events in the FINMONICA myocardial infarction register study
    V Salomaa
    KTL National Public Health Institute, Helsinki, Finland
    Circulation 101:1913-8. 2000
    ..There are, however, very little data on the relation of SES to the incidence, recurrence, and prognosis of myocardial infarction (MI) events...
  22. ncbi A simple Chinese risk score for undiagnosed diabetes
    W G Gao
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Diabet Med 27:274-81. 2010
    ..A diabetes risk score for screening undiagnosed diabetes was constructed and validated in Chinese adults...
  23. ncbi Trends in lipid levels and hypercholesterolemia in hypertensive and normotensive finnish adults from 1982 to 1997
    M Kastarinen
    Department of Public Health, University of Kuopio, Finland
    J Intern Med 247:53-62. 2000
    ..To assess the trends in lipid levels and awareness of hypercholesterolemia in hypertensive and normotensive population in Finland from 1982 to 97...
  24. ncbi Socioeconomic status and ischemic stroke: The FINMONICA Stroke Register
    D Jakovljevic
    KTL National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
    Stroke 32:1492-8. 2001
    ..The purpose of the present study was to examine the association of socioeconomic status with ischemic stroke. Besides mortality, we analyzed the incidence, case-fatality ratio, and prognosis of ischemic stroke events...
  25. ncbi Relation of socioeconomic position to the case fatality, prognosis and treatment of myocardial infarction events; the FINMONICA MI Register Study
    V Salomaa
    KTL National Public Health Institute, Helsinki, Finland
    J Epidemiol Community Health 55:475-82. 2001
    ....
  26. ncbi Blood lipid levels in relation to glucose status in seven populations of Asian origin without a prior history of diabetes: the DECODA study
    L Zhang
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Diabetes Metab Res Rev 25:549-57. 2009
    ..Dyslipidaemia commonly coexists with diabetes. We investigated the association of lipid profiles with glucose levels in populations of Asian origin without a prior history of diabetes...
  27. ncbi Relationship between body mass index and mortality among Europeans
    X Song
    Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland
    Eur J Clin Nutr 66:156-65. 2012
    ..To investigate the relationship between body mass index (BMI) and mortality from various causes...
  28. ncbi Joint association of coffee consumption and other factors to the risk of type 2 diabetes: a prospective study in Finland
    G Hu
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Int J Obes (Lond) 30:1742-9. 2006
    ..OBJECTIVe: To examine joint associations of coffee consumption and other factors (including physical activity, obesity and alcohol consumption) with the risk of type 2 diabetes...
  29. ncbi Five-year risk of developing clinical diabetes after first myocardial infarction; the FINAMI study
    P Pajunen
    National Public Health Institute KTL, Helsinki, Finland
    Diabet Med 22:1334-7. 2005
    ....
  30. ncbi Leptin concentrations and their relation to body fat distribution and weight loss--a prospective study in individuals with impaired glucose tolerance. DPS-study group
    J Eriksson
    National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
    Horm Metab Res 31:616-9. 1999
    ..Body fat distribution was also of importance, especially among females. Gender associated differences in leptin concentrations appear to be largely influenced by gender differences in body fat distribution...
  31. ncbi Coffee consumption and risk of total and cardiovascular mortality among patients with type 2 diabetes
    S Bidel
    Diabetes and Genetic Epidemiology Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Diabetologia 49:2618-26. 2006
    ..This study was designed to assess the association between coffee consumption and CVD mortality among patients with type 2 diabetes...
  32. ncbi Size at birth, childhood growth and obesity in adult life
    J Eriksson
    National Public Health Institute, Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, Helsinki, Finland
    Int J Obes Relat Metab Disord 25:735-40. 2001
    ..Several studies have shown tracking of obesity from childhood to adult life. People who develop obesity in adult life may therefore have had a particular path of growth from birth through childhood...
  33. ncbi Seasonal variation in the occurrence of stroke in a Finnish adult population. The FINMONICA Stroke Register. Finnish Monitoring Trends and Determinants in Cardiovascular Disease
    D Jakovljevic
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Stroke 27:1774-9. 1996
    ..The aim of this study was to examine seasonal variation in the incidence, mortality, and case-fatality rate of stroke in data from the FINMONICA population-based stroke register...
