Leo K Niskanen

Summary

Affiliation: Kuopio University Hospital
Country: Finland

Publications

  1. pmc Perceived need to increase physical activity levels among adults at high risk of type 2 diabetes: a cross-sectional analysis within a community-based diabetes prevention project FIN-D2D
    Kati Vähäsarja
    Department of Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland
    BMC Public Health 12:514. 2012
  2. pmc Elevated levels of serum IL-5 are associated with an increased likelihood of major depressive disorder
    Antti Pekka Elomaa
    Department of Psychiatry, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland
    BMC Psychiatry 12:2. 2012
  3. pmc Population-level effects of the national diabetes prevention programme (FIN-D2D) on the body weight, the waist circumference, and the prevalence of obesity
    Titta M Salopuro
    Pirkanmaa Hospital District, Tampere, Finland
    BMC Public Health 11:350. 2011
  4. pmc Feasibility of a lifestyle intervention in early pregnancy to prevent deterioration of glucose tolerance
    Eeva A L Korpi-Hyövälti
    Department of Internal Medicine, Seinajoki Central Hospital, Seinajoki, Finland
    BMC Public Health 11:179. 2011
  5. pmc Leisure-time physical activity, cardiorespiratory fitness and feelings of hopelessness in men
    Maarit Valtonen
    Department of Medicine, Central Finland Central Hospital, Keskussairaalantie 19, 40620 Jyvaskyla, Finland
    BMC Public Health 9:204. 2009
  6. pmc Unemployment and ill health: a connection through inflammation?
    Jukka Hintikka
    Department of Psychiatry, Kuopio University Hospital and Department of Clinical Medicine, University of Kuopio, FI 70210 KUOPIO, Finland
    BMC Public Health 9:410. 2009
  7. ncbi Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men: a prospective cohort study
    Leo K Niskanen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Arch Intern Med 164:1546-51. 2004
  8. ncbi Does postmenopausal hormone replacement therapy affect cardiac autonomic regulation in osteoporotic women?
    Leo Niskanen
    Department of Medicine, Building Number 5, Kuopio University Hospital, PO Box 1777, FIN 70211 Kuopio, Finland
    Menopause 9:52-7. 2002
  9. doi A clinical and health economic review of a prefilled insulin pen
    L Niskanen
    Department of Medicine Diabetology and Endocrinology, Kuopio University Hospital, Kuopio, Finland
    Curr Med Res Opin 26:2431-9. 2010
  10. ncbi Randomized, multinational, open-label, 2-period, crossover comparison of biphasic insulin aspart 30 and biphasic insulin lispro 25 and pen devices in adult patients with type 2 diabetes mellitus
    Leo Niskanen
    Department of Medicine, Kuopio University Hospital, Building No 5, PO Box 1777, 70211 Kuopio, Finland
    Clin Ther 26:531-40. 2004

Detail Information

Publications64

  1. pmc Perceived need to increase physical activity levels among adults at high risk of type 2 diabetes: a cross-sectional analysis within a community-based diabetes prevention project FIN-D2D
    Kati Vähäsarja
    Department of Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland
    BMC Public Health 12:514. 2012
    ..In order to improve understanding of diabetes prevention through increased physical activity levels (PAL), we assessed factors associated with perceiving a need to increase PAL among adults at high risk of diabetes...
  2. pmc Elevated levels of serum IL-5 are associated with an increased likelihood of major depressive disorder
    Antti Pekka Elomaa
    Department of Psychiatry, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland
    BMC Psychiatry 12:2. 2012
    ..Nevertheless, relatively little is known about the role of the T-helper (Th)-2 effector cytokines interleukin (IL)-5 and IL-13 in MDD...
  3. pmc Population-level effects of the national diabetes prevention programme (FIN-D2D) on the body weight, the waist circumference, and the prevalence of obesity
    Titta M Salopuro
    Pirkanmaa Hospital District, Tampere, Finland
    BMC Public Health 11:350. 2011
    ..The implementation project of the national diabetes prevention programme in Finland, FIN-D2D, was carried out in primary health care in the area of five hospital districts during 2003-2007...
