T Partonen

Summary

Affiliation: National Public Health Institute
Country: Finland

Publications

  1. ncbi request reprint Time patterns of attempted suicide
    Hanna Valtonen
    Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, FI 00300 Helsinki, Finland
    J Affect Disord 90:201-7. 2006
  2. doi request reprint Mixture model clustering of phenotype features reveals evidence for association of DTNBP1 to a specific subtype of schizophrenia
    Jaana Wessman
    Department of Molecular Medicine, Helsinki, Finland
    Biol Psychiatry 66:990-6. 2009
  3. pmc Indoors illumination and seasonal changes in mood and behavior are associated with the health-related quality of life
    Sharon Grimaldi
    National Public Health Institute, Department of Mental Health and Alcohol Research, Helsinki, Finland
    Health Qual Life Outcomes 6:56. 2008
  4. pmc Daylight saving time transitions and hospital treatments due to accidents or manic episodes
    Tuuli A Lahti
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    BMC Public Health 8:74. 2008
  5. pmc Drop-out and mood improvement: a randomised controlled trial with light exposure and physical exercise [ISRCTN36478292]
    Sami Leppämäki
    Department of Mental Health and Alcohol Research, Unit for Epidemiology and Genetics of Mental Health, National Public Health Institute, Helsinki, Finland
    BMC Psychiatry 4:22. 2004
  6. pmc Psychosis among "healthy" siblings of schizophrenia patients
    Ritva Arajärvi
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    BMC Psychiatry 6:6. 2006
  7. pmc Effect of simulated dawn on quality of sleep--a community-based trial
    Sami Leppämäki
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    BMC Psychiatry 3:14. 2003
  8. pmc Family-based clusters of cognitive test performance in familial schizophrenia
    Fabian Hoti
    Department of Mathematical Sciences, University of Oulu, Finland
    BMC Psychiatry 4:20. 2004
  9. pmc Seasonal changes, sleep length and circadian preference among twins with bipolar disorder
    Reeta Hakkarainen
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    BMC Psychiatry 3:6. 2003
  10. pmc Transitions into and out of daylight saving time compromise sleep and the rest-activity cycles
    Tuuli A Lahti
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    BMC Physiol 8:3. 2008

Detail Information

Publications86

  1. ncbi request reprint Time patterns of attempted suicide
    Hanna Valtonen
    Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, FI 00300 Helsinki, Finland
    J Affect Disord 90:201-7. 2006
    ..The association of mental disorders with time patterns of attempted suicide is poorly understood...
  2. doi request reprint Mixture model clustering of phenotype features reveals evidence for association of DTNBP1 to a specific subtype of schizophrenia
    Jaana Wessman
    Department of Molecular Medicine, Helsinki, Finland
    Biol Psychiatry 66:990-6. 2009
    ..Possible explanations for this are that the genes might be relevant only to certain subtypes of the disease and/or only in certain populations...
  3. pmc Indoors illumination and seasonal changes in mood and behavior are associated with the health-related quality of life
    Sharon Grimaldi
    National Public Health Institute, Department of Mental Health and Alcohol Research, Helsinki, Finland
    Health Qual Life Outcomes 6:56. 2008
    ..Because the shortage of exposure to daylight or artificial bright light has been linked to the occurrence of the seasonal changes, we wanted to know whether illumination indoors contributes to the HRQoL...
  4. pmc Daylight saving time transitions and hospital treatments due to accidents or manic episodes
    Tuuli A Lahti
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    BMC Public Health 8:74. 2008
    ..The aim of this study was to explore the effects of transitions into and out of daylight saving time on the incidence of accidents and manic episodes in the Finnish population during the years of 1987 to 2003...
  5. pmc Drop-out and mood improvement: a randomised controlled trial with light exposure and physical exercise [ISRCTN36478292]
    Sami Leppämäki
    Department of Mental Health and Alcohol Research, Unit for Epidemiology and Genetics of Mental Health, National Public Health Institute, Helsinki, Finland
    BMC Psychiatry 4:22. 2004
    ..We explored background variables possibly explaining the individual variation in treatment response or failure in a randomised trial...
