A Nevalainen

Summary

Affiliation: National Public Health Institute
Country: Finland

Publications

  1. ncbi Of microbes and men
    A Nevalainen
    National Public Health Institute, Department of Environmental Health, Kuopio, Finland
    Indoor Air 15:58-64. 2005
  2. ncbi Induction of cytotoxicity and production of inflammatory mediators in raw264.7 macrophages by spores grown on six different plasterboards
    T Murtoniemi
    National Public Health Institute, Division of Environmental Health, PO Box 95, FIN 70701 Kuopio, Finland
    Inhal Toxicol 13:233-47. 2001
  3. ncbi Effect of growth medium on potential of Streptomyces Anulatus spores to induce inflammatory responses and cytotoxicity in RAW264.7 macrophages
    M R Hirvonen
    National Public Health Institute, Division of Environmental Health, Laboratory of Toxicology, PO Box 95, FIN 70701 Kuopio, Finland
    Inhal Toxicol 13:55-68. 2001
  4. ncbi Moisture damage and childhood asthma: a population-based incident case-control study
    J Pekkanen
    Dept of Environmental Health, National Public Health Institute, P O Box 95, 70701 Kuopio, Finland
    Eur Respir J 29:509-15. 2007
  5. ncbi Differences in inflammatory responses and cytotoxicity in RAW264.7 macrophages induced by Streptomyces Anulatus grown on different building materials
    M Roponen
    Laboratory of Toxicology, National Public Health Institute, P O Box 95, FIN 70701 Kuopio, Finland
    Indoor Air 11:179-84. 2001
  6. ncbi Nitric oxide and proinflammatory cytokines in nasal lavage fluid associated with symptoms and exposure to moldy building microbes
    M R Hirvonen
    Division of Environmental Health, National Public Health Institute, Kuopio, Finland
    Am J Respir Crit Care Med 160:1943-6. 1999
  7. ncbi Skin-prick test findings in students from moisture- and mould-damaged schools: a 3-year follow-up study
    J Immonen
    National Public Health Institute, P O B 95, FIN 70701, Kuopio, Finland
    Pediatr Allergy Immunol 12:87-94. 2001
  8. pmc An approach to management of critical indoor air problems in school buildings
    U Haverinen
    National Public Health Institute, Laboratory of Environmental Microbiology and Unit of Epidemiology, Kuopio, Finland
    Environ Health Perspect 107:509-14. 1999
  9. ncbi Effects of moisture-damage repairs on microbial exposure and symptoms in schoolchildren
    T Meklin
    Department of Environmental Health, National Public Health Institute, Kuopio, Finland
    Indoor Air 15:40-7. 2005
  10. ncbi Comparison of two-level and three-level classifications of moisture-damaged dwellings in relation to health effects
    U Haverinen
    National Public Health Institute, Laboratory of Environmental Microbiology and Unit of Environmental Epidemiology, POB 95, FIN 70701 Kuopio, Finland
    Indoor Air 11:192-9. 2001