  4. pmc Feasibility of a lifestyle intervention in early pregnancy to prevent deterioration of glucose tolerance
    Eeva A L Korpi-Hyövälti
    Department of Internal Medicine, Seinajoki Central Hospital, Seinajoki, Finland
    BMC Public Health 11:179. 2011
    ..The aim of the study was to evaluate if a lifestyle intervention since early pregnancy is feasible in improving the glucose tolerance of women at a high-risk for GDM in Finland...
  5. pmc Leisure-time physical activity, cardiorespiratory fitness and feelings of hopelessness in men
    Maarit Valtonen
    Department of Medicine, Central Finland Central Hospital, Keskussairaalantie 19, 40620 Jyvaskyla, Finland
    BMC Public Health 9:204. 2009
    ..Previous studies have focused on physical exercise and depression. We examined the associations of LTPA and cardiorespiratory fitness with feelings of hopelessness...
  6. pmc Unemployment and ill health: a connection through inflammation?
    Jukka Hintikka
    Department of Psychiatry, Kuopio University Hospital and Department of Clinical Medicine, University of Kuopio, FI 70210 KUOPIO, Finland
    BMC Public Health 9:410. 2009
    ..Acute and chronic psychosocial stress can induce pronounced changes in human immune responses. In this study we tested our hypothesis that stress-induced low-grade tissue inflammation is more prevalent among the unemployed...
  7. ncbi Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men: a prospective cohort study
    Leo K Niskanen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Arch Intern Med 164:1546-51. 2004
    ..Despite abundant epidemiologic evidence, the role of elevated serum uric acid level as a cardiovascular risk factor is controversial. We assessed the predictive value of serum uric acid levels for cardiovascular and overall mortality...
  8. ncbi Does postmenopausal hormone replacement therapy affect cardiac autonomic regulation in osteoporotic women?
    Leo Niskanen
    Department of Medicine, Building Number 5, Kuopio University Hospital, PO Box 1777, FIN 70211 Kuopio, Finland
    Menopause 9:52-7. 2002
    ..One possibility is that estrogen would act via enhancement of cardiac autonomic regulation...
  9. doi A clinical and health economic review of a prefilled insulin pen
    L Niskanen
    Department of Medicine Diabetology and Endocrinology, Kuopio University Hospital, Kuopio, Finland
    Curr Med Res Opin 26:2431-9. 2010
    ..The aim of this review is to summarize the clinical and health economic data of FP and its modified version...
  10. ncbi Randomized, multinational, open-label, 2-period, crossover comparison of biphasic insulin aspart 30 and biphasic insulin lispro 25 and pen devices in adult patients with type 2 diabetes mellitus
    Leo Niskanen
    Department of Medicine, Kuopio University Hospital, Building No 5, PO Box 1777, 70211 Kuopio, Finland
    Clin Ther 26:531-40. 2004
    ..Also assessed was patients' preference for pen device--the NovoMix 30 FlexPen /NovoLog Mix 70/30 FlexPen (FlexPen) versus the Humalog Mix25 Pen/Humalog Mix75/25 Pen (Humalog Pen)...
  11. ncbi Serum uric acid as a harbinger of metabolic outcome in subjects with impaired glucose tolerance: the Finnish Diabetes Prevention Study
    Leo Niskanen
    Department of Medicine, Kuopio University Hospital, Bld nro 5, FIN 70210, Kuopio, Finland
    Diabetes Care 29:709-11. 2006
  12. ncbi Changes in sex hormone-binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome
    L Niskanen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Diabetes Obes Metab 6:208-15. 2004
    ..Little is known about the short- and long-term effects of weight loss on sex steroids in abdominally obese men, however...
