Markku Laakso

Summary

Affiliation: Kuopio University Hospital
Country: Finland

Publications

  1. ncbi request reprint Metabolic syndrome: to be or not to be?
    Markku Laakso
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Ann Med 38:32-3. 2006
  2. pmc Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men
    Alena Stancakova
    Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
    Diabetes 61:1895-902. 2012
  3. pmc SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity
    Jarno Rutanen
    Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Diabetes 59:829-35. 2010
  4. pmc Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men
    Alena Stancakova
    Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
    Diabetes 60:1608-16. 2011
  5. pmc Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men
    Alena Stancakova
    Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Diabetes 58:2129-36. 2009
  6. pmc Non-cholesterol sterol levels predict hyperglycemia and conversion to type 2 diabetes in Finnish men
    Henna Cederberg
    Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
    PLoS ONE 8:e67406. 2013
  7. pmc Thoracoabdominal calcifications predict cardiovascular disease mortality in type 2 diabetic and nondiabetic subjects: 18-year follow-up study
    Auni Juutilainen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Diabetes Care 33:583-5. 2010
  8. pmc Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men
    Alena Stancakova
    Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Diabetes 58:1212-21. 2009
  9. pmc Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men
    Yuvaraj Mahendran
    Corresponding author Markku Laakso
    Diabetes Care 36:3732-8. 2013
  10. pmc Adipose co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes
    Blake E Haas
    Department of Human Genetics, Gonda Center, Los Angeles, California, 90095 7088, USA
    BMC Med Genomics 5:61. 2012

Detail Information

Publications168 found, 100 shown here

  1. ncbi request reprint Metabolic syndrome: to be or not to be?
    Markku Laakso
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Ann Med 38:32-3. 2006
  2. pmc Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men
    Alena Stancakova
    Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
    Diabetes 61:1895-902. 2012
    ..Only one single nucleotide polymorphism regulating hyperglycemia was significantly associated with amino acid levels...
  3. pmc SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity
    Jarno Rutanen
    Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Diabetes 59:829-35. 2010
    ..No studies are available in humans to demonstrate that SIRT1 expression in insulin-sensitive tissues is associated with energy expenditure and insulin sensitivity...
  4. pmc Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men
    Alena Stancakova
    Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
    Diabetes 60:1608-16. 2011
    ..We investigated the effects of 34 genetic risk variants for hyperglycemia/type 2 diabetes on lipoprotein subclasses and particle composition in a large population-based cohort...
  5. pmc Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men
    Alena Stancakova
    Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Diabetes 58:2129-36. 2009
    ..We investigated the effects of 18 confirmed type 2 diabetes risk single nucleotide polymorphisms (SNPs) on insulin sensitivity, insulin secretion, and conversion of proinsulin to insulin...
  6. pmc Non-cholesterol sterol levels predict hyperglycemia and conversion to type 2 diabetes in Finnish men
    Henna Cederberg
    Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
    PLoS ONE 8:e67406. 2013
    ..In conclusion, the levels of some, but not all non-cholesterol sterols are markers of the worsening of hyperglycemia and type 2 diabetes. ..
  7. pmc Thoracoabdominal calcifications predict cardiovascular disease mortality in type 2 diabetic and nondiabetic subjects: 18-year follow-up study
    Auni Juutilainen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Diabetes Care 33:583-5. 2010
    ..CONCLUSIONS Thoracoabdominal calcifications in native radiograms are significant predictors of CVD and total mortality, especially in type 2 diabetic and nondiabetic women with elevated high-sensitivity C-reactive protein level...
  8. pmc Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men
    Alena Stancakova
    Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Diabetes 58:1212-21. 2009
    ....
  9. pmc Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men
    Yuvaraj Mahendran
    Corresponding author Markku Laakso
    Diabetes Care 36:3732-8. 2013
    ..We investigated the association of fasting serum glycerol and fatty acids (FAs) as predictors for worsening of hyperglycemia and incident type 2 diabetes...
  10. pmc Adipose co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes
    Blake E Haas
    Department of Human Genetics, Gonda Center, Los Angeles, California, 90095 7088, USA
    BMC Med Genomics 5:61. 2012
    ..Fat is stored in the form of TGs in human adipose tissue. We hypothesized that gene co-expression networks in human adipose tissue may be correlated with serum TG levels and help reveal novel genes involved in TG regulation...
  11. doi request reprint Glucose control in diabetes: which target level to aim for?
    M Laakso
    Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
    J Intern Med 272:1-12. 2012
    ..5% may be reasonable for patients with a short duration of type 2 diabetes and without extensive atherosclerosis...
