V Salomaa

Summary

Affiliation: National Public Health Institute
Country: Finland

Publications

  1. pmc Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project
    Marie Lise Grisoni
    INSERM, UMR_S 937, Paris, France
    BMC Med Genet 10:44. 2009
  2. pmc Are coronary event rates declining slower in women than in men - evidence from two population-based myocardial infarction registers in Finland?
    Hanna Riikka Lehto
    Turku University Hospital, Turku, Finland
    BMC Cardiovasc Disord 7:35. 2007
  3. pmc Ankle blood pressure as a predictor of total and cardiovascular mortality
    Heikki Hietanen
    Helsinki Deaconess Institute, Alppikatu 2, Helsinki, Finland
    BMC Cardiovasc Disord 8:3. 2008
  4. ncbi request reprint Cross-sectional association of soluble thrombomodulin with mild peripheral artery disease; the ARIC study. Atherosclerosis Risk in Communities
    V Salomaa
    KTL National Public Health Institute, Department of Epidemiology and Health Promotion, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    Atherosclerosis 157:309-14. 2001
  5. ncbi request reprint Hemostatic factors as predictors of coronary events and total mortality: The FINRISK '92 Hemostasis Study
    Veikko Salomaa
    Department of Epidemiology and Health Promotion, KTL National Public Health Institute, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 22:353-8. 2002
  6. ncbi request reprint Use of secondary preventive medications after the first attack of acute coronary syndrome
    Veikko Salomaa
    KTL National Public Health Institute, Helsinki, Finland
    Eur J Cardiovasc Prev Rehabil 14:386-91. 2007
  7. ncbi request reprint Genetic background of Lewis negative blood group phenotype and its association with atherosclerotic disease in the NHLBI family heart study
    V Salomaa
    National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
    J Intern Med 247:689-98. 2000
  8. ncbi request reprint Trends in coronary events in Finland during 1983-1997. The FINAMI study
    V Salomaa
    KTL National Public Health Institute, Helsinki, Finland
    Eur Heart J 24:311-9. 2003
  9. ncbi request reprint Decline in out-of-hospital coronary heart disease deaths has contributed the main part to the overall decline in coronary heart disease mortality rates among persons 35 to 64 years of age in Finland: the FINAMI study
    V Salomaa
    KTL National Public Health Institute, Department of Epidemiology and Health Promotion, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Circulation 108:691-6. 2003
  10. ncbi request reprint The effect of correcting for troponins on trends in coronary heart disease events in Finland during 1993-2002: the FINAMI study
    Veikko Salomaa
    KTL National Public Health Institute, Mannerheimintie 166, FI 00300 Helsinki, Finland
    Eur Heart J 27:2394-9. 2006

Detail Information

Publications105 found, 100 shown here

  1. pmc Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project
    Marie Lise Grisoni
    INSERM, UMR_S 937, Paris, France
    BMC Med Genet 10:44. 2009
    ....
  2. pmc Are coronary event rates declining slower in women than in men - evidence from two population-based myocardial infarction registers in Finland?
    Hanna Riikka Lehto
    Turku University Hospital, Turku, Finland
    BMC Cardiovasc Disord 7:35. 2007
    ..Therefore, we aimed to examine whether the incidence, attack rate and mortality of myocardial infarction (MI) events have declined less in women than in men...
  3. pmc Ankle blood pressure as a predictor of total and cardiovascular mortality
    Heikki Hietanen
    Helsinki Deaconess Institute, Alppikatu 2, Helsinki, Finland
    BMC Cardiovasc Disord 8:3. 2008
    ..We examined the value of ankle blood pressure, together with the exercise blood pressure, as a predictor of cardiovascular (CVD) and total mortality...
  4. ncbi request reprint Cross-sectional association of soluble thrombomodulin with mild peripheral artery disease; the ARIC study. Atherosclerosis Risk in Communities
    V Salomaa
    KTL National Public Health Institute, Department of Epidemiology and Health Promotion, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    Atherosclerosis 157:309-14. 2001
    ..In conclusion, the present results provide some additional evidence on the role of thrombomodulin-protein C pathway in atherosclerotic disease and support our earlier observation on interaction between sTM and factor VIII:C...
  5. ncbi request reprint Hemostatic factors as predictors of coronary events and total mortality: The FINRISK '92 Hemostasis Study
    Veikko Salomaa
    Department of Epidemiology and Health Promotion, KTL National Public Health Institute, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 22:353-8. 2002
    ..Factor VII antigen or coagulant activity or lipoprotein(a) were not independent predictors of CHD risk. These findings support the role of plasminogen as a risk factor for CHD events...
  6. ncbi request reprint Use of secondary preventive medications after the first attack of acute coronary syndrome
    Veikko Salomaa
    KTL National Public Health Institute, Helsinki, Finland
    Eur J Cardiovasc Prev Rehabil 14:386-91. 2007
    ....
  7. ncbi request reprint Genetic background of Lewis negative blood group phenotype and its association with atherosclerotic disease in the NHLBI family heart study
    V Salomaa
    National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
    J Intern Med 247:689-98. 2000
    ..An additional objective was to explore the hypothesis that these mutations are associated with coronary heart disease and inflammatory reaction...
