Vesa Olkkonen

Summary

Affiliation: National Public Health Institute
Country: Finland

Publications

  1. doi request reprint Interactions of oxysterols with membranes and proteins
    Vesa M Olkkonen
    National Public Health Institute and FIMM, Institute for Molecular Medicine Finland, Biomedicum, Helsinki, Finland
    Mol Aspects Med 30:123-33. 2009
  2. ncbi request reprint When intracellular logistics fails--genetic defects in membrane trafficking
    Vesa M Olkkonen
    Department of Molecular Medicine, National Public Health Institute KTL, Biomedicum, POBox 104, FI 00251 Helsinki, Finland
    J Cell Sci 119:5031-45. 2006
  3. ncbi request reprint The OSBP-related proteins (ORPs): global sterol sensors for co-ordination of cellular lipid metabolism, membrane trafficking and signalling processes?
    V M Olkkonen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, Helsinki, Finland
    Biochem Soc Trans 34:389-91. 2006
  4. ncbi request reprint [Role of oxysterols in atherosclerotic plaque and lipid metabolism]
    Vesa Olkkonen
    Kansanterveyslaitos, molekyylilääketieteen osasto Biomedicum, Helsinki
    Duodecim 121:515-22. 2005
  5. ncbi request reprint Oxysterol binding protein and its homologues: new regulatory factors involved in lipid metabolism
    Vesa M Olkkonen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, PO Box 104, FI 00251 Helsinki, Finland
    Curr Opin Lipidol 15:321-7. 2004
  6. ncbi request reprint Oxysterol binding proteins: in more than one place at one time?
    Vesa M Olkkonen
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Biochem Cell Biol 82:87-98. 2004
  7. ncbi request reprint Targeting of OSBP-related protein 3 (ORP3) to endoplasmic reticulum and plasma membrane is controlled by multiple determinants
    Markku Lehto
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, P O Box 104, FI 00251 Helsinki, Finland
    Exp Cell Res 310:445-62. 2005
  8. pmc The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have different intracellular localization, and are functionally distinct
    Marie Johansson
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, Fin 00251 Helsinki, Finland
    Mol Biol Cell 14:903-15. 2003
  9. doi request reprint Characteristics of oxysterol binding proteins
    Daoguang Yan
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, FI 00290 Helsinki, Finland
    Int Rev Cytol 265:253-85. 2008
  10. ncbi request reprint OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages
    Daoguang Yan
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, FI 00251 Helsinki, Finland
    J Biol Chem 283:332-40. 2008

Collaborators

  • Elina Ikonen
  • Matti Jauhiainen
  • A M Band
  • B Staels
  • P T Kovanen
  • A Moustakas
  • Andrew J Brown
  • D Yan
  • C Thiele
  • Markku Lehto
  • Christian Ehnholm
  • Marie Johansson
  • Jari Metso
  • Sarah Siggins
  • Minna T Jänis
  • Saara Laitinen
  • Riikka Vikstedt
  • Maria Kauppi
  • Reijo Käkelä
  • Kimmo Tanhuanpää
  • Riikka Hynynen
  • Sanna Lehtonen
  • Minna Kärkkäinen
  • Pentti Somerharju
  • Esa Tahvanainen
  • Esa Kuismanen
  • Kati Hyvärinen
  • Jukka Tenhunen
  • Eero Lehtonen
  • Noora Kaivo-oja
  • Teijo Pellinen
  • Johanna Ivaska
  • Pekka Ihalmo
  • Mikko I Mäyränpää
  • Per Henrik Groop
  • Jukka Hakala
  • Tomas Strandin
  • Hilkka Lankinen
  • Sari Lusa
  • Kerry Anne Rye
  • Katja Karjalainen
  • Timothy L Cover
  • Jukka Tienari
  • Marja Riitta Taskinen
  • Arpo Aromaa
  • Kaisa Silander
  • Janne Koskimies
  • Jonas Bondestam
  • Giulia Chinetti
  • Virginie Bocher
  • Kaisa Vuojolainen
  • Aaron J W Hsueh
  • Janne P Kallio
  • Meerit Kämäräinen
  • Mark Cranfield
  • Olli Ritvos
  • Ursula Vitt
  • Nigel P Groome
  • Peter Ten Dijke
  • Masaru Hayashi
  • Anne Simonsen
  • Gerd Wohlfahrt
  • Bjørn Bremnes
  • Sanna Heino
  • Harald Stenmark
  • Hiroaki Hattori
  • Tomoichiro Oka
  • Amandio Vieira
  • Judy Callaghan

