Tiina Paunio

Summary

Affiliation: National Public Health Institute
Country: Finland

Publications

  1. ncbi request reprint Tissue distribution and levels of gelsolin mRNA in normal individuals and patients with gelsolin-related amyloidosis
    T Paunio
    Department of Human Molecular Genetics, National Public Health Institute, Helsinki, Finland
    FEBS Lett 406:49-55. 1997
  2. ncbi request reprint Genome-wide scan in a nationwide study sample of schizophrenia families in Finland reveals susceptibility loci on chromosomes 2q and 5q
    T Paunio
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, PL 104, 00251 Helsinki, Finland
    Hum Mol Genet 10:3037-48. 2001
  3. doi request reprint Longitudinal study on poor sleep and life dissatisfaction in a nationwide cohort of twins
    Tiina Paunio
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Am J Epidemiol 169:206-13. 2009
  4. ncbi request reprint Search for cognitive trait components of schizophrenia reveals a locus for verbal learning and memory on 4q and for visual working memory on 2q
    Tiina Paunio
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Hum Mol Genet 13:1693-702. 2004
  5. pmc Association of a nonsynonymous variant of DAOA with visuospatial ability in a bipolar family sample
    Pia Soronen
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Biol Psychiatry 64:438-42. 2008
  6. pmc Linkage analysis of schizophrenia controlling for population substructure
    Tiina Paunio
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Am J Med Genet B Neuropsychiatr Genet 150:827-35. 2009
  7. ncbi request reprint Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1
    William Hennah
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Hum Mol Genet 16:453-62. 2007
  8. pmc Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance
    Siddheshwar J Utge
    Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland
    PLoS ONE 5:e9259. 2010
  9. doi request reprint Mixture model clustering of phenotype features reveals evidence for association of DTNBP1 to a specific subtype of schizophrenia
    Jaana Wessman
    Department of Molecular Medicine, Helsinki, Finland
    Biol Psychiatry 66:990-6. 2009
  10. pmc Shared genetic background for regulation of mood and sleep: association of GRIA3 with sleep duration in healthy Finnish women
    Siddheshwar Utge
    Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland
    Sleep 34:1309-16. 2011

Detail Information

Publications51

  1. ncbi request reprint Tissue distribution and levels of gelsolin mRNA in normal individuals and patients with gelsolin-related amyloidosis
    T Paunio
    Department of Human Molecular Genetics, National Public Health Institute, Helsinki, Finland
    FEBS Lett 406:49-55. 1997
    ..The high level of expression of the gelsolin gene in the skin in general could locally contribute to the characteristic skin amyloidosis in FAF patients...
  2. ncbi request reprint Genome-wide scan in a nationwide study sample of schizophrenia families in Finland reveals susceptibility loci on chromosomes 2q and 5q
    T Paunio
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, PL 104, 00251 Helsinki, Finland
    Hum Mol Genet 10:3037-48. 2001
    ..The chromosome 5q finding is of particular interest, since several other studies have also shown evidence for linkage in the vicinity of this locus...
  3. doi request reprint Longitudinal study on poor sleep and life dissatisfaction in a nationwide cohort of twins
    Tiina Paunio
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Am J Epidemiol 169:206-13. 2009
    ..21 for men and 0.27 for women in a multivariate genetic model. This finding is consistent with the hypothesis that poor sleep may have direct effects on the brain, emotions, and mood...
  4. ncbi request reprint Search for cognitive trait components of schizophrenia reveals a locus for verbal learning and memory on 4q and for visual working memory on 2q
    Tiina Paunio
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Hum Mol Genet 13:1693-702. 2004
    ..Our results reveal initial information on the effect of the loci associated with schizophrenia in multiple studies, and emphasize the value of trait components in the search for susceptibility loci for complex diseases...
  5. pmc Association of a nonsynonymous variant of DAOA with visuospatial ability in a bipolar family sample
    Pia Soronen
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Biol Psychiatry 64:438-42. 2008
    ..Bipolar disorder and schizophrenia are hypothesized to share some genetic background...
  6. pmc Linkage analysis of schizophrenia controlling for population substructure
    Tiina Paunio
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Am J Med Genet B Neuropsychiatr Genet 150:827-35. 2009
    ..18). Thus the detailed genealogical information led us to identification of distinct linkage signals for schizophrenia susceptibility loci between the three analyses we performed...