  8. ncbi request reprint Trends in coronary events in Finland during 1983-1997. The FINAMI study
    V Salomaa
    KTL National Public Health Institute, Helsinki, Finland
    Eur Heart J 24:311-9. 2003
    ..To analyse the trends in incidence, recurrence, case fatality, and treatments of acute coronary events in Finland during the 15-year period 1983-97...
  9. ncbi request reprint Decline in out-of-hospital coronary heart disease deaths has contributed the main part to the overall decline in coronary heart disease mortality rates among persons 35 to 64 years of age in Finland: the FINAMI study
    V Salomaa
    KTL National Public Health Institute, Department of Epidemiology and Health Promotion, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Circulation 108:691-6. 2003
    ..Out-of-hospital deaths constitute the majority of all coronary heart disease (CHD) deaths and are therefore of considerable public health significance...
  10. ncbi request reprint The effect of correcting for troponins on trends in coronary heart disease events in Finland during 1993-2002: the FINAMI study
    Veikko Salomaa
    KTL National Public Health Institute, Mannerheimintie 166, FI 00300 Helsinki, Finland
    Eur Heart J 27:2394-9. 2006
    ..The object of this study is to analyse the trends in coronary events in Finland during 1993-2002, correcting for the effect of troponins...
  11. ncbi request reprint A new definition for myocardial infarction: what difference does it make?
    Veikko Salomaa
    Department of Epidemiology, KTL National Public Health Institute, Mannerheimintie 166, FI 00300 Helsinki, Finland
    Eur Heart J 26:1719-25. 2005
    ..We assessed the new definition in hospitalized patients in a large population-based MI register study...
  12. pmc Relation of socioeconomic position to the case fatality, prognosis and treatment of myocardial infarction events; the FINMONICA MI Register Study
    V Salomaa
    KTL National Public Health Institute, Helsinki, Finland
    J Epidemiol Community Health 55:475-82. 2001
    ....
  13. ncbi request reprint Decline of coronary heart disease mortality in Finland during 1983 to 1992: roles of incidence, recurrence, and case-fatality. The FINMONICA MI Register Study
    V Salomaa
    National Public Health Institute, Helsinki, Finland
    Circulation 94:3130-7. 1996
    ..The aim of the present study was to examine the contributions of incidence, recurrence, and case fatality of coronary events to the trends in CHD mortality in three areas of Finland...
  14. ncbi request reprint Intra- and interindividual variability of hemostatic factors and traditional cardiovascular risk factors in a three-year follow-up
    V Salomaa
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Thromb Haemost 79:969-74. 1998
    ..FVII:Ag and plasminogen did not have very good repeatability and more than one measurement of them should be considered if they are used as predictors of cardiovascular disease in prospective studies...
  15. ncbi request reprint Decreasing mortality from acute myocardial infarction: effect of incidence and prognosis
    V Salomaa
    National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
    J Cardiovasc Risk 6:69-75. 1999
    ..There is a need to re-emphasize primary prevention, since heavy reliance on expensive treatments for the post-war baby-boom generation presents a major concern for public health resources...
  16. ncbi request reprint Relationship of socioeconomic status to the incidence and prehospital, 28-day, and 1-year mortality rates of acute coronary events in the FINMONICA myocardial infarction register study
    V Salomaa
    KTL National Public Health Institute, Helsinki, Finland
    Circulation 101:1913-8. 2000
    ..There are, however, very little data on the relation of SES to the incidence, recurrence, and prognosis of myocardial infarction (MI) events...
  17. ncbi request reprint Myocardial infarction in diabetic and non-diabetic persons with and without prior myocardial infarction: the FINAMI Study
    P Pajunen
    KTL National Public Health Institute, Department of Epidemiology and Health Promotion, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    Diabetologia 48:2519-24. 2005
    ..We compared the risk of acute coronary events in diabetic and non-diabetic persons with and without prior myocardial infarction (MI), stratified by age and sex...
  18. ncbi request reprint The association of c-reactive protein, serum amyloid a and fibrinogen with prevalent coronary heart disease--baseline findings of the PAIS project
    P Jousilahti
    Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    Atherosclerosis 156:451-6. 2001
    ..Central obesity needs to be considered as a confounding factor in the observed associations. These findings support the hypothesis that cholesterol-lowering drugs have an anti-inflammatory effect...
  19. ncbi request reprint Socioeconomic status and ischemic stroke: The FINMONICA Stroke Register
    D Jakovljevic
    KTL National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
    Stroke 32:1492-8. 2001
    ..The purpose of the present study was to examine the association of socioeconomic status with ischemic stroke. Besides mortality, we analyzed the incidence, case-fatality ratio, and prognosis of ischemic stroke events...
  20. ncbi request reprint Seasonal variation in the occurrence of stroke in a Finnish adult population. The FINMONICA Stroke Register. Finnish Monitoring Trends and Determinants in Cardiovascular Disease
    D Jakovljevic
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Stroke 27:1774-9. 1996
    ..The aim of this study was to examine seasonal variation in the incidence, mortality, and case-fatality rate of stroke in data from the FINMONICA population-based stroke register...
