William Hennah

Summary

Affiliation: National Public Health Institute
Country: Finland

Publications

  1. ncbi Haplotype analysis and identification of genes for a complex trait: examples from schizophrenia
    William Hennah
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Ann Med 36:322-31. 2004
  2. pmc Genes and schizophrenia: beyond schizophrenia: the role of DISC1 in major mental illness
    William Hennah
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Schizophr Bull 32:409-16. 2006
  3. pmc Association of a nonsynonymous variant of DAOA with visuospatial ability in a bipolar family sample
    Pia Soronen
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Biol Psychiatry 64:438-42. 2008
  4. doi Mixture model clustering of phenotype features reveals evidence for association of DTNBP1 to a specific subtype of schizophrenia
    Jaana Wessman
    Department of Molecular Medicine, Helsinki, Finland
    Biol Psychiatry 66:990-6. 2009
  5. pmc Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses
    Liisa Tomppo
    Institute for Molecular Medicine Finland FIMM and National Public Health Institute, Helsinki, Finland
    Biol Psychiatry 65:1055-62. 2009
  6. pmc Association of variants in DISC1 with psychosis-related traits in a large population cohort
    Liisa Tomppo
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Arch Gen Psychiatry 66:134-41. 2009
  7. ncbi The role of DTNBP1, NRG1, and AKT1 in the genetics of schizophrenia in Finland
    Joni A Turunen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, P O Box 104, FI 00251, Helsinki, Finland
    Schizophr Res 91:27-36. 2007
  8. pmc DISC1 conditioned GWAS for psychosis proneness in a large Finnish birth cohort
    Liisa Tomppo
    Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland
    PLoS ONE 7:e30643. 2012
  9. ncbi Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1
    William Hennah
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Hum Mol Genet 16:453-62. 2007
  10. pmc Association of AKT1 with verbal learning, verbal memory, and regional cortical gray matter density in twins
    Olli P H Pietiläinen
    FIMM, Institute for Molecular Medicine Finland and National Public Health Institute, Biomedicum, Helsinki, Finland
    Am J Med Genet B Neuropsychiatr Genet 150:683-92. 2009

Collaborators

Detail Information

Publications15

  1. ncbi Haplotype analysis and identification of genes for a complex trait: examples from schizophrenia
    William Hennah
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Ann Med 36:322-31. 2004
    ....
  2. pmc Genes and schizophrenia: beyond schizophrenia: the role of DISC1 in major mental illness
    William Hennah
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Schizophr Bull 32:409-16. 2006
    ..Thus, both genetic and functional data provide evidence for a critical role for DISC1 in schizophrenia and related disorders, supporting the neurodevelopmental hypothesis for the molecular pathogenesis of these devastating illnesses...
  3. pmc Association of a nonsynonymous variant of DAOA with visuospatial ability in a bipolar family sample
    Pia Soronen
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Biol Psychiatry 64:438-42. 2008
    ..Bipolar disorder and schizophrenia are hypothesized to share some genetic background...
  4. doi Mixture model clustering of phenotype features reveals evidence for association of DTNBP1 to a specific subtype of schizophrenia
    Jaana Wessman
    Department of Molecular Medicine, Helsinki, Finland
    Biol Psychiatry 66:990-6. 2009
    ..Possible explanations for this are that the genes might be relevant only to certain subtypes of the disease and/or only in certain populations...
  5. pmc Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses
    Liisa Tomppo
    Institute for Molecular Medicine Finland FIMM and National Public Health Institute, Helsinki, Finland
    Biol Psychiatry 65:1055-62. 2009
    ..Because both DISC1 and NDE1 display association in our study sample, we hypothesized that other genes interacting with DISC1 might also have a role in the etiology of schizophrenia...
  6. pmc Association of variants in DISC1 with psychosis-related traits in a large population cohort
    Liisa Tomppo
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Arch Gen Psychiatry 66:134-41. 2009
    ..There is an abundance of data from human genetic studies and animal models that implies a role for the disrupted in schizophrenia 1 gene (DISC1) in the etiology of schizophrenia and other major mental illnesses...
  7. ncbi The role of DTNBP1, NRG1, and AKT1 in the genetics of schizophrenia in Finland
    Joni A Turunen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, P O Box 104, FI 00251, Helsinki, Finland
    Schizophr Res 91:27-36. 2007
    ..Furthermore, results do not support a major role for NRG1, but we cannot completely exclude a minor role of this gene in the Finnish population...
  8. pmc DISC1 conditioned GWAS for psychosis proneness in a large Finnish birth cohort
    Liisa Tomppo
    Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland
    PLoS ONE 7:e30643. 2012
    ..As part of the studies of this Finnish birth cohort genome-wide association analysis has recently been performed...
  9. ncbi Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1
    William Hennah
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Hum Mol Genet 16:453-62. 2007
    ..Notably, this and other converging lines of evidence underline the importance of DISC1-related functional pathways in the etiology of schizophrenia...
  10. pmc Association of AKT1 with verbal learning, verbal memory, and regional cortical gray matter density in twins
    Olli P H Pietiläinen
    FIMM, Institute for Molecular Medicine Finland and National Public Health Institute, Biomedicum, Helsinki, Finland
    Am J Med Genet B Neuropsychiatr Genet 150:683-92. 2009
    ..The established association of the same allelic variant of AKT1 with both cognitive and neuroanatomical aberrations could suggest that AKT1 exerts its effect on verbal learning and memory via neural networks involving prefrontal cortex...
  11. ncbi Association of distinct allelic haplotypes of DISC1 with psychotic and bipolar spectrum disorders and with underlying cognitive impairments
    Outi M Palo
    Department of Molecular Medicine, National Public Health Insitute, Helsinki, Finland
    Hum Mol Genet 16:2517-28. 2007
    ..Finding of alternative associating haplotypes in the same set of BPD families gives evidence for allelic heterogeneity within DISC1, eventually leading to heterogeneity in the clinical outcome as well...
  12. ncbi Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects
    William Hennah
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Hum Mol Genet 12:3151-9. 2003
    ..Our findings would also encourage more detailed analyses of the effect of DISC1 on the component-traits of schizophrenia...
  13. pmc Allele-specific regulation of DISC1 expression by miR-135b-5p
    Mari Rossi
    1 Institute for Molecular Medicine, Finland FIMM, University of Helsinki, Helsinki, Finland 2 Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland
    Eur J Hum Genet 22:840-3. 2014
    ..Thus, the G allele may be functionally related to the DISC1-associated phenotypes by abolishing regulation by miR-135b-5p, leading to elevated DISC1 levels. ..
  14. ncbi Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory
    Tyrone D Cannon
    Department of Psychology, 1285 Franz Hall, University of California Los Angeles, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 62:1205-13. 2005
    ..Chromosome 1q42 is among several genomic regions showing replicated evidence of linkage with schizophrenia, but the specific susceptibility mechanisms underlying this relationship remain to be identified...
  15. pmc Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice
    Weidong Li
    Department of Neurobiology, Semel Institute, Brain Research Institute, and Department of Urology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:18280-5. 2007
    ..Our findings demonstrate that alterations in DISC1 function during brain development contribute to schizophrenia pathogenesis...