Research Topics
Species | Susanna TervoSummaryAffiliation: Kuopio University Hospital Country: Finland Publications
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Detail Information
Publications
Incidence and risk factors for mild cognitive impairment: a population-based three-year follow-up study of cognitively healthy elderly subjectsSusanna Tervo
Department of Neuroscience and Neurology, Brain Research Unit, Clinical Research Centre, Mediteknia, University of Kuopio, Kuopio, Finland
Dement Geriatr Cogn Disord 17:196-203. 2004..Both the apolipoprotein E (ApoE) epsilon4 allele and vascular factors have been associated with a higher risk for AD, recently they have also been linked to the risk of MCI...
CSF Abeta42, Tau and phosphorylated Tau, APOE epsilon4 allele and MCI type in progressive MCISanna Kaisa Herukka
Department of Neuroscience and Neurology, Brain Research Unit, Clinical Research Center, Mediteknia, University of Kuopio, 70211 Kuopio, Finland
Neurobiol Aging 28:507-14. 2007..Especially the amnestic MCI is seen as prodrome of AD. Apolipoprotein E (APOE) epsilon4 allele, abnormal CSF Abeta42, Tau and phosphorylated Tau (phospho-Tau) levels are associated with elevated risk for AD...
The effect of apolipoprotein polymorphism on brain in mild cognitive impairment: a voxel-based morphometric studyCorina Pennanen
Department of Neuroscience and Neurology, University of Kuopio, Canthia, Kuopio, Finland
Dement Geriatr Cogn Disord 22:60-6. 2006..In cases homozygous for the epsilon4 allele (n = 8) versus noncarriers, the greatest atrophy was located in the right amygdala followed by the right parahippocampal gyrus, the left amygdala and the left medial dorsal thalamic nucleus...
Increased fMRI responses during encoding in mild cognitive impairmentAnne Hämäläinen
Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
Neurobiol Aging 28:1889-903. 2007..We suggest that the increased fMRI activation in MCI in the posterior medial temporal and closely connected fusiform regions is compensatory due to the incipient atrophy in the anterior medial temporal lobe...
MRI of hippocampus and entorhinal cortex in mild cognitive impairment: a follow-up studyTero Tapiola
Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
Neurobiol Aging 29:31-8. 2008..The MTL volumetry helps in identifying among the MCI subjects a group, which is at high risk for developing AD...
Voxel-based morphometry to detect brain atrophy in progressive mild cognitive impairmentAnne Hämäläinen
Department of Neurology, University of Kuopio and Brain Research Unit, Clinical Research Center, Mediteknia, and Kuopio University Hospital, Finland
Neuroimage 37:1122-31. 2007..We conclude that widespread cortical atrophy is present already two and a half years before a clinical diagnosis of dementia can be set...
Discriminating accuracy of medial temporal lobe volumetry and fMRI in mild cognitive impairmentAnne M Jauhiainen
Institute of Clinical Medicine, Unit of Neurology, University of Kuopio, Kuopio, Finland
Hippocampus 19:166-75. 2009..Future technical improvements may improve the utilization of hippocampal fMRI for early diagnostic purposes...
Differential hypometabolism patterns according to mild cognitive impairment subtypesAnne M Jauhiainen
Unit of Neurology, Institute of Clinical Medicine, Mediteknia, Kuopio, Finland
Dement Geriatr Cogn Disord 26:490-8. 2008..The present study investigated cerebral glucose metabolism and structural atrophy in controls and subjects with mild cognitive impairment (MCI)...
Whole brain atrophy rate predicts progression from MCI to Alzheimer's diseaseGabriela Spulber
Institute of Clinical Medicine, Unit of Neurology, Kuopio University, Kuopio, Finland
Neurobiol Aging 31:1601-5. 2010..These findings suggest that IPCA could be an effective brain-imaging marker of progression to AD and useful tool for the evaluation of disease-modifying treatments...