  21. ncbi request reprint The validity of hospital discharge register data on coronary heart disease in Finland
    M Mahonen
    National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
    Eur J Epidemiol 13:403-15. 1997
    ..Therefore, these data should not be used without confirmation in studies where correct classification of individual outcomes is of crucial importance, such as follow-up studies and case-control studies...
  22. ncbi request reprint Socioeconomic differences in the incidence, mortality and prognosis of intracerebral hemorrhage in Finnish Adult Population. The FINMONICA Stroke Register
    D Jakovljevic
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Neuroepidemiology 20:85-90. 2001
    ..12, 95% confidence interval 1.02-4.40). In conclusion, marked socioeconomic differences were found in the incidence and mortality of ICH, in particular among working aged men...
  23. ncbi request reprint Five-year risk of developing clinical diabetes after first myocardial infarction; the FINAMI study
    P Pajunen
    National Public Health Institute KTL, Helsinki, Finland
    Diabet Med 22:1334-7. 2005
    ....
  24. ncbi request reprint The feasibility of routine mortality and morbidity register data linkage to study the occurrence of acute coronary heart disease events in Finland. The Finnish Cardiovascular Diseases Registers (CVDR) Project
    M Mahonen
    Department of Epidemiology and Health Promotion, KTL National Public Health Institute, Helsinki, Finland
    Eur J Epidemiol 16:701-11. 2000
    ..The CVDR Project data will be instrumental in further research addressing these issues...
  25. ncbi request reprint Symptoms of chronic bronchitis, haemostatic factors, and coronary heart disease risk
    P Jousilahti
    National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
    Atherosclerosis 142:403-7. 1999
    ..Thus, fibrinogen may be associated with a possible mechanism to link chronic bronchitis to coronary heart disease risk, even though the causality of the association cannot be verified in a cross-sectional study...
  26. pmc Contribution of regulatory and structural variations in APOE to predicting dyslipidemia
    Jari H Stengård
    National Public Health Institute, Helsinki, Finland
    J Lipid Res 47:318-28. 2006
    ..Our study suggests that both regulatory and structural variations should be considered when evaluating the utility of APOE for predicting dyslipidemia in the population at large...
  27. ncbi request reprint Array-based multiplex analysis of candidate genes reveals two independent and additive genetic risk factors for myocardial infarction in the Finnish population
    T Pastinen
    Department of Human Molecular Genetics, National Public Health Institute, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    Hum Mol Genet 7:1453-62. 1998
    ..The observation of two separate genes contributing an additive risk of developing MI exemplifies the advantages of multiplex analysis of genetic variation...
  28. doi request reprint Changes in traditional risk factors no longer explain time trends in cardiovascular mortality and its socioeconomic differences
    K Harald
    National Public Health Institute, Mannerheimintie 160, FIN 00300, Helsinki, Finland
    J Epidemiol Community Health 62:251-7. 2008
    ....
  29. ncbi request reprint Socioeconomic inequalities in the incidence, mortality and prognosis of subarachnoid hemorrhage: the FINMONICA Stroke Register
    D Jakovljevic
    KTL National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
    Cerebrovasc Dis 12:7-13. 2001
    ..In conclusion, there is a clear excess mortality and morbidity of SAH in young individuals with low income, particularly among men...
  30. pmc Association of markers of systemic inflammation, C reactive protein, serum amyloid A, and fibrinogen, with socioeconomic status
    P Jousilahti
    National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
    J Epidemiol Community Health 57:730-3. 2003
    ..The aim of this study was to analyse the association of three sensitive markers of systemic inflammation: C reactive protein (CRP), serum amyloid A protein (SAA), and fibrinogen, with socioeconomic status...
  31. ncbi request reprint The feasibility of combining data from routine Hospital Discharge and Causes-of-Death Registers for epidemiological studies on stroke
    M Mahonen
    Department of Epidemiology and Health Promotion, KTL National Public Health Institute, Helsinki, Finland
    Eur J Epidemiol 16:815-7. 2000
    ..The results showed that such data can, with some caution, be used for incidence studies and for identifying first stroke events. They cannot, however, be used for assessing secular trends in all stroke events...
  32. ncbi request reprint Utility of the Arg/Gln polymorphism of the factor VII (FVII) gene, serum lipid levels and body mass index in the prediction of the FVII:C and FVII:Ag in North Karelia; a cross-sectional and prospective study
    J H Stengard
    Department of Epidemiology and Health Promotion, KTL National Public Health Institute, Helsinki, Finland
    Blood Coagul Fibrinolysis 12:445-52. 2001
    ..061 for FVII:Ag). A consequence of these complex genetic architectures is that predictive utility of the Arg/Gln genotypes depends on population, gender, serum lipid levels, and BMI, and changes in these factors over time...
