Riku Fagerlund

Summary

Affiliation: National Public Health Institute
Country: Finland

Publications

  1. ncbi request reprint NF-{kappa}B is transported into the nucleus by importin {alpha}3 and importin {alpha}4
    Riku Fagerlund
    Departments of Viral Diseases and Immunology and Epidemiology and Health Promotion, National Public Health Institute, FIN 00300, Helsinki, Finland
    J Biol Chem 280:15942-51. 2005
  2. ncbi request reprint Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5
    Riku Fagerlund
    Laboratory of Infectious Disease Immunology, Department of Microbiology, National Public Health Institute, FIN 00300 Helsinki, Finland
    J Biol Chem 277:30072-8. 2002
  3. doi request reprint NF-kappaB p52, RelB and c-Rel are transported into the nucleus via a subset of importin alpha molecules
    Riku Fagerlund
    Department of Viral Diseases and Immunology, National Public Health Institute, FIN 00300, Helsinki, Finland
    Cell Signal 20:1442-51. 2008
  4. ncbi request reprint Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein
    Krister Melen
    Laboratory of Infectious Disease Immunology, Department of Microbiology, National Public Health Institute, FIN 00300 Helsinki, Finland
    J Biol Chem 278:28193-200. 2003
  5. ncbi request reprint Expression of hepatitis C virus core protein inhibits interferon-induced nuclear import of STATs
    Krister Melen
    Laboratory of Infectious Disease Immunology, Department of Microbiology, National Public Health Institute, Helsinki, Finland
    J Med Virol 73:536-47. 2004
  6. ncbi request reprint TNF-alpha and IFN-alpha enhance influenza-A-virus-induced chemokine gene expression in human A549 lung epithelial cells
    Ville Veckman
    Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Virology 345:96-104. 2006
  7. pmc Influenza A H3N2 subtype virus NS1 protein targets into the nucleus and binds primarily via its C-terminal NLS2/NoLS to nucleolin and fibrillarin
    Krister Melen
    Virology Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare THL, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Virol J 9:167. 2012
  8. pmc Incoming influenza A virus evades early host recognition, while influenza B virus induces interferon expression directly upon entry
    Pamela Osterlund
    Department of Infectious Disease Surveillance and Control, Virology Unit, National Institute for Health and Welfare, Helsinki, Finland
    J Virol 86:11183-93. 2012
  9. pmc Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes
    Krister Melen
    Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    J Virol 81:5995-6006. 2007
  10. pmc Severe acute respiratory syndrome coronavirus fails to activate cytokine-mediated innate immune responses in cultured human monocyte-derived dendritic cells
    Thedi Ziegler
    Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    J Virol 79:13800-5. 2005

Detail Information

Publications12

  1. ncbi request reprint NF-{kappa}B is transported into the nucleus by importin {alpha}3 and importin {alpha}4
    Riku Fagerlund
    Departments of Viral Diseases and Immunology and Epidemiology and Health Promotion, National Public Health Institute, FIN 00300, Helsinki, Finland
    J Biol Chem 280:15942-51. 2005
    ..The present study demonstrates that the nuclear import of NF-kappaB is a highly regulated process mediated by a subset of importin alpha molecules...
  2. ncbi request reprint Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5
    Riku Fagerlund
    Laboratory of Infectious Disease Immunology, Department of Microbiology, National Public Health Institute, FIN 00300 Helsinki, Finland
    J Biol Chem 277:30072-8. 2002
    ..Our results demonstrate that specific NLSs in STATs mediate direct interactions of STAT dimers with importin alpha, which activates the nuclear import process...
  3. doi request reprint NF-kappaB p52, RelB and c-Rel are transported into the nucleus via a subset of importin alpha molecules
    Riku Fagerlund
    Department of Viral Diseases and Immunology, National Public Health Institute, FIN 00300, Helsinki, Finland
    Cell Signal 20:1442-51. 2008
    ..Moreover, we show that the nuclear import of p52/RelB heterodimers is mediated exclusively by the NLS of RelB. In addition, we found that the NLS of p52 mediates the nuclear import of p52/p65 heterodimers...
  4. ncbi request reprint Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein
    Krister Melen
    Laboratory of Infectious Disease Immunology, Department of Microbiology, National Public Health Institute, FIN 00300 Helsinki, Finland
    J Biol Chem 278:28193-200. 2003
    ....
  5. ncbi request reprint Expression of hepatitis C virus core protein inhibits interferon-induced nuclear import of STATs
    Krister Melen
    Laboratory of Infectious Disease Immunology, Department of Microbiology, National Public Health Institute, Helsinki, Finland
    J Med Virol 73:536-47. 2004
    ..The results demonstrate a novel mechanism by which HCV gene expression may interfere with IFN-mediated host defence systems...
  6. ncbi request reprint TNF-alpha and IFN-alpha enhance influenza-A-virus-induced chemokine gene expression in human A549 lung epithelial cells
    Ville Veckman
    Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Virology 345:96-104. 2006
    ..Our results suggest that IFN-alpha and TNF-alpha have a significant role in priming epithelial cells for higher cytokine and chemokine production in influenza A virus infection...
  7. pmc Influenza A H3N2 subtype virus NS1 protein targets into the nucleus and binds primarily via its C-terminal NLS2/NoLS to nucleolin and fibrillarin
    Krister Melen
    Virology Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare THL, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Virol J 9:167. 2012
    ....
  8. pmc Incoming influenza A virus evades early host recognition, while influenza B virus induces interferon expression directly upon entry
    Pamela Osterlund
    Department of Infectious Disease Surveillance and Control, Virology Unit, National Institute for Health and Welfare, Helsinki, Finland
    J Virol 86:11183-93. 2012
    ..Collectively, our data provide new evidence of a novel antiviral evasion strategy for influenza A virus without a contribution of the viral NS1 protein, and this opens up new insights into different influenza virus pathogenicities...
  9. pmc Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes
    Krister Melen
    Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    J Virol 81:5995-6006. 2007
    ..It is likely that the evolutionarily well-conserved nucleolar targeting function of NS1A protein plays a role in the pathogenesis of influenza A virus...
  10. pmc Severe acute respiratory syndrome coronavirus fails to activate cytokine-mediated innate immune responses in cultured human monocyte-derived dendritic cells
    Thedi Ziegler
    Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    J Virol 79:13800-5. 2005
    ..Our data strongly suggest that SCV fails to activate host cell cytokine gene expression in human macrophages and DCs...
  11. doi request reprint Nuclear translocation of hypoxia-inducible factors (HIFs): involvement of the classical importin alpha/beta pathway
    Reinhard Depping
    Department of Physiology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Biochim Biophys Acta 1783:394-404. 2008
    ..In contrast, the supposed N-terminal NLS is not effective. Our findings provide new insight into the mechanism of the regulation of nuclear transport of hypoxia-inducible factors...
  12. ncbi request reprint Serum antibodies to putative proteinase maturation protein A in children with acute otitis media
    Anni Vainio
    Department of Bacterial and Inflammatory Diseases, National Public Health Institute KTL, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Vaccine 24:1792-9. 2006
    ..We conclude that PpmA is immunogenic in humans, and therefore an interesting antigen to study further in developing pneumococcal multicomponent protein vaccines...