  6. pmc Psychosis among "healthy" siblings of schizophrenia patients
    Ritva Arajärvi
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    BMC Psychiatry 6:6. 2006
    ..We also analyzed the emergence of psychotic disorders among siblings of patients with schizophrenia during seven to eleven years of follow-up...
  7. pmc Effect of simulated dawn on quality of sleep--a community-based trial
    Sami Leppämäki
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    BMC Psychiatry 3:14. 2003
    ..Disturbances in sleep patterns are common and may compromise wellbeing even in the short term. Our hypothesis was that simulated dawn could improve the subjective quality of sleep during winter...
  8. pmc Family-based clusters of cognitive test performance in familial schizophrenia
    Fabian Hoti
    Department of Mathematical Sciences, University of Oulu, Finland
    BMC Psychiatry 4:20. 2004
    ..The aim of the study was to detect family clusters with similar cognitive test performance...
  9. pmc Seasonal changes, sleep length and circadian preference among twins with bipolar disorder
    Reeta Hakkarainen
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    BMC Psychiatry 3:6. 2003
    ..We aimed at studying the seasonal changes in mood and behaviour, the distribution of hospital admissions by season, and the persistence of the circadian type in twins with bipolar disorder and their healthy co-twins...
  10. pmc Transitions into and out of daylight saving time compromise sleep and the rest-activity cycles
    Tuuli A Lahti
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    BMC Physiol 8:3. 2008
    ..Rest-activity cycles were measured using wrist-worn accelerometers. The participants filled in the Morningness-Eveningness and Seasonal Pattern Assessment Questionnaires before starting the study and kept a sleep diary during the study...
  11. ncbi request reprint [Light modulates the rhythm of circadian time]
    Timo Partonen
    Kansanterveyslaitos, mielenterveyden ja alkoholitutkimuksen osasto, Helsinki
    Duodecim 121:2544-50. 2005
  12. pmc Transition into daylight saving time influences the fragmentation of the rest-activity cycle
    Tuuli A Lahti
    Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, FI 00300 Helsinki, Finland
    J Circadian Rhythms 4:1. 2006
    ..01). CONCLUSION : Transition into daylight saving time may have a disruptive effect on the rest-activity cycle in those healthy adults who are short-sleepers or more of the evening type...
  13. ncbi request reprint Cyclic time patterns of death from suicide in northern Finland
    Timo Partonen
    Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    J Affect Disord 78:11-9. 2004
    ..Seasonal variations in day length and temperature seem likely to contribute to the timing of the suicide process...
  14. ncbi request reprint Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression
    Timo Partonen
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Ann Med 39:229-38. 2007
    ..We hypothesized that sequence variations in three genes, including Per2, Arntl, and Npas2, which form a functional unit at the core of the circadian clock, predispose to winter depression...
  15. ncbi request reprint [Circadian clocks]
    Timo Partonen
    Kansanterveyslaitos, mielenterveyden ja alkoholitutkimuksen osasto, Helsinki
    Duodecim 120:2663-9. 2004
  16. ncbi request reprint Analysis of the seasonal pattern in suicide
    Timo Partonen
    Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    J Affect Disord 81:133-9. 2004
    ..Suicide has been attributed to social and psychological factors but also to geophysical effects. Of the latter, changes in solar radiation and geomagnetic activities may contribute to the frequency and the seasonal pattern of suicides...
  17. ncbi request reprint Time patterns and seasonal mismatch in suicide
    T Partonen
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Acta Psychiatr Scand 109:110-5. 2004
    ..Physical time-givers may have a modifying effect on the time patterns of death from suicide...
  18. ncbi request reprint Bright light improves vitality and alleviates distress in healthy people
    T Partonen
    Department of Psychiatry, University of Helsinki, Helsinki, Finland
    J Affect Disord 57:55-61. 2000
    ..The relative shortage of light during the decreasing photoperiod may compromise well-being. Earlier studies suggest that bright-light exposure may be of help to alleviate winter-bound symptoms...