  33. pmc Changes in premature deaths in Finland: successful long-term prevention of cardiovascular diseases
    P Puska
    Division of Health and Chronic Diseases, National Public Health Institute of Finland, Helsinki, Finland
    Bull World Health Organ 76:419-25. 1998
    ..These results show that a major reduction in CVD mortality among the working-age population can take place in association with active reduction of major risk factors, with a favourable impact on cancer and all-causes mortality...
  34. pmc TRIB1 constitutes a molecular link between regulation of sleep and lipid metabolism in humans
    H M Ollila
    Public Health Genomics Unit and Institute for Molecular Medicine FIMM, National Institute for Health and Welfare, Helsinki, Finland
    Transl Psychiatry 2:e97. 2012
    ..The shared genetic background may at least partially explain the mechanism behind the well-established connection between diseases with disrupted metabolism and sleep...
  35. ncbi request reprint C-reactive protein, interleukin-6 and tumor necrosis factor alpha as predictors of incident coronary and cardiovascular events and total mortality. A population-based, prospective study
    Karolina Tuomisto
    Dept of Epidemiology and Health Promotion, KTL National Public Health Institute, Mannerheimintie 166, FI 00300 Helsinki, Finland
    Thromb Haemost 95:511-8. 2006
    ..In conclusion, CRP and TNFalpha were significant, independent predictors of CHD and CVD events and total mortality among men. These findings provide further support to the important role of inflammation in the pathogenesis of CVD...
  36. doi request reprint Increased stroke risk is related to a binge-drinking habit
    Laura Sundell
    National Public Health Institute, Helsinki, Finland
    Stroke 39:3179-84. 2008
    ..The purpose of this study was to evaluate the effect of different drinking patterns on stroke risk, independent of average alcohol intake...
  37. ncbi request reprint Geographical variation in the incidence of acute myocardial infarction in eastern Finland--a Bayesian perspective
    Maarit Viik-Kajander
    National Public Health Institute, Helsinki, Finland
    Ann Med 35:43-50. 2003
    ..We undertook this study to estimate the geographical distribution of Acute Myocardial Infarction (AMI) incidence in the high-risk province of North Karelia and in the province of Kuopio...
  38. pmc The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts
    Juha Karvanen
    Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
    Genet Epidemiol 33:237-46. 2009
    ..1) were associated with blood pressure. These findings underline the need for replication studies in prospective settings and confirm the candidacy of several SNPs that may play a role in the etiology of cardiovascular disease...
  39. pmc Risk alleles of USF1 gene predict cardiovascular disease of women in two prospective studies
    Kati Komulainen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, Helsinki, Finland
    PLoS Genet 2:e69. 2006
    ....
  40. ncbi request reprint Trends in fatal and nonfatal strokes among persons aged 35 to > or =85 years during 1991-2002 in Finland
    Pia Pajunen
    KTL National Public Health Institute, Helsinki, Finland
    Stroke 36:244-8. 2005
    ..Declining trends in the incidence and mortality of stroke have been observed in Finland since the beginning of the 1980s until 1997. In this study we analyzed the trends in fatal and nonfatal strokes in Finland during 1991-2002...
  41. doi request reprint Thirty-five-year trends in cardiovascular risk factors in Finland
    Erkki Vartiainen
    National Institute for Health and Welfare, Helsinki, Finland
    Int J Epidemiol 39:504-18. 2010
    ..From 1972 to 2007, risk factor surveys have been carried out to monitor risk factor trends and assess their contribution to declining mortality in Finland...
  42. doi request reprint Association of serum C-reactive protein level with sex-specific type 2 diabetes risk: a prospective finnish study
    Gang Hu
    Departments of Health Promotion and Chronic Diseases Prevention, National Public Health Institute, Helsinki FIN 00300, Finland
    J Clin Endocrinol Metab 94:2099-105. 2009
    ..Our objective was to assess whether the association of serum C-reactive protein (CRP) with type 2 diabetes risk is modified by sex...
  43. doi request reprint Associations between interleukin-1 (IL-1) gene variations or IL-1 receptor antagonist levels and the development of type 2 diabetes
    K Luotola
    Department of Medicine, Helsinki University Hospital, Helsinki, Finland
    J Intern Med 269:322-32. 2011
    ..We further examined whether genetic variants at the interleukin-1 (IL-1) locus would predict clinically incident diabetes...
  44. doi request reprint Further evidence for the role of ENPP1 in obesity: association with morbid obesity in Finns
    Kaisa Valli-Jaakola
    Department of Medicine and Research Program for Molecular Medicine, University of Helsinki, Helsinki, Finland
    Obesity (Silver Spring) 16:2113-9. 2008
    ..In this study, we did not find association between the frequently studied ENPP1 K121Q variant, nor SNPs in the MCR or POMC genes and obesity or type 2 diabetes...
  45. pmc High prevalence of four long QT syndrome founder mutations in the Finnish population
    Annukka Marjamaa
    Research Program in Molecular Medicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Ann Med 41:234-40. 2009
    ..In the present survey, we sought to estimate the actual prevalence of the founder mutations and to determine their effect sizes in the general Finnish population...