Collaborators

Detail Information

Publications36

  1. ncbi Of microbes and men
    A Nevalainen
    National Public Health Institute, Department of Environmental Health, Kuopio, Finland
    Indoor Air 15:58-64. 2005
    ..To better describe microbial exposures in buildings, current method development focuses on chemical markers of biomass and assays for specific genetic sequences...
  2. ncbi Induction of cytotoxicity and production of inflammatory mediators in raw264.7 macrophages by spores grown on six different plasterboards
    T Murtoniemi
    National Public Health Institute, Division of Environmental Health, PO Box 95, FIN 70701 Kuopio, Finland
    Inhal Toxicol 13:233-47. 2001
    ..versicolor. These data suggest that growth condition of microbes on different plasterboards affect the ability of microbial spores to induce inflammatory responses and cytotoxicity in macrophages...
  3. ncbi Effect of growth medium on potential of Streptomyces Anulatus spores to induce inflammatory responses and cytotoxicity in RAW264.7 macrophages
    M R Hirvonen
    National Public Health Institute, Division of Environmental Health, Laboratory of Toxicology, PO Box 95, FIN 70701 Kuopio, Finland
    Inhal Toxicol 13:55-68. 2001
    ..Altogether, our results suggest that the growth medium of S. anulatus has a fundamental role in the ability of the spores to induce inflammatory responses and cytotoxicity in mammalian cells...
  4. ncbi Moisture damage and childhood asthma: a population-based incident case-control study
    J Pekkanen
    Dept of Environmental Health, National Public Health Institute, P O Box 95, 70701 Kuopio, Finland
    Eur Respir J 29:509-15. 2007
    ..The present results, using standardised assessment of exposure and asthma, suggest that moisture damage and mould growth in the main living quarters are associated with the development of asthma in early childhood...
  5. ncbi Differences in inflammatory responses and cytotoxicity in RAW264.7 macrophages induced by Streptomyces Anulatus grown on different building materials
    M Roponen
    Laboratory of Toxicology, National Public Health Institute, P O Box 95, FIN 70701 Kuopio, Finland
    Indoor Air 11:179-84. 2001
    ..These results indicate that the ability of S. anulatus to induce inflammatory responses and cytotoxicity in macrophages is dependent on the growth conditions provided by different building materials...
  6. ncbi Nitric oxide and proinflammatory cytokines in nasal lavage fluid associated with symptoms and exposure to moldy building microbes
    M R Hirvonen
    Division of Environmental Health, National Public Health Institute, Kuopio, Finland
    Am J Respir Crit Care Med 160:1943-6. 1999
    ..These results point to an association between inflammatory markers in the nasal lavage fluid, the high prevalence of respiratory symptoms among the occupants, and chronic exposure to molds in the indoor environment...
  7. ncbi Skin-prick test findings in students from moisture- and mould-damaged schools: a 3-year follow-up study
    J Immonen
    National Public Health Institute, P O B 95, FIN 70701, Kuopio, Finland
    Pediatr Allergy Immunol 12:87-94. 2001
    ..In conclusion, mould allergy diagnosed by SPTs was rare in students. Most reactions to moulds were in students older than 14 years with multiple SPT reactions to common allergens, and there was no significant association with asthma...
  8. pmc An approach to management of critical indoor air problems in school buildings
    U Haverinen
    National Public Health Institute, Laboratory of Environmental Microbiology and Unit of Epidemiology, Kuopio, Finland
    Environ Health Perspect 107:509-14. 1999
    ..The prevalence of asthma was high (13%) among the upper secondary school students. During the last 4 years, the incidence of asthma was 3-fold that of the previous 4-year period...
  9. ncbi Effects of moisture-damage repairs on microbial exposure and symptoms in schoolchildren
    T Meklin
    Department of Environmental Health, National Public Health Institute, Kuopio, Finland
    Indoor Air 15:40-7. 2005
    ..The change in the prevalence of symptoms in the reference schools was minor. The results suggest that increased symptom prevalence among schoolchildren in moisture-damaged schools can be managed with proper repair of the moisture damage...
  10. ncbi Comparison of two-level and three-level classifications of moisture-damaged dwellings in relation to health effects
    U Haverinen
    National Public Health Institute, Laboratory of Environmental Microbiology and Unit of Environmental Epidemiology, POB 95, FIN 70701 Kuopio, Finland
    Indoor Air 11:192-9. 2001
    ..Although the results did not unambiguously support the three-level model, they underline the importance of developing more accurate exposure models in assessing the severity of moisture damage...
  11. ncbi Children's homes--determinants of moisture damage and asthma in Finnish residences
    U Haverinen-Shaughnessy
    National Public Health Institute, Department of Environmental Health, Kuopio, Finland
    Indoor Air 16:248-55. 2006
