Riku Fagerlund

Summary

Affiliation: National Public Health Institute
Country: Finland

Publications

  1. ncbi NF-{kappa}B is transported into the nucleus by importin {alpha}3 and importin {alpha}4
    Riku Fagerlund
    Departments of Viral Diseases and Immunology and Epidemiology and Health Promotion, National Public Health Institute, FIN 00300, Helsinki, Finland
    J Biol Chem 280:15942-51. 2005
  2. ncbi Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5
    Riku Fagerlund
    Laboratory of Infectious Disease Immunology, Department of Microbiology, National Public Health Institute, FIN 00300 Helsinki, Finland
    J Biol Chem 277:30072-8. 2002
  3. ncbi NF-kappaB p52, RelB and c-Rel are transported into the nucleus via a subset of importin alpha molecules
    Riku Fagerlund
    Department of Viral Diseases and Immunology, National Public Health Institute, FIN 00300, Helsinki, Finland
    Cell Signal 20:1442-51. 2008
  4. ncbi Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein
    Krister Melen
    Laboratory of Infectious Disease Immunology, Department of Microbiology, National Public Health Institute, FIN 00300 Helsinki, Finland
    J Biol Chem 278:28193-200. 2003
  5. ncbi Expression of hepatitis C virus core protein inhibits interferon-induced nuclear import of STATs
    Krister Melen
    Laboratory of Infectious Disease Immunology, Department of Microbiology, National Public Health Institute, Helsinki, Finland
    J Med Virol 73:536-47. 2004
  6. ncbi TNF-alpha and IFN-alpha enhance influenza-A-virus-induced chemokine gene expression in human A549 lung epithelial cells
    Ville Veckman
    Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Virology 345:96-104. 2006
  7. pmc Influenza A H3N2 subtype virus NS1 protein targets into the nucleus and binds primarily via its C-terminal NLS2/NoLS to nucleolin and fibrillarin
    Krister Melen
    Virology Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare THL, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Virol J 9:167. 2012
  8. pmc Incoming influenza A virus evades early host recognition, while influenza B virus induces interferon expression directly upon entry
    Pamela Osterlund
    Department of Infectious Disease Surveillance and Control, Virology Unit, National Institute for Health and Welfare, Helsinki, Finland
    J Virol 86:11183-93. 2012
  9. pmc Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes
    Krister Melen
    Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    J Virol 81:5995-6006. 2007
  10. ncbi Serum antibodies to putative proteinase maturation protein A in children with acute otitis media
    Anni Vainio
    Department of Bacterial and Inflammatory Diseases, National Public Health Institute KTL, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Vaccine 24:1792-9. 2006

Detail Information

Publications12

  1. ncbi NF-{kappa}B is transported into the nucleus by importin {alpha}3 and importin {alpha}4
    Riku Fagerlund
    Departments of Viral Diseases and Immunology and Epidemiology and Health Promotion, National Public Health Institute, FIN 00300, Helsinki, Finland
    J Biol Chem 280:15942-51. 2005
    ..The present study demonstrates that the nuclear import of NF-kappaB is a highly regulated process mediated by a subset of importin alpha molecules...
  2. ncbi Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5
    Riku Fagerlund
    Laboratory of Infectious Disease Immunology, Department of Microbiology, National Public Health Institute, FIN 00300 Helsinki, Finland
    J Biol Chem 277:30072-8. 2002
    ..Our results demonstrate that specific NLSs in STATs mediate direct interactions of STAT dimers with importin alpha, which activates the nuclear import process...
  3. ncbi NF-kappaB p52, RelB and c-Rel are transported into the nucleus via a subset of importin alpha molecules
    Riku Fagerlund
    Department of Viral Diseases and Immunology, National Public Health Institute, FIN 00300, Helsinki, Finland
    Cell Signal 20:1442-51. 2008
    ..Moreover, we show that the nuclear import of p52/RelB heterodimers is mediated exclusively by the NLS of RelB. In addition, we found that the NLS of p52 mediates the nuclear import of p52/p65 heterodimers...
  4. ncbi Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein
    Krister Melen
    Laboratory of Infectious Disease Immunology, Department of Microbiology, National Public Health Institute, FIN 00300 Helsinki, Finland
    J Biol Chem 278:28193-200. 2003
    ....
  5. ncbi Expression of hepatitis C virus core protein inhibits interferon-induced nuclear import of STATs
    Krister Melen
    Laboratory of Infectious Disease Immunology, Department of Microbiology, National Public Health Institute, Helsinki, Finland
    J Med Virol 73:536-47. 2004
    ..The results demonstrate a novel mechanism by which HCV gene expression may interfere with IFN-mediated host defence systems...
  6. ncbi TNF-alpha and IFN-alpha enhance influenza-A-virus-induced chemokine gene expression in human A549 lung epithelial cells
    Ville Veckman
    Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Virology 345:96-104. 2006
    ..Our results suggest that IFN-alpha and TNF-alpha have a significant role in priming epithelial cells for higher cytokine and chemokine production in influenza A virus infection...
  7. pmc Influenza A H3N2 subtype virus NS1 protein targets into the nucleus and binds primarily via its C-terminal NLS2/NoLS to nucleolin and fibrillarin
    Krister Melen
    Virology Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare THL, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Virol J 9:167. 2012
    ....
  8. pmc Incoming influenza A virus evades early host recognition, while influenza B virus induces interferon expression directly upon entry
    Pamela Osterlund
    Department of Infectious Disease Surveillance and Control, Virology Unit, National Institute for Health and Welfare, Helsinki, Finland
    J Virol 86:11183-93. 2012
    ..Collectively, our data provide new evidence of a novel antiviral evasion strategy for influenza A virus without a contribution of the viral NS1 protein, and this opens up new insights into different influenza virus pathogenicities...
  9. pmc Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes
    Krister Melen
    Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    J Virol 81:5995-6006. 2007
    ..It is likely that the evolutionarily well-conserved nucleolar targeting function of NS1A protein plays a role in the pathogenesis of influenza A virus...
  10. ncbi Serum antibodies to putative proteinase maturation protein A in children with acute otitis media
    Anni Vainio
    Department of Bacterial and Inflammatory Diseases, National Public Health Institute KTL, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Vaccine 24:1792-9. 2006
    ..We conclude that PpmA is immunogenic in humans, and therefore an interesting antigen to study further in developing pneumococcal multicomponent protein vaccines...
  11. pmc Severe acute respiratory syndrome coronavirus fails to activate cytokine-mediated innate immune responses in cultured human monocyte-derived dendritic cells
    Thedi Ziegler
    Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    J Virol 79:13800-5. 2005
    ..Our data strongly suggest that SCV fails to activate host cell cytokine gene expression in human macrophages and DCs...
  12. doi Nuclear translocation of hypoxia-inducible factors (HIFs): involvement of the classical importin alpha/beta pathway
    Reinhard Depping
    Department of Physiology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Biochim Biophys Acta 1783:394-404. 2008
    ..In contrast, the supposed N-terminal NLS is not effective. Our findings provide new insight into the mechanism of the regulation of nuclear transport of hypoxia-inducible factors...