  13. ncbi [Oral drugs for diabetes--update of current use and availability]
    Leo Niskanen
    Kuopion yliopiston sisätautien klinikka Niuvantie 12 70200 Kuopio
    Duodecim 120:983-90. 2004
  14. ncbi Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects
    L Niskanen
    Department of Clinical Nutrition, University of Kuopio, Finland
    J Clin Endocrinol Metab 85:2266-9. 2000
    ..165; P = 0.024) after adjustment for known risk factors. Thus, the presence of the Pro7 substitution in the prepro-NPY associates with increased carotid atherosclerosis...
  15. ncbi Reduced cardiovascular morbidity and mortality in hypertensive diabetic patients on first-line therapy with an ACE inhibitor compared with a diuretic/beta-blocker-based treatment regimen: a subanalysis of the Captopril Prevention Project
    L Niskanen
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Diabetes Care 24:2091-6. 2001
    ..One planned subanalysis of the CAPPP was to evaluate the outcome in the diabetic patient group...
  16. ncbi Fasting plasma glucose variability as a marker of nocturnal hypoglycemia in diabetes: evidence from the PREDICTIVE study
    Leo Niskanen
    Department of Medicine, Kuopio University Hospital, 70210 Kuopio, Finland
    Diabetes Res Clin Pract 86:e15-8. 2009
    ..An HbA(1c)-corrected correlation was found between these endpoints, suggesting FG variability can serve as a useful marker for this risk in clinical practice...
  17. ncbi Leucine 7 to proline 7 polymorphism in the neuropeptide y gene is associated with retinopathy in type 2 diabetes
    L Niskanen
    Department of Clinical Nutrition, University of Kuopio, Finland
    Exp Clin Endocrinol Diabetes 108:235-6. 2000
    ..97 (95% confidence intervals 1.09-98.0; p=0.049). Our finding based on elderly Finnish Type 2 diabetic subjects suggests that the Leu7Pro7-genotype in preproNPY gene is associated with the development of diabetic retinopathy...
  18. ncbi Hyperglycemia and compositional lipoprotein abnormalities as predictors of cardiovascular mortality in type 2 diabetes: a 15-year follow-up from the time of diagnosis
    L Niskanen
    Department of Clinical Nutrition, University of Kuopio, Finland
    Diabetes Care 21:1861-9. 1998
    ..We studied the 15-year cardiovascular mortality and morbidity of newly diagnosed patients with type 2 diabetes and of nondiabetic control subjects and the predictors of cardiovascular mortality in diabetic patients...
  19. pmc Crosslinking with transglutaminase does not change metabolic effects of sodium caseinate in model beverage in healthy young individuals
    Kristiina R Juvonen
    Food and Health Research Centre, Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    Nutr J 11:35. 2012
    ..Our aim was to study the effect of transglutaminase (TG)-induced crosslinking of sodium caseinate on postprandial metabolic and appetite responses. Whey protein was included as reference protein...
  20. ncbi Structural differences between rye and wheat breads but not total fiber content may explain the lower postprandial insulin response to rye bread
    Katri S Juntunen
    Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 78:957-64. 2003
    ..Rye bread has a beneficial effect on the postprandial insulin response in healthy subjects. The role of rye fiber in insulin and glucose metabolism is not known...
  21. ncbi High-fiber rye bread and insulin secretion and sensitivity in healthy postmenopausal women
    Katri S Juntunen
    Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 77:385-91. 2003
    ..Fiber and whole-cereal intakes may protect against hyperinsulinemia and the risk of type 2 diabetes...
  22. doi Depression and major weight gain: a 6-year prospective follow-up of outpatients
    Tuula H Heiskanen
    Department of Psychiatry, Kuopio University Hospital, PO Box 1777, FIN 70210 Kuopio, Finland
    Compr Psychiatry 54:599-604. 2013
    ..The present study investigated how risk factors for a weight gain of at least 10% (major weight gain) and mental health modify their mutual association during a 6-year prospective follow-up of depressed outpatients...