  34. ncbi Decline in out-of-hospital coronary heart disease deaths has contributed the main part to the overall decline in coronary heart disease mortality rates among persons 35 to 64 years of age in Finland: the FINAMI study
    V Salomaa
    KTL National Public Health Institute, Department of Epidemiology and Health Promotion, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Circulation 108:691-6. 2003
    ..Out-of-hospital deaths constitute the majority of all coronary heart disease (CHD) deaths and are therefore of considerable public health significance...
  35. ncbi Effects of smoking, obesity and physical activity on the risk of type 2 diabetes in middle-aged Finnish men and women
    K Patja
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    J Intern Med 258:356-62. 2005
    ..Prevention of smoking should be encouraged as a part of efforts to reduce the risk of type 2 diabetes, and it will result in other health benefits, too...
  36. ncbi Educational level, relative body weight, and changes in their association over 10 years: an international perspective from the WHO MONICA Project
    A Molarius
    MONICA Data Centre, Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Am J Public Health 90:1260-8. 2000
    ....
  37. ncbi The effects of physical activity and body mass index on cardiovascular, cancer and all-cause mortality among 47 212 middle-aged Finnish men and women
    G Hu
    Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Int J Obes (Lond) 29:894-902. 2005
    ..To examine the association of physical activity and body mass index (BMI), and their combined effect, with the risk of total, cardiovascular disease (CVD) and cancer mortality...
  38. ncbi Myocardial infarction in diabetic and non-diabetic persons with and without prior myocardial infarction: the FINAMI Study
    P Pajunen
    KTL-National Public Health Institute, Department of Epidemiology and Health Promotion, Mannerheimintie 166, FIN-00300, Helsinki, Finland
    Diabetologia 48:2519-24. 2005
    ..Among diabetic women, the risk of suffering a first MI was similar to the risk that non-diabetic women with prior MI had of suffering a recurrent MI...
  39. ncbi Occupational, commuting, and leisure-time physical activity in relation to risk for Type 2 diabetes in middle-aged Finnish men and women
    G Hu
    Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    Diabetologia 46:322-9. 2003
    ..This study is to examine the relationship of occupational, commuting and leisure-time physical activity with the incidence of Type 2 diabetes...
  40. ncbi The validity of hospital discharge register data on coronary heart disease in Finland
    M Mahonen
    National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
    Eur J Epidemiol 13:403-15. 1997
    ..Therefore, these data should not be used without confirmation in studies where correct classification of individual outcomes is of crucial importance, such as follow-up studies and case-control studies...
  41. ncbi Quality indicators for the prevention of type 2 diabetes in Europe--IMAGE
    P Pajunen
    Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
    Horm Metab Res 42:S56-63. 2010
    ..It is targeted to the persons responsible for diabetes prevention at different levels of the health care systems...
  42. ncbi Association of leisure time physical activity and abdominal obesity with fasting serum insulin and 2-h postchallenge plasma glucose levels
    K Borodulin
    National Public Health Institute, Helsinki, Finland
    Diabet Med 23:1025-8. 2006
    ..We investigated the joint associations of leisure time physical activity and abdominal obesity with fasting insulin and 2-h glucose levels and with the risk of impaired glucose tolerance (IGT) and Type 2 diabetes (Type 2 DM)...
  43. ncbi Safety assessment of common foods enriched with natural nonesterified plant sterols
    J Tuomilehto
    Department of Health Promotion and Chronic Disease Prevention, Division of Biochemistry, National Public Health Institute, University of Helsinki, Finland
    Eur J Clin Nutr 63:684-91. 2009
    ..To assess safety during a diet based on low-fat foods enriched with nonesterified wood-derived plant sterols and mineral nutrients related to serum phytosterol, sex hormone and fat-soluble vitamin metabolism...
  44. ncbi Role of known risk factors in explaining the difference in the risk of coronary heart disease between eastern and southwestern Finland
    P Jousilahti
    National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
    Ann Med 30:481-7. 1998
    ..In addition to the classical risk factors, regional differences in body height and socioeconomic status were associated with the regional differences in CHD risk...
  45. ncbi Progression to clinically diagnosed and treated diabetes from impaired glucose tolerance and impaired fasting glycaemia
    Q Qiao
    Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Diabet Med 20:1027-33. 2003
    ..To evaluate the risk of diabetes in subjects with impaired fasting glycemia (IFG) as compared with impaired glucose tolerance (IGT) and normal glucose tolerance...
