Research Topics
Genomes and GenesSpecies | Hannu AlhoSummaryAffiliation: National Public Health Institute Country: Finland Publications
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Publications
A retrospective evaluation of patients switched from buprenorphine (Subutex) to the buprenorphine/naloxone combination (Suboxone)Kaarlo Simojoki
Espoo Treatment and Rehabilitation Center, A clinic Foundation, Espoo, Finland
Subst Abuse Treat Prev Policy 3:16. 2008..In order to curb this problem, many treatment centres transferred ("forced transfer") their buprenorphine patients to the buprenorphine plus naloxone (Suboxone) combination product in late 2003...
Abuse liability of buprenorphine-naloxone tablets in untreated IV drug usersHannu Alho
National Public Health Institute, Department of Mental Health and Alcohol Research, Helsinki, Finland
Drug Alcohol Depend 88:75-8. 2007..Its street price was less than half that of buprenorphine alone. The buprenorphine+naloxone combination appears to be a feasible tool, along with easier access to addiction treatment, for decreasing IV abuse of buprenorphine...- Long-term effects of and physiological responses to nitrous oxide gas treatment during alcohol withdrawal: a double-blind, placebo-controlled trialHannu Alho
National Public Health Institute, Department of Mental Health and Alcohol Research, Helsinki, Finland
Alcohol Clin Exp Res 26:1816-22. 2002..The aim of the present study was to characterize other effects and side effects of the N2O treatment using several objective measures and to study the possible long-term efficacy of the treatment... 
Hazardous drinking: prevalence and associations in the Finnish general populationJukka T Halme
Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
Alcohol Clin Exp Res 32:1615-22. 2008..This study aimed to investigate the prevalence and associations of hazardous drinking in comparison to AUDs, moderate drinking, and abstinence...- Alcohol consumption and all-cause mortality among elderly in FinlandJukka T Halme
National Institute for Health and Welfare, Helsinki, Finland
Drug Alcohol Depend 106:212-8. 2010..To estimate the gender-specific prevalences of alcohol consumption levels and to investigate the association between heavy drinking and all-cause mortality among elderly males... - Treatment of alcohol dependence in patients with co-morbid major depressive disorder--predictors for the outcomes with memantine and escitalopram medicationLeea H Muhonen
National Public Health Institute, Department of Mental Health and Alcohol Research, Finland
Subst Abuse Treat Prev Policy 3:20. 2008.... - Age at onset of first depressive episode as a predictor for escitalopram treatment of major depression comorbid with alcohol dependenceLeea H Muhonen
National Public Health Institute, Department of Mental Health and Alcohol Research, Helsinki, Finland
Psychiatry Res 167:115-22. 2009..Our study provides evidence that the onset of the first major depressive episode might be a clinically relevant predictor of a response to escitalopram treatment in patients with major depression and comorbid alcohol dependence... - Memory function in opioid-dependent patients treated with methadone or buprenorphine along with benzodiazepine: longitudinal change in comparison to healthy individualsPekka Rapeli
Unit for Drug Dependence, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
Subst Abuse Treat Prev Policy 4:6. 2009..The present study is the first to examine longitudinal stability of memory function in OST patients with BZD use, thus providing a new tool for health policy authorities in evaluating the usefulness of OST... - Serotonin transporter polymorphism as a predictor for escitalopram treatment of major depressive disorder comorbid with alcohol dependenceLeea H Muhonen
National Institute for Health and Welfare, Department of Mental Health and Substance Abuse Services, Helsinki, Finland
Psychiatry Res 186:53-7. 2011..This is the first study in the treatment of depression in dual diagnosis patients to report a significant association between outcomes with escitalopram and the 5-HTTLPR gene polymorphism... - The Alcohol Use Disorders Identification Test (AUDIT) and its derivatives in screening for heavy drinking among the elderlyMauri Aalto
Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland
Int J Geriatr Psychiatry 26:881-5. 2011..The aim of the present study was to determine whether tailoring the cut point improves the performance of the AUDIT and its derivatives in this age group... - Treatment of pathological gambling with naltrexone pharmacotherapy and brief intervention: a pilot studyTuuli Lahti
National Institute for Health and Welfare, Department of Mental Health and Substance Abuse Services, Helsinki, Finland
Psychopharmacol Bull 43:35-44. 2010..These positive changes suggest that this simple, inexpensive treatment helps pathological gamblers. The role of naltrexone in the treatment effect, however, needs to be determined with a larger, placebo-controlled study... - AUDIT and its abbreviated versions in detecting heavy and binge drinking in a general population surveyMauri Aalto
National Institute for Health and Welfare, Helsinki, Finland
Drug Alcohol Depend 103:25-9. 2009.... - Analysis of naltrexone and its metabolite 6-beta-naltrexol in serum with high-performance liquid chromatographyPekka Heinälä
National Public Health Institute, Helsinki, Finland