  7. ncbi request reprint Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1
    William Hennah
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Hum Mol Genet 16:453-62. 2007
    ..Notably, this and other converging lines of evidence underline the importance of DISC1-related functional pathways in the etiology of schizophrenia...
  8. pmc Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance
    Siddheshwar J Utge
    Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland
    PLoS ONE 5:e9259. 2010
    ..These findings support a connection between circadian genes and gender-dependent depression and defective sleep regulation...
  9. doi request reprint Mixture model clustering of phenotype features reveals evidence for association of DTNBP1 to a specific subtype of schizophrenia
    Jaana Wessman
    Department of Molecular Medicine, Helsinki, Finland
    Biol Psychiatry 66:990-6. 2009
    ..Possible explanations for this are that the genes might be relevant only to certain subtypes of the disease and/or only in certain populations...
  10. pmc Shared genetic background for regulation of mood and sleep: association of GRIA3 with sleep duration in healthy Finnish women
    Siddheshwar Utge
    Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland
    Sleep 34:1309-16. 2011
    ..Here, we examined whether, in healthy individuals, sleep duration is associated with genes that we earlier found to be associated with depressive disorder...
  11. pmc Replication of association between working memory and Reelin, a potential modifier gene in schizophrenia
    Juho Wedenoja
    Institute for Molecular Medicine Finland FIMM, University of Helsinki and National Institute for Health and Welfare, Helsinki, Finland
    Biol Psychiatry 67:983-91. 2010
    ....
  12. doi request reprint Identification of susceptibility loci at 7q31 and 9p13 for bipolar disorder in an isolated population
    Outi M Palo
    FIMM, Institute for Molecular Medicine and National Institute for Health and Welfare, Helsinki, Finland
    Am J Med Genet B Neuropsychiatr Genet 153:723-35. 2010
    ..The loci on the centromeric region of 9p13 and the telomeric region of 7q31 may represent susceptibility loci for mood disorder in the Finnish population...
  13. doi request reprint Concomitants of family histories of mood disorders and alcoholism in a clinical cohort of patients with bipolar I and II disorder
    Outi Mantere
    Department of Mental Health and Substance Abuse Services, National Institute of Health and Welfare, Helsinki, Finland
    J Nerv Ment Dis 200:388-94. 2012
    ..The strongest associations are between FH of mood disorders and presence of comorbid anxiety disorders...
  14. ncbi request reprint The role of DTNBP1, NRG1, and AKT1 in the genetics of schizophrenia in Finland
    Joni A Turunen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, P O Box 104, FI 00251, Helsinki, Finland
    Schizophr Res 91:27-36. 2007
    ..Furthermore, results do not support a major role for NRG1, but we cannot completely exclude a minor role of this gene in the Finnish population...
  15. pmc Association of AKT1 with verbal learning, verbal memory, and regional cortical gray matter density in twins
    Olli P H Pietiläinen
    FIMM, Institute for Molecular Medicine Finland and National Public Health Institute, Biomedicum, Helsinki, Finland
    Am J Med Genet B Neuropsychiatr Genet 150:683-92. 2009
    ..The established association of the same allelic variant of AKT1 with both cognitive and neuroanatomical aberrations could suggest that AKT1 exerts its effect on verbal learning and memory via neural networks involving prefrontal cortex...
  16. ncbi request reprint Association of distinct allelic haplotypes of DISC1 with psychotic and bipolar spectrum disorders and with underlying cognitive impairments
    Outi M Palo
    Department of Molecular Medicine, National Public Health Insitute, Helsinki, Finland
    Hum Mol Genet 16:2517-28. 2007
    ..Finding of alternative associating haplotypes in the same set of BPD families gives evidence for allelic heterogeneity within DISC1, eventually leading to heterogeneity in the clinical outcome as well...
  17. doi request reprint An association between both low and high birth weight and increased disorganized and negative symptom severity in schizophrenia and other psychoses
    Asko Wegelius
    National Institute for Health and Welfare, Department of Mental Health and Substance Abuse Services, Helsinki, Finland
    Psychiatry Res 205:18-24. 2013
    ..Our findings suggest that both low and high birth weight can influence the symptom severity of psychotic disorders. Our results implicate an association between both low and high birth weight and disorganized and negative symptoms...