  46. ncbi Sex, age, cardiovascular risk factors, and coronary heart disease: a prospective follow-up study of 14 786 middle-aged men and women in Finland
    P Jousilahti
    National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
    Circulation 99:1165-72. 1999
    ..In both sexes, CHD risk increases with age, but the increase is sharper in women. We analyzed the extent to which major cardiovascular risk factors can explain the sex difference and the age-related increase in CHD risk...
  47. ncbi Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study
    T Valle
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Diabetes Care 21:949-58. 1998
    ..To map and identify susceptibility genes for NIDDM and for the intermediate quantitative traits associated with NIDDM...
  48. ncbi Risk factors associated with the dramatic increase in the prevalence of diabetes in the adult Chinese population in Qingdao, China
    F Ning
    Department of Public Health, University of Helsinki, FIN 00014 Helsinki, Finland
    Diabet Med 26:855-63. 2009
    ..To investigate the major risk factors and their association with the dramatic increase in the prevalence of diabetes from 2001-2002 to 2006 in Qingdao, China...
  49. ncbi Estimation of contribution of changes in classic risk factors to trends in coronary-event rates across the WHO MONICA Project populations
    K Kuulasmaa
    Department of Epidemiology and Health Promotion, National Public Health Institute KTL, Helsinki, Finland
    Lancet 355:675-87. 2000
    ..We assessed the extent to which changes in these risk factors explain the variation in the trends in coronary-event rates across the populations...
  50. ncbi Socioeconomic differences in the incidence, mortality and prognosis of intracerebral hemorrhage in Finnish Adult Population. The FINMONICA Stroke Register
    D Jakovljevic
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Neuroepidemiology 20:85-90. 2001
    ..12, 95% confidence interval 1.02-4.40). In conclusion, marked socioeconomic differences were found in the incidence and mortality of ICH, in particular among working aged men...
  51. ncbi The effect of diabetes and stroke at baseline and during follow-up on stroke mortality
    G Hu
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Diabetologia 49:2309-16. 2006
    ..The aim of this study was to compare the magnitude of the effect of diabetes and stroke at baseline and during follow-up on risk of stroke mortality...
  52. ncbi Prevalence of diabetes and impaired glucose regulation in 45- to 64-year-old individuals in three areas of Finland
    H Ylihärsilä
    Department of Epidemiology and Health Promotion, National Public Health Institute, 00300 Helsinki, Finland
    Diabet Med 22:88-91. 2005
    ..To determine the prevalence of diabetes mellitus (DM), impaired glucose tolerance (IGT) and impaired fasting glycaemia (IFG) and possible regional differences in Finnish adults aged between 45 and 64 years...
  53. ncbi High-fibre, low-fat diet predicts long-term weight loss and decreased type 2 diabetes risk: the Finnish Diabetes Prevention Study
    J Lindstrom
    Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Diabetologia 49:912-20. 2006
    ..The aim of this study was to investigate the association of dietary macronutrient composition and energy density with the change in body weight and waist circumference and diabetes incidence in the Finnish Diabetes Prevention Study...
  54. ncbi Blood lipid levels in relation to glucose status in European men and women without a prior history of diabetes: the DECODE Study
    L Zhang
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Diabetes Res Clin Pract 82:364-77. 2008
    ..The purpose of this study is to investigate the relationship between lipid and glucose levels in a large European population without a prior history of diabetes...
  55. ncbi Risk prediction models for the development of diabetes in Mauritian Indians
    W G Gao
    Department of Public Health, University of Helsinki, FIN 00014 Helsinki, Finland
    Diabet Med 26:996-1002. 2009
    ..To develop risk prediction models of future diabetes in Mauritian Indians...
  56. ncbi Childhood BMI trajectories and the risk of developing young adult-onset diabetes
    N Lammi
    Diabetes Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Mannerheimintie 166, 00300, Helsinki, Finland
    Diabetologia 52:408-14. 2009
    ..The aim of this study was to examine the effects of childhood BMI growth dynamics on the risk of developing young adult-onset type 1 and type 2 diabetes...