  46. pmc Associations of traffic related air pollutants with hospitalisation for first acute myocardial infarction: the HEAPSS study
    T Lanki
    Environmental Epidemiology Unit, National Public Health Institute KTL, Kuopio, Finland
    Occup Environ Med 63:844-51. 2006
    ..Acute myocardial infarction (AMI) is the leading cause of death attributed to cardiovascular diseases. An association between traffic related air pollution and AMI has been suggested, but the evidence is still limited...
  47. ncbi request reprint Associations of fine and ultrafine particulate air pollution with stroke mortality in an area of low air pollution levels
    Jaana Kettunen
    Environmental Epidemiology Unit, Kuopio, Finland
    Stroke 38:918-22. 2007
    ..We therefore evaluated the effects of several particle measures including, for the first time to our knowledge, ultrafine particles (<0.1 microm) on stroke...
  48. ncbi request reprint The association of sensitive systemic inflammation markers with bronchial asthma
    Pekka Jousilahti
    University of Helsinki, Department of Public Health, Finland
    Ann Allergy Asthma Immunol 89:381-5. 2002
    ..Airway inflammation is a characteristic feature of bronchial asthma. Previous studies have shown an increased local inflammatory activity in the airway mucosa of asthma patients...
  49. ncbi request reprint Modifiable risk factors have an impact on socio-economic differences in coronary heart disease events
    Kennet Harald
    National Public Health Institute, Helsinki, Finland
    Scand Cardiovasc J 40:87-95. 2006
    ....
  50. ncbi request reprint Environmental tobacco smoke and the risk of cardiovascular disease
    Pekka Jousilahti
    University of Helsinki, Department of Public Health, Finland
    Scand J Work Environ Health 28:41-51. 2002
    ..Firm and timely actions are needed to protect people from exposure to environmental tobacco smoke, both in occupational and other environments...
  51. pmc Contributions of 18 additional DNA sequence variations in the gene encoding apolipoprotein E to explaining variation in quantitative measures of lipid metabolism
    Jari H Stengård
    National Public Health Institute, Helsinki, Finland
    Am J Hum Genet 71:501-17. 2002
    ....
  52. ncbi request reprint Coronary heart disease: from a disease of middle-aged men in the late 1970s to a disease of elderly women in the 2000s
    Anna Kattainen
    Department of Health and Functional Capacity, National Public Health Institute, Mannerheimintie 166, FI 00300 Helsinki, Finland
    Eur Heart J 27:296-301. 2006
    ..To analyse secular changes in the prevalence of coronary heart disease (CHD) and to assess changes in the burden of CHD at population level...
  53. ncbi request reprint The validation of the Finnish Hospital Discharge Register and Causes of Death Register data on stroke diagnoses
    Hanna Tolonen
    Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute KTL, Helsinki, Finland
    Eur J Cardiovasc Prev Rehabil 14:380-5. 2007
    ..The purpose of this study was to evaluate the validity of the Finnish hospital discharge registers and causes of death registers stroke diagnoses against the population-based FINSTROKE register...
  54. pmc Non-participation and mortality in different socioeconomic groups: the FINRISK population surveys in 1972-92
    Kennet Harald
    National Public Health Institute, Mannerheimintie 160, FIN 00300, Helsinki, Finland
    J Epidemiol Community Health 61:449-54. 2007
    ....
  55. pmc Combined effects of thrombosis pathway gene variants predict cardiovascular events
    Kirsi Auro
    0Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    PLoS Genet 3:e120. 2007
    ..These results suggest that variants in these four thrombosis genes contribute to arterial cardiovascular events at population level...
  56. pmc Gender differences in genetic risk profiles for cardiovascular disease
    Kaisa Silander
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    PLoS ONE 3:e3615. 2008
    ..We aimed to estimate whether the genetic risk profiles of coronary heart disease (CHD), ischemic stroke and the composite end-point of CVD differ between the genders...
  57. ncbi request reprint Gender differences in the treatment and secondary prevention of CHD at population level
    Anna Kattainen
    Department of Health and Functional Capacity, National Public Health Institute, Helsinki and Turku, Finland
    Scand Cardiovasc J 39:327-33. 2005
    ..The aim of this study was to investigate the state of treatment and secondary prevention of CHD in a population-based sample and to analyze possible gender differences in different age groups...
  58. ncbi request reprint Variation in the selenoprotein S gene locus is associated with coronary heart disease and ischemic stroke in two independent Finnish cohorts
    Mervi Alanne
    Department of Molecular Medicine, KTL National Public Health Institute, Biomedicum, Helsinki, Finland
    Hum Genet 122:355-65. 2007
    ..This observation should stimulate further investigations of the role of this gene and protein in the pathogenesis of CVD...
  59. ncbi request reprint The validity of the Finnish Hospital Discharge Register and Causes of Death Register data on coronary heart disease
    Pia Pajunen
    National Public Health Institute, Helsinki, Finland
    Eur J Cardiovasc Prev Rehabil 12:132-7. 2005
    ....