  19. ncbi request reprint Seasonal affective disorder
    T Partonen
    Department of Psychiatry, University of Helsinki, National Public Health Institute, Finland
    Lancet 352:1369-74. 1998
    ..The best treatment regimens include 2500 Ix of artificial light exposure in the morning. When patients seem to have no response or to prefer another treatment, antidepressants should be considered...
  20. ncbi request reprint Association of low serum total cholesterol with major depression and suicide
    T Partonen
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Br J Psychiatry 175:259-62. 1999
    ..It has been suggested that low serum total cholesterol is associated with an increased risk of suicide...
  21. pmc Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance
    Siddheshwar J Utge
    Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland
    PLoS ONE 5:e9259. 2010
    ..These findings support a connection between circadian genes and gender-dependent depression and defective sleep regulation...
  22. ncbi request reprint Familial loading associates with impairment in visual span among healthy siblings of schizophrenia patients
    Annamari Tuulio-Henriksson
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Biol Psychiatry 54:623-8. 2003
    ..The present study examined this effect among healthy siblings of schizophrenia patients in a Finnish isolate with high prevalence of schizophrenia...
  23. ncbi request reprint Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families
    J Wedenoja
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Mol Psychiatry 13:673-84. 2008
    ..0004-0.0000000004), memory (P=0.02-0.0001) and executive functioning (P=0.001). Our findings suggest that allelic variants of RELN contribute to the endophenotypes of schizophrenia...
  24. ncbi request reprint Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1
    William Hennah
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Hum Mol Genet 16:453-62. 2007
    ..Notably, this and other converging lines of evidence underline the importance of DISC1-related functional pathways in the etiology of schizophrenia...
  25. pmc Association of a nonsynonymous variant of DAOA with visuospatial ability in a bipolar family sample
    Pia Soronen
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Biol Psychiatry 64:438-42. 2008
    ..Bipolar disorder and schizophrenia are hypothesized to share some genetic background...
  26. pmc Replication of association between working memory and Reelin, a potential modifier gene in schizophrenia
    Juho Wedenoja
    Institute for Molecular Medicine Finland FIMM, University of Helsinki and National Institute for Health and Welfare, Helsinki, Finland
    Biol Psychiatry 67:983-91. 2010
    ....
  27. pmc Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses
    Liisa Tomppo
    Institute for Molecular Medicine Finland FIMM and National Public Health Institute, Helsinki, Finland
    Biol Psychiatry 65:1055-62. 2009
    ..Because both DISC1 and NDE1 display association in our study sample, we hypothesized that other genes interacting with DISC1 might also have a role in the etiology of schizophrenia...
  28. doi request reprint Circadian phenotype in patients with the co-morbid alcohol use and bipolar disorders
    Taina Hätönen
    Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, FI 00300 Helsinki, Finland
    Alcohol Alcohol 43:564-8. 2008
    ..We aimed at analysing the behavioural trait of the preference to morning or evening hours for the daily activities in bipolar disorder patients with or without the co-morbid alcohol use...
  29. ncbi request reprint Reduced left hemispheric white matter volume in twins with bipolar I disorder
    Tuula Kieseppä
    Department of Mental Health and Alcohol Research, University of Helsinki, Finland
    Biol Psychiatry 54:896-905. 2003
    ....
  30. ncbi request reprint Association of distinct allelic haplotypes of DISC1 with psychotic and bipolar spectrum disorders and with underlying cognitive impairments
    Outi M Palo
    Department of Molecular Medicine, National Public Health Insitute, Helsinki, Finland
    Hum Mol Genet 16:2517-28. 2007
    ..Finding of alternative associating haplotypes in the same set of BPD families gives evidence for allelic heterogeneity within DISC1, eventually leading to heterogeneity in the clinical outcome as well...
  31. ncbi request reprint Evidence of susceptibility loci on 4q32 and 16p12 for bipolar disorder
    Jenny M Ekholm
    Department of Molecular Medicine, National Public Health Institute, 00251 Helsinki, Finland
    Hum Mol Genet 12:1907-15. 2003
    ..7. Since the identified chromosomal regions replicate earlier linkage findings in either bipolar disorder or other mental disorders, they should be considered good targets for further genetic analyses...