  12. pmc Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice
    Suvi E Heinonen
    Department of Biotechnology and Molecular Medicine at A I Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI 70211 Kuopio, Finland
    Cardiovasc Diabetol 10:59. 2011
    ..We examined the effects of type 2 diabetes on coronary artery disease and cardiac function in hypercholesterolemic low-density lipoprotein receptor-deficient apolipoprotein B100-only mice (LDLR-/-ApoB100/100)...
  13. pmc Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects
    Peter Weyrich
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tubingen, Tubingen, Germany
    BMC Med Genet 10:77. 2009
    ..In this study, we assessed whether common genetic variation within the NR4A3 locus, encoding Nor-1, contributes to the development of prediabetic phenotypes, such as glucose intolerance, insulin resistance, or beta-cell dysfunction...
  14. ncbi request reprint Gene variants, insulin resistance, and dyslipidaemia
    Markku Laakso
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Curr Opin Lipidol 15:115-20. 2004
    ..The purpose of this review is to give some examples from recent studies on gene variants regulating primarily insulin signalling or lipoprotein metabolism...
  15. ncbi request reprint Prevention of type 2 diabetes
    M Laakso
    Department of Medicine, University of Kuopio, Finland
    Curr Mol Med 5:365-74. 2005
    ..However, we can safely conclude that the current evidence strongly favors the notion that lifestyle changes are the primary means to tackle the epidemic of T2DM...
  16. ncbi request reprint Retinopathy predicts cardiovascular mortality in type 2 diabetic men and women
    Auni Juutilainen
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    Diabetes Care 30:292-9. 2007
    ....
  17. ncbi request reprint [New criteria and care for metabolic syndrome]
    Markku Laakso
    sisãtautien klinikka, Kuopion yliopisto ja KYS
    Duodecim 121:1521-30. 2005
  18. doi request reprint Diabetes as a 'cardiovascular disease equivalent': implications for treatment
    Markku Laakso
    Academy of Finland, Helsinki and Department of Medicine, University of Kuopio, Kuopio, Finland
    Nat Clin Pract Cardiovasc Med 5:682-3. 2008
    ..Epidemiological evidence reported by Schramm et al. is in line with these recommendations...
  19. ncbi request reprint Lipids in type 2 diabetes
    Markku Laakso
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Semin Vasc Med 2:59-66. 2002
    ....
  20. ncbi request reprint Cardiovascular disease in type 2 diabetes: challenge for treatment and prevention
    M Laakso
    Department of Medicine, University of Kuopio, Kuopio, Finland
    J Intern Med 249:225-35. 2001
    ..Beta-blocking agents, angiotensin-converting enzyme inhibitors, aspirin, and thrombolytic therapy are also effective in the treatment of CVD amongst diabetic patients...
  21. doi request reprint Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: The Finnish Diabetes Prevention
    Tuomas O Kilpeläinen
    Institute of Biomedicine, Physiology, University of Kuopio, Kuopio 70211, Finland
    Metabolism 57:428-36. 2008
    ..In conclusion, genetic variation may modify the magnitude of the beneficial effects of PA on characteristics of the metabolic syndrome in persons with IGT...
  22. ncbi request reprint Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study
    Olli Laukkanen
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    J Clin Endocrinol Metab 89:6286-90. 2004
    ..2 gene...
  23. ncbi request reprint Two novel mutations in the beta-myosin heavy chain gene associated with dilated cardiomyopathy
    Satu Kärkkäinen
    Department of Medicine, Kuopio University Hospital, P O Box 1777, 70211 Kuopio, Finland
    Eur J Heart Fail 6:861-8. 2004
    ..Dilated cardiomyopathy (DCM) is familial in approximately 20-35% of cases of idiopathic DCM. Several mutations in the different sarcomere protein genes have been reported to cause DCM...
  24. ncbi request reprint Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome
    Urpu Salmenniemi
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Circulation 110:3842-8. 2004
    ..Detailed metabolic defects in glucose and energy metabolism and abnormalities in a variety of cardiovascular risk factors are largely unknown in subjects with the metabolic syndrome...
  25. pmc Low-grade inflammation and the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy
    Johanna Kuusisto
    Kuopio University Hospital, Department of Medicine Center for Medicine and Clinical Research, Puijonlaaksontie 2, Finland
    Heart 98:1007-13. 2012
    ..To investigate the role of inflammation in the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy (HCM)...
  26. ncbi request reprint The G-250A polymorphism in the hepatic lipase gene promoter is associated with changes in hepatic lipase activity and LDL cholesterol: The KANWU Study
    Virpi Lindi
    University of Kuopio, Department of Clinical Nutrition, P O Box 1627, FIN 70211 Kuopio, Finland
    Nutr Metab Cardiovasc Dis 18:88-95. 2008
    ..A common G-250A polymorphism in the promoter of the hepatic lipase gene (LIPC) has been described. The aim was to study the effects of the G-250A polymorphism on HL activity, serum lipid profile and insulin sensitivity...