  18. doi request reprint Impact of temperament on depression and anxiety symptoms and depressive disorder in a population-based birth cohort
    Emma Nyman
    Public Health Genomics Unit, Institute for Molecular Medicine Finland FIMM, University of Helsinki and National Institute for Health and Welfare, Helsinki, Finland
    J Affect Disord 131:393-7. 2011
    ..The aim of this study was to characterize at the population level how innate features of temperament relate to experience of depressive mood and anxiety, and whether these symptoms have separable temperamental backgrounds...
  19. doi request reprint A population-based association study of candidate genes for depression and sleep disturbance
    Siddheshwar Utge
    Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland
    Am J Med Genet B Neuropsychiatr Genet 153:468-76. 2010
    ..These differences may partially explain the broad spectrum of depressive symptoms, and their systematic monitoring could potentially be used for diagnostic purposes...
  20. doi request reprint Contribution of adenosine related genes to the risk of depression with disturbed sleep
    Natalia Gass
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    J Affect Disord 126:134-9. 2010
    ..One of the key substances regulating sleep is adenosine. We hypothesized that variations in polymorphic sites of adenosine related genes may predispose to depression with sleep disturbances...
  21. doi request reprint Neuroticism mediates the effect of P2RX7 on outcomes of mood disorders
    Outi Mantere
    Department of Mental Health and Substance Use, National Institute for Health and Welfare, Helsinki, Finland
    Depress Anxiety 29:816-23. 2012
    ..Here, we test whether the personality trait neuroticism mediates the effect of P2RX7 on the course of mood disorders...
  22. ncbi request reprint Heritability of cognitive functions in families with bipolar disorder
    Mervi Antila
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Am J Med Genet B Neuropsychiatr Genet 144:802-8. 2007
    ..Genetic contribution was low to verbal learning functions. High heritability, in executive functioning and psychomotor processing speed suggest that these may be valid endophenotypic traits for genetic studies of bipolar disorder...
  23. pmc Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits
    Ulla Broms
    Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland
    Nicotine Tob Res 14:720-33. 2012
    ..In this study, we included all 15 tagging single nucleotide polymorphisms (SNPs) within the CHRNA5-CHRNA3-CHRNB4 cluster and tested associations with 30 smoking-related phenotypes...
  24. doi request reprint P2RX7 gene is associated consistently with mood disorders and predicts clinical outcome in three clinical cohorts
    Pia Soronen
    Public Health Genomics Unit, Institute for Molecular Medicine FIMM, National Institute for Health and Welfare, Helsinki, Finland
    Am J Med Genet B Neuropsychiatr Genet 156:435-47. 2011
    ..The same risk alleles resulted in clinically significant differences in outcome of patients with major depressive and bipolar disorder...
  25. ncbi request reprint Haplotype analysis and identification of genes for a complex trait: examples from schizophrenia
    William Hennah
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Ann Med 36:322-31. 2004
    ....
  26. doi request reprint Inter-tissue networks between the basal forebrain, hippocampus, and prefrontal cortex in a model for depression caused by disturbed sleep
    Markus Lagus
    Public Health Genomics Unit and Institute for Molecular Medicine FIMM, National Institute for Health and Welfare, Helsinki, Finland
    J Neurogenet 26:397-412. 2012
    ..We used two already existing tools in a new way, and by careful planning of the input data, managed to extrapolate intricate hidden inter-tissue networks to build a molecular picture of disease...
  27. doi request reprint An association between high birth weight and schizophrenia in a Finnish schizophrenia family study sample
    Asko Wegelius
    National Institute for Health and Welfare, Department of Mental Health and Substance Abuse Services, Helsinki, Finland
    Psychiatry Res 190:181-6. 2011
    ..Our results also point to a potential birth-weight independent association between maternal type 2 diabetes and schizophrenia among offspring...
  28. ncbi request reprint Evidence of susceptibility loci on 4q32 and 16p12 for bipolar disorder
    Jenny M Ekholm
    Department of Molecular Medicine, National Public Health Institute, 00251 Helsinki, Finland
    Hum Mol Genet 12:1907-15. 2003
    ..7. Since the identified chromosomal regions replicate earlier linkage findings in either bipolar disorder or other mental disorders, they should be considered good targets for further genetic analyses...
