H Kayhty

Summary

Affiliation: National Public Health Institute
Country: Finland

Publications

  1. pmc Safety and immunogenicity of three doses of an eleven-valent diphtheria toxoid and tetanus protein--conjugated pneumococcal vaccine in Filipino infants
    Maria Z Rosario Capeding
    Research Institute for Tropical Medicine, Metro Manila, Philippines
    BMC Infect Dis 3:17. 2003
  2. pmc Salivary antibodies induced by the seven-valent PncOMPC conjugate vaccine in the Finnish Otitis Media Vaccine Trial
    Anu Nurkka
    Department of Vaccines, National Public Health Institute KTL, Helsinki, Finland
    BMC Infect Dis 5:41. 2005
  3. pmc New vaccines for the prevention of pneumococcal infections
    H Kayhty
    Department of Vaccines, National Public Health Institute, Helsinki, Finland
    Emerg Infect Dis 2:289-98. 1996
  4. ncbi request reprint Nasopharyngeal colonization: a target for pneumococcal vaccination
    Helena Kayhty
    National Public Health Institute, Department of Vaccines, Helsinki, Finland
    Expert Rev Vaccines 5:651-67. 2006
  5. ncbi request reprint Bridging phase 2 and phase 3 pneumococcal immunologic data for future combination vaccines
    H Kayhty
    National Public Health Institute, 00300 Helsinki, Finland
    Clin Infect Dis 33:S292-8. 2001
  6. ncbi request reprint Serum and salivary anti-capsular antibodies in infants and children vaccinated with octavalent pneumococcal conjugate vaccines, PncD and PncT
    A Nurkka
    National Public Health Institute, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    Vaccine 20:194-201. 2001
  7. ncbi request reprint Avidity and subclasses of IgG after immunization of infants with an 11-valent pneumococcal conjugate vaccine with or without aluminum adjuvant
    T Wuorimaa
    Department of Vaccines, Vaccine Immunology Laboratory, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    J Infect Dis 184:1211-5. 2001
  8. ncbi request reprint Pneumococcal conjugate vaccination in adults: circulating antibody secreting cell response and humoral antibody responses in saliva and in serum
    T Nieminen
    National Public Health Institute, Helsinki, Finland
    Vaccine 16:630-6. 1998
  9. pmc Contribution of serotype-specific IgG concentration, IgG subclasses and relative antibody avidity to opsonophagocytic activity against Streptococcus pneumoniae
    M Anttila
    National Public Health Institute, Department of Vaccines, Helsinki, Finland
    Clin Exp Immunol 118:402-7. 1999
  10. ncbi request reprint Natural development of antibodies to pneumococcal surface protein A, pneumococcal surface adhesin A, and pneumolysin in relation to pneumococcal carriage and acute otitis media
    S Rapola
    National Public Health Institute, Dept of Vaccines, 00300 Helsinki, Finland
    J Infect Dis 182:1146-52. 2000