  60. ncbi request reprint Trends in fatal and non-fatal coronary heart disease events in Finland during 1991-2001
    Pia Pajunen
    KTL National Public Health Institute, Helsinki, Finland
    Scand Cardiovasc J 38:340-4. 2004
    ..To analyse the trends in fatal and non-fatal coronary heart disease (CHD) events in Finland during an 11-year period 1991-2001...
  61. ncbi request reprint Hemostatic factors as predictors of stroke and cardiovascular diseases: the FINRISK '92 Hemostasis Study
    Maria Rajecki
    Department of Epidemiology and Health Promotion, KTL National Public Health Institute, Helsinki, Finland
    Blood Coagul Fibrinolysis 16:119-24. 2005
    ..25; 95% CI, 0.99-1.58). In conclusion, the present study supports the observations that fibrinogen and plasminogen are significant predictors of CVD events, independently of conventional risk factors...
  62. ncbi request reprint Associations of leisure time physical activity, self-rated physical fitness, and estimated aerobic fitness with serum C-reactive protein among 3,803 adults
    Katja Borodulin
    Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Atherosclerosis 185:381-7. 2006
    ..Serum C-reactive protein (CRP), a marker of systemic inflammation, is a risk factor for cardiovascular disease. Obesity and physical activity are associated with CRP, though population studies are sparse...
  63. ncbi request reprint Explaining the decline in coronary heart disease mortality in Finland between 1982 and 1997
    Tiina Laatikainen
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Am J Epidemiol 162:764-73. 2005
    ..It also emphasizes the importance of maximizing population coverage of effective treatments...
  64. ncbi request reprint Socioeconomic inequities in invasive cardiac procedures after first myocardial infarction in Finland in 1995
    Tiina Hetemaa
    National Research and Development Centre for Welfare and Health STAKES, Outcome and Equity Research, Lintulahdenkuja 4, 00530, Helsinki, Finland
    J Clin Epidemiol 57:301-8. 2004
    ..We examined socioeconomic disparities in coronary procedure rates after first events among hospitalized myocardial infarction (MI) patients...
  65. doi request reprint Geographic patterns of incidence of ischemic stroke and acute myocardial infarction in Finland during 1991-2003
    Aki S Havulinna
    Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
    Ann Epidemiol 18:206-13. 2008
    ..To examine geographic variation in the incidence of ischemic stroke (IS) and acute myocardial infarction (AMI) in Finland during 1991-2003...
  66. ncbi request reprint Predictive value of electrocardiographic QT interval and T-wave morphology parameters for all-cause and cardiovascular mortality in a general population sample
    Kimmo Porthan
    Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
    Heart Rhythm 6:1202-8, 1208.e1. 2009
    ..The predictive value of ECG QT interval for mortality in the general population has been weak. Only a few population studies on the predictive value of ECG T-wave morphology parameters for mortality have been reported...
  67. pmc Genetic association and interaction analysis of USF1 and APOA5 on lipid levels and atherosclerosis
    Pirkka Pekka Laurila
    Public Health Genomics Unit, National Institute for Health and Welfare and Institute for Molecular Medicine, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 30:346-52. 2010
    ..No detailed studies about the effect of APOA5 on atherosclerotic lesion formation have been conducted, nor has its potential interaction with USF1 been examined...
  68. ncbi request reprint Evaluating whole genome amplification via multiply-primed rolling circle amplification for SNP genotyping of samples with low DNA yield
    Kaisa Silander
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Twin Res Hum Genet 8:368-75. 2005
    ..Thus, WGA is applicable for low DNA yield samples, especially if using pooled WGA samples. A higher rate of genotyping errors requires that increased attention be paid to genotyping quality control, and caution when interpreting results...
  69. pmc Total and cause specific mortality among participants and non-participants of population based health surveys: a comprehensive follow up of 54 372 Finnish men and women
    Pekka Jousilahti
    National Public Health Institute, Department of Epidemiology and Health Promotion, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    J Epidemiol Community Health 59:310-5. 2005
    ..To assess total and cause specific mortality among participants and non-participants of large population based health surveys...
  70. doi request reprint The return of unexpected research results in a biobank study and referral to health care for heritable long QT syndrome
    A Haukkala
    Department of Social Research, University of Helsinki, Helsinki, Finland
    Public Health Genomics 16:241-50. 2013
    ....
  71. pmc Common candidate gene variants are associated with QT interval duration in the general population
    A Marjamaa
    Research Program in Molecular Medicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    J Intern Med 265:448-58. 2009
    ..As 30-40% of the QT-interval variability is heritable, we tested the association of common LQTS and NOS1AP gene variants with QT interval in a Finnish population-based sample...
  72. ncbi request reprint Thrombomodulin gene polymorphisms and haplotypes and the risk of cardiovascular events: a prospective follow-up study
    K Auro
    Department of Molecular Medicine, KTL, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 26:942-7. 2006
    ....
  73. ncbi request reprint Antibodies to periodontal pathogens are associated with coronary heart disease
    Pirkko J Pussinen
    Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 23:1250-4. 2003
    ....