    ..0-87.7% of the homes (kappa values 0.10-0.47) as functions of housing characteristics. None of the models qualified as a significant determinant of the case-control status of the children...
  12. ncbi Evaluation of quantitative PCR and culture methods for detection of house dust fungi and streptomycetes in relation to moisture damage of the house
    U Lignell
    National Public Health Institute, Department of Environmental Health, Kuopio, Finland
    Lett Appl Microbiol 47:303-8. 2008
    ..Microbial concentrations in vacuumed house dust samples (n = 71) were analysed by culture and quantitative polymerase chain reaction (qPCR) methods and their association with extent of moisture damage in the house was studied...
  13. doi Exposure to environmental bacteria may have differing effects on tumour necrosis factor-alpha and interleukin-6-producing capacity in infancy
    M H J Lappalainen
    Department of Environmental Health, National Public Health Institute, Kuopio, Finland
    Clin Exp Allergy 38:1483-92. 2008
    ..Our previous study showed an association between increased concentration of endotoxin in house dust and elevated IFN-gamma responses in neonates. The impact of other microbial agents on immune responses in infancy is poorly known...
  14. ncbi Effect of viability of actinomycete spores on their ability to stimulate production of nitric oxide and reactive oxygen species in RAW264.7 macrophages
    M R Hirvonen
    Division of Environmental Health, National Public Health Institute, Kuopio, Finland
    Toxicology 124:105-14. 1997
    ..The production of NO and ROS did not depend directly on the viability of the spores, suggesting an important role for cell wall components in the activation of the cells...
  15. ncbi Comparison of the indoor air quality in mould damaged and reference buildings in a subarctic climate
    A Hyvarinen
    Division of Environmental Health, National Public Health Institute, P O Box 95, FIN 70701, Kuopio, Finland
    Cent Eur J Public Health 9:133-9. 2001
    ..In the moist building materials, some fungal genera, such as Ulocladium and Chaetophoma were detected that were not found in indoor air showing that building material samples give additional information on the microflora of the building...
  16. ncbi The remediation of mold damaged school--a three-year follow-up study on teachers' health
    R L Patovirta
    National Public Health Institute, Kuopio, Finland
    Cent Eur J Public Health 12:36-42. 2004
    ..Some of the asthmatics had low values in the spirometry but no changes in the lung function were observed at the group level. The remediation of the mold damage had beneficial effects on teachers' health...
  17. ncbi Indoor air microbes and respiratory symptoms of children in moisture damaged and reference schools
    T Meklin
    National Public Health Institute, Department of Environmental Health, Department of Environmental Sciences, University of Kuopio, Kuopio, Finland
    Indoor Air 12:175-83. 2002
    ..The highest symptom prevalence was found during spring seasons, after a long exposure period in damaged schools. The results emphasize the importance of the building frame as a determinant of exposure and symptoms...
  18. ncbi The relation between growth of four microbes on six different plasterboards and biological activity of spores
    T Murtoniemi
    National Public Health Institute, Division of Environmental Health, Kuopio, Finland
    Indoor Air 13:65-73. 2003
    ..spinulosum and S. californicus. These data suggest that both the microbial growth on plasterboard and the resulting bioactivity of spores vary and might be affected by changing the growth conditions provided by the plasterboards...
  19. ncbi Starch in plasterboard sustains Streptomyces californicus growth and bioactivity of spores
    T Murtoniemi
    Department of Environmental Health, National Public Health Institute, Kuopio, Finland
    J Appl Microbiol 94:1059-65. 2003
    ..The effects of plasterboard composition on Streptomyces californicus growth and bioactivity of spores were studied...
  20. doi Co-occurrence of toxic bacterial and fungal secondary metabolites in moisture-damaged indoor environments
    M Täubel
    Department of Environmental Health, National Institute for Health and Welfare, Kuopio, Finland
    Indoor Air 21:368-75. 2011
    ..We show that toxic bacterial metabolites need to be considered as being part of very complex and diverse microbial exposures in 'moldy' buildings...
  21. ncbi Personal exposures to particles and microbes in relation to microenvironmental concentrations
    M Toivola
    National Public Health Institute, Department of Environmental Health, Kuopio, Finland
    Indoor Air 14:351-9. 2004
    ..The mass concentration of total fungi and bacteria was <1% of the total particle mass concentration...
  22. doi Occurrence of moisture problems in schools in three countries from different climatic regions of Europe based on questionnaires and building inspections - the HITEA study
    U Haverinen-Shaughnessy
    National Institute for Health and Welfare, Environmental Health Department, Kuopio, Finland
    Indoor Air 22:457-66. 2012