  23. ncbi Low levels of leisure-time physical activity and cardiorespiratory fitness predict development of the metabolic syndrome
    David E Laaksonen
    Department of Physiology, University of Kuopio, Kuopio, Finland Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Diabetes Care 25:1612-8. 2002
    ..We studied the associations of LTPA and cardiorespiratory fitness with development of the metabolic syndrome (World Health Organization [WHO] and the National Cholesterol Education Program [NCEP] definitions)...
  24. ncbi The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
    Hanna Maaria Lakka
    Research Institute of Public Health, University of Kuopio, Finland
    JAMA 288:2709-16. 2002
    ..Despite its high prevalence, little is known of the prospective association of the metabolic syndrome with cardiovascular and overall mortality...
  25. ncbi Plasma ghrelin levels after two high-carbohydrate meals producing different insulin responses in patients with metabolic syndrome
    Miika V Heinonen
    Department of Biotechnology and Molecular Medicine, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Finland
    Regul Pept 138:118-25. 2007
    ..This indicates that regulation of ghrelin might be altered in obese patients with metabolic syndrome independently of insulin...
  26. ncbi Weight loss and weight maintenance, ambulatory blood pressure and cardiac autonomic tone in obese persons with the metabolic syndrome
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    J Hypertens 21:371-8. 2003
    ..Most studies on the effects of weight loss on blood pressure and autonomic function do not distinguish between acute or continuing weight loss and steady-state weight maintenance after weight loss...
  27. ncbi Metabolic syndrome and development of diabetes mellitus: application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Am J Epidemiol 156:1070-7. 2002
    ..The NCEP definition including waist > 102 cm also identifies persons at high risk for diabetes, but it is relatively insensitive in predicting diabetes...
  28. doi Structure modification of a milk protein-based model food affects postprandial intestinal peptide release and fullness in healthy young men
    Kristiina R Juvonen
    Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, Food and Health Research Centre, University of Eastern Finland, 70211 Kuopio, Finland
    Br J Nutr 106:1890-8. 2011
    ..Modification of protein-based food structure could thus offer a possible tool for lowering postprandial glucose and insulin concentrations and enhancing postprandial fullness...
  29. doi Metabolic syndrome is associated with impaired health-related quality of life: Lapinlahti 2005 study
    Juhani Miettola
    Family Practice Unit, Kuopio University Hospital and University of Kuopio, P O Box 1777, 70211, Kuopio, Finland
    Qual Life Res 17:1055-62. 2008
    ..Association of Metabolic Syndrome (MetS) with Health-Related Quality of Life (HRQoL) is poorly documented. Our objective was to examine this association in an adult general population...
  30. ncbi Leucine7 to proline7 polymorphism in prepro-NPY gene and femoral neck bone mineral density in postmenopausal women
    Anna Mari Heikkinen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, FIN 70211 Kuopio, Finland
    Bone 35:589-94. 2004
    ..In the HRT group, the changes in BMD were quite modest and not significantly modified by Leu7/Pro7 genotype. We conclude that the Leu7/Pro7 polymorphism in NPY signal gene may favorably affect femoral neck BMD in postmenopausal women...
  31. doi The effect of glycaemic control on the quantitative characteristics of retinopathy lesions in patients with type 2 diabetes mellitus: 10-year follow-up study
    V Kalesnykiene
    Department of Ophthalmology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, FIN 70211, Kuopio, Finland
    Graefes Arch Clin Exp Ophthalmol 247:335-41. 2009
    ..The aim of our study was to investigate the association of selected glycaemic parameters with particular DR abnormalities and their characteristics in patients with type 2 diabetes...
  32. ncbi Effect of obesity on the response to insulin therapy in noninsulin-dependent diabetes mellitus
    H Yki-Jarvinen
    Department of Medicine, University of Helsinki, Finland
    J Clin Endocrinol Metab 82:4037-43. 1997
    ....