  27. doi request reprint The common variant in the FTO gene did not modify the effect of lifestyle changes on body weight: the Finnish Diabetes Prevention Study
    Tiina J Lappalainen
    School of Public Health and Clinical Nutrition, Department of Clinical Nutrition, Food and Health Research Centre, University of Kuopio, Kuopio, Finland
    Obesity (Silver Spring) 17:832-6. 2009
    ..Based on the results from the DPS, it is unlikely that the common variant of the FTO gene affects the success of lifestyle modification on weight loss...
  28. ncbi request reprint The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia
    Agata Kubaszek
    Department of Medicine, University of Kuopio, Finland
    Diabetes Care 26:464-7. 2003
    ..To investigate the relationship of the K121Q polymorphism of the plasma cell glycoprotein 1 (PC-1) gene with insulin resistance, insulin secretion, and lipids and lipoproteins...
  29. ncbi request reprint The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain
    Jarno Rutanen
    Department of Medicine, Kuopio University Hospital, PB 1777, 70211 Kuopio, Finland
    Obes Res 12:1060-6. 2004
    ..The melanocortin-4 receptor (MC4R) regulates energy intake. On the basis of animal studies, it may also regulate energy expenditure...
  30. ncbi request reprint Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes
    Yuvaraj Mahendran
    Institute of Clinical Sciences, Internal Medicine YM, HC, JV, As, JK, and ML, the Institute of Biomedicine Physiology JÅ, and the Institute of Public Health and Clinical Nutrition MU and US, University of Eastern Finland, Kuopio, Finland, and the Research Unit MU and the Department of Medicine HC, JK, and ML, Kuopio University Hospital, Kuopio, Finland
    Am J Clin Nutr 99:79-85. 2014
    ..The significance of erythrocyte membrane fatty acids (EMFAs) and their ratios to predict hyperglycemia and incident type 2 diabetes is unclear...
  31. pmc Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men
    Yuvaraj Mahendran
    Department of Medicine, University of Eastern Finland, Kuopio, Finland
    Diabetes 62:3618-26. 2013
    ..In conclusion, high levels of KBs predicted subsequent worsening of hyperglycemia, and a common variant of GCKR was significantly associated with BHB levels. ..
  32. ncbi request reprint HLA genotyping is useful in the evaluation of the risk for coeliac disease in the 1st-degree relatives of patients with coeliac disease
    Hannele Karinen
    Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Scand J Gastroenterol 41:1299-304. 2006
    ....
  33. ncbi request reprint Association of adiponectin level and variants in the adiponectin gene with glucose metabolism, energy expenditure, and cytokines in offspring of type 2 diabetic patients
    Urpu Salmenniemi
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    J Clin Endocrinol Metab 90:4216-23. 2005
    ..Adiponectin is an adipose-specific secretory protein abundantly present in the circulation. The role of adiponectin in the control of energy expenditure and substrate utilization has not yet been established...
  34. ncbi request reprint Polymorphisms in the SLC2A2 (GLUT2) gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study
    Olli Laukkanen
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    Diabetes 54:2256-60. 2005
    ..56 [1.78-17.39], P = 0.003) but not in the intervention group. We conclude that the SNPs of SLC2A2 predict the conversion to diabetes in obese subjects with IGT...
  35. ncbi request reprint SNPs in PPARG associate with type 2 diabetes and interact with physical activity
    Tuomas O Kilpeläinen
    Institute of Biomedicine, Physiology, University of Kuopio, Kuopio, Finland
    Med Sci Sports Exerc 40:25-33. 2008
    ....
  36. doi request reprint The metabolism of plant sterols is disturbed in postmenopausal women with coronary artery disease
    Helena Gylling
    Department of Clinical Nutrition, University of Kuopio, FIN 70211 Kuopio, Finland
    Metabolism 58:401-7. 2009
    ..Other relative markers of cholesterol metabolism were related to the absolute ones in both groups. ABCG5 and ABCG8 genes were not associated with the risk of CAD...
  37. ncbi request reprint Promoter polymorphisms of the TNF-alpha (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study
    Agata Kubaszek
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Diabetes 52:1872-6. 2003
    ..Furthermore, this polymorphism seems to have a gene-gene interaction with the C-174C genotype of the IL-6 gene...
  38. ncbi request reprint The Leu7Pro polymorphism of the neuropeptide Y gene regulates free fatty acid metabolism
    Jussi Pihlajamaki
    Departments of Medicine and Clinical Nutrition, University of Kuopio, Kuopio, Finland and the Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland
    Metabolism 52:643-6. 2003
    ..003). In conclusion, the Leu7Pro polymorphism of the NPY gene associates with alterations in FFA metabolism but does not have an impact on insulin sensitivity, insulin secretion, or glucose metabolism...
