O Heinonen

Summary

Affiliation: National Public Health Institute
Country: Finland

Publications

  1. ncbi Expression of palmitoyl protein thioesterase in neurons
    O Heinonen
    Department of Human Molecular Genetics, National Public Health Institute, Helsinki, 00300, Finland
    Mol Genet Metab 69:123-9. 2000
  2. ncbi CLN-1 and CLN-5, genes for infantile and variant late infantile neuronal ceroid lipofuscinoses, are expressed in the embryonic human brain
    O Heinonen
    National Public Health Institute, Department of Human Molecular Genetics, FIN 00300 Helsinki, Finland
    J Comp Neurol 426:406-12. 2000
  3. ncbi Adenovirus-mediated gene transfer results in decreased lysosomal storage in brain and total correction in liver of aspartylglucosaminuria (AGU) mouse
    M Peltola
    Department of Human Molecular Genetics, University of Helsinki, Finland
    Gene Ther 5:1314-21. 1998
  4. ncbi Developmental expression of palmitoyl protein thioesterase in normal mice
    J Isosomppi
    Department of Human Molecular Genetics, National Public Health Institute and Department of Medical Genetics, University of Helsinki, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    Brain Res Dev Brain Res 118:1-11. 1999
  5. ncbi Expression and endocytosis of lysosomal aspartylglucosaminidase in mouse primary neurons
    A Kyttälä
    Department of Human Molecular Genetics, National Public Health Institute, University of Helsinki, FIN 00300 Helsinki, Finland
    J Neurosci 18:7750-6. 1998
  6. ncbi Palmitoyl protein thioesterase (PPT) localizes into synaptosomes and synaptic vesicles in neurons: implications for infantile neuronal ceroid lipofuscinosis (INCL)
    M Lehtovirta
    National Public Health Institute, Department of Human Molecular Genetics, Mannerheimintie 166, 00300 Helsinki, Finland
    Hum Mol Genet 10:69-75. 2001
  7. ncbi Toward understanding the neuronal pathogenesis of aspartylglucosaminuria: expression of aspartylglucosaminidase in brain during development
    A Uusitalo
    National Public Health Institute and Department of Medical Genetics, University of Helsinki, Mannerheimintie 166, Helsinki, FIN 00300, Finland
    Mol Genet Metab 67:294-307. 1999

Collaborators

Detail Information

Publications7

  1. ncbi Expression of palmitoyl protein thioesterase in neurons
    O Heinonen
    Department of Human Molecular Genetics, National Public Health Institute, Helsinki, 00300, Finland
    Mol Genet Metab 69:123-9. 2000
    ..Furthermore, since a substantial amount of PPT is secreted by neurons, it is tempting to speculate that the enzyme could also have an extracellular substrate...
  2. ncbi CLN-1 and CLN-5, genes for infantile and variant late infantile neuronal ceroid lipofuscinoses, are expressed in the embryonic human brain
    O Heinonen
    National Public Health Institute, Department of Human Molecular Genetics, FIN 00300 Helsinki, Finland
    J Comp Neurol 426:406-12. 2000
    ..These findings indicate that expression of CLN-1 and CLN-5 may be significant for development of a wide range of maturating neurons...
  3. ncbi Adenovirus-mediated gene transfer results in decreased lysosomal storage in brain and total correction in liver of aspartylglucosaminuria (AGU) mouse
    M Peltola
    Department of Human Molecular Genetics, University of Helsinki, Finland
    Gene Ther 5:1314-21. 1998
    ..These data demonstrate that the lysosomal storage in AGU can be biologically corrected and furthermore, in the brain a limited number of transduced cells can distribute AGA enzyme to the surrounding areas...
  4. ncbi Developmental expression of palmitoyl protein thioesterase in normal mice
    J Isosomppi
    Department of Human Molecular Genetics, National Public Health Institute and Department of Medical Genetics, University of Helsinki, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    Brain Res Dev Brain Res 118:1-11. 1999
    ..A notable correlation with synaptophysin would suggest that PPT may have a role in the function of the synaptic machinery...
  5. ncbi Expression and endocytosis of lysosomal aspartylglucosaminidase in mouse primary neurons
    A Kyttälä
    Department of Human Molecular Genetics, National Public Health Institute, University of Helsinki, FIN 00300 Helsinki, Finland
    J Neurosci 18:7750-6. 1998
    ..This indicates that PC12 and N18 are not feasible cell lines to describe neuronal uptake of mannose-6-phosphate-tagged proteins. This in vitro data will form an important basis for the brain-targeted therapy of AGU...
  6. ncbi Palmitoyl protein thioesterase (PPT) localizes into synaptosomes and synaptic vesicles in neurons: implications for infantile neuronal ceroid lipofuscinosis (INCL)
    M Lehtovirta
    National Public Health Institute, Department of Human Molecular Genetics, Mannerheimintie 166, 00300 Helsinki, Finland
    Hum Mol Genet 10:69-75. 2001
    ..The current data imply that PPT has a role outside the lysosomes in the brain and may be associated with synaptic functioning. This finding opens a new route to study the neuropathological events associated with INCL...
  7. ncbi Toward understanding the neuronal pathogenesis of aspartylglucosaminuria: expression of aspartylglucosaminidase in brain during development
    A Uusitalo
    National Public Health Institute and Department of Medical Genetics, University of Helsinki, Mannerheimintie 166, Helsinki, FIN 00300, Finland
    Mol Genet Metab 67:294-307. 1999
    ..This is consistent with previous magnetic resonance imaging findings in the brains of aspartylglucosaminuria patients, revealing delayed myelination in childhood...