  32. ncbi request reprint Frequencies of seasonal major depressive symptoms at high latitudes
    T Partonen
    National Public Health Institute, Department of Mental Health, Helsinki, Finland
    Eur Arch Psychiatry Clin Neurosci 243:189-92. 1993
    ..The results suggest that high latitudes with large variations in the daily lightperiod may not be responsible for high prevalence of major depression with a seasonal pattern...
  33. ncbi request reprint Genome-wide scan in a nationwide study sample of schizophrenia families in Finland reveals susceptibility loci on chromosomes 2q and 5q
    T Paunio
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, PL 104, 00251 Helsinki, Finland
    Hum Mol Genet 10:3037-48. 2001
    ..The chromosome 5q finding is of particular interest, since several other studies have also shown evidence for linkage in the vicinity of this locus...
  34. ncbi request reprint Transition to daylight saving time reduces sleep duration plus sleep efficiency of the deprived sleep
    Tuuli A Lahti
    Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, FI 00300 Helsinki, Finland
    Neurosci Lett 406:174-7. 2006
    ..14min (P<0.01) and sleep efficiency was reduced by 10% (P<0.01) on average. Transition to daylight saving time appears to compromise the process of sleep by decreasing both sleep duration and sleep efficiency...
  35. pmc Linkage analysis of schizophrenia controlling for population substructure
    Tiina Paunio
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Am J Med Genet B Neuropsychiatr Genet 150:827-35. 2009
    ..18). Thus the detailed genealogical information led us to identification of distinct linkage signals for schizophrenia susceptibility loci between the three analyses we performed...
  36. doi request reprint General health and quality-of-life measures in active, recent, and comorbid mental disorders: a population-based health 2000 study
    Sami Pirkola
    Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
    Compr Psychiatry 50:108-14. 2009
    ..We studied the impact of comorbidity and recency in psychiatric disorders on psychological well-being, perceived health, and quality of life and compared their effect with the effect of a chronic medical condition, type 2 diabetes mellitus...
  37. doi request reprint Identification of susceptibility loci at 7q31 and 9p13 for bipolar disorder in an isolated population
    Outi M Palo
    FIMM, Institute for Molecular Medicine and National Institute for Health and Welfare, Helsinki, Finland
    Am J Med Genet B Neuropsychiatr Genet 153:723-35. 2010
    ..The loci on the centromeric region of 9p13 and the telomeric region of 7q31 may represent susceptibility loci for mood disorder in the Finnish population...
  38. doi request reprint Contribution of adenosine related genes to the risk of depression with disturbed sleep
    Natalia Gass
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    J Affect Disord 126:134-9. 2010
    ..One of the key substances regulating sleep is adenosine. We hypothesized that variations in polymorphic sites of adenosine related genes may predispose to depression with sleep disturbances...
  39. pmc TRIB1 constitutes a molecular link between regulation of sleep and lipid metabolism in humans
    H M Ollila
    Public Health Genomics Unit and Institute for Molecular Medicine FIMM, National Institute for Health and Welfare, Helsinki, Finland
    Transl Psychiatry 2:e97. 2012
    ..The shared genetic background may at least partially explain the mechanism behind the well-established connection between diseases with disrupted metabolism and sleep...
  40. ncbi request reprint A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia
    W Hennah
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Mol Psychiatry 10:1097-103. 2005
    ..This finding should stimulate studies aiming at the molecular characterization of how the specific alleles of DISC1 affect the visual memory functions and eventually participates in the development of schizophrenia...
  41. ncbi request reprint Incidence of schizophrenia in a nationwide cohort of patients with type 1 diabetes mellitus
    Hannu Juvonen
    Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    Arch Gen Psychiatry 64:894-9. 2007
    ..Patients with schizophrenia have an increased risk of type 2 diabetes mellitus. However, very few studies have dealt with the association of type 1 diabetes and schizophrenia. Preliminary evidence points to a possible inverse association...