  39. doi request reprint The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis
    Taina Koponen
    Biotechnology and Molecular Medicine, A I Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, Kuopio Campus, P O Box 1627, 70211, Kuopio, Finland
    Amino Acids 42:427-40. 2012
    ....
  40. ncbi request reprint Leptin receptor gene variation predicts weight change in subjects with impaired glucose tolerance
    Jelena Zacharova
    Department of Medicine, University of Kuopio, Finland
    Obes Res 13:501-6. 2005
    ..However, this polymorphism was associated with a significant weight change, suggesting that it may potentially modulate the risk for type 2 diabetes...
  41. pmc Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study
    Titta Salopuro
    University of Kuopio, Department of Clinical Nutrition and Food and Health Research Center, Kuopio, Finland
    BMC Med Genet 10:94. 2009
    ..2 +/- 4.5 kg/m2, age: 55 +/- 7 years) for whom DNA was available were randomized to either an intensified diet and physical activity group or to a conventional care control group...
  42. ncbi request reprint Markers of endothelial dysfunction and low-grade inflammation are associated in the offspring of type 2 diabetic subjects
    Eija Ruotsalainen
    University of Kuopio, Department of Medicine, 70210 Kuopio, Finland
    Atherosclerosis 197:271-7. 2008
    ..Inflammatory markers and adhesion molecules were correlated suggesting that low-grade inflammation may precede the elevation of levels of adhesion molecules...
  43. doi request reprint Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans
    Jarno Rutanen
    Department of Medicine, University of Kuopio and Kuopio University Hospital, 70210 Kuopio, Finland
    Obesity (Silver Spring) 15:2902-7. 2007
    ..No differences in BMI, waist circumference, or glucose or insulin levels in an oral glucose tolerance test among the genotypes were found. In conclusion, SNPs of MCHR1 did not have effects on metabolic variables in humans...
  44. ncbi request reprint Changes in cytokine levels during acute hyperinsulinemia in offspring of type 2 diabetic subjects
    Eija Ruotsalainen
    University of Kuopio, Department of Medicine, Kuopio, Finland
    Atherosclerosis 210:536-41. 2010
    ..To investigate the changes in the levels of cytokines and adhesion molecules in response to acute hyperinsulinemia in the offspring of type 2 diabetic subjects...
  45. ncbi request reprint Plasma cell membrane glycoprotein-1 K121Q polymorphism in preeclampsia
    Tanja Saarela
    Department of Obstetrics and Gynaecology, University of Kuopio, Kuopio, Finland
    Gynecol Obstet Invest 61:124-7. 2006
    ..We wanted to determine whether genetic variability in the gene encoding plasma cell membrane glycoprotein-1 (PC-1) contributes to individual susceptibility to the development of preeclampsia...
  46. doi request reprint Electrocardiographic alterations during hyperinsulinemic hypoglycemia in healthy subjects
    Tomi Laitinen
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Kuopio, Kuopio, Finland
    Ann Noninvasive Electrocardiol 13:97-105. 2008
    ..We evaluated the arrhythmogenic potential of hypoglycemia by studying electrocardiographic (ECG) changes in response to hyperinsulinemic hypoglycemia and associated sympathoadrenal counterregulatory responses in healthy subjects...
  47. ncbi request reprint The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study
    Boryana Todorova
    Department of Medicine, University of Kuopio, 70210 Kuopio
    J Clin Endocrinol Metab 89:2019-23. 2004
    ..001). We conclude that the G-250G genotype of the LIPC gene is a risk factor for type 2 diabetes. Therefore, genes regulating lipid and lipoprotein metabolism may be potential candidate genes for type 2 diabetes...
  48. ncbi request reprint Visceral obesity is associated with high levels of serum squalene
    Paula Peltola
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Obesity (Silver Spring) 14:1155-63. 2006
    ..To investigate the impact of visceral obesity on cholesterol metabolism in normoglycemic offspring of patients with type 2 diabetes...
  49. ncbi request reprint Cine MR imaging of myocardial contractile impairment in patients with hypertrophic cardiomyopathy attributable to Asp175Asn mutation in the alpha-tropomyosin gene
    Petri Sipola
    Department of Clinical Radiology, Kuopio University Hospital, Puijonlaaksontie 2, Kuopio FIN 70210, Finland
    Radiology 236:815-24. 2005
    ....
  50. ncbi request reprint Association of the Pro12Ala polymorphism in the PPAR-gamma2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study
    Virpi I Lindi
    Department of Clinical Nutrition, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Diabetes 51:2581-6. 2002
    ..However, beneficial changes in diet, increases in physical activity, and weight loss may reverse, to some extent, the diabetogenic impact of the Ala12 allele, possibly due to an improved insulin sensitivity...