  33. doi Effect of diet-induced weight loss on plasma apelin and cytokine levels in individuals with the metabolic syndrome
    M V Heinonen
    A I Virtanen Institute for Molecular Sciences, University of Kuopio, Finland
    Nutr Metab Cardiovasc Dis 19:626-33. 2009
    ..The aim of this study was to measure abdominal fat, blood pressure and circulating apelin, adiponectin, leptin, ghrelin, TNF-alpha and IL-6 levels in patients with the metabolic syndrome after a diet-induced weight loss...
  34. ncbi Metabolic syndrome and depression: a cross-sectional analysis
    Tuula H Heiskanen
    Department of Psychiatry, Kuopio University Hospital, Kuopio, Finland
    J Clin Psychiatry 67:1422-7. 2006
    ..To examine the prevalence of the metabolic syndrome in depressive outpatients and to identify its correlates in depression...
  35. ncbi Clustering of cardiovascular risk factors in type 2 diabetes mellitus: prognostic significance and tracking
    J Kaukua
    Department of Medicine, Kuopio University Hospital and University of Kuopio, Kuopio, Finland
    Diabetes Obes Metab 3:17-23. 2001
    ..CONCLUSIONS: The risk factor clusters among type 2 diabetic subjects are of great predictive value and when not aggressively treated, show a relentless increase despite selective mortality...
  36. ncbi Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on long-term body weight change in Finnish type 2 diabetic and non-diabetic control subjects
    K Sivenius
    Department of Clinical Nutrition, University of Kuopio, Finland
    Int J Obes Relat Metab Disord 24:514-9. 2000
    ....
  37. ncbi Weight reduction modulates expression of genes involved in extracellular matrix and cell death: the GENOBIN study
    M Kolehmainen
    School of Public Health and Clinical Nutrition, Clinical Nutrition and Food and Health Research Center, University of Kuopio, Kuopio, Finland
    Int J Obes (Lond) 32:292-303. 2008
    ....
  38. doi Health-related quality of life among subjects with long-term mental symptoms in a population-based sample
    T Saharinen
    Department of Psychiatry, Kuopio University Hospital, P O Box 1777, 70211 Kuopio, Finland
    J Psychiatr Ment Health Nurs 17:260-7. 2010
    ..Men and women had similarly poor scores for PCS and MCS. Mental health-related factors were main correlates of HRQL and this knowledge could be used in nursing practice and in health promotion...
  39. doi Serum adiponectin and resistin levels in major depressive disorder
    S M Lehto
    Department of Psychiatry, Kuopio University Hospital and University of Kuopio, Kuopio, Finland
    Acta Psychiatr Scand 121:209-15. 2010
    ..To examine the role of the adipose-tissue-derived low-grade inflammation markers adiponectin and resistin in major depressive disorder (MDD) in a population-based sample...
  40. ncbi Effect of a three-amino acid deletion in the alpha2B-adrenergic receptor gene on long-term body weight change in Finnish non-diabetic and type 2 diabetic subjects
    K Sivenius
    Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Int J Obes Relat Metab Disord 25:1609-14. 2001
    ..We investigated the effects of this polymorphism on changes in body weight in Finnish non-diabetic and type 2 diabetic subjects during a 10 y follow-up...
  41. doi Association of depressive symptoms and metabolic syndrome in men
    H Viinamaki
    Institute of Clinical Medicine, University of Kuopio, Kuopio University Hospital, Kuopio, Finland
    Acta Psychiatr Scand 120:23-9. 2009
    ..To explore the relationship between several indicators of depression and metabolic syndrome (MetS)...
  42. ncbi Changes in body weight and onset of hypertension in perimenopausal women
    M Juntunen
    Research Institute of Public Health, University of Kuopio, Finland
    J Hum Hypertens 17:775-9. 2003
    ..Therefore, preventing weight gain by dietary means and exercise is of great importance at menopausal age...
  43. ncbi Age and gender dependency of baroreflex sensitivity in healthy subjects
    T Laitinen
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Finland
    J Appl Physiol (1985) 84:576-83. 1998
    ..In addition, we demonstrate that BRS values that have been proposed to be useful in identifying postinfarction patients at high risk of sudden death are frequently found in healthy subjects...