  42. ncbi request reprint Heritability of cognitive functions in families with bipolar disorder
    Mervi Antila
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Am J Med Genet B Neuropsychiatr Genet 144:802-8. 2007
    ..Genetic contribution was low to verbal learning functions. High heritability, in executive functioning and psychomotor processing speed suggest that these may be valid endophenotypic traits for genetic studies of bipolar disorder...
  43. ncbi request reprint Field trial of timed bright light exposure for jet lag among airline cabin crew
    Tuuli Lahti
    National Public Health Institute Department of Mental Health and Alcohol Research, FI 00300, Helsinki, Finland
    Int J Circumpolar Health 66:365-9. 2007
    ..Following rapid changes in circadian rhythm may lead to several symptoms known as jet lag. Our aim was to alleviate jet-lag symptoms by timed exposure to bright light (natural sunlight if present, otherwise artificial bright light)...
  44. doi request reprint A population-based association study of candidate genes for depression and sleep disturbance
    Siddheshwar Utge
    Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland
    Am J Med Genet B Neuropsychiatr Genet 153:468-76. 2010
    ..These differences may partially explain the broad spectrum of depressive symptoms, and their systematic monitoring could potentially be used for diagnostic purposes...
  45. ncbi request reprint Effect of controlled-release melatonin on sleep quality, mood, and quality of life in subjects with seasonal or weather-associated changes in mood and behaviour
    Sami Leppämäki
    Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Eur Neuropsychopharmacol 13:137-45. 2003
    ..03) and vitality (P=0.02) in the subjects with s-SAD, but attenuated the improvement of atypical symptoms and physical parameters of quality of life compared to placebo in the subjects with WAS, positive type...
  46. doi request reprint Trends in self-reported sleep duration and insomnia-related symptoms in Finland from 1972 to 2005: a comparative review and re-analysis of Finnish population samples
    Erkki Kronholm
    The National Public Health Institute, Turku, Finland
    J Sleep Res 17:54-62. 2008
    ..In conclusion, the Finnish data during the past 33 years indicate a general decrease in self-reported sleep duration of about 18 min and an increase of sleep complaints, especially among the employed middle-aged population...
  47. ncbi request reprint Timed bright-light exposure and complaints related to shift work among women
    Sami Leppämäki
    National Public Health Institute, Department of Mental Health and Alcohol Research, Helsinki, Finland
    Scand J Work Environ Health 29:22-6. 2003
    ..A secondary objective was to investigate whether this response differed by season (summer or winter), seasonality, or age...
  48. ncbi request reprint Heritability and number of quantitative trait loci of neurocognitive functions in families with schizophrenia
    Annamari Tuulio-Henriksson
    Department of Mental Health and Alcohol Research, National Public Health Institute of Finland, Helsinki
    Am J Med Genet 114:483-90. 2002
    ..Our results suggest that neurocognitive measures, particularly working memory, may provide valid quantitative phenotypic traits for linkage analyses searching predisposing genes for schizophrenia...
  49. doi request reprint Cognitive functioning of bipolar I patients and relatives from families with or without schizophrenia or schizoaffective disorder
    Mervi Antila
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    J Affect Disord 116:70-9. 2009
    ....
  50. doi request reprint Antidepressant use and mortality in Finland: a register-linkage study from a nationwide cohort
    Jari Haukka
    National Institute for Health and Welfare, Helsinki, Finland
    Eur J Clin Pharmacol 65:715-20. 2009
    ..It is generally acknowledged that depressed patients need specific attention during the first weeks after initiation of antidepressant (AD) treatment because of the increased risk of suicide...
  51. ncbi request reprint Self-reported sleep duration in Finnish general population
    Erkki Kronholm
    Department of Health and Functional Capacity, National Public Health Institute, Turku, Finland
    J Sleep Res 15:276-90. 2006
    ..A more detailed analysis of the clinical status of the short and long sleep duration groups is needed to evaluate the possible importance of these findings for health risks associated with sleep duration...