Detail Information

Publications30

  1. doi request reprint Interactions of oxysterols with membranes and proteins
    Vesa M Olkkonen
    National Public Health Institute and FIMM, Institute for Molecular Medicine Finland, Biomedicum, Helsinki, Finland
    Mol Aspects Med 30:123-33. 2009
    ....
  2. ncbi request reprint When intracellular logistics fails--genetic defects in membrane trafficking
    Vesa M Olkkonen
    Department of Molecular Medicine, National Public Health Institute KTL, Biomedicum, POBox 104, FI 00251 Helsinki, Finland
    J Cell Sci 119:5031-45. 2006
    ..Studies of the gene defects in trafficking disorders therefore not only open avenues for new therapeutic approaches but also significantly contribute to our knowledge of the fundamental mechanisms of intracellular membrane transport...
  3. ncbi request reprint The OSBP-related proteins (ORPs): global sterol sensors for co-ordination of cellular lipid metabolism, membrane trafficking and signalling processes?
    V M Olkkonen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, Helsinki, Finland
    Biochem Soc Trans 34:389-91. 2006
    ..We believe, rather, that the common denominator for ORP function is acting as sterol sensors that relay information to a spectrum of cellular processes...
  4. ncbi request reprint [Role of oxysterols in atherosclerotic plaque and lipid metabolism]
    Vesa Olkkonen
    Kansanterveyslaitos, molekyylilääketieteen osasto Biomedicum, Helsinki
    Duodecim 121:515-22. 2005
  5. ncbi request reprint Oxysterol binding protein and its homologues: new regulatory factors involved in lipid metabolism
    Vesa M Olkkonen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, PO Box 104, FI 00251 Helsinki, Finland
    Curr Opin Lipidol 15:321-7. 2004
    ..This review discusses recent findings that provide important clues to the mode of action of these proteins...
  6. ncbi request reprint Oxysterol binding proteins: in more than one place at one time?
    Vesa M Olkkonen
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Biochem Cell Biol 82:87-98. 2004
    ..Specifically, we suggest a model in which a general property of ORPs is to function at membrane contact sites, specialized zones of communication between two different organelles...
  7. ncbi request reprint Targeting of OSBP-related protein 3 (ORP3) to endoplasmic reticulum and plasma membrane is controlled by multiple determinants
    Markku Lehto
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, P O Box 104, FI 00251 Helsinki, Finland
    Exp Cell Res 310:445-62. 2005
    ..Based on the present data, we introduce a model for the inter-relationships of the functional domains of ORP3 in the membrane targeting of the protein...
  8. pmc The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have different intracellular localization, and are functionally distinct
    Marie Johansson
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, Fin 00251 Helsinki, Finland
    Mol Biol Cell 14:903-15. 2003
    ..The results suggest that the two forms of ORP1 are functionally distinct and that ORP1L is involved in control of cellular lipid metabolism...
  9. doi request reprint Characteristics of oxysterol binding proteins
    Daoguang Yan
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, FI 00290 Helsinki, Finland
    Int Rev Cytol 265:253-85. 2008
    ..Our working hypothesis is that mammalian ORPs mainly act as sterol sensors that relay information to a spectrum of different cellular processes...
  10. ncbi request reprint OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages
    Daoguang Yan
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, FI 00251 Helsinki, Finland
    J Biol Chem 283:332-40. 2008
    ..Our data identify ORP8 as a negative regulator of ABCA1 expression and macrophage cholesterol efflux. ORP8 may, thus, modulate the development of atherosclerosis...
  11. ncbi request reprint The OSBP-related proteins: a novel protein family involved in vesicle transport, cellular lipid metabolism, and cell signalling
    Markku Lehto
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, PO Box 104, Haartmaninkatu 8, FIN 00251, Helsinki, Finland
    Biochim Biophys Acta 1631:1-11. 2003
