Mari Strengell

Summary

Affiliation: National Public Health Institute
Country: Finland

Publications

  1. ncbi IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response
    Mari Strengell
    Department of Microbiology, National Public Health Institute, Helsinki, Finland
    J Immunol 169:3600-5. 2002
  2. ncbi IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells
    Mari Strengell
    Department of Microbiology, National Public Health Institute, Helsinki, Finland
    J Immunol 170:5464-9. 2003
  3. ncbi IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cells
    Mari Strengell
    Department of Microbiology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    J Leukoc Biol 76:416-22. 2004
  4. ncbi IL-21 enhances SOCS gene expression and inhibits LPS-induced cytokine production in human monocyte-derived dendritic cells
    Mari Strengell
    Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    J Leukoc Biol 79:1279-85. 2006
  5. ncbi Cytokine and contact-dependent activation of natural killer cells by influenza A or Sendai virus-infected macrophages
    Jukka Sirén
    Department of Microbiology, National Public Health Institute, Helsinki, Finland
    J Gen Virol 85:2357-64. 2004
  6. pmc Critical immunological pathways are downregulated in APECED patient dendritic cells
    Nora Pöntynen
    National Public Health Institute and FIMM, Institute for Molecular Medicine Finland, Biomedicum, Helsinki, Finland
    J Mol Med (Berl) 86:1139-52. 2008
  7. doi Antibody responses against influenza A(H1N1)pdm09 virus after sequential vaccination with pandemic and seasonal influenza vaccines in Finnish healthcare professionals
    Mari Strengell
    Virology Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Helsinki, Finland
    Influenza Other Respir Viruses 7:431-8. 2013
  8. doi Multiple signaling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells
    Sanna M Mäkelä
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    J Leukoc Biol 85:664-72. 2009
  9. pmc Incoming influenza A virus evades early host recognition, while influenza B virus induces interferon expression directly upon entry
    Pamela Osterlund
    Department of Infectious Disease Surveillance and Control, Virology Unit, National Institute for Health and Welfare, Helsinki, Finland
    J Virol 86:11183-93. 2012
  10. pmc Minor changes in the hemagglutinin of influenza A(H1N1)2009 virus alter its antigenic properties
    Mari Strengell
    Viral Infections Unit, Department of Vaccines and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    PLoS ONE 6:e25848. 2011

Collaborators

Detail Information

Publications10

  1. ncbi IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response
    Mari Strengell
    Department of Microbiology, National Public Health Institute, Helsinki, Finland
    J Immunol 169:3600-5. 2002
    ..Moreover, the enhanced transcription of these genes in T cells establishes a significant role for IL-21 also in the Th1 response...
  2. ncbi IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells
    Mari Strengell
    Department of Microbiology, National Public Health Institute, Helsinki, Finland
    J Immunol 170:5464-9. 2003
    ..IL-18, however, activated the binding of NF-kappa B to the IFN-gamma promoter NF-kappa B site. Our results suggest that both IL-15 and IL-21 have an important role in activating the NK cell-associated innate immune response...
  3. ncbi IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cells
    Mari Strengell
    Department of Microbiology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    J Leukoc Biol 76:416-22. 2004
    ..In conclusion, our results suggest a novel role for IFN-alpha/beta in the regulation of IL-21 response...
  4. ncbi IL-21 enhances SOCS gene expression and inhibits LPS-induced cytokine production in human monocyte-derived dendritic cells
    Mari Strengell
    Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    J Leukoc Biol 79:1279-85. 2006
    ..Our results demonstrate that IL-21, a cytokine produced by activated T cells, can directly inhibit the activation and cytokine production of myeloid DCs, providing a negative feedback loop between DCs and T lymphocytes...
  5. ncbi Cytokine and contact-dependent activation of natural killer cells by influenza A or Sendai virus-infected macrophages
    Jukka Sirén
    Department of Microbiology, National Public Health Institute, Helsinki, Finland
    J Gen Virol 85:2357-64. 2004
    ..In conclusion, these results show that virus-infected macrophages activate NK cells via cytokines and direct cellular interactions and further emphasize the role of IFN-alpha in the activation of innate immunity...
  6. pmc Critical immunological pathways are downregulated in APECED patient dendritic cells
    Nora Pöntynen
    National Public Health Institute and FIMM, Institute for Molecular Medicine Finland, Biomedicum, Helsinki, Finland
    J Mol Med (Berl) 86:1139-52. 2008
    ..Our observations support a role for AIRE in peripheral tolerance and are the first ones to show that AIRE has a critical role in DC responses to microbial stimuli in humans...
  7. doi Antibody responses against influenza A(H1N1)pdm09 virus after sequential vaccination with pandemic and seasonal influenza vaccines in Finnish healthcare professionals
    Mari Strengell
    Virology Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Helsinki, Finland
    Influenza Other Respir Viruses 7:431-8. 2013
    ....
  8. doi Multiple signaling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells
    Sanna M Mäkelä
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    J Leukoc Biol 85:664-72. 2009
    ..Our data suggest that TLR-dependent, synergistic cytokine gene expression results from enhanced activation and cooperation among NF-kappaB, IRF, MAPK, PI-3K, and STAT signaling pathways...
  9. pmc Incoming influenza A virus evades early host recognition, while influenza B virus induces interferon expression directly upon entry
    Pamela Osterlund
    Department of Infectious Disease Surveillance and Control, Virology Unit, National Institute for Health and Welfare, Helsinki, Finland
    J Virol 86:11183-93. 2012
    ..Collectively, our data provide new evidence of a novel antiviral evasion strategy for influenza A virus without a contribution of the viral NS1 protein, and this opens up new insights into different influenza virus pathogenicities...
  10. pmc Minor changes in the hemagglutinin of influenza A(H1N1)2009 virus alter its antigenic properties
    Mari Strengell
    Viral Infections Unit, Department of Vaccines and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    PLoS ONE 6:e25848. 2011
    ....