Detail Information

Publications34

  1. pmc Safety and immunogenicity of three doses of an eleven-valent diphtheria toxoid and tetanus protein--conjugated pneumococcal vaccine in Filipino infants
    Maria Z Rosario Capeding
    Research Institute for Tropical Medicine, Metro Manila, Philippines
    BMC Infect Dis 3:17. 2003
    ..An 11-valent pneumococcal conjugate vaccine could provide significantly larger reduction in pneumococcal disease burden than the currently available 7-valent vaccine formulation in many countries...
  2. pmc Salivary antibodies induced by the seven-valent PncOMPC conjugate vaccine in the Finnish Otitis Media Vaccine Trial
    Anu Nurkka
    Department of Vaccines, National Public Health Institute KTL, Helsinki, Finland
    BMC Infect Dis 5:41. 2005
    ..Mucosal antibodies have been suggested to have a role in defence against pneumococcal infections. We investigated here the ability of a seven-valent pneumococcal conjugate vaccine, PncOMPC, to induce mucosal immune response...
  3. pmc New vaccines for the prevention of pneumococcal infections
    H Kayhty
    Department of Vaccines, National Public Health Institute, Helsinki, Finland
    Emerg Infect Dis 2:289-98. 1996
    ..The protective efficacy of the conjugate vaccines against carriage, acute otitis media, and invasive infections is being studied...
  4. ncbi request reprint Nasopharyngeal colonization: a target for pneumococcal vaccination
    Helena Kayhty
    National Public Health Institute, Department of Vaccines, Helsinki, Finland
    Expert Rev Vaccines 5:651-67. 2006
    ..Owing to the general reduced virulence of the latter, this has only had a modest effect on disease, but the possibility of more virulent nonvaccine serotypes arising cannot be ignored and should be the focus of continued surveillance...
  5. ncbi request reprint Bridging phase 2 and phase 3 pneumococcal immunologic data for future combination vaccines
    H Kayhty
    National Public Health Institute, 00300 Helsinki, Finland
    Clin Infect Dis 33:S292-8. 2001
    ..However, data are still missing on the minimal protective immune response and serologic correlates or surrogates of protection...
  6. ncbi request reprint Serum and salivary anti-capsular antibodies in infants and children vaccinated with octavalent pneumococcal conjugate vaccines, PncD and PncT
    A Nurkka
    National Public Health Institute, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    Vaccine 20:194-201. 2001
    ..Mucosal antibodies were found rarely after the primary series but in a greater proportion after the booster. In conclusion, both vaccines were immunogenic...
  7. ncbi request reprint Avidity and subclasses of IgG after immunization of infants with an 11-valent pneumococcal conjugate vaccine with or without aluminum adjuvant
    T Wuorimaa
    Department of Vaccines, Vaccine Immunology Laboratory, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    J Infect Dis 184:1211-5. 2001
    ..In conclusion, the immunization of infants with this 11-valent pneumococcal conjugate vaccine increased avidity of IgG, suggesting successful immunologic priming...
  8. ncbi request reprint Pneumococcal conjugate vaccination in adults: circulating antibody secreting cell response and humoral antibody responses in saliva and in serum
    T Nieminen
    National Public Health Institute, Helsinki, Finland
    Vaccine 16:630-6. 1998
    ..Furthermore, the different structure of the two conjugate vaccines might affect the nature of the response. Thus a different vaccine may be optimal for induction of a mucosal response than is of systemic responses...
  9. pmc Contribution of serotype-specific IgG concentration, IgG subclasses and relative antibody avidity to opsonophagocytic activity against Streptococcus pneumoniae
    M Anttila
    National Public Health Institute, Department of Vaccines, Helsinki, Finland
    Clin Exp Immunol 118:402-7. 1999
    ..Thus, avidity was probably not a limiting factor influencing OPA. The effect of IgG2/IgG1 ratio on OPA was mostly negative but insignificant...
  10. ncbi request reprint Natural development of antibodies to pneumococcal surface protein A, pneumococcal surface adhesin A, and pneumolysin in relation to pneumococcal carriage and acute otitis media
    S Rapola
    National Public Health Institute, Dept of Vaccines, 00300 Helsinki, Finland
    J Infect Dis 182:1146-52. 2000
    ..All age groups were capable of producing antibodies to the 3 proteins. The antibody concentrations increased with age and were strongly associated with pneumococcal exposure, whether by carriage or infection (acute otitis media)...
  11. ncbi request reprint Avidity of IgG for Streptococcus pneumoniae type 6B and 23F polysaccharides in infants primed with pneumococcal conjugates and boosted with polysaccharide or conjugate vaccines
    M Anttila
    National Public Health Institute, Department of Vaccines, Helsinki, Finland