  57. ncbi Does abnormal insulin action or insulin secretion explain the increase in prevalence of impaired glucose metabolism with age in populations of different ethnicities?
    F Ning
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Diabetes Metab Res Rev 26:245-53. 2010
    ....
  58. ncbi A high incidence of type 1 diabetes and an alarming increase in the incidence of type 2 diabetes among young adults in Finland between 1992 and 1996
    N Lammi
    Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Mannerheimintie 166, 00300, Helsinki, Finland
    Diabetologia 50:1393-400. 2007
    ..The aim of this study was to examine the incidence and trends of type 1 and type 2 diabetes in the 15-39 year-old population between 1992 and 1996 in Finland...
  59. ncbi Acarbose treatment does not change the habitual diet of patients with Type 2 diabetes mellitus. The Finnish Acargbos Study Group
    J Lindstrom
    National Public Health Institute, Department of Epidemiology and Health Promotion, Mannerheimintie, Helsinki, Finland
    Diabet Med 17:20-5. 2000
    ..The aim of this study was to determine whether poor metabolic control can be improved by acarbose, and whether this might be because the acarbose supplementation provokes changes in diet...
  60. ncbi Early growth and coronary heart disease in later life: longitudinal study
    J G Eriksson
    National Public Health Institute, Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    BMJ 322:949-53. 2001
    ..To determine how growth during infancy and childhood modifies the increased risk of coronary heart disease associated with small body size at birth...
  61. ncbi High serum insulin-like growth factor binding protein-1 is associated with increased cardiovascular mortality in elderly men
    M Harrela
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Horm Metab Res 34:144-9. 2002
    ..91 95 % CI 1.18 - 3.09; p < 0.008) and coronary heart disease (OR 2.02. 95 % CI 1.18 - 3.47; p < 0.01). In conclusion, high fasting serum IGFBP-1 is related to increased five-year total and cardiovascular mortality in elderly men...
  62. ncbi Trends in cigarette smoking in 36 populations from the early 1980s to the mid-1990s: findings from the WHO MONICA Project
    A Molarius
    National Public Health Institute (KTL, Helsinki, Finland
    Am J Public Health 91:206-12. 2001
    ..CONCLUSIONS: These data illustrate the evolution of the smoking epidemic in populations and provide the basis for targeted public health interventions to support the WHO priority for tobacco control...
  63. ncbi Two-hour glucose is a better risk predictor for incident coronary heart disease and cardiovascular mortality than fasting glucose
    Q Qiao
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Eur Heart J 23:1267-75. 2002
    ..The results of our study indicate that 2-h glucose is superior to fasting glucose in assessing the risk of future cardiovascular disease events...
  64. ncbi The feasibility of combining data from routine Hospital Discharge and Causes-of-Death Registers for epidemiological studies on stroke
    M Mahonen
    Department of Epidemiology and Health Promotion, KTL National Public Health Institute, Helsinki, Finland
    Eur J Epidemiol 16:815-7. 2000
    ..The results showed that such data can, with some caution, be used for incidence studies and for identifying first stroke events. They cannot, however, be used for assessing secular trends in all stroke events...
  65. ncbi Distinct ethnic differences in lipid profiles across glucose categories
    Lei Zhang
    Department of Public Health, University of Helsinki, PL41, Mannerheimintie 172, FIN 00014 Helsinki, Finland
    J Clin Endocrinol Metab 95:1793-801. 2010
    ..Dyslipidemia coexists with hyperglycemia. However, little is known about the ethnic differences in lipid profiles at comparable glucose tolerance status...
  66. ncbi Coffee consumption, serum gamma-glutamyltransferase and risk of type II diabetes
    S Bidel
    Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
    Eur J Clin Nutr 62:178-85. 2008
    ..To study the joint association of coffee consumption and serum gamma-glutamyltransferase (GGT) levels on the risk of developing type II diabetes...
  67. ncbi Sex differences in cardiovascular and total mortality among diabetic and non-diabetic individuals with or without history of myocardial infarction
    G Hu
    Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    Diabetologia 48:856-61. 2005
    ..We investigated the associations of type 2 diabetes and a history of myocardial infarction (MI) with coronary heart disease, stroke, cardiovascular and total mortality, and whether these effects are different in men and women...