  52. ncbi request reprint Clinical phenotype of schizophrenia in a Finnish isolate
    Ritva Arajärvi
    Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, Helsinki 00300, Finland
    Schizophr Res 67:195-205. 2004
    ..Findings in this schizophrenia OCCPI phenotype study suggest that the clinical picture of schizophrenia in a genetically isolated and homogeneous population closely resembles our nationwide findings in Finland...
  53. ncbi request reprint Is low dietary intake of omega-3 fatty acids associated with depression?
    Reeta Hakkarainen
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Am J Psychiatry 161:567-9. 2004
    ..This study examined the association between the dietary intake of omega-3 fatty acids and low mood, major depression, and suicide...
  54. ncbi request reprint Search for cognitive trait components of schizophrenia reveals a locus for verbal learning and memory on 4q and for visual working memory on 2q
    Tiina Paunio
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Hum Mol Genet 13:1693-702. 2004
    ..Our results reveal initial information on the effect of the loci associated with schizophrenia in multiple studies, and emphasize the value of trait components in the search for susceptibility loci for complex diseases...
  55. ncbi request reprint Prevalence and diagnosis of schizophrenia based on register, case record and interview data in an isolated Finnish birth cohort born 1940-1969
    Ritva Arajärvi
    Dept of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, 00300, Helsinki, Finland
    Soc Psychiatry Psychiatr Epidemiol 40:808-16. 2005
    ....
  56. ncbi request reprint High concordance of bipolar I disorder in a nationwide sample of twins
    Tuula Kieseppä
    Department of Mental Health and Alcohol Research, National Public Health Institute, 00300 Helsinki 30, Finland
    Am J Psychiatry 161:1814-21. 2004
    ..The authors report what appears to be the first twin study of bipolar I disorder involving a population-based twin sample, in which the diagnoses were made by using structured, personal interviews...
  57. ncbi request reprint Memory and verbal learning functions in twins with bipolar-I disorder, and the role of information-processing speed
    Tuula Kieseppä
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Psychol Med 35:205-15. 2005
    ..The authors compared verbal learning and memory functioning in twins with BP I and co-twins to control twins, and examined whether the observed deficits are related to information-processing speed...
  58. ncbi request reprint The role of DTNBP1, NRG1, and AKT1 in the genetics of schizophrenia in Finland
    Joni A Turunen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, P O Box 104, FI 00251, Helsinki, Finland
    Schizophr Res 91:27-36. 2007
    ..Furthermore, results do not support a major role for NRG1, but we cannot completely exclude a minor role of this gene in the Finnish population...
  59. ncbi request reprint Lifetime prevalence of psychotic and bipolar I disorders in a general population
    Jonna Perälä
    Department of Mental Health and Alcohol Research, National Public Health Institute, University of Helsinki, Mannerheimintie 166, 0300 Helsinki, Finland
    Arch Gen Psychiatry 64:19-28. 2007
    ..Recent general population surveys of psychotic disorders have found low lifetime prevalences. However, this may be owing to methodological problems. Few studies have reported the prevalences of all specific psychotic disorders...
  60. ncbi request reprint Affective flattening and alogia associate with the familial form of schizophrenia
    Ritva Arajärvi
    National Public Health Institute, Department of Mental Health and Alcohol Research, University of Helsinki, Mannerheimintie 166, 00300 Helsinki, Finland
    Psychiatry Res 141:161-72. 2006
    ..This may be related to genetic homogeneity in the isolate. We conclude that patients with first-degree relatives with psychotic disorder have more severe negative symptoms...
  61. ncbi request reprint Age at onset and cognitive functioning in schizophrenia
    Annamari Tuulio-Henriksson
    National Public Health Institute, Department of Mental Health and Alcohol Research, Mannerheimintie 166, 00300 Helsinki, Finland
    Br J Psychiatry 185:215-9. 2004
    ..Impairments in cognitive functioning are common in schizophrenia, and the degree of impairment may be associated with the individual's age at onset of the disorder...
