Anne Lehtonen

Summary

Affiliation: National Public Health Institute
Country: Finland

Publications

  1. ncbi Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced STAT5 activation and target-gene expression during human monocyte/macrophage differentiation
    Anne Lehtonen
    Laboratory of Viral and Molecular Immunology, Department of Microbiology, National Public Health Institute, Mannerheimintie 166, FIN 0300 Helsinki, Finland
    J Leukoc Biol 71:511-9. 2002
  2. ncbi IFN-alpha and IL-12 activate IFN regulatory factor 1 (IRF-1), IRF-4, and IRF-8 gene expression in human NK and T cells
    Anne Lehtonen
    Department of Microbiology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Cytokine 24:81-90. 2003
  3. ncbi Differential expression of IFN regulatory factor 4 gene in human monocyte-derived dendritic cells and macrophages
    Anne Lehtonen
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    J Immunol 175:6570-9. 2005
  4. ncbi IL-21 enhances SOCS gene expression and inhibits LPS-induced cytokine production in human monocyte-derived dendritic cells
    Mari Strengell
    Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    J Leukoc Biol 79:1279-85. 2006
  5. ncbi Gene expression profiling during differentiation of human monocytes to macrophages or dendritic cells
    Anne Lehtonen
    Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FI 00300 Helsinki, Finland
    J Leukoc Biol 82:710-20. 2007
  6. ncbi Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells
    Taija E Pietila
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    J Immunol 178:253-61. 2007
  7. ncbi IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells
    Mari Strengell
    Department of Microbiology, National Public Health Institute, Helsinki, Finland
    J Immunol 170:5464-9. 2003
  8. ncbi KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA
    Fang Cheng
    Genome Scale Biology Program, Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    PLoS Pathog 5:e1000324. 2009

Collaborators

Detail Information

Publications8

  1. ncbi Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced STAT5 activation and target-gene expression during human monocyte/macrophage differentiation
    Anne Lehtonen
    Laboratory of Viral and Molecular Immunology, Department of Microbiology, National Public Health Institute, Mannerheimintie 166, FIN 0300 Helsinki, Finland
    J Leukoc Biol 71:511-9. 2002
    ..Our results demonstrate that STAT5 isoform expression, GM-CSF-induced STAT5 activation, and STAT5 target-gene expression are altered significantly during monocyte/macrophage differentiation...
  2. ncbi IFN-alpha and IL-12 activate IFN regulatory factor 1 (IRF-1), IRF-4, and IRF-8 gene expression in human NK and T cells
    Anne Lehtonen
    Department of Microbiology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Cytokine 24:81-90. 2003
    ..Our results suggest that IFN-alpha and IL-12 may enhance innate and Th1 immune responses by inducing IRF-1, IRF-4, and IRF-8 gene expression...
  3. ncbi Differential expression of IFN regulatory factor 4 gene in human monocyte-derived dendritic cells and macrophages
    Anne Lehtonen
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    J Immunol 175:6570-9. 2005
    ..Our results suggest that IRF4 is likely to play an important role in myeloid DC differentiation and gene regulatory functions...
  4. ncbi IL-21 enhances SOCS gene expression and inhibits LPS-induced cytokine production in human monocyte-derived dendritic cells
    Mari Strengell
    Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    J Leukoc Biol 79:1279-85. 2006
    ..Our results demonstrate that IL-21, a cytokine produced by activated T cells, can directly inhibit the activation and cytokine production of myeloid DCs, providing a negative feedback loop between DCs and T lymphocytes...
  5. ncbi Gene expression profiling during differentiation of human monocytes to macrophages or dendritic cells
    Anne Lehtonen
    Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FI 00300 Helsinki, Finland
    J Leukoc Biol 82:710-20. 2007
    ..Our results reveal significant differences in gene expression profiles between macrophages and DC, and these differences can partially explain the functional differences between these two important cell types...
  6. ncbi Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells
    Taija E Pietila
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    J Immunol 178:253-61. 2007
    ..Our experiments reveal that expression of the CCL19 gene is regulated by a combined action of several members of the NF-kappaB, IRF, and STAT family transcription factors...
  7. ncbi IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells
    Mari Strengell
    Department of Microbiology, National Public Health Institute, Helsinki, Finland
    J Immunol 170:5464-9. 2003
    ..IL-18, however, activated the binding of NF-kappa B to the IFN-gamma promoter NF-kappa B site. Our results suggest that both IL-15 and IL-21 have an important role in activating the NK cell-associated innate immune response...
  8. ncbi KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA
    Fang Cheng
    Genome Scale Biology Program, Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    PLoS Pathog 5:e1000324. 2009
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