  68. ncbi Effects of coffee consumption on glucose tolerance, serum glucose and insulin levels--a cross-sectional analysis
    S Bidel
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Horm Metab Res 38:38-43. 2006
    ..Coffee has several metabolic effects that could reduce the risk of type 2 diabetes. Our objective was to examine the effects of coffee consumption on glucose tolerance, glucose and insulin levels...
  69. ncbi Hyperglycemia and stroke mortality: comparison between fasting and 2-h glucose criteria
    Marjukka Hyvärinen
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Diabetes Care 32:348-54. 2009
    ..We investigated stroke mortality in individuals in different categories of glycemia and compared hazard ratios (HRs) corresponding to a 1-SD increase in 2-h plasma glucose and fasting plasma glucose (FPG) criteria...
  70. ncbi The validity of the Finnish Diabetes Risk Score for the prediction of the incidence of coronary heart disease and stroke, and total mortality
    Karri Silventoinen
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Eur J Cardiovasc Prev Rehabil 12:451-8. 2005
    ....
  71. ncbi Nonpharmacologic therapy and exercise in the prevention of type 2 diabetes
    Jaakko Tuomilehto
    Department of Public Health, University of Helsinki, Helsinki, Finland, South Ostrobothnia Central Hospital, Seinajoki, Finland
    Diabetes Care 32:S189-93. 2009
    ..To review the current knowledge about nonpharmacologic approaches in the prevention and early treatment of type 2 diabetes...
  72. ncbi Perinatal risk factors in young adult-onset type 1 and type 2 diabetes - a population-based case-control study
    Niina Lammi
    Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
    Acta Obstet Gynecol Scand 88:468-674. 2009
    ..To examine the effects of the size of the mother and the newborn, including placental weight and gestational age at delivery, on the risk for young adult-onset type 1 diabetes (T1DM) and type 2 diabetes (T2DM)...
  73. ncbi A population-specific diabetogenic haplotype HLA-A2,Cw1,B56,DR4,DQ8 is associated with high birthweight in Finnish diabetic families
    T M Järvinen
    Diabetes Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
    Genes Immun 9:207-13. 2008
    ..The high proportion of infants having a birthweight >or=4000 g in families with a diabetic offspring raises a concern of potential adverse health outcomes that high birthweight can have...
  74. ncbi Heritability of leptin levels and the shared genetic effects on body mass index and leptin in adult Finnish twins
    J Kaprio
    University of Helsinki, Department of Public Health, The Finnish Twin Cohort Study, Helsinki, Finland
    Int J Obes Relat Metab Disord 25:132-7. 2001
    ..Leptin is involved in the regulation of body weight, but the relative role of genetic and environmental influences on inter-individual variation in leptin levels is unknown...
  75. ncbi BMI compared with central obesity indicators as a predictor of diabetes incidence in Mauritius
    Regzedmaa Nyamdorj
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Obesity (Silver Spring) 17:342-8. 2009
    ..05). The relation of BMI with the development of diabetes was as strong as that for indicators of central obesity in this study population...
  76. ncbi Hyperglycemia and incidence of ischemic and hemorrhagic stroke-comparison between fasting and 2-hour glucose criteria
    Marjukka Hyvärinen
    Department of Public Health, University of Helsinki, PL 41, Mannerheimintie 172, Helsinki, Finland
    Stroke 40:1633-7. 2009
    ..We examined the impact of hyperglycemia on ischemic and hemorrhagic stroke incidence comparing criteria based on fasting plasma glucose (FPG) and 2-hour plasma glucose (2-hour PG)...
  77. ncbi Comparison of body mass index with waist circumference, waist-to-hip ratio, and waist-to-stature ratio as a predictor of hypertension incidence in Mauritius
    Regzedmaa Nyamdorj
    Department of Public Health, University of Helsinki, Helsinki, Finland
    J Hypertens 26:866-70. 2008
    ..Comparison of BMI with waist circumference, waist-to-hip ratio (WHR), and waist-to-stature ratio (WSR) as a predictor of hypertension incidence...
  78. ncbi Geographical variation in the incidence of acute myocardial infarction in eastern Finland--a Bayesian perspective
    Maarit Viik-Kajander
    National Public Health Institute, Helsinki, Finland
    Ann Med 35:43-50. 2003
    ....