  74. ncbi request reprint Evaluation of HLA-DRB1 imputation using a Finnish dataset
    E Vlachopoulou
    Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, FI 00014, Finland
    Tissue Antigens 83:350-5. 2014
    ..The imputation success for HLA-DRB1 alleles was very low pointing to the importance of population-specific reference material...
  75. ncbi request reprint Association of celiac disease genes with inflammatory bowel disease in Finnish and Swedish patients
    A S Parmar
    Research Program for Molecular Medicine, University of Helsinki, Helsinki, Finland
    Genes Immun 13:474-80. 2012
    ..Multiple CelD risk loci also confer susceptibility for CD and/or UC in the Finnish and Swedish populations. Certain genetic risk variants may furthermore predispose an individual for developing a particular disease phenotype...
  76. pmc Distinct variants at LIN28B influence growth in height from birth to adulthood
    Elisabeth Widen
    Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
    Am J Hum Genet 86:773-82. 2010
    ..These findings imply a critical role for LIN28B in the regulation of human growth...
  77. ncbi request reprint A candidate gene study in low HDL-cholesterol families provides evidence for the involvement of the APOA2 gene and the APOA1C3A4 gene cluster
    Heidi E Lilja
    Department of Human Molecular Genetics, National Public Health Institute, Helsinki, Finland
    Atherosclerosis 164:103-11. 2002
    ....
  78. ncbi request reprint A two-base deletion -439delGC in the melanocortin-4 receptor promoter associated with early-onset obesity
    Kaisa Valli-Jaakola
    Department of Medicine and Research Program in Molecular Medicine, University of Helsinki, Helsinki, Finland
    Horm Res 66:61-9. 2006
    ..We searched for mutations in MC4R promoter and Nhlh2 gene in 152 children with severe early-onset obesity. Lean subjects (n = 447) served as controls...
  79. pmc Relationship of common candidate gene variants to electrocardiographic T-wave peak to T-wave end interval and T-wave morphology parameters
    Kimmo Porthan
    Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
    Heart Rhythm 7:898-903. 2010
    ....
  80. pmc Fibrinogen, social position, and "Mendelian randomisation"
    Pekka Jousilahti
    J Epidemiol Community Health 58:883. 2004
  81. ncbi request reprint Endotoxemia, immune response to periodontal pathogens, and systemic inflammation associate with incident cardiovascular disease events
    Pirkko J Pussinen
    Institute of Dentistry, University of Helsinki, Haartmaninkatu 8, PO Box 63, FI 00014 Helsinki, Finland
    Arterioscler Thromb Vasc Biol 27:1433-9. 2007
    ..We investigated in a prospective study the associations of serum endotoxin, antibodies to periodontal pathogens, and inflammation markers with the risk of incident CVD...
  82. ncbi request reprint Association of criteria pollutants with plasma hemostatic/inflammatory markers: a population-based study
    Duanping Liao
    Department of Health Evaluation Sciences, Pennsylvania State University College of Medicine, Hershey, 17033, USA
    J Expo Anal Environ Epidemiol 15:319-28. 2005
    ....
  83. ncbi request reprint Declining incidence and mortality of stroke in persons aged > or = 75 years in Finland; the FINSTROKE study
    Aapo Lehtonen
    Turku City Hospital, Turku, Finland
    Eur J Cardiovasc Prev Rehabil 11:466-70. 2004
    ..The aim of the present study was to analyse the trends in incidence, mortality and prognosis of acute stroke events in persons aged > or = 75 years in Finland...
  84. ncbi request reprint The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster
    Stephanie M Fullerton
    Department of Anthropology, Penn State University, 409 Carpenter Bldg, University Park, PA 16802, USA
    Hum Genet 115:36-56. 2004
    ..The implications of these findings for other haplotype-based descriptions of human variation are discussed...
  85. ncbi request reprint Continuous 15-year decrease in incidence and mortality of stroke in Finland: the FINSTROKE study
    Juhani Sivenius
    University Hospital of Kuopio, Brain Research and Rehabilitation Center Neuron, Kuopio, Finland
    Stroke 35:420-5. 2004
    ..The purpose of this study was to analyze the incidence and mortality trends in stroke events among persons 25 to 74 years of age in Finland during 1983 to 1997...
  86. pmc The SLC6A14 gene shows evidence of association with obesity
    Elina Suviolahti
    Department of Human Genetics, University of California, Los Angeles, USA
    J Clin Invest 112:1762-72. 2003
    ..003). The SLC6A14 gene is an interesting novel candidate for obesity because it encodes an amino acid transporter, which potentially regulates tryptophan availability for serotonin synthesis and thus possibly affects appetite control...
  87. pmc Insulin-regulated increase of soluble vascular adhesion protein-1 in diabetes
    Marko Salmi
    MediCity Research Laboratory, University of Turku, Tykistokatu 6A, 20520 Turku, Finland
    Am J Pathol 161:2255-62. 2002
    ..In conclusion insulin appears to regulate shedding or clearance of VAP-1, and an increase in sVAP-1 because of absolute or relative insulin deficiency may be directly involved in the pathogenesis of diabetic angiopathy...