  44. ncbi Relationships between changes in abdominal fat distribution and insulin sensitivity during a very low calorie diet in abdominally obese men and women
    D E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Nutr Metab Cardiovasc Dis 13:349-56. 2003
    ..We assessed the role of visceral and subcutaneous fat as determinants of insulin sensitivity during rapid weight loss in obese persons with the metabolic syndrome...
  45. ncbi Depression and associated factors in coronary heart disease
    M Valkamo
    Department of Psychiatry, Kuopio University Hospital, Kuopio, Finland
    Scand Cardiovasc J 35:259-63. 2001
    ..CONCLUSION: Depression is a common finding and should be looked for independently of other risk factors in patients with CHD...
  46. ncbi Psychiatric morbidity and the presence and absence of angiographic coronary disease in patients with chest pain
    M Valkamo
    Department of Psychiatry, Kuopio University Hospital, FI 70211 Kuopio, Finland
    Acta Psychiatr Scand 104:391-6. 2001
    ..To assess psychiatric morbidity in coronary angiogram patients...
  47. doi Downregulation of genes involved in NFkappaB activation in peripheral blood mononuclear cells after weight loss is associated with the improvement of insulin sensitivity in individuals with the metabolic syndrome: the GENOBIN study
    V D F de Mello
    Department of Clinical Nutrition, Food and Health Research Centre, University of Kuopio, Kuopio 70211, Finland
    Diabetologia 51:2060-7. 2008
    ..The genes studied were: TNF receptors TNFRSF1A and TNFRSF1B, and IL1R1, TLR4, TLR2, ICAM1, CCL5 and IKBKB...
  48. ncbi Association of the PRO12ALA polymorphism of the PPAR-gamma2 gene with oxidized low-density lipoprotein and cardiolipin autoantibodies in nondiabetic and type 2 diabetic subjects
    L Niskanen
    Department of Clinical Nutrition, and the A I Virtanen Institute of Molecular Sciences, University of Kuopio, Kuopio, Finland
    Metabolism 52:213-7. 2003
    ..Genotype may therefore modulate the oxidative modification of LDL in hyperglycemic milieu...
  49. pmc Feasibility and antihypertensive effect of replacing regular salt with mineral salt -rich in magnesium and potassium- in subjects with mildly elevated blood pressure
    Essi S Sarkkinen
    Oy Foodfiles Ltd, CRO in the field of nutrition, Neulaniementie 2 L 6, 70210 Kuopio, Finland
    Nutr J 10:88. 2011
    ....
  50. ncbi Postprandial glucose, insulin, and incretin responses to grain products in healthy subjects
    Katri S Juntunen
    Department of Clinical Nutrition, The University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 75:254-62. 2002
    ..Various botanical and structural characteristics of starchy food modify the postprandial glucose and insulin responses in humans...
  51. ncbi C-reactive protein and the development of the metabolic syndrome and diabetes in middle-aged men
    D E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Diabetologia 47:1403-10. 2004
    ..We investigated the association between C-reactive protein (CRP) levels and the development of the metabolic syndrome and diabetes in men...
  52. ncbi Sympathovagal balance is major determinant of short-term blood pressure variability in healthy subjects
    T Laitinen
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, FIN 70211 Kuopio, Finland
    Am J Physiol 276:H1245-52. 1999
    ..We conclude that sympathovagal balance of cardiovascular regulation is the major determinant of BPV. Other factors associated with BPV are age, gender, body mass index, blood pressure, and BRS...
  53. ncbi Aldose reductase gene polymorphisms and susceptibility to microvascular complications in Type 2 diabetes
    K Sivenius
    Department of Clinical Nutrition, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Diabet Med 21:1325-33. 2004
    ....