    ..Functional studies carried out on the ORP proteins in different organisms indicate roles of the gene family in diverse cellular processes including control of lipid metabolism, regulation of vesicle transport, and cell signalling events...
  12. ncbi request reprint Oxysterols and oxysterol binding proteins: role in lipid metabolism and atherosclerosis
    Vesa M Olkkonen
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Ann Med 36:562-72. 2004
    ..This finding has recently moved oxysterols and the protein mediators of their biological effects, liver X receptors and cytosolic oxysterol binding proteins, into the center stage of atherosclerosis research...
  13. ncbi request reprint Assays for interaction between Rab7 and oxysterol binding protein related protein 1L (ORP1L)
    Marie Johansson
    Methods Enzymol 403:743-58. 2005
    ..When it is coexpressed with the dominant inhibitory Rab7 mutant T22N, the clustering is inhibited, suggesting that the effect involves interaction of the fragment with active Rab7...
  14. ncbi request reprint The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking
    Maria Kauppi
    Department of Molecular Medicine, National Public Health Institute KTL, Biomedicum, PO Box 104, Fin 00251 Helsinki, Finland
    J Cell Sci 115:899-911. 2002
    ..These results suggest that Rab22a may regulate the dynamic interactions of endosomal compartments and it may be involved in the communication between the biosynthetic and early endocytic pathways...
  15. ncbi request reprint ORP2, a homolog of oxysterol binding protein, regulates cellular cholesterol metabolism
    Saara Laitinen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, P O Box 104, Fin 00251 Helsinki, Finland
    J Lipid Res 43:245-55. 2002
    ..The results implicate ORP2 as a novel regulator of cellular sterol homeostasis and intracellular membrane trafficking...
  16. ncbi request reprint Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis
    Daoguang Yan
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, P O Box 104, FI 00251 Helsinki, Finland
    Arterioscler Thromb Vasc Biol 27:1108-14. 2007
    ..Oxysterol binding protein (OSBP) has previously been implicated as a sterol sensor that regulates sphingomyelin synthesis and the activity of extracellular signal-regulated kinases (ERK)...
  17. ncbi request reprint Cholesterol efflux from macrophage foam cells is enhanced by active phospholipid transfer protein through generation of two types of acceptor particles
    Riikka Vikstedt
    National Public Health Institute, Department of Molecular Medicine, Biomedicum, P O Box 104, FI 00251 Helsinki, Finland
    Biochemistry 46:11979-86. 2007
    ..These observations demonstrate that only HA-PLTP increases macrophage cholesterol efflux, via formation of efficient cholesterol acceptors, prebeta-HDL and large fused HDL particles...
  18. doi request reprint The R-Ras interaction partner ORP3 regulates cell adhesion
    Markku Lehto
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, FI 00251 Helsinki, Finland
    J Cell Sci 121:695-705. 2008
    ..The present findings demonstrate a new function of ORP3 as part of the machinery that controls the actin cytoskeleton, cell polarity and cell adhesion...
  19. ncbi request reprint Overexpression of OSBP-related protein 2 (ORP2) in CHO cells induces alterations of phospholipid species composition
    Reijo Käkelä
    Department of Biochemistry, Insitute of Biomedicine, P O Box 63, University of Helsinki, Finland
    Biochem Cell Biol 83:677-83. 2005
    ..The results provide evidence for a delicate integration of cholesterol, PL, and NL metabolism and a role of ORP2 as a regulator of the cellular lipidome...
  20. pmc The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments
    Marie Johansson
    Department of Molecular Medicine, National Public Health Institute, FI 00251 Helsinki, Finland
    Mol Biol Cell 16:5480-92. 2005
    ..This is the first report of a direct connection between the OSBP-related protein family and the Rab GTPases...
  21. ncbi request reprint Growth differentiation factor-9 induces Smad2 activation and inhibin B production in cultured human granulosa-luteal cells
    Noora Kaivo-oja