    J Infect Dis 177:1614-21. 1998
    ..In the latter group, however, the avidity of anti-6B was high before boosting...
  12. ncbi request reprint Differences in the avidity of antibodies evoked by four different pneumococcal conjugate vaccines in early childhood
    M Anttila
    Department of Vaccines, National Public Health Institute, Helsinki, Finland
    Vaccine 17:1970-7. 1999
    ..No vaccine specific differences were found in avidity of anti-14 or -19F antibodies. By contrast, antibody avidity to 6B and 23F differed significantly between the vaccine groups, PncCRM and PncT inducing antibodies of highest avidity...
  13. ncbi request reprint Salivary anti-capsular antibodies in infants and children immunised with Streptococcus pneumoniae capsular polysaccharides conjugated to diphtheria or tetanus toxoid
    M Korkeila
    National Public Health Institute, Helsinki, Finland
    Vaccine 18:1218-26. 2000
    ....
  14. ncbi request reprint Streptococcus pneumoniae capsular polysaccharide-diphtheria toxoid conjugate vaccine is immunogenic in early infancy and able to induce immunologic memory
    H Ahman
    National Public Health Institute, Helsinki, Finland
    Pediatr Infect Dis J 17:211-6. 1998
    ..Pneumococcal polysaccharide vaccines are not protective against the most common pneumococcal infections in infancy. The importance of pneumococcal diseases and emerging antimicrobial resistance emphasize the need for prophylaxis...
  15. ncbi request reprint The infant rat model adapted to evaluate human sera for protective immunity to group B meningococci
    M Toropainen
    Department of Vaccines, National Public Health Institute, Helsinki, Finland
    Vaccine 17:2677-89. 1999
    ....
  16. ncbi request reprint Tolerability and immunogenicity of an 11-valent pneumococcal conjugate vaccine in adults
    T Wuorimaa
    National Public Health Institute, Mannerheimintie 166, 00300, Helsinki, Finland
    Vaccine 19:1863-9. 2001
    ....
  17. ncbi request reprint Salivary antibody response to vaccination with meningococcal A/C polysaccharide vaccine in previously vaccinated and unvaccinated Gambian children
    A Nurkka
    Department of Vaccines, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    Vaccine 19:547-56. 2000
    ..The previous vaccination had not induced long lasting IgA-mediated memory. IgA antibodies were secretory, and most of IgG was serum derived. The IgG salivary response seen was similar to the serum response...
  18. ncbi request reprint Pneumococcal conjugate vaccination in toddlers: mucosal antibody response measured as circulating antibody-secreting cells and as salivary antibodies
    T Nieminen
    National Public Health Institute, Helsinki, Finland
    Pediatr Infect Dis J 18:764-72. 1999
    ..We believe that the mucosal immune response is potentially an important characteristic of the pneumococcal vaccines and should thus be measured when the new pneumococcal conjugate vaccines are evaluated...
  19. ncbi request reprint IgG subclass distribution of antibodies after vaccination of adults with pneumococcal conjugate vaccines
    A Soininen
    Department of Vaccines, National Public Health Institute KTL, Helsinki, Finland
    Vaccine 17:1889-97. 1999
    ..Antibodies induced by PncT, however, had a significantly altered IgG2/IgG1 ratio (P < 0.05), with a higher proportion of IgG1...
  20. pmc Assignment of immunoglobulin G1 and G2 concentrations to pneumococcal capsular polysaccharides 3, 6B, 14, 19F, and 23F in pneumococcal reference serum 89-SF
    A Soininen
    Department of Vaccines, National Public Health Institute KTL, Helsinki, Finland
    Clin Diagn Lab Immunol 5:561-6. 1998
    ..Furthermore, the IgG2/IgG1 ratio did not affect the detection of IgG1, the isotype usually represented by a lower concentration...
  21. ncbi request reprint Cross-reactivity of antibodies to type 6B and 6A polysaccharides of Streptococcus pneumoniae, evoked by pneumococcal conjugate vaccines, in infants
    M Vakevainen
    Department of Vaccines, National Public Health Institute, Helsinki, Finland
    J Infect Dis 184:789-93. 2001
    ..Although pneumococcal type 6B conjugate vaccines elicit antibodies that cross-react with type 6A, not all anti-6B antibodies are functionally cross-reactive...
  22. ncbi request reprint Do antibodies to pneumococcal surface adhesin a prevent pneumococcal involvement in acute otitis media?
    S Rapola
    National Public Health Institute, Department of Vaccines, 00300 Helsinki, Finland
    J Infect Dis 184:577-81. 2001
    ..This was true in children 9-24 months old (odds ratio [OR], 0.49; 95% confidence interval [CI], 0.31-0.78) but not in children <9 months old (OR, 0.81; 95% CI, 0.48-1.35)...
  23. pmc Nasopharyngeal antibodies to pneumococcal pneumolysin in children with acute otitis media
    A Virolainen
    National Public Health Institute, Helsinki, Finland
    Clin Diagn Lab Immunol 2:704-7. 1995