  54. ncbi Alexithymia in patients with coronary heart disease
    M Valkamo
    Department of Psychiatry, Kuopio University Hospital, P.O. Box 1777, FI-70211 Kuopio, Finland
    J Psychosom Res 50:125-30. 2001
    ..Alexithymia is associated with the enhanced psychosocial burden of suffering CHD. This patient group may need more individual support and attention than other CHD patients...
  55. ncbi Cardiac power during exercise and the risk of stroke in men
    S Kurl
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Stroke 36:820-4. 2005
    ..The aim of this study was to examine the relationship of exercise cardiac power (ECP), defined as a ratio of VO2max with peak systolic blood pressure (SBP) during exercise, with the risk for stroke...
  56. ncbi Glycemic responses of oat bran products in type 2 diabetic patients
    N Tapola
    Oy Foodfiles Ltd, Kuopio, Finland
    Nutr Metab Cardiovasc Dis 15:255-61. 2005
    ..In addition, we investigated the effects of oat bran flour on postprandial glucose response following an oral glucose load...
  57. doi Glucose regulation and chronic pain at multiple sites
    P Mäntyselkä
    Family Practice Unit, University of Kuopio and Kuopio University Hospital, PO Box 1777, Kuopio, FIN 70211, Finland
    Rheumatology (Oxford) 47:1235-8. 2008
    ..To analyse how glucose regulation status is associated with chronic regional pain and chronic widespread pain (CWP) in the adult population...
  58. ncbi Maculopathy and visual acuity in newly diagnosed type 2 diabetic patients and non-diabetic subjects: a 10-year follow-up study
    R Voutilainen-Kaunisto
    Department of Ophthalmology, Kuopio University Hospital, Kuopio, Finland
    Acta Ophthalmol Scand 79:163-8. 2001
    ..CONCLUSIONS: In newly diagnosed patients with Type 2 diabetes one-fifth had developed maculopathy which deteriorated their visual acuity. Poor glycaemic control was the most important predictor of maculopathy...
  59. ncbi Life satisfaction in patients with chest pain subsequently diagnosed as coronary heart disease--connection through depressive symptoms?
    M Valkamo
    Department of Psychiatry, Kuopio University Hospital, Finland
    Qual Life Res 12:1099-105. 2003
    ..81). To conclude, life dissatisfaction is not primarily determined by the severity of CHD but by the existence of depressive symptoms...
  60. ncbi Adherence to the salt restriction diet among people with mildly elevated blood pressure
    M H Korhonen
    Department of Clinical Nutrition, University of Kuopio, Kuopio
    Eur J Clin Nutr 53:880-5. 1999
    ..The aim of the study was to examine the adherence to a salt restriction diet and the effect of salt restriction on blood pressure in free living subjects with mildly elevated blood pressure...
  61. ncbi Does apolipoprotein E genotype relate to BMD and bone markers in postmenopausal women?
    A M Heikkinen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, Finland
    Maturitas 34:33-41. 2000
    ..Additionally, the influence of apo E genotype on BMD changes during a 5-year follow-up with or without hormone replacement therapy (HRT) was investigated...
  62. ncbi Is discordance in bone measurements affected by body composition or anthropometry? A comparative study between peripheral and central devices
    J Saarelainen
    Bone and Cartilage Research Unit, Clinical Research Center, University of Kuopio, Kuopio, Finland
    J Clin Densitom 10:312-8. 2007
    ..To avoid diagnostic bias, comparative assessment of the devices using the same population is recommended...
  63. ncbi Increased resting and exercise-induced oxidative stress in young IDDM men
    D E Laaksonen
    Department of Physiology, University of Kuopio, Finland
    Diabetes Care 19:569-74. 1996
    ..To assess the effect of acute physical exercise on oxidative stress and glutathione redox status and the relation to physical fitness in otherwise healthy young men with IDDM...
  64. ncbi Sedentary lifestyle, poor cardiorespiratory fitness, and the metabolic syndrome
    Timo A Lakka
    Research Institute of Public Health, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808 4124, USA
    Med Sci Sports Exerc 35:1279-86. 2003
    ....