  79. ncbi Serum uric acid, plasma glucose and diabetes
    - Hairong Nan
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Diab Vasc Dis Res 7:40-6. 2010
    ..UA may serve as a potential biomarker of deterioration in glucose metabolism, but its clinical implication need to be further studied...
  80. ncbi Effects of sympatholytic therapy on insulin sensitivity indices in hypertensive postmenopausal women
    R Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Int J Clin Pharmacol Ther 45:394-401. 2007
    ....
  81. ncbi Is the effect of smoking on the risk for coronary heart disease even stronger than was previously thought?
    P Jousilahti
    National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
    J Cardiovasc Risk 6:293-8. 1999
    ....
  82. ncbi Mealtime glucose regulation in type 2 diabetes
    J Tuomilehto
    Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Mannerheimintie 166, FIN-003000 Helsinki, Finland
    Int J Clin Pract 55:380-3. 2001
    ....
  83. ncbi Changes in premature deaths in Finland: successful long-term prevention of cardiovascular diseases
    P Puska
    Division of Health and Chronic Diseases, National Public Health Institute of Finland, Helsinki, Finland
    Bull World Health Organ 76:419-25. 1998
    ..These results show that a major reduction in CVD mortality among the working-age population can take place in association with active reduction of major risk factors, with a favourable impact on cancer and all-causes mortality...
  84. ncbi Aerobic endurance exercise or circuit-type resistance training for individuals with impaired glucose tolerance?
    J Eriksson
    National Public Health Institute, Helsinki, Finland
    Horm Metab Res 30:37-41. 1998
    ..However, by improving insulin sensitivity, circuit-type resistance training may postpone the manifestations of NIDDM in these high-risk individuals and should therefore be included in an exercise program for IGT subjects...
  85. ncbi Serum uric acid and components of the metabolic syndrome in non-diabetic populations in Mauritian Indians and Creoles and in Chinese in Qingdao, China
    Hairong Nan
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Metab Syndr Relat Disord 6:47-57. 2008
    ..To assess the association of serum uric acid (UA) with components of metabolic syndrome (MetS) in different ethnic groups...
  86. ncbi The likelihood of diabetes based on the proposed definitions for impaired fasting glucose
    Weiguo Gao
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Diabetes Res Clin Pract 79:151-5. 2008
    ..6-6.0 mmol/l than in those with FPG of 6.1-6.9 mmol/l. The clinical and social implication of labelling more individuals with impaired fasting glucose needs to be further studied...
  87. ncbi The diabetes-cardiovascular risk paradox: results from a Finnish population-based prospective study
    Noel C Barengo
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Eur Heart J 29:1889-95. 2008
    ..To assess changes in coronary heart disease (CHD) event rates and CHD mortality rates among diabetic and non-diabetic individuals between two large study cohorts with baseline assessments 10 years apart and followed up for 10 years...
  88. ncbi Association of serum C-reactive protein level with sex-specific type 2 diabetes risk: a prospective finnish study
    Gang Hu
    Departments of Health Promotion and Chronic Diseases Prevention, National Public Health Institute, Helsinki FIN 00300, Finland
    J Clin Endocrinol Metab 94:2099-105. 2009
    ..Our objective was to assess whether the association of serum C-reactive protein (CRP) with type 2 diabetes risk is modified by sex...
  89. ncbi Development and validation of a risk-score model for subjects with impaired glucose tolerance for the assessment of the risk of type 2 diabetes mellitus-The STOP-NIDDM risk-score
    Jaakko Tuomilehto
    Department of Public Health, University of Helsinki, Finland
    Diabetes Res Clin Pract 87:267-74. 2010
    ..To develop a risk-score model, based on available clinical data to assess absolute risk of type 2 diabetes among people with impaired glucose tolerance (IGT)...
  90. ncbi Prevention of diabetes mellitus in subjects with impaired glucose tolerance in the Finnish Diabetes Prevention Study: results from a randomized clinical trial
    Jaana Lindström
    National Public Health Institute, Department of Epidemiology, Diabetes and Genetic Epidemiology Unit, Helsinki, Finland
    J Am Soc Nephrol 14:S108-13. 2003
    ..In conclusion, the DPS is the first controlled trial demonstrating that type 2 diabetes can be prevented by changes in lifestyle in high-risk subjects...