    Program for Developmental and Reproductive Biology, Biomedicum Helsinki, and Department of Bacteriology, Haartman Institute, University of Helsinki, 00014 Helsinki, Finland
    J Clin Endocrinol Metab 88:755-62. 2003
    ....
  22. ncbi request reprint PLTP secreted by HepG2 cells resembles the high-activity PLTP form in human plasma
    Sarah Siggins
    National Public Health Institute, Department of Molecular Medicine, Biomedicum, P O Box 104, Fin 00251 Helsinki, Finland
    J Lipid Res 44:1698-704. 2003
    ..These results show that the HepG2-derived PLTP resembles in several aspects the high-activity form of PLTP found in human plasma...
  23. ncbi request reprint Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7
    Markku Lehto
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, PO Box 104, 00251 Helsinki, Finland
    Cell Tissue Res 315:39-57. 2004
    ..The dual targeting of the proteins indicates a putative role in communication between the ER and the plasma membrane...
  24. ncbi request reprint Quantitation of the active and low-active forms of human plasma phospholipid transfer protein by ELISA
    Sarah Siggins
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, Fin 00251 Helsinki, Finland
    J Lipid Res 45:387-95. 2004
    ..The HA-PLTP mass (mean, 1.87 +/- 0.85 mg/l) correlated significantly with serum PLTP activity, whereas that of LA-PLTP (mean, 3.94 +/- 1.4 mg/l) showed no correlation with phospholipid transfer activity...
  25. ncbi request reprint Endogenous plasma membrane t-SNARE syntaxin 4 is present in rab11 positive endosomal membranes and associates with cortical actin cytoskeleton
    Arja M Band
    Department of Biosciences, Division of Biochemistry, Viikki Biocenter, University of Helsinki, P O Box 56, Viikinkaari 5, 00014, Helsinki, Finland
    FEBS Lett 531:513-9. 2002
    ..Taken together, these data suggest that syntaxin 4 regulates secretion at the actin-rich areas of the plasma membrane and may be recycled through rab11 positive intracellular membranes...
  26. ncbi request reprint Active and low-active forms of serum phospholipid transfer protein in a normal Finnish population sample
    Minna T Jänis
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, Helsinki, Finland
    J Lipid Res 45:2303-9. 2004
    ..The present data on PLTP activity and concentration reveal novel connections of the two PLTP forms to lipid and carbohydrate metabolism...
  27. ncbi request reprint Analysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3
    Maria Kauppi
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, P O Box 104, Fin 00251 Helsinki, Finland
    J Biol Chem 277:43973-9. 2002
    ..This suggests that, although syntaxin 3 is the main target SNARE operating in exocytic transport to the apical plasma membrane in certain epithelial cell types, syntaxin 2 may play an important role in this trafficking route in others...
  28. ncbi request reprint Apolipoprotein E activates the low-activity form of human phospholipid transfer protein
    Minna T Jänis
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, P O Box 104, Fin 00251 Helsinki, Finland
    Biochem Biophys Res Commun 331:333-40. 2005
    ..These observations suggest that PLTP is capable of interacting with apoE, apoA-I, and apoA-IV, and that these interactions regulate PLTP-activity levels in plasma...
  29. pmc Overexpression of OSBP-related protein 2 (ORP2) induces changes in cellular cholesterol metabolism and enhances endocytosis
    Riikka Hynynen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, P O Box 104, Helsinki FI 00251, Finland
    Biochem J 390:273-83. 2005
    ..Our results suggest a function of ORP2 in both cholesterol trafficking and control of endocytic membrane transport...
  30. ncbi request reprint Isolation and partial characterization of the inactive and active forms of human plasma phospholipid transfer protein (PLTP)
    Minna Kärkkäinen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, P O Box 104, Helsinki FIN 00251, Finland
    J Biol Chem 277:15413-8. 2002
    ..During or after the transfer of lipolytic surface remnants to HDL, PLTP is transferred to apoA-I-containing HDL particles and thereby becomes part of the low activity complex...