Aija Kyttälä

Summary

Affiliation: National Public Health Institute
Country: Finland

Publications

  1. ncbi AP-1 and AP-3 facilitate lysosomal targeting of Batten disease protein CLN3 via its dileucine motif
    Aija Kyttälä
    National Public Health Institute, Department of Molecular Medicine, Biomedicum Helsinki, FIN 00290 Helsinki, Finland
    J Biol Chem 280:10277-83. 2005
  2. ncbi Functional biology of the neuronal ceroid lipofuscinoses (NCL) proteins
    Aija Kyttälä
    National Public Health Institute, Department of Molecular Medicine, Biomedicum Helsinki, Helsinki, Finland
    Biochim Biophys Acta 1762:920-33. 2006
  3. doi Novel interactions of CLN3 protein link Batten disease to dysregulation of fodrin-Na+, K+ ATPase complex
    Kristiina Uusi-Rauva
    Department of Molecular Medicine, National Public Health Institute and FIMM, Institute for Molecular Medicine Finland, Biomedicum, PO 104, 00251 Helsinki, Finland
    Exp Cell Res 314:2895-905. 2008
  4. doi Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments
    Kristiina Uusi-Rauva
    National Institute for Health and Welfare and FIMM, Institute for Molecular Medicine Finland, Biomedicum Helsinki, Finland
    Cell Mol Life Sci 69:2075-89. 2012
  5. pmc Exacerbated neuronal ceroid lipofuscinosis phenotype in Cln1/5 double-knockout mice
    Tea Blom
    National Institute for Health and Welfare, Public Health Genomics Unit, Helsinki, Finland
    Dis Model Mech 6:342-57. 2013
  6. doi The neuronal ceroid lipofuscinosis protein CLN5: new insights into cellular maturation, transport, and consequences of mutations
    Mia Lisa Schmiedt
    National Institute for Health and Welfare THL, Public Health Genomics Unit, Helsinki, Finland
    Hum Mutat 31:356-65. 2010
  7. ncbi Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathway
    Kaisu Luiro
    National Public Health Institute, Department of Molecular Medicine, Biomedicum Helsinki, Finland
    Hum Mol Genet 13:3017-27. 2004
  8. doi Deficiency of the INCL protein Ppt1 results in changes in ectopic F1-ATP synthase and altered cholesterol metabolism
    Annina Lyly
    National Public Health Institute and FIMM, Institute for Molecular Medicine, Biomedicum Helsinki, PO Box 104, Fin 00251 Helsinki, Finland
    Hum Mol Genet 17:1406-17. 2008
  9. pmc Glycosylation, transport, and complex formation of palmitoyl protein thioesterase 1 (PPT1)--distinct characteristics in neurons
    Annina Lyly
    Department of Molecular Medicine, National Public Health Institute, Biomedicum Helsinki, Haartmaninkatu 8, Helsinki, Finland
    BMC Cell Biol 8:22. 2007

Collaborators

Detail Information

Publications9

  1. ncbi AP-1 and AP-3 facilitate lysosomal targeting of Batten disease protein CLN3 via its dileucine motif
    Aija Kyttälä
    National Public Health Institute, Department of Molecular Medicine, Biomedicum Helsinki, FIN 00290 Helsinki, Finland
    J Biol Chem 280:10277-83. 2005
    ..Our data indicate the involvement of complex sorting machinery in the trafficking of CLN3 and emphasize the diversity of parallel and sequential sorting pathways in the trafficking of membrane proteins...
  2. ncbi Functional biology of the neuronal ceroid lipofuscinoses (NCL) proteins
    Aija Kyttälä
    National Public Health Institute, Department of Molecular Medicine, Biomedicum Helsinki, Helsinki, Finland
    Biochim Biophys Acta 1762:920-33. 2006
    ..The aim of this review is to summarize the current knowledge of the functions, or proposed functions, of the different NCL proteins...
  3. doi Novel interactions of CLN3 protein link Batten disease to dysregulation of fodrin-Na+, K+ ATPase complex
    Kristiina Uusi-Rauva
    Department of Molecular Medicine, National Public Health Institute and FIMM, Institute for Molecular Medicine Finland, Biomedicum, PO 104, 00251 Helsinki, Finland
    Exp Cell Res 314:2895-905. 2008
    ....
  4. doi Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments
    Kristiina Uusi-Rauva
    National Institute for Health and Welfare and FIMM, Institute for Molecular Medicine Finland, Biomedicum Helsinki, Finland
    Cell Mol Life Sci 69:2075-89. 2012
    ..The data presented in this study provide novel insights into the role of CLN3 in late endosomal/lysosomal membrane transport...
  5. pmc Exacerbated neuronal ceroid lipofuscinosis phenotype in Cln1/5 double-knockout mice
    Tea Blom
    National Institute for Health and Welfare, Public Health Genomics Unit, Helsinki, Finland
    Dis Model Mech 6:342-57. 2013
    ....
  6. doi The neuronal ceroid lipofuscinosis protein CLN5: new insights into cellular maturation, transport, and consequences of mutations
    Mia Lisa Schmiedt
    National Institute for Health and Welfare THL, Public Health Genomics Unit, Helsinki, Finland
    Hum Mutat 31:356-65. 2010
    ..This study furthers our understanding of the basic properties of the CLN5 protein, necessary for the characterization of the consequences of disease mutations and for the planning of future therapies for vLINCL...
  7. ncbi Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathway
    Kaisu Luiro
    National Public Health Institute, Department of Molecular Medicine, Biomedicum Helsinki, Finland
    Hum Mol Genet 13:3017-27. 2004
    ..These novel interactions between the microtubule-binding Hook1 and the large family of Rab GTPases also suggest a link between CLN3 function, microtubule cytoskeleton and endocytic membrane trafficking...
  8. doi Deficiency of the INCL protein Ppt1 results in changes in ectopic F1-ATP synthase and altered cholesterol metabolism
    Annina Lyly
    National Public Health Institute and FIMM, Institute for Molecular Medicine, Biomedicum Helsinki, PO Box 104, Fin 00251 Helsinki, Finland
    Hum Mol Genet 17:1406-17. 2008
    ..These data indicate neuron-specific changes for F(1)-complex in the Ppt1-deficient cells and give clues for a possible link between lipid metabolism and neurodegeneration in INCL...
  9. pmc Glycosylation, transport, and complex formation of palmitoyl protein thioesterase 1 (PPT1)--distinct characteristics in neurons
    Annina Lyly
    Department of Molecular Medicine, National Public Health Institute, Biomedicum Helsinki, Haartmaninkatu 8, Helsinki, Finland
    BMC Cell Biol 8:22. 2007
    ..To understand the function of PPT1 in more detail, we have further analyzed the basic properties of the protein, especially focusing on possible differences in non-neuronal and neuronal cells...