  62. doi request reprint Determinants and outcomes of serious attempted suicide: a nationwide study in Finland, 1996-2003
    Jari Haukka
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Am J Epidemiol 167:1155-63. 2008
    ..57, 2.21) and mood disorders (SHR = 1.72, 95% CI: 1.47, 2.01) were associated with the risk of suicide. The risks of suicide and all-cause mortality were extremely high immediately after hospitalization for attempted suicide...
  63. ncbi request reprint Impaired executive performance in healthy siblings of schizophrenia patients in a population-based study
    Annamaria Kuha
    Department of Mental Health and Alcohol Research, National Public Health Institute, 00300 Helsinki Finland
    Schizophr Res 92:142-50. 2007
    ..In conclusion, in a study of representative, population-based sample the healthy siblings of schizophrenia patients demonstrated deficits in processing speed and executive functions...
  64. ncbi request reprint Association of dietary amino acids with low mood
    Reeta Hakkarainen
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Depress Anxiety 18:89-94. 2003
    ..There is no consistent association between dietary intake of amino acids and low mood...
  65. ncbi request reprint Cognitive functioning in patients with familial bipolar I disorder and their unaffected relatives
    Mervi Antila
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Psychol Med 37:679-87. 2007
    ..The aim was to discover whether any cognitive function would indicate genetic liability to the disorder and could thus be regarded as endophenotypes of BPD...
  66. pmc Seasonal changes in mood and behavior are linked to metabolic syndrome
    Reeta Rintamäki
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    PLoS ONE 3:e1482. 2008
    ..Metabolic syndrome is a risk factor to the cardiovascular diseases. It has been reported that disruptions of the circadian clockwork are associated with and may predispose to metabolic syndrome...
  67. ncbi request reprint Seasonal changes in mood and behavior in relation to work conditions among the general population
    Pia Pajunen
    National Public Health Institute, Department of Mental Health and Alcohol Research, Mannerheimintie 166, FI 00300 Helsinki, Finland
    Scand J Work Environ Health 33:198-203. 2007
    ..This study explored seasonal changes in mood and behavior in relation to work conditions...
  68. doi request reprint Work-related accidents and daylight saving time in Finland
    T Lahti
    Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Mannerheimintie 166, FI 00300, Helsinki, Finland
    Occup Med (Lond) 61:26-8. 2011
    ..Sleep deprivation may have negative effects on motivation, attention and alertness and thus it is possible that transitions into and out of DST may increase accident rates...
  69. ncbi request reprint Effects of light treatment on sleep structure in seasonal affective disorder
    T Partonen
    Ullanlinna Sleep Disorders Clinic and Research Centre, Helsinki, Finland
    Eur Arch Psychiatry Clin Neurosci 242:310-3. 1993
    ..m. This minimal influence of bright light on sleep structure is unlikely to explain the well-documented antidepressant effect...
  70. ncbi request reprint Chromosome 1 loci in Finnish schizophrenia families
    J Ekelund
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Hum Mol Genet 10:1611-7. 2001
    ..These results are consistent with the presence of susceptibility gene(s) in this chromosomal region, a result also implied in other recent family studies of schizophrenia...
  71. doi request reprint Climate impact on suicide rates in Finland from 1971 to 2003
    Reija Ruuhela
    Finnish Meteorological Institute, Helsinki, Finland
    Int J Biometeorol 53:167-75. 2009
    ..Long-term variations in global radiation may also explain, in part, the observed increasing trend in the suicide rate until 1990 and the decreasing trend since then in Finland...
  72. doi request reprint Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption
    Leena Kovanen
    Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland
    Alcohol Alcohol 45:303-11. 2010
    ..Our aim was to study whether circadian clock gene polymorphisms predispose to alcohol dependence or abuse or other alcohol-related characteristics...
  73. ncbi request reprint Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects
    William Hennah
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Hum Mol Genet 12:3151-9. 2003
    ..Our findings would also encourage more detailed analyses of the effect of DISC1 on the component-traits of schizophrenia...
