Research Topics
Genomes and Genes
Species | Sami PirkolaSummaryAffiliation: National Public Health Institute Country: Finland Publications
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Detail Information
Publications
Suicide in alcohol-dependent individuals: epidemiology and managementSami P Pirkola
Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
CNS Drugs 18:423-36. 2004....
DSM-IV mood-, anxiety- and alcohol use disorders and their comorbidity in the Finnish general population--results from the Health 2000 StudySami P Pirkola
Dept of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
Soc Psychiatry Psychiatr Epidemiol 40:1-10. 2005..Information on prevalence, accumulation and variation of common mental disorders is essential for both etiological research and development of mental health service systems...
Childhood adversities as risk factors for adult mental disorders: results from the Health 2000 studySami Pirkola
Dept of Mental Health and Alcohol Research, National Public Health Institute KTL, Mannerheimintie 166, 00300, Helsinki, Finland
Soc Psychiatry Psychiatr Epidemiol 40:769-77. 2005..The sex-specific role of stressful or traumatic childhood experiences and adverse circumstances in developing adulthood mental disorders is complex and still in need of comprehensive research...
Currently active and remitted alcohol dependence in a nationwide adult general population--results from the Finnish Health 2000 studySami P Pirkola
Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
Alcohol Alcohol 41:315-20. 2006..To study the factors relating to remission from alcohol dependence in the general population...
Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumptionLeena Kovanen
Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland
Alcohol Alcohol 45:303-11. 2010..Our aim was to study whether circadian clock gene polymorphisms predispose to alcohol dependence or abuse or other alcohol-related characteristics...
Geographic variation and sociodemographic characteristics of psychotic disorders in FinlandJonna Perälä
National Public Health Institute, Department of Mental Health and Alcohol Research, Helsinki, Finland
Schizophr Res 106:337-47. 2008..We examined the geographical variation in the lifetime prevalence of psychotic disorders in a comprehensive general population study...
Treatment of major depressive disorder in the Finnish general populationJuha Hämäläinen
Department of Mental Health and Alcohol Research, National Public Health Institute, 00300 Helsinki, Finland
Depress Anxiety 26:1049-59. 2009..We estimated the rates of different treatments and the effect of individual and disorder characteristics plus provider type on treatment received...
Support for involvement of glutamate decarboxylase 1 and neuropeptide Y in anxiety susceptibilityJonas Donner
Research Programs Unit, Molecular Neurology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
Am J Med Genet B Neuropsychiatr Genet 159:316-27. 2012..003). In conclusion, we provide further support for involvement of mainly GAD1, but also NPY in determining predisposition to anxiety disorders...
Alcohol consumption and all-cause mortality among elderly in FinlandJukka T Halme
National Institute for Health and Welfare, Helsinki, Finland
Drug Alcohol Depend 106:212-8. 2010..To estimate the gender-specific prevalences of alcohol consumption levels and to investigate the association between heavy drinking and all-cause mortality among elderly males...
General health and quality-of-life measures in active, recent, and comorbid mental disorders: a population-based health 2000 studySami Pirkola
Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
Compr Psychiatry 50:108-14. 2009..We studied the impact of comorbidity and recency in psychiatric disorders on psychological well-being, perceived health, and quality of life and compared their effect with the effect of a chronic medical condition, type 2 diabetes mellitus...
Type 2 diabetes among persons with schizophrenia and other psychotic disorders in a general population surveyJaana Suvisaari
Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
Eur Arch Psychiatry Clin Neurosci 258:129-36. 2008....
Childhood and current determinants of heavy drinking in early adulthoodLaura Kestilä
Department of Health and Functional Capacity, National Public Health Institute KTL, Mannerheimintie 166, FI 00300 Helsinki, Finland
Alcohol Alcohol 43:460-9. 2008..To explore the association of parental education, childhood living conditions and several adversities with heavy drinking in early adulthood, and to analyze the effect of the respondent's current circumstances on these associations...
Antidepressant utilisation patterns and determinants of short-term and non-psychiatric use in the Finnish general adult populationSinikka Sihvo
STAKES National Research and Development Centre for Welfare and Health, Helsinki, Finland
J Affect Disord 110:94-105. 2008..The aim was to study utilisation patterns and determinants of antidepressant use in the general population >30 years, especially short-term use or use not related to known psychiatric morbidity...
Alcohol consumption, abstaining, health utility, and quality of life--a general population survey in FinlandSamuli I Saarni
National Public Health Institute, Department of Mental Health and Alcohol Research, Helsinki, Finland
Alcohol Alcohol 43:376-86. 2008..To examine the associations between alcohol consumption and utility-based health-related quality of life (HRQoL), subjective quality of life (QoL), self-rated health (SRH), and mental distress...
Hazardous drinking: prevalence and associations in the Finnish general populationJukka T Halme
Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
Alcohol Clin Exp Res 32:1615-22. 2008..This study aimed to investigate the prevalence and associations of hazardous drinking in comparison to AUDs, moderate drinking, and abstinence...
Contribution of adenosine related genes to the risk of depression with disturbed sleepNatalia Gass
Department of Physiology, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
J Affect Disord 126:134-9. 2010..One of the key substances regulating sleep is adenosine. We hypothesized that variations in polymorphic sites of adenosine related genes may predispose to depression with sleep disturbances...
Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbanceSiddheshwar J Utge
Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland
PLoS ONE 5:e9259. 2010..These findings support a connection between circadian genes and gender-dependent depression and defective sleep regulation...
An association analysis of circadian genes in anxiety disordersTessa Sipilä
Research Program of Molecular Neurology, University of Helsinki, Helsinki, Finland
Biol Psychiatry 67:1163-70. 2010..We tested this hypothesis with a genetic association analysis...
Living arrangements, heavy drinking and alcohol dependenceKaisla Joutsenniemi
National Public Health Institute KTL, Department of Health and Functional Capacity, Mannerheimintie 166, Helsinki, Finland
Alcohol Alcohol 42:480-91. 2007..To assess the variation in heavy drinking and alcohol dependence by living arrangements, and the contribution of social and behavioural factors to this variation...
Impact of psychiatric disorders on health-related quality of life: general population surveySamuli I Saarni
Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
Br J Psychiatry 190:326-32. 2007..Measurement of health-related quality of life (HRQoL) with generic preference-based instruments enables comparisons of severity across different conditions and treatments. This is necessary for rational public health policy...
Lifetime prevalence of psychotic and bipolar I disorders in a general populationJonna Perälä
Department of Mental Health and Alcohol Research, National Public Health Institute, University of Helsinki, Mannerheimintie 166, 0300 Helsinki, Finland
Arch Gen Psychiatry 64:19-28. 2007..Recent general population surveys of psychotic disorders have found low lifetime prevalences. However, this may be owing to methodological problems. Few studies have reported the prevalences of all specific psychotic disorders...
Alcohol-induced psychotic disorder and delirium in the general populationJonna Perälä
National Institute for Health and Welfare, Department of Mental Health and Substance Abuse Services, Helsinki, Finland
Br J Psychiatry 197:200-6. 2010..Epidemiological data on alcohol-induced psychotic disorder and delirium (alcohol-induced psychotic syndrome, AIPS) are scarce...
Influence of parental education, childhood adversities, and current living conditions on daily smoking in early adulthoodLaura Kestilä
Department of Health and Functional Capacity, National Public Health Institute KTL, Helsinki, Finland
Eur J Public Health 16:617-26. 2006....
Do means matter?: Differences in characteristics of Finnish suicide completers using different methodsSami Pirkola
Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
J Nerv Ment Dis 191:745-50. 2003..For instance, carefulness in the practice of prescribing of intoxicating substances to particular psychiatric patients seems justified...
Childhood adversities are associated with shorter telomere length at adult age both in individuals with an anxiety disorder and controlsLaura Kananen
Research Program of Molecular Neurology, Faculty of Medicine, University of Helsinki, Helsinki, Finland
PLoS ONE 5:e10826. 2010..This finding has potentially important implications supporting the view that childhood adversities might have a considerable impact on well being later in life...
Alcohol dependence in relation to burnout among the Finnish working populationKirsi Ahola
Finnish Institute of Occupational Health, Helsinki, Finland
Addiction 101:1438-43. 2006..To investigate the relationship of burnout to alcohol dependence and high alcohol consumption...
Living arrangements and mental health in FinlandKaisla Joutsenniemi
National Public Health Institute KTL, Department of Health and Functional Capacity, Mannerheimintie 166, 00300 Helsinki, Finland
J Epidemiol Community Health 60:468-75. 2006..This study aims to establish the extent and determinants of mental health differences by living arrangement in terms of psychological distress (GHQ) and DSM-IV psychiatric disorders (CIDI)...
The Beck Depression Inventory and General Health Questionnaire as measures of depression in the general population: a validation study using the Composite International Diagnostic Interview as the gold standardAnna Mari Aalto
National Institute for Health and Welfare, Helsinki, Finland
Psychiatry Res 197:163-71. 2012..Even the 6-item version of the BDI showed acceptable criterion validity, although replication in an independent dataset is needed to confirm its validity...
Cyclic time patterns of death from suicide in northern FinlandTimo Partonen
Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
J Affect Disord 78:11-9. 2004..Seasonal variations in day length and temperature seem likely to contribute to the timing of the suicide process...
Assessment of the neuropeptide S system in anxiety disordersJonas Donner
Research Program of Molecular Neurology, Biomedicum Helsinki, Helsinki, Finland
Biol Psychiatry 68:474-83. 2010..We addressed here the role of NPS and NPSR1 as susceptibility genes for human anxiety disorders...
Community mental-health services and suicide rate in Finland: a nationwide small-area analysisSami Pirkola
Mental Health Group, National Research and Development Centre for Welfare and Health STAKES, Helsinki, Finland
Lancet 373:147-53. 2009..We investigated this reform by assessing the relation between suicide risk and different ways of organising mental-health services...
A population-based association study of candidate genes for depression and sleep disturbanceSiddheshwar Utge
Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland
Am J Med Genet B Neuropsychiatr Genet 153:468-76. 2010..These differences may partially explain the broad spectrum of depressive symptoms, and their systematic monitoring could potentially be used for diagnostic purposes...