    ..In conclusion, moisture problems (such as moisture damage, dampness, and mold) are relatively common in schools. The occurrence and severity may vary across geographical areas, which can be partly explained by building characteristics...
  23. ncbi Dust sampling methods for endotoxin - an essential, but underestimated issue
    A Hyvarinen
    Department of Environmental Health, National Public Health Institute, Kuopio, Finland
    Indoor Air 16:20-7. 2006
    ..Floor dust samples with moderate reproducibility may be the best choice for sampling of endotoxin in large field studies...
  24. doi Survival of amoebae on building materials
    T Yli-Pirilä
    Department of Environmental Health, National Public Health Institute, Kuopio, Finland
    Indoor Air 19:113-21. 2009
    ..In contrast, amoebae were quickly killed on fresh pine wood and they did not survive on concrete or linoleum. In conclusion, our data show that amoebae can persist on several common building materials once these materials become wet...
  25. ncbi PCR primers targeting the 16S rRNA gene for the specific detection of streptomycetes
    H Rintala
    National Public Health Institute, Department of Environmental Health, 70701 Kuopio, Finland
    Mol Cell Probes 15:337-47. 2001
    ..No false-positive results were achieved. Both primer sets proved to be specific for streptomycetes, and applicable for the detection of streptomycetes in environmental samples...
  26. ncbi Detection of streptomycetes in house dust--comparison of culture and PCR methods
    H Rintala
    Laboratory of Environmental Microbiology, National Public Health Institute KTL, PO Box 95, FIN 70701 Kuopio, Finland
    Indoor Air 14:112-9. 2004
    ..054 for PCR, and P = 0.127 for culture, Fisher's exact test). Altogether, the presence of streptomycetes in house dust seems to indicate the presence of moisture damage in the building...
  27. ncbi Asthma and respiratory infections in school children with special reference to moisture and mold problems in the school
    T Taskinen
    Department of Paediatrics, Kuopio University Hospital, Finland
    Acta Paediatr 88:1373-9. 1999
    ..The objective of the study was to evaluate whether exposure to moisture and sensitization to molds are associated with respiratory manifestations in school children...
  28. ncbi Diversity of streptomycetes in water-damaged building materials based on 16S rDNA sequences
    H Rintala
    National Public Health Institute KTL, Laboratory of Environmental Microbiology, Kuopio, Finland
    Lett Appl Microbiol 34:439-43. 2002
    ..The diversity of streptomycetes in two different types of water-damaged building materials was investigated...
  29. ncbi pH effects on 10 Streptomyces spp. growth and sporulation depend on nutrients
    M Kontro
    Laboratory of Environmental Microbiology, Division of Environmental Health, National Public Health Institute, Kuopio, Finland
    Lett Appl Microbiol 41:32-8. 2005
    ..Therefore, the dependence of 10 Streptomyces spp. pH tolerance on nutrients was determined...
  30. ncbi Immunoglobulin G antibodies to moulds in school-children from moisture problem schools
    T M Taskinen
    Kiuruvesi Health Center, Kuopio, Finland
    Allergy 57:9-16. 2002
    ....
  31. ncbi Fungal spores as such do not cause nasal inflammation in mold exposure
    Marjut Roponen
    Laboratory of Toxicology, National Public Health Institute, PO Box 95, FIN 70701 Kuopio, Finland
    Inhal Toxicol 14:541-9. 2002
    ..We suggest that the type of microbial flora or microbial products in the occupational environment determines the proinflammatory potency of microbial exposure...
  32. pmc Analysis of fungal flora in indoor dust by ribosomal DNA sequence analysis, quantitative PCR, and culture
    M Pitkäranta
    Institute of Biotechnology, P O Box 56, FIN 00014 University of Helsinki, Finland
    Appl Environ Microbiol 74:233-44. 2008
    ..The current restrictions of the methods are discussed...
  33. ncbi Moulds, bacteria and cancer among Finns: an occupational cohort study
    A Laakkonen
    Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FI 00250 Helsinki, Finland
    Occup Environ Med 65:489-93. 2008
    ..Some environmental moulds and bacteria produce carcinogenic toxins...
  34. ncbi A preliminary study on the association between ventilation rates in classrooms and student performance
    R J Shaughnessy
    Indoor Air Program, The University of Tulsa, Tulsa, OK 74104, USA
    Indoor Air 16:465-8. 2006
    ....
  35. ncbi Airborne contaminants in conventional laboratory rabbit rooms
    E Kaliste
    National Laboratory Animal Center, University of Kuopio
    Lab Anim 36:43-50. 2002
    ..However, moderate or high levels of airborne bacteria and fungi were found occasionally during work routines. Airborne contaminants should be considered as a potential occupational health risk for persons working with laboratory animals...
  36. ncbi The bedding of laboratory animals as a source of airborne contaminants
    E Kaliste
    National Laboratory Animal Center, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    Lab Anim 38:25-37. 2004
    ..The dustiness of different bedding types is an important factor affecting the amount and quality of the occupational exposure of the personnel to airborne contaminants...