- Potent inhibition of gap junctional intercellular communication by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in BALB/c 3T3 cellsPasi Hakulinen
National Public Health Institute, Laboratory of Toxicology, P O Box 95, Kuopio FIN 70701, Finland
Toxicol Lett 151:439-49. 2004..MCA also has a specific potential to inhibit GJIC whereas MCF and CMCF affected GJIC at concentrations, similar to those evoking genotoxicity in vitro...
- Altered expression of connexin43 in the inhibition of gap junctional intercellular communication by chlorohydroxyfuranones in WB-F344 rat liver epithelial cellsPasi Hakulinen
National Public Health Institute, Laboratory of Toxicology, P O B 95, FI 70701 Kuopio, Finland
Toxicol Appl Pharmacol 212:146-55. 2006..The results indicate that all the studied CHFs inhibit GJIC in WB-F344 cells by altering Cx43 expression...
- Expression of p53 and p21 Ki-ras proteins in rat thyroid gland tumors induced by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX)Pasi Hakulinen
Laboratory of Toxicology, National Public Health Institute, Kuopio, Finland
Anticancer Res 22:703-6. 2002..No expression of p21 Ki-ras was observed in any of the samples. CONCLUSION: These data indicate that p53 and Ki-ras proteins are not overexpressed in the MX-induced thyroid tumors in rats...