    ..We suggest that nasopharyngeal IgA antibody to pneumolysin can be produced early in life by pneumococcal colonization...
  24. ncbi request reprint Effect of transplacentally acquired tetanus antibodies on the antibody responses to Haemophilus influenzae type b-tetanus toxoid conjugate and tetanus toxoid vaccines in Filipino infants
    H Nohynek
    National Public Health Institute, Helsinki, Finland
    Pediatr Infect Dis J 18:25-30. 1999
    ....
  25. pmc Are the enzyme immunoassays for antibodies to pneumococcal capsular polysaccharides serotype specific?
    A Soininen
    Department of Vaccines, National Public Health Institute KTL, Helsinki, Finland
    Clin Diagn Lab Immunol 7:468-76. 2000
    ..The specificity of antibodies, especially in sera from nonimmunized subjects, measured by EIA can be questioned...
  26. ncbi request reprint Natural development of antibodies to pneumococcal capsular polysaccharides depends on the serotype: association with pneumococcal carriage and acute otitis media in young children
    A Soininen
    Department of Vaccines, National Public Health Institute, 00300 Helsinki, Finland
    J Infect Dis 184:569-76. 2001
    ..Antibodies increased modestly, even in children without known contact with Streptococcus pneumoniae and in children with contact with heterologous serotypes. Antibody concentrations were equal after carriage or AOM...
  27. pmc Are the opsonophagocytic activities of antibodies in infant sera measured by different pneumococcal phagocytosis assays comparable?
    M Vakevainen
    National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Clin Diagn Lab Immunol 8:363-9. 2001
    ..Since the sensitivities of the OPA assays differed, the most prominent discrepancies between the techniques were found at low antibody concentrations...
  28. ncbi request reprint Activation of cell-mediated immunity following immunization with pneumococcal conjugate or polysaccharide vaccine
    T Wuorimaa
    National Public Health Institute, Department of Vaccines, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Scand J Immunol 53:422-8. 2001
    ..The conjugate vaccine with adjuvant was associated with Th2 type of activation indicated by an enhanced IL-5 secretion in response to the tetanus and diphtheria protein antigens...
  29. ncbi request reprint Early immunization with conjugate vaccines
    J Eskola
    National Public Health Institute, Helsinki, Finland
    Vaccine 16:1433-8. 1998
    ..Noteworthy, immunologic memory seems to be induced already by first doses during newborn period. These data suggest that protection against invasive Hib infections may be achieved early in life...
  30. ncbi request reprint Booster response to the tetanus and diphtheria toxoid carriers of 11-valent pneumococcal conjugate vaccine in adults and toddlers
    R M Olander
    National Public Health Institute, Mannerhiemintie 166, 00300 Helsinki, Finland
    Vaccine 20:336-41. 2001
    ..Thus, the effect on the tetanus and diphtheria immunity of multivalent conjugate vaccines containing tetanus and diphtheria toxoids as carriers needs to be evaluated before such vaccines are routinely implemented...
  31. pmc Subclass distribution of natural salivary IgA antibodies against pneumococcal capsular polysaccharide of type 14 and pneumococcal surface adhesin A (PsaA) in children
    B Simell
    Dept of Vaccines, National Public Health Institute KTL, Mannerheimintie 166, 00300 Helsinki, Finland
    Clin Exp Immunol 143:543-9. 2006
    ..The possible impact of the IgA subclass distribution on protection of mucosal surfaces by natural or vaccine-induced antibodies needs to be determined...
  32. ncbi request reprint Murine monoclonal antibodies to PorA of Neisseria meningitidis show reduced protective activity in vivo against B:15:P1.7,16 subtype variants in an infant rat infection model
    M Toropainen
    National Public Health Institute, Helsinki, Finland
    Microb Pathog 30:139-48. 2001
    ..7,16a, variably against the P1.7,16b and P1.7,16c, but not against the P1.7,16d variant. Our findings therefore suggest that certain subtype variants may escape protection in vivo conferred by PorA specific antibodies...
  33. ncbi request reprint A randomized study on donor immunization with tetanus-diphtheria, Haemophilus influenzae type b and inactivated poliovirus vaccines to improve the recipient responses to the same vaccines after allogeneic bone marrow transplantation
    T Parkkali
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Bone Marrow Transplant 39:179-88. 2007
    ..Especially patients whose donors have low-specific antibody concentrations may benefit from donor vaccination with protein and conjugate vaccines...
  34. pmc Effects of sample collection and storage methods on antipneumococcal immunoglobulin A in saliva
    A Nurkka
    National Public Health Institute, Department of Vaccines, Helsinki, Finland
    Clin Diagn Lab Immunol 10:357-61. 2003
    ..0005)...