BMC Res Notes 5:439. 2012..In this article we introduce a reliable and simple method developed for the simultaneous determination of naltrexone and 6-β-naltrexol in human serum by using high-performance liquid chromatography (HPLC)... - Methadone vs. buprenorphine/naloxone during early opioid substitution treatment: a naturalistic comparison of cognitive performance relative to healthy controlsPekka Rapeli
Unit for Drug Dependence, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
BMC Clin Pharmacol 7:5. 2007..Therefore, we investigated attention, working memory, and verbal memory of opioid-dependent patients within six weeks after the introduction of OST in a naturalistic setting and compared to those of healthy controls... - Magnesium treatment in alcoholics: a randomized clinical trialKari Poikolainen
Finnish Foundation for Alcohol Studies, Helsinki, Finland
Subst Abuse Treat Prev Policy 3:1. 2008..Magnesium (Mg) deficiency is common among alcoholics. Earlier research suggests that Mg treatment may help to normalize elevated enzyme activities and some other clinically relevant parameters among alcoholics but the evidence is weak... - The impacts of nitrous oxide gas on sleep quality during alcohol withdrawalTuuli Lahti
Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland
BMC Res Notes 4:108. 2011..abstract:.. - Opposite associations of carbohydrate-deficient transferrin and gamma-glutamyltransferase with prevalent coronary heart diseasePekka Jousilahti
University of Helsinki, Department of Public Health, PO Box 41, FIN 00014 University of Helsinki, Finland
Arch Intern Med 162:817-21. 2002..We analyzed the association of 2 commonly used markers of alcohol consumption-carbohydrate-deficient transferrin (CDT) and gamma-glutamyltransferase (GGT)-and self-reported alcohol consumption with prevalent CHD... - Do drug treatment variables predict cognitive performance in multidrug-treated opioid-dependent patients? A regression analysis studyPekka Rapeli
Unit for Drug Dependence, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
Subst Abuse Treat Prev Policy 7:45. 2012..Therefore, we examined whether the cognitive performance of patients in opioid-substitution treatment (OST) is associated with their drug treatment variables... - Self-reported alcohol consumption and association to carbohydrate-deficient transferrin and gamma-glutamyltransferase in a random sample of the general population in the Republic of Karelia, Russia and in North Karelia, FinlandTiina Laatikainen
Department of Epidemiology, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
Alcohol Alcohol 37:282-8. 2002..These results suggest that alcohol consumption especially in Russia may not be reliably estimated by self-reporting, and that alcohol consumption is relatively high, especially among men, in RUS... - Alcohol misuse increases serum antibodies to oxidized LDL and C-reactive proteinHannu Alho
Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
Alcohol Alcohol 39:312-5. 2004..CONCLUSION: We propose that alcohol misuse may result in increased inflammation leading to oxidation of LDL... - The association of alcohol dependency with employment probability: evidence from the population survey 'Health 2000 in Finland'Edvard Johansson
Swedish School of Economics and Business Administration, Helsinki, Finland
Health Econ 16:739-54. 2007..However, accounting for endogeneity increases the negative effect to some 50 percentage points for men and to some 40 percentage points for women... - Double-blind, randomized comparison of memantine and escitalopram for the treatment of major depressive disorder comorbid with alcohol dependenceLeea H Muhonen
Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
J Clin Psychiatry 69:392-9. 2008.... - Comparison of new alcohol use test, the Helsinki Alcohol Use Test questionnaire, and Alcohol Use Disorders Identification Test and laboratory markers serum gamma-glutamyl transferase and carbohydrate-deficient transferrinAnnukka Merikallio-Pajunen
Eira Hospital, Helsinki, Finland
Addict Behav 29:717-22. 2004..Our results seem to indicate that the HAUT has good performance as screening instrument for alcohol-related problems in the general population... - Abstaining from alcohol and labour market underperformance--have we forgotten the 'dry' alcoholics?Edvard Johansson
The Research Institute of the Finnish Economy, Lonnrotinkatu 4B, 00120 Helsinki, Finland
Alcohol Alcohol 41:574-9. 2006..To investigate whether abstainers fare worse than non-abstainers on the labour market because a subset of the abstainers are ex-drinkers with alcohol problems... - [Care of alcohol addiction]Mikko Salaspuro
Duodecim 121:1786-7. 2005 - Accuracy of quantity-frequency and graduated frequency questionnaires in measuring alcohol intake: comparison with daily diary and commonly used laboratory markersKari Poikolainen
Finnish Foundation for Alcohol Studies, P O Box 220, FIN-00531 Helsinki, Finland
Alcohol Alcohol 37:573-6. 2002..41-0.67) but not with CDT. CONCLUSIONS: In adults motivated to recall alcohol intake, both QF and GF classify individuals in the correct rank order, but GF probably overestimates actual alcohol consumption... - A randomized, multicentre, open-label, comparative trial of disulfiram, naltrexone and acamprosate in the treatment of alcohol dependenceE Laaksonen
University of Turku and Turku Health Centre, Finland
Alcohol Alcohol 43:53-61. 2008..To compare the effects in alcohol-dependent patients of three pharmacotherapies, disulfiram (DIS), naltrexone (NTX), and acamprosate (ACA), when used with a brief manual-based cognitive-behavioural intervention... - Naltrexone for alcohol dependenceJohn David Sinclair
N Engl J Med 346:1329-31; author reply 1329-31. 2002