  88. ncbi request reprint The risk of stroke following coronary revascularization -- a population-based long-term follow-up study
    Minna M Kaarisalo
    Department of Neurology, University of Turku, Turku, Finland
    Scand Cardiovasc J 36:231-6. 2002
    ..To study the incidence and risk factors of stroke after coronary artery bypass grafting (CABG) or percutaneous transluminal coronary angioplasty (PTCA)...
  89. ncbi request reprint Sequence polymorphism at the human apolipoprotein AII gene ( APOA2): unexpected deficit of variation in an African-American sample
    Stephanie M Fullerton
    Institute of Molecular Evolutionary Genetics, Department of Biology, Pennsylvania State University, University Park 16802, USA
    Hum Genet 111:75-87. 2002
    ..The deficit of polymorphism is consistent with a population-specific non-neutral increase in the relative frequency of several haplotypes in Jackson...
  90. ncbi request reprint Return to work after first myocardial infarction in 1991-1996 in Finland
    Helena Hämäläinen
    Social Insurance Institution, Research Department, Turku, Finland
    Eur J Public Health 14:350-3. 2004
    ..A substantial number of myocardial infarctions (MI) occur at working age. It is, however, insufficiently well known how many of these patients return to work after their MI...
  91. ncbi request reprint Association of European population levels of thrombotic and inflammatory factors with risk of coronary heart disease: the MONICA Optional Haemostasis Study
    John Yarnell
    Department of Epidemiology and Public Health, Queen s University of Belfast, UK
    Eur Heart J 26:332-42; discussion 317-8. 2005
    ..We therefore measured thrombotic and inflammatory markers in a substudy of the WHO MONICA project and correlated these with CHD event rates...
  92. pmc A common variant of HMGA2 is associated with adult and childhood height in the general population
    Michael N Weedon
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter EX1 2LU, UK
    Nat Genet 39:1245-50. 2007
    ..There are few examples of common genetic variants reproducibly associated with human quantitativetraits; these results represent, to our knowledge, the first consistently replicated association with adult and childhood height...
  93. ncbi request reprint Prevalence and incidence of primary biliary cirrhosis are increasing in Finland
    Henna Rautiainen
    Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, Finland
    Scand J Gastroenterol 42:1347-53. 2007
    ..To examine the epidemiology of primary biliary cirrhosis (PBC) in Finland and to evaluate whether the possible increase in prevalence was attributable to the increasing incidence, better survival, or both...
  94. ncbi request reprint DNA variants, plasma levels and variability of C-reactive protein in myocardial infarction survivors: results from the AIRGENE study
    Melanie Kolz
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Eur Heart J 29:1250-8. 2008
    ..This study evaluated the association of gene polymorphisms with differences in C-reactive protein concentrations and assessed its intra-individual variability as a marker of individual response...
  95. ncbi request reprint Trends in lifestyle factors affecting blood pressure in hypertensive and normotensive Finns during 1982-2002
    Mika Kastarinen
    Department of Internal Medicine, Kuopio University Hospital, Kuopio, Finland
    J Hypertens 25:299-305. 2007
    ..To assess the trends in blood pressure (BP) affecting lifestyle factors in hypertensive and normotensive Finns from 1982 to 2002...
  96. ncbi request reprint Evaluation of lipid-lowering therapy and cholesterol goal attainment in Finland: the National FINRISK Study
    Evo Alemao
    Outcomes Research, Merck and Co, Inc, Whitehouse Station, New Jersey, USA
    Am J Cardiovasc Drugs 6:349-55. 2006
    ..European and US study findings show that patients in primary care and specialty care are not adequately treated for cholesterol reduction...
  97. pmc Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
    Sekar Kathiresan
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 40:189-97. 2008
    ..Understanding the molecular, cellular and clinical consequences of the newly identified loci may inform therapy and clinical care...
  98. ncbi request reprint Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism
    Elina Suviolahti
    Department of Molecular Medicine, National Public Health Institute
    Hum Mol Genet 15:377-86. 2006
    ....
  99. ncbi request reprint Coronary events in persons aged 75 years or older in Finland from 1995 to 2002: the FINAMI study
    Heli Koukkunen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Am J Geriatr Cardiol 17:78-86. 2008
    ..In conclusion, one-half of all CHD events occur among persons aged 75 years or older, and elderly patients with CHD represent an increasing burden to the health care system...
  100. ncbi request reprint Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies
    Josefin Ahnström
    Department of Laboratory Medicine, Clinical Chemistry, University of Lund, University Hospital, Malmo, Sweden
    J Lipid Res 49:1912-7. 2008
    ..97 (0.74-1.27) and 0.92 (0.84-1.02), respectively]. In conclusion, no association between apoM and CHD could be found in this study...
  101. ncbi request reprint Diabetes worsens the outcome of acute ischemic stroke
    Minna M Kaarisalo
    Turku City Hospital, Turku, Finland
    Diabetes Res Clin Pract 69:293-8. 2005
    ..To characterize acute stroke events in diabetic patients in a population-based stroke register and to determine the influence of diabetes on the outcome of acute stroke...