  29. pmc Environmental stress affects DNA methylation of a CpG rich promoter region of serotonin transporter gene in a nurse cohort
    Jukka S Alasaari
    Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland
    PLoS ONE 7:e45813. 2012
    ..We explored the effect of environmental stress on serotonin transporter gene (SLC6A4) promoter methylation among nurses from high and low work stress environments...
  30. doi request reprint Family history of psychiatric disorders and the outcome of psychiatric patients with DSM-IV major depressive disorder
    K Mikael Holma
    Mood, Depression, and Suicidal Behavior Unit, National Institute for Health and Welfare, Helsinki, Finland
    J Affect Disord 131:251-9. 2011
    ..The correlates of a family history (FH) of mood disorders but not of comorbid disorders among MDD patients have been investigated. Since bipolar disorder (BD) is highly heritable, latent BD may bias findings...
  31. pmc The genome-wide patterns of variation expose significant substructure in a founder population
    Eveliina Jakkula
    Department of Molecular Medicine, National Public Health Institute and Institute for Molecular Medicine Finland FIMM, Helsinki, Finland
    Am J Hum Genet 83:787-94. 2008
    ..Further, the results provide interesting lessons concerning the impact of population history on the genome landscape of humans, as well as approaches to identify rare variants enriched in these subpopulations...
  32. pmc Temperament clusters in a normal population: implications for health and disease
    Jaana Wessman
    Helsinki Institute for Information Technology and Department of Computer Science, University of Helsinki, Helsinki, Finland
    PLoS ONE 7:e33088. 2012
    ..The object of this study was to identify temperament patterns in the Finnish population, and to determine the relationship between these profiles and life habits, socioeconomic status, and health...
  33. pmc Phenotype mining in CNV carriers from a population cohort
    Olli P H Pietiläinen
    Institute for Molecular Medicine Finland, and Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Hum Mol Genet 20:2686-95. 2011
    ..Observation of extensive shared single nucleotide polymorphism haplotypes around deletions suggests an opportunity to expand phenotype mining from cohort samples to the populations from which they derive...
  34. pmc Liability to anxiety and severe life events as predictors of new-onset sleep disturbances
    Jussi Vahtera
    Finnish Institute of Occupational Health, Helsinki, Finland
    Sleep 30:1537-46. 2007
    ..This study examined the effects of liability to anxiety and stressful life events on the onset of sleep disturbances...
  35. doi request reprint Data on schizotypy and affective scales are gender and education dependent--study in the Northern Finland 1966 Birth Cohort
    Jouko Miettunen
    Department of Psychiatry, Oulu University and Oulu University Hospital, Oulu, Finland Academy of Finland, Helsinki, Finland
    Psychiatry Res 178:408-13. 2010
    ..These differences should be taken into account when considering normal values in these scales. The findings indicate that commonly used student samples are likely to be biased when compared to community based samples...
  36. pmc Interaction of early environment, gender and genes of monoamine neurotransmission in the aetiology of depression in a large population-based Finnish birth cohort
    Emma S Nyman
    Public Health Genomics Unit, Institute for Molecular Medicine Finland FIMM, University of Helsinki and National Institute for Health and Welfare, Helsinki, Finland
    BMJ Open 1:e000087. 2011
    ..The results support the role of genes of monoamine neurotransmission in the aetiology of depression conditional on environmental risk and sex, but not direct major effects of monoaminergic genes in this unselected population...
  37. ncbi request reprint Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects
    William Hennah
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Hum Mol Genet 12:3151-9. 2003
    ..Our findings would also encourage more detailed analyses of the effect of DISC1 on the component-traits of schizophrenia...
  38. doi request reprint Gene expression patterns in a rodent model for depression
    Markus Lagus
    Institute for Molecular Medicine FIMM, National Institute for Health and Welfare, Biomedicum, Helsinki, Finland
    Eur J Neurosci 31:1465-73. 2010
    ..The results also highlight the molecular mechanisms in the murine clomipramine model, previously shown to be a valid model for depression...
  39. ncbi request reprint The interval of linkage disequilibrium (LD) detected with microsatellite and SNP markers in chromosomes of Finnish populations with different histories
    Teppo Varilo
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, Helsinki, Finland
    Hum Mol Genet 12:51-9. 2003
    ..1 cM. Our results demonstrate the complexity of the concept of 'detectable LD' and emphasize the importance of understanding population history when designing a strategy for disease gene mapping...
