Research Topics
Genomes and GenesSpecies | Mari StrengellSummaryAffiliation: National Public Health Institute Country: Finland Publications
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Detail Information
Publications
IL-21 up-regulates the expression of genes associated with innate immunity and Th1 responseMari Strengell
Department of Microbiology, National Public Health Institute, Helsinki, Finland
J Immunol 169:3600-5. 2002..Moreover, the enhanced transcription of these genes in T cells establishes a significant role for IL-21 also in the Th1 response...- IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cellsMari Strengell
Department of Microbiology, National Public Health Institute, Helsinki, Finland
J Immunol 170:5464-9. 2003..IL-18, however, activated the binding of NF-kappa B to the IFN-gamma promoter NF-kappa B site. Our results suggest that both IL-15 and IL-21 have an important role in activating the NK cell-associated innate immune response... - IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cellsMari Strengell
Department of Microbiology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
J Leukoc Biol 76:416-22. 2004..In conclusion, our results suggest a novel role for IFN-alpha/beta in the regulation of IL-21 response... - IL-21 enhances SOCS gene expression and inhibits LPS-induced cytokine production in human monocyte-derived dendritic cellsMari Strengell
Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
J Leukoc Biol 79:1279-85. 2006..Our results demonstrate that IL-21, a cytokine produced by activated T cells, can directly inhibit the activation and cytokine production of myeloid DCs, providing a negative feedback loop between DCs and T lymphocytes... - Cytokine and contact-dependent activation of natural killer cells by influenza A or Sendai virus-infected macrophagesJukka Sirén
Department of Microbiology, National Public Health Institute, Helsinki, Finland
J Gen Virol 85:2357-64. 2004..In conclusion, these results show that virus-infected macrophages activate NK cells via cytokines and direct cellular interactions and further emphasize the role of IFN-alpha in the activation of innate immunity... 
Critical immunological pathways are downregulated in APECED patient dendritic cellsNora Pöntynen
National Public Health Institute and FIMM, Institute for Molecular Medicine Finland, Biomedicum, Helsinki, Finland
J Mol Med (Berl) 86:1139-52. 2008..Our observations support a role for AIRE in peripheral tolerance and are the first ones to show that AIRE has a critical role in DC responses to microbial stimuli in humans...
Multiple signaling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cellsSanna M Mäkelä
Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
J Leukoc Biol 85:664-72. 2009..Our data suggest that TLR-dependent, synergistic cytokine gene expression results from enhanced activation and cooperation among NF-kappaB, IRF, MAPK, PI-3K, and STAT signaling pathways...- Incoming influenza A virus evades early host recognition, while influenza B virus induces interferon expression directly upon entryPamela Osterlund
Department of Infectious Disease Surveillance and Control, Virology Unit, National Institute for Health and Welfare, Helsinki, Finland
J Virol 86:11183-93. 2012..Collectively, our data provide new evidence of a novel antiviral evasion strategy for influenza A virus without a contribution of the viral NS1 protein, and this opens up new insights into different influenza virus pathogenicities... - Minor changes in the hemagglutinin of influenza A(H1N1)2009 virus alter its antigenic propertiesMari Strengell
Viral Infections Unit, Department of Vaccines and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
PLoS ONE 6:e25848. 2011....