  74. ncbi request reprint The volumetric findings in MRI brain study of bipolar twins and their healthy co-twins
    T Kieseppä
    Department of Mental Health, Alcohol Research National Public Health Institute, Helsinki, Finland
    Bipolar Disord 4:29-30. 2002
  75. ncbi request reprint Bright-light exposure combined with physical exercise elevates mood
    S Leppämäki
    Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    J Affect Disord 72:139-44. 2002
    ..Our objective was to compare the effect of exercise alone or combined with morning bright light on mood and the health-related quality of life in healthy subjects...
  76. doi request reprint Night-time work predisposes to non-Hodgkin lymphoma
    Tuuli A Lahti
    Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, Helsinki, Finland
    Int J Cancer 123:2148-51. 2008
    ..28 (1.03-1.59) for men who worked in night-time shifts to a high degree as compared with those who had not been exposed to night-time work. Night-time workers are cancer prone and have a greater risk of NHL than population on average...
  77. pmc NPAS2 and PER2 are linked to risk factors of the metabolic syndrome
    Ani Englund
    Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, FI 00300 Helsinki, Finland
    J Circadian Rhythms 7:5. 2009
    ..Our aim was to analyze whether circadian clock polymorphisms contribute to seasonal variations in behavior and to the metabolic syndrome...
  78. doi request reprint Work-family conflicts and subsequent sleep medication among women and men: a longitudinal registry linkage study
    T Lallukka
    Hjelt Institute, Department of Public Health, University of Helsinki, Finland
    Soc Sci Med 79:66-75. 2013
    ..In conclusion, in particular family to work conflicts, but also work to family conflicts, are clear determinants of women's sleep medication...
  79. doi request reprint Hormonal contraception and mental health: results of a population-based study
    E Toffol
    Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare THL, Helsinki, Finland
    Hum Reprod 26:3085-93. 2011
    ..The aim of this study was to analyse the association between the use of OCs and the LNG-IUS and psychological well-being and psychopathology...
  80. ncbi request reprint Bright light as an inhibitor of adenosine transport
    T Partonen
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Med Hypotheses 54:343-4. 2000
    ....
  81. ncbi request reprint [Suicide mortality in Finland during 1979-2001]
    Timo Partonen
    Kansanterveyslaitos, mielenterveyden ja alkoholitutkimuksen osasto Mannerheimintie 166, 00300 Helsinki
    Duodecim 119:1827-34. 2003
  82. ncbi request reprint Alexithymia, depression and sleep disturbance symptoms
    Erkki Kronholm
    Psychother Psychosom 77:63-5. 2008
  83. ncbi request reprint Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference
    Carolina Johansson
    Neurogenetics Unit, Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Neuropsychopharmacology 28:734-9. 2003
    ..In conclusion, our results suggest involvement of circadian clock-related polymorphisms both in susceptibility to SAD and diurnal preference...
  84. ncbi request reprint CREB-regulated diurnal activity patterns are not indicative for depression-like symptoms in mice and men
    Sabine Chourbaji
    Central Institute of Mental Health Mannheim ZI, University of Heidelberg, Germany
    Med Hypotheses 70:117-21. 2008
    ..Thus it is reasonable to assume that CREB Ser142 represents a molecular switch in mice and men, which is responsible for the (dys)regulation of circadian rhythms...
  85. ncbi request reprint Seasonal affective disorder and the G-protein beta-3-subunit C825T polymorphism
    Carolina Johansson
    Neurogenetics Unit, Department of Molecular Medicine, Center for Molecular Medicine L8 00, Karolinska Institutet and Karolinska Hospital, S 171 76 Stockholm, Sweden
    Biol Psychiatry 55:317-9. 2004
    ..Association with seasonal affective disorder (SAD) has been found for the higher activity T-allele of the G-protein beta-3-subunit C825T polymorphism...
  86. ncbi request reprint The diagnosis, symptomatology, and epidemiology of seasonal affective disorder
    Andres Magnusson
    Department of Psychiatry, Aker University Hospital, Oslo, Norway
    CNS Spectr 10:625-34; quiz 1-14. 2005
    ..SAD probably possibly occurs in children although not as commonly as in young adults. Some studies have found that certain ethnic groups who live at high northern latitudes may have adapted to the long arctic winter...