  91. ncbi Safety aspects and cholesterol-lowering efficacy of low fat dairy products containing plant sterols
    R Korpela
    Foundation for Nutrition Research, Helsinki, Finland
    Eur J Clin Nutr 60:633-42. 2006
    ....
  92. ncbi Prevalence of coronary heart disease indicated by electrocardiogram abnormalities and risk factors in developing countries
    N Li
    Department of Epidemiology, National Public Health Institute, Helsinki, Finland
    J Clin Epidemiol 47:599-611. 1994
    ....
  93. ncbi Trends in obesity and energy supply in the WHO MONICA Project
    K Silventoinen
    Department of Public Health, University of Helsinki, Finland
    Int J Obes Relat Metab Disord 28:710-8. 2004
    ..To examine the relationship between secular trends in energy supply and body mass index (BMI) among several countries...
  94. ncbi Assessing the preprandial glucose target: 100 mg/dL versus 110 mg/dL
    Jaakko Tuomilehto
    University of Helsinki, Finland
    Endocr Pract 12:67-70. 2006
    ..CONCLUSION: Lowering the cut point for IFG from 6.1 mmol/L to 5.6 mmol/L (110 mg/dL to 100 mg/dL) increases the prevalence of IFG but does not predict mortality below 7 mmol/L (126 mg/dL)...
  95. ncbi The difference between acute coronary heart disease and ischaemic stroke risk with regard to gender and age in Finnish and Swedish populations
    Marjukka Hyvärinen
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Int J Stroke 5:152-6. 2010
    ..We studied the age and gender difference between acute coronary heart disease and ischaemic stroke risk and examined the extent to which such a difference may be explained by known risk factors...
  96. ncbi Genetic and environmental effects on fasting and postchallenge plasma glucose and serum insulin values in Finnish twins
    Shuichi Katoh
    Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Helsinki, Finland
    J Clin Endocrinol Metab 90:2642-7. 2005
    ..81). In conclusion, additive genetic effects are important for the insulin secretion, whereas nonshared environmental effects contribute strongly to peripheral insulin resistance...
  97. ncbi Educational inequalities in the metabolic syndrome and coronary heart disease among middle-aged men and women
    Karri Silventoinen
    Department of Public Health, University of Helsinki, PO Box 41, Mannerheimintie 172, FIN 00014, Finland
    Int J Epidemiol 34:327-34. 2005
    ..We investigated this question in a prospective study of middle-aged men and women...
  98. ncbi Genetic random effects model for family data with long-term survivors: analysis of diabetic nephropathy in type 1 diabetes
    Janne Pitkäniemi
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Genet Epidemiol 31:697-708. 2007
    ..According to the variance components estimated a substantial familial variation in the susceptibility to DN exist among families, while time to DN is less influenced by shared familial factors...
  99. ncbi Epidemiological studies of exercise in diabetes prevention
    Gang Hu
    Diabetes Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Appl Physiol Nutr Metab 32:583-95. 2007
    ..Our review of the scientific evidence confirms that 30 min/d of moderate- or high-level physical activity is an effective and safe way to prevent type 2 diabetes in all populations...
  100. ncbi The association between thinness and socio-economic disadvantage, health indicators, and adverse health behaviour: a study of 28 000 Finnish men and women
    S Sarlio-Lähteenkorva
    Department of Public Health, University of Helsinki, Finland
    Int J Obes Relat Metab Disord 28:568-73. 2004
    ..To examine how thinness is associated with indicators of socio-economic disadvantage, health-related behaviours, and health indicators including mortality...
  101. ncbi Does the constellation of risk factors with and without abdominal adiposity associate with different cardiovascular mortality risk?
    W Gao
    Department of Public Health, University of Helsinki, Mannerheimintie 172, 6th Floor, KTTL, 6krs, PL 41, Helsinki FIN 00014, Finland
    Int J Obes (Lond) 32:757-62. 2008
    ....

Research Grants3

  1. Risk of Type 1 and Type 2 Diabetes among Young Finns
    Jaakko Tuomilehto; Fiscal Year: 2005
    ..The detailed epidemiological data obtained in this study will also lay a foundation for further research of etiological factors, genetic and environmental, predisposing to DMI and DM2 in this age group. ..