  51. doi request reprint Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis
    Eija Pirinen
    Department of Medicine, University of Kuopio, P O Box 1777, 70211, Kuopio, Finland
    Amino Acids 38:549-60. 2010
    ..In summary, activated-polyamine catabolism is a novel mechanism to regulate bile acid synthesis. Therefore, polyamine catabolism could be a potential therapeutic target to control hepatic CYP7A1 expression...
  52. doi request reprint Desmosterol in human nonalcoholic steatohepatitis
    Marko Simonen
    Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Finland
    Hepatology 58:976-82. 2013
    ..Whether desmosterol has a more specific role in the pathophysiology of NASH compared to other cholesterol precursors needs to be investigated...
  53. pmc Adipose tissue TCF7L2 splicing is regulated by weight loss and associates with glucose and fatty acid metabolism
    Dorota Kaminska
    Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    Diabetes 61:2807-13. 2012
    ..Our study shows that the short TCF7L2 mRNA variant in subcutaneous fat is regulated by weight loss and is associated with hyperglycemia and impaired insulin action in adipose tissue...
  54. doi request reprint Identification of undiagnosed type 2 diabetic individuals by the finnish diabetes risk score and biochemical and genetic markers: a population-based study of 7232 Finnish men
    Jianjun Wang
    Department of Medicine, University of Kuopio and Kuopio University Hospital, 70210 Kuopio, Finland
    J Clin Endocrinol Metab 95:3858-62. 2010
    ..However, it is unknown whether biochemical markers or confirmed type 2 diabetes risk genes improve the risk evaluation beyond the FINDRISC...
  55. ncbi request reprint Single nucleotide polymorphisms of the melanocortin-3 receptor gene are associated with substrate oxidation and first-phase insulin secretion in offspring of type 2 diabetic subjects
    Jarno Rutanen
    Departments of Medicine, University of Kuopio and Kuopio University Hospital, 70210 Kuopio, Finland
    J Clin Endocrinol Metab 92:1112-7. 2007
    ..The Thr/Thr 6 and Val/Val81 [corrected] polymorphisms of the MC3R gene have been previously associated with high insulin levels and obesity in children...
  56. ncbi request reprint Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzheimer's disease in the Finnish population
    Anne M Koivisto
    Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    Dement Geriatr Cogn Disord 22:449-53. 2006
    ..026). These results suggest that the PPARgamma gene may modify the age of onset in LOAD...
  57. ncbi request reprint Cholesterol synthesis prevails over absorption in metabolic syndrome
    Helena Gylling
    Department of Clinical Nutrition, Food and Health Research Centre, Institute of Biomedicine, University of Kuopio, Kuopio, Finland
    Transl Res 149:310-6. 2007
    ..The perturbations of cholesterol metabolism seem to be related to abdominal obesity, and weight reduction might normalize cholesterol metabolism...
  58. ncbi request reprint The effect of the -308A allele of the TNF-alpha gene on insulin action is dependent on obesity
    Jussi Pihlajamaki
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Obes Res 11:912-7. 2003
    ..We investigated whether the effect of the G-308A polymorphism of the TNF-alpha gene on insulin action depends on BMI...
  59. ncbi request reprint Effects of euglycaemic and hypoglycaemic hyperinsulinaemia on sympathetic and parasympathetic regulation of haemodynamics in healthy subjects
    Tomi Laitinen
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, P O Box 1777, FIN 70211, Kuopio, Finland
    Clin Sci (Lond) 105:315-22. 2003
    ..Counter-regulation during hyperinsulinaemic hypoglycaemia involves selective adrenomedullary sympathetic activation, and does not influence cardiac parasympathetic regulation or baroreflex control of heart rate...
  60. pmc Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism
    Eija Pirinen
    Department of Medicine, University of Kuopio, P O Box 1777, FI 70211 Kuopio, Finland
    Mol Cell Biol 27:4953-67. 2007
    ..The involvement of polyamine catabolism in the regulation of energy and glucose metabolism may offer a novel target for drug development for obesity and type 2 diabetes...
  61. ncbi request reprint Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta gene are associated with skeletal muscle glucose uptake
    Markku Vänttinen
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    Diabetes 54:3587-91. 2005
    ..Our results give evidence that SNPs of PPARD regulate insulin sensitivity particularly in skeletal muscle...
  62. ncbi request reprint Polymorphisms of interleukin-6, hepatic lipase and calpain-10 genes, and preeclampsia
    Tanja Saarela
    Department of Obstetrics and Gynecology, University of Kuopio, Finland
    Eur J Obstet Gynecol Reprod Biol 128:175-9. 2006
    ..We determined whether single nucleotide polymorphisms (SNPs) in interleukin-6 (IL-6), hepatic lipase (HL) and calpain-10 (CAPN-10) genes contribute to susceptibility to develop preeclampsia...
  63. ncbi request reprint Serum zinc level and coronary heart disease events in patients with type 2 diabetes
    Minna Soinio
    Department of Medicine, University of Turku, Turku, Finland
    Diabetes Care 30:523-8. 2007
    ..Low serum zinc level may predispose nondiabetic subjects to cardiovascular diseases. Our aim was to investigate whether serum zinc level predicts coronary heart disease (CHD) events in subjects with type 2 diabetes..
  64. pmc Insulin secretion and its determinants in the progression of impaired glucose tolerance to type 2 diabetes in impaired glucose-tolerant individuals: the Finnish Diabetes Prevention Study
    Vanessa D F de Mello
    Institute of Public Health and Clinical Nutrition, Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    Diabetes Care 35:211-7. 2012
    ....
  65. pmc Impact of positive family history and genetic risk variants on the incidence of diabetes: the Finnish Diabetes Prevention Study
    Matti I Uusitupa
    Institute of Public Health and Clinical Nutrition, Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    Diabetes Care 34:418-23. 2011
    ....
  66. ncbi request reprint The Pro12Ala polymorphism of the PPAR gamma 2 gene regulates weight from birth to adulthood
    Jussi Pihlajamaki
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Obes Res 12:187-90. 2004
    ..In this study, the effect of the Pro12Ala polymorphism on long-term changes in weight and body composition was investigated...
  67. ncbi request reprint Similarity of the impact of type 1 and type 2 diabetes on cardiovascular mortality in middle-aged subjects
    Auni Juutilainen
    Kuopio University Hospital, Kuopio, Finland
    Diabetes Care 31:714-9. 2008
    ..To compare the risk of cardiovascular disease (CVD) death and the impact of hyperglycemia on the risk of CVD mortality associated with type 1 diabetes to that associated with type 2 diabetes...
  68. doi request reprint Long-term consumption of plant stanol and sterol esters, vascular function and genetic regulation
    Helena Gylling
    Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Br J Nutr 101:1688-95. 2009
    ....
  69. ncbi request reprint Single nucleotide polymorphisms of the HNF4alpha gene are associated with the conversion to type 2 diabetes mellitus: the STOP-NIDDM trial
    Laura Andrulionyte
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    J Mol Med (Berl) 84:701-8. 2006
    ..Our results suggest that SNPs of HNF4A and their haplotypes predispose to type 2 diabetes mellitus in female subjects of the STOP-NIDDM study population...
  70. ncbi request reprint Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial
    Laura Andrulionyte
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    Diabetes 55:2148-52. 2006
    ..We conclude that SNPs in PPARD modify the conversion from IGT to type 2 diabetes, particularly in combination with the SNPs of PGC-1A and PPARG2...
  71. ncbi request reprint A novel mutation, Ser143Pro, in the lamin A/C gene is common in finnish patients with familial dilated cardiomyopathy
    Satu Kärkkäinen
    Department of Medicine, University of Kuopio, P O Box 1777, Kuopio, Finland
    Eur Heart J 25:885-93. 2004
    ..The mutations most frequently associated with dilated cardiomyopathy (DCM) have been reported in the lamin A/C gene. The role of variants of the lamin A/C gene was investigated in patients with DCM from eastern and southern Finland...
  72. doi request reprint Two founder mutations in the alpha-tropomyosin and the cardiac myosin-binding protein C genes are common causes of hypertrophic cardiomyopathy in the Finnish population
    Pertti Jääskeläinen
    Heart Center, Kuopio University Hospital, Kuopio, Finland
    Ann Med 45:85-90. 2013
    ..However, two prevalent founder mutations for HCM in the alpha-tropomyosin (TPM1-D175N) and myosin-binding protein C (MYBPC3-Q1061X) genes have previously been identified in eastern Finland...
  73. ncbi request reprint Changes in inflammatory cytokines are related to impaired glucose tolerance in offspring of type 2 diabetic subjects
    Eija Ruotsalainen
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    Diabetes Care 29:2714-20. 2006
    ..We sought to determine whether levels of inflammatory markers and different cytokines are abnormal in nondiabetic offspring of type 2 diabetic subjects...
  74. ncbi request reprint Type 2 diabetes as a "coronary heart disease equivalent": an 18-year prospective population-based study in Finnish subjects
    Auni Juutilainen
    University of Kuopio and Kuopio University Hospital, Department of Medicine, 70210 Kuopio, Finland
    Diabetes Care 28:2901-7. 2005
    ....
  75. ncbi request reprint Adiponectin gene haplotype is associated with preeclampsia
    Tanja Saarela
    Department of Obstetrics and Gynaecology, University of Kuopio, Kuopio, Finland
    Genet Test 10:35-9. 2006
    ..042 +/- 0.005). Polymorphisms of the adiponectin gene show a weak, but statistically significant, haplotype association with susceptibility to preeclampsia in Finnish women...
  76. ncbi request reprint Progression of kidney disease varies between families with defects in the polycystic kidney disease type 1 gene in eastern Finland
    Anne Lumiaho
    Department of Medicine, Kuopio University Hospital, Finland
    Scand J Urol Nephrol 37:352-8. 2003
    ..To characterize, for the first time, the phenotype and clinical course of autosomal dominant polycystic kidney disease (ADPKD) in Finnish patients...
  77. ncbi request reprint Increased atherosclerotic lesion calcification in a novel mouse model combining insulin resistance, hyperglycemia, and hypercholesterolemia
    Suvi E Heinonen
    Department of Biotechnology and Molecular Medicine, A I Virtanen Institute, University of Kuopio, PO Box 1627, FI 70211, Kuopio, Finland
    Circ Res 101:1058-67. 2007
    ..In conclusion, type 2 diabetic factors induce increased calcification and lesion progression without any lipid changes in a new mouse model of diabetic macroangiopathy...
  78. doi request reprint The metabolic syndrome predicts incident stroke: a 14-year follow-up study in elderly people in Finland
    Jianjun Wang
    Department of Medicine, Cardiology Unit, Kuopio University Hospital, P O Box 1777, 70211 Kuopio, Finland
    Stroke 39:1078-83. 2008
    ..We investigated the relationship of the MetS and its single components, defined by 6 different criteria, with stroke in a prospective population-based study...
  79. ncbi request reprint Genetics of hypertrophic cardiomyopathy in eastern Finland: few founder mutations with benign or intermediary phenotypes
    Pertti Jääskeläinen
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Ann Med 36:23-32. 2004
    ..We conclude that the genetic profile of HCM in eastern Finland is unique, characterized by few founder mutations with benign or intermediary phenotypes...
  80. ncbi request reprint Tumour necrosis factor-alpha gene haplotype is associated with pre-eclampsia
    Tanja Saarela
    Department of Obstetrics and Gynaecology, University of Kuopio, Kuopio, Finland
    Mol Hum Reprod 11:437-40. 2005
    ..035+/-0.003), compared with the controls. In conclusion, the polymorphisms of the TNF-alpha gene showed a significant haplotype association with susceptibility to pre-eclampsia in the Finnish population...
  81. ncbi request reprint Metabolic syndrome and incident end-stage peripheral vascular disease: a 14-year follow-up study in elderly Finns
    Jianjun Wang
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Diabetes Care 30:3099-104. 2007
    ..We investigated the relationship of the metabolic syndrome and its single components, defined by four different criteria, with peripheral vascular disease (PVD) in a prospective population-based study...
  82. ncbi request reprint Genetics and phenotypic characteristics of autosomal dominant polycystic kidney disease in Finns
    Paula Peltola
    Department of Medicine, University of Kuopio, P O Box 1777, 70211 Kuopio, Finland
    J Mol Med (Berl) 83:638-46. 2005
    ....
  83. ncbi request reprint The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity
    Agata Kubaszek
    Department of Medicine, University of Kuopio, Finland
    Diabetes 52:558-61. 2003
    ..Whether this polymorphism is a risk factor for obesity or type 2 diabetes can be estimated only in prospective population-based studies...
  84. ncbi request reprint Insulin resistance syndrome predicts coronary heart disease events in elderly type 2 diabetic men
    J Kuusisto
    Department of Medicine, University of Kuopio, FIN-70211 Kuopio, Finland
    Diabetes Care 24:1629-33. 2001
    ..34, 1.03-1.74, P = 0.03). CONCLUSIONS: IRS is a risk factor for CHD in elderly type 2 diabetic men...
  85. ncbi request reprint New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes
    H Wang
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Diabetes 50:1949-51. 2001
    ..Thus, the variants in the coding part of the IRS-2 gene are unlikely to have a major role in the development of type 2 diabetes in Finnish or Chinese subjects...
  86. ncbi request reprint The association of the K121Q polymorphism of the plasma cell glycoprotein-1 gene with type 2 diabetes and hypertension depends on size at birth
    Agata Kubaszek
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    J Clin Endocrinol Metab 89:2044-7. 2004
    ..We conclude that the interaction between the K121Q polymorphism of the PC-1 gene and birth length affects insulin sensitivity and increases susceptibility to type 2 diabetes and hypertension in adulthood...
  87. ncbi request reprint The common polymorphisms (single nucleotide polymorphism [SNP] +45 and SNP +276) of the adiponectin gene predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial
    Jelena Zacharova
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    Diabetes 54:893-9. 2005
    ..004). In conclusion, the G-allele of SNP +45 is a predictor for the conversion to type 2 diabetes. Furthermore, the combined effect of SNP +45 and SNP +276 on the development of type 2 diabetes was stronger than that of each SNP alone...
  88. ncbi request reprint Association of leucine 7 to proline 7 polymorphism in the preproneuropeptide Y with serum lipids in patients with coronary heart disease
    Arja T Erkkilä
    Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Mol Genet Metab 75:260-4. 2002
    ..In conclusion, the Pro7 allele in the NPY gene was associated with higher serum total cholesterol concentration only in women with CHD who did not use lipid-lowering drugs...
  89. ncbi request reprint Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men
    Jussi Pihlajamaki
    Department of Medicine, University of Kuopio, Kuopio, Finland
    J Lipid Res 45:507-12. 2004
    ....
  90. ncbi request reprint Variants of the fatty acid-binding protein 2 gene are not associated with coronary heart disease in nondiabetic subjects and in patients with NIDDM
    L Saarinen
    Department of Medicine, University of Kuopio, Finland
    Diabetes Care 21:849-50. 1998
    ..To investigate the association of variants of the fatty acid-binding protein (FABP) 2 gene with coronary heart disease (CHD) in nondiabetic subjects and in patients with NIDDM...
  91. ncbi request reprint Promoter polymorphisms -359T/C and -303A/G of the catalytic subunit p110beta gene of human phosphatidylinositol 3-kinase are not associated with insulin secretion or insulin sensitivity in finnish subjects
    Maija Kossila
    A I Virtanen Institute for Molecular Sciences, Kuopio Department of Medicine, University of Kuopio, Kuopio, Finland
    Diabetes Care 26:179-82. 2003
    ..In this study, we determined the effects of these polymorphisms on insulin secretion and insulin sensitivity...
  92. ncbi request reprint Carriers of an inactivating beta-cell ATP-sensitive K(+) channel mutation have normal glucose tolerance and insulin sensitivity and appropriate insulin secretion
    Hanna Huopio
    Department of Pediatrics, University of Kuopio, Kuopio, Finland
    Diabetes Care 25:101-6. 2002
    ..The aim of our study was to investigate in vivo the glucose homeostasis of heterozygous SUR1 mutation carriers...
  93. ncbi request reprint Gender difference in the impact of type 2 diabetes on coronary heart disease risk
    Auni Juutilainen
    University of Kuopio, Department of Medicine, 70210 Kuopio, Finland
    Diabetes Care 27:2898-904. 2004
    ..To explain the stronger effect of type 2 diabetes on the risk of coronary heart disease (CHD) in women compared with men...
  94. ncbi request reprint Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease
    Hannele Karinen
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Scand J Gastroenterol 41:191-9. 2006
    ..Conflicting data have been published on the gene dose effect of these HLA alleles on the risk and severity of CD. In this study the aim was to investigate the association between the number of HLA risk alleles and the severity of CD...
  95. ncbi request reprint A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1
    Hanna Huopio
    Department of Paediatrics, University of Kuopio, Kuopio, Finland
    Lancet 361:301-7. 2003
    ..We aimed to characterise glucose metabolism in adults heterozygous for the E1506K mutation...
  96. ncbi request reprint Common polymorphisms in the genes regulating the early insulin signalling pathway: effects on weight change and the conversion from impaired glucose tolerance to Type 2 diabetes. The Finnish Diabetes Prevention Study
    O Laukkanen
    Department of Medicine, University of Kuopio, Finland
    Diabetologia 47:871-7. 2004
    ....
  97. ncbi request reprint Variation in the fatty acid binding protein 2 gene is not associated with markers of metabolic syndrome in patients with coronary heart disease
    A T Erkkilä
    Department of Clinical Nutrition, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Nutr Metab Cardiovasc Dis 12:53-9. 2002
    ....
  98. ncbi request reprint [Autosomal dominant polycystic kidney disease]
    Anne Lumiaho
    KYS n sisätautien klinikka, ja Kuopion yliopisto
    Duodecim 122:200-7. 2006
  99. ncbi request reprint Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity
    Helena Gylling
    Department of Clinical Nutrition, University of Kuopio, Kuopio University Hospital, Kuopio, Finland
    J Lipid Res 45:1660-5. 2004
    ..Low serum cholesterol and cholesterol absorption were linked to the D19H polymorphism of the ABCG8 gene, and characteristics of the insulin resistance syndrome in men were linked with the Q604E polymorphism of the ABCG5 gene...