  40. ncbi request reprint Heritability and number of quantitative trait loci of neurocognitive functions in families with schizophrenia
    Annamari Tuulio-Henriksson
    Department of Mental Health and Alcohol Research, National Public Health Institute of Finland, Helsinki
    Am J Med Genet 114:483-90. 2002
    ..Our results suggest that neurocognitive measures, particularly working memory, may provide valid quantitative phenotypic traits for linkage analyses searching predisposing genes for schizophrenia...
  41. ncbi request reprint Role of proprotein convertases in the pathogenic processing of the amyloidosis-associated form of secretory gelsolin
    Hannele Kangas
    Biomedicum Helsinki, Department of Molecular Medicine, National Public Health Institute, Finland
    Amyloid 9:83-7. 2002
    ....
  42. ncbi request reprint Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression
    Timo Partonen
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Ann Med 39:229-38. 2007
    ..We hypothesized that sequence variations in three genes, including Per2, Arntl, and Npas2, which form a functional unit at the core of the circadian clock, predispose to winter depression...
  43. ncbi request reprint Early age at onset of bipolar disorder is associated with more severe clinical features but delayed treatment seeking
    Kirsi Suominen
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Bipolar Disord 9:698-705. 2007
    ..Our aim was to obtain a comprehensive view of differences between bipolar disorder (BD) patients with onset at early versus adult age in a representative study cohort...
  44. pmc RHD maternal-fetal genotype incompatibility increases schizophrenia susceptibility
    Christina G S Palmer
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 90095, USA
    Am J Hum Genet 71:1312-9. 2002
    ..This is the first candidate-gene study to explicitly test for and provide evidence of a maternal-fetal genotype incompatibility mechanism in schizophrenia...
  45. pmc Large recurrent microdeletions associated with schizophrenia
    Hreinn Stefansson
    CNS Division, deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nature 455:232-6. 2008
    ..CNV analysis may also point the way to the identification of additional and more prevalent risk variants in genes and pathways involved in schizophrenia...
  46. ncbi request reprint Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference
    Carolina Johansson
    Neurogenetics Unit, Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Neuropsychopharmacology 28:734-9. 2003
    ..In conclusion, our results suggest involvement of circadian clock-related polymorphisms both in susceptibility to SAD and diurnal preference...
  47. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia
    Cathryn M Lewis
    Division of Genetics and Development, Guy s, King s and St Thomas School of Medicine, London, UK
    Am J Hum Genet 73:34-48. 2003
    ..There is greater consistency of linkage results across studies than has been previously recognized. The results suggest that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations...
  48. ncbi request reprint Gelsolin-related familial amyloidosis, Finnish type, in a Portuguese family: clinical and neurophysiological studies
    Isabel Conceição
    Department of Neurology, Hospital de Santa Maria, Centro de Estudos Egas Moniz, Faculty of Medicine, Institute for Molecular Medicine, Av Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Muscle Nerve 28:715-21. 2003
    ..The Finnish mutation of gelsolin protein (G654A) was detected in five family members. The utility of neurophysiological testing in the evaluation and follow-up of this type of amyloidosis is discussed...
  49. ncbi request reprint Seasonal affective disorder and the G-protein beta-3-subunit C825T polymorphism
    Carolina Johansson
    Neurogenetics Unit, Department of Molecular Medicine, Center for Molecular Medicine L8 00, Karolinska Institutet and Karolinska Hospital, S 171 76 Stockholm, Sweden
    Biol Psychiatry 55:317-9. 2004
    ..Association with seasonal affective disorder (SAD) has been found for the higher activity T-allele of the G-protein beta-3-subunit C825T polymorphism...
  50. ncbi request reprint RHD maternal-fetal genotype incompatibility and schizophrenia: extending the MFG test to include multiple siblings and birth order
    Peter Kraft
    Department of Epidemiology and Biostatistics, Harvard School of Public Health, University of California, Los Angeles, USA
    Eur J Hum Genet 12:192-8. 2004
    ..7, consistent with earlier estimates. Our extension of the MFG test has general application to family-based studies of maternal-genotype and MFG interaction effects...
  51. ncbi request reprint [Epigenetic mechanism underlying psychiatric disorders]
    Tiina Paunio
    